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1 d within the first 48 h of development (late gastrula).
2 dorsal-specific gene expression in amphioxus gastrula.
3 te, ppl) cell migration within the zebrafish gastrula.
4 m during gut endoderm formation in the mouse gastrula.
5 ic endodermal expression in the blastula and gastrula.
6 for both D/V and A/P patterning of the early gastrula.
7 eron-inducible transmembrane proteins in the gastrula.
8 naling centers that pattern the blastula and gastrula.
9 stributed mesodermal fields within the early gastrula.
10 ed out by redundant enzymes in the zebrafish gastrula.
11 mesodermal extension exists in the zebrafish gastrula.
12 anging from the mid-blastula through the mid-gastrula.
13 convergent extension movements in zebrafish gastrula.
14 ein activity specifies cell fates within the gastrula.
15 nd signaling mechanisms patterning the human gastrula.
16 ed in a loss of Sox17alpha expression in the gastrula.
17 sue and regulates somite size in the Xenopus gastrula.
18 he prospective notochord region of the early gastrula.
19 osteriorization of neuroectoderm in the late gastrula.
20 sed in the presumptive mesoderm of the early gastrula.
21 rostral to the primitive streak in the early gastrula.
22 in embryonic mesendoderm cells from Xenopus gastrula.
23 ed throughout the nonaxial region of the spt gastrula.
24 de variety of posterior tissues of the mouse gastrula.
25 ted by the dorsal and ventral centers of the gastrula.
26 ntributes to defective cell movements in the gastrula.
27 mes exclusively in bottle cells in the early gastrula.
28 sors to potential Wnt targets in the Xenopus gastrula.
29 albeit incomplete, is already evident in the gastrula.
30 nt in a broad, crescent-shaped region of the gastrula.
31 in patterning the A/P axis of the amphioxus gastrula.
32 ifically in the dorsolateral mesoderm of the gastrula, a domain that is established by the interactio
36 us endoderm patterning such that during late gastrula and early somite stages of embryogenesis, Wnt a
39 ongest in the presumptive neural ectoderm at gastrula and neural plate stages, but there is minor par
41 Loss of NRH1 function is followed, during gastrula and neurula stages, by a dramatic increase in a
47 -catenin is present in endoderm cells of the gastrula, and depletion of beta-catenin from embryos res
48 extent of mesoderm formation in the Xenopus gastrula, and point to related roles for Xenopus HNF3bet
49 a BMP antagonist in the context of the frog gastrula, and that it acts cooperatively with chordin to
51 evel the observation that cells of the early gastrula are less committed to one germ layer than are c
52 lino concentrations specifically cause a pre-gastrula arrest of cell division and morphogenesis, and
53 x is expressed in the foregut region of late gastrula avian and mammalian embryos in a pattern that o
54 h dorsal and ventral mesoderm across the pre-gastrula axis historically called the dorsal-ventral axi
55 ses, STELLA was immunolocalized to the mouse gastrula between Early Streak (ES) and 12-somite pair (-
58 are essential in generating the presumptive gastrula BMP activity gradient that patterns the dorsal-
59 nction, we find that larvae with reduced mid-gastrula Bmp signaling cannot properly excrete waste.
61 in and zic2, weakly represses sox11 at early gastrula but later (st12) induces it; weakly represses s
62 ed early in development, in the blastula and gastrula, but not at later stages when a putative chemos
64 s a cross-species functional screen of mouse gastrula cDNA libraries for components of endoderm and m
67 he ventral and dorsal tail bud, whereas post-gastrula Chordin activity patterns the derivatives of th
69 ue territories are specified, early and late gastrula, during which important morphogenetic events oc
70 , FGF, and other signaling molecules in late gastrula-early neurula stage embryos generate the border
71 tero-posterior and dorso-ventral axis in the gastrula ectoderm and also has trunk- and tail-promoting
76 ellular levels of Sizzled and Chordin in the gastrula embryo and enzyme reaction constants were all i
78 lusively within the organizer of the Xenopus gastrula embryo and therefore are predicted to act as bo
80 st steps in germ layer patterning of the pre-gastrula embryo to tissue healing, regeneration and home
81 ly restricted to the ventral mesoderm of the gastrula embryo under the signaling control of bone morp
85 c dorsal/ventral (back-to-belly) axis in pre-gastrula embryos and allowed the assignment of the rostr
86 ted by tyrosine autophosphorylation in early gastrula embryos and this upregulation of Wee1 activity
88 an4 (a Wnt co-receptor) and frizzled7 mutant gastrula embryos with disrupted non-canonical Wnt signal
89 r lateral (AL) endoderm and mesoderm of late gastrula embryos, and the earliest stages of liver and h
90 derm in individual cells from early and late gastrula embryos, by both in situ hybridization and sing
97 ntified over 300 transcripts enriched in the gastrula endoderm, including most of the known endoderm
98 t originate from specific regions of the pre-gastrula epiblast, but the plasticity of cells within th
103 ntire antero-posterior axis of the zebrafish gastrula including prechordal plate and ventral dienceph
104 coordinate with WNT signaling to pattern the gastrula, increase the beta-catenin response in a manner
105 mammalian cells, and cells of the Drosophila gastrula inhibit Cdk1 to delay the entry into mitosis.
107 al4-UAS-mediated fezl overexpression in late gastrula is capable of expanding the prethalamus telence
108 dherens junctions in Drosophila melanogaster gastrula is delayed until mesoderm is internalized, desp
109 We report that FoxD3 function in the Xenopus gastrula is essential for dorsal mesodermal development
110 Dorsoventral specification of the zebrafish gastrula is governed by the functions of the dorsal shie
112 in the yolk cell and hypoblast in the early gastrula, just preceding the appearance of the bib mesod
113 show that BMP signaling is nearly absent in gastrula lacking both maternal and zygotic Laf/Alk8 acti
114 Inhibition of Bmp signaling in the early gastrula leads to increased beta-cell numbers and partia
115 expression domains of Xnr-2 and Xbra in the gastrula marginal zone appear to mark presumptive blood
117 le, and in the embryo it is expressed in the gastrula marginal zone, neural plate, and cranial and tr
119 al (trunk and tail) regions of the zebrafish gastrula, neural specification is initiated at all DV po
123 During vertebrate development the dorsal gastrula or Spemann-Mangold organizer orchestrates axis
125 eta-catenin-mediated induction of the dorsal gastrula organizer and place boz at the top of a hierarc
126 es for prdm1 in limiting the function of the gastrula organizer and regulating cell fate specificatio
127 boz and Nodal signaling largely cooperate in gastrula organizer formation, they have opposing roles i
132 een shown to be a determinant at the Xenopus gastrula organizer region and a segment-polarity determi
137 lled to the opposite cell edges in zebrafish gastrula parallels their distribution in fly, and sugges
139 se results we conclude that in the amphioxus gastrula RA signaling primarily acts via regulation of H
140 linker region localizes to a ventral vegetal gastrula region that could coordinate DV patterning with
142 ONT1 expression in the organizer of the late gastrula stabilizes the gradient of BMP signaling that i
143 the injected quadrant, while at mid- to late-gastrula stage and beyond, more PMCs are found outside t
144 fic GFP reporter DNA construct were grown to gastrula stage and their fluorescence recorded as a seri
147 ned along the dorsal-ventral axis during the gastrula stage by opposing gradients of Bmps and Bmp inh
149 different steps: first, an induction at the gastrula stage dependent on signals arising from the dor
150 non-axial mesoderm occurs across the classic gastrula stage DV axis while DV patterning aligns along
151 plate precursor cells in the epiblast of the gastrula stage embryo, and does not share a lineage with
152 should be highest on the dorsal side of the gastrula stage embryo, we have found that while Smad2 ph
154 strate that HBX2 specifically interacts with gastrula stage embryonic extracts and that in vitro tran
155 trulation, we manipulated Notch signaling in gastrula stage embryos and examined gene expression in r
156 al mesendoderm (Spemann organizer tissue) of gastrula stage embryos and that its expression is regula
157 However, our analysis of these pathways in gastrula stage embryos indicates that the MAP kinase pat
159 Smurf1 is enriched on the dorsal side of gastrula stage embryos, and blocking Smurf1 disturbs neu
160 vation of the Notch pathway, specifically in gastrula stage embryos, results in a dramatic decrease i
165 ntral halves of axin-depleted embryos at the gastrula stage have dramatically increased levels of cho
166 m, transcripts first being detectable at the gastrula stage in a ring of mesendoderm just inside the
168 ters containing more than 72000 cDNAs from a gastrula stage library were hybridized with differential
169 pts are detected in the visceral endoderm of gastrula stage mouse embryos, suggesting a signaling rol
170 n of the Xenopus ABCE1 arrests growth at the gastrula stage of development, consistent with a block i
176 etal cells of Xenopus embryos from the early gastrula stage onwards, when these cells become committe
178 own that retinoic acid (RA) signaling at the gastrula stage strongly influences anterior-posterior (A
179 gly, we find that Bmp signaling from the mid-gastrula stage through early somitogenesis is important
180 gnaling acts from early cleavage through the gastrula stage to specify and maintain dorsal/anterior d
181 have undertaken a transcriptomic analysis on gastrula stage Xenopus embryos in which MyoD has been kn
182 estricted to lateral and ventral mesoderm in gastrula stage Xenopus embryos, leading us to investigat
183 study, mesendodermal cells and tissues from gastrula stage Xenopus laevis embryos demonstrate that d
184 bra in the presumptive trunk and tail at the gastrula stage, and find that they fate to presumptive s
185 xtends across to the ventral side by the mid-gastrula stage, and is then turned off in the dorsal ect
186 in presumptive dorsal cells from cleavage to gastrula stage, and provided functional evidence that Wn
187 ior development while, starting at the early gastrula stage, BMP signaling promotes ventral/posterior
188 axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not
189 tral mesoderm of the zebrafish embryo at the gastrula stage, by directly interfering with the binding
190 ssed in the S. purpuratus embryo, up to late gastrula stage, by means of high-resolution custom tilin
191 amming onset was first observed at the early gastrula stage, even if the cells to be replaced were re
194 igate the targets of RA signaling during the gastrula stage, we used the basal chordate amphioxus, in
195 g in the basal chordate amphioxus during the gastrula stage, which is the RA-sensitive period for ant
196 mesoderm and endoderm cells up to the early gastrula stage, while module 24 generates late endoderma
210 lateral edges of the neural plate at the mid-gastrula stage; in contrast to its mouse and chick ortho
212 n patterns of these markers in blastula- and gastrula-stage chick embryos, using whole-mount in situ
214 a critical window of development in the late gastrula-stage embryo when vitamin A is essential for no
215 limiting for nuclear growth, we encapsulated gastrula-stage embryonic cytoplasm and nuclei in droplet
216 tides results in normal development of early gastrula-stage embryos but abnormal, asymmetric larvae.
217 mal mouse development when transplanted into gastrula-stage embryos, providing in vivo functional val
219 have identified a molecular pathway linking gastrula-stage endoderm patterning to organ specificatio
221 xpression of the homeobox gene Pitx2 links a gastrula-stage intercellular signalling cascade to the l
223 animal cap explants, although expression of gastrula-stage mesodermal markers was very weak and subs
224 orting from disaggregated late blastula- and gastrula-stage sea urchin embryos according to the regul
225 l of neural transformation in which a planar gastrula-stage Wnt8 signal, promoted by Nodal signaling
227 at is expressed ubiquitously at blastula and gastrula stages and is enriched in neural tissues and th
228 with nlz1 in a broad posterior domain during gastrula stages as well as at the midbrain-hindbrain bou
229 ion of plakoglobin protein during the egg to gastrula stages caused collapse of embryonic architectur
230 ly asymmetric cell divisions at blastula and gastrula stages give rise to the superficial (apical) an
231 urprise, levels of Xbra are elevated at late gastrula stages in such embryos, and over-expression of
232 ors ectopically accumulate in the PS at late gastrula stages in Wnt5a(-/-); Wnt11(-/-) embryos and th
233 th, while cell death during the blastula and gastrula stages is random and predominantly caspase-medi
236 d dynamic pattern in the nervous system from gastrula stages onward, with lesser expression in mesode
238 on of Smad2 signaling in the neural plate at gastrula stages results in inhibition of neural markers,
239 ct in the regulation of Cdx genes and during gastrula stages the normal expression of the Cdx genes r
240 lation, but becomes insensitive during early gastrula stages when Hairy2a/Dlx5 requires an inhibition
242 rmal and non-neural ectodermal fates even at gastrula stages, after the conventionally assigned end o
243 sumptive rhombomere (r) 3/r4 boundary during gastrula stages, and its expression progressively expand
244 erm expresses lvnumb during the blastula and gastrula stages, and that the protein is localized to th
248 h the NP is sensitive to BMP levels at early gastrula stages, Hairy2a/Dlx5 expression is unaffected.
251 ucts of an FGF induction at the blastula and gastrula stages, initially express neural plate-specific
252 signaling plays an essential role during the gastrula stages, it has not been possible with mutants o
255 al skeleton first occurs around mid- to late-gastrula stages, when some PMCs from an aboral quadrant
256 pus embryos are large, and during the egg to gastrula stages, when there is little extracellular matr
278 expressed as early as 30% epiboly and during gastrula stages: in the germ ring, shield, prechordal pl
279 of the blastoderm and for rare cells of the gastrula that involute into the hypoblast, motility appe
280 the entire vegetal half was removed at early gastrula, the animal caps reprogrammed and replaced the
281 embryos transcriptionally capture the mouse gastrula, their ability to recapitulate complex morphoge
282 le many of these proteins are expressed post-gastrula, their later roles have typically remained uncl
283 last of pre-streak embryos, and in the early gastrula they are located in the mid-primitive streak, f
285 ange in BMP necessity from BMP inhibition at gastrula to BMP activation at neurula stages is further
291 ling molecules are found in the blastula and gastrula vegetal pole and induce both endoderm and mesod
295 fate maps of the zebrafish late blastula and gastrula, we demonstrate that individual cells can give
296 be expressed in the mesoendoderm of Xenopus gastrula were characterized according to their modes of
297 The dorsal/anterior endoderm of the Xenopus gastrula, which expresses Hex and the putative head-indu
298 -cripto, which begins in the epiblast of the gastrula, with a pattern similar to EGF-CFC genes of oth