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1 and postimplantation mouse embryo, including gastrulation.
2 aling dynamics in an in vitro model of human gastrulation.
3 an of primate development from blastocyst to gastrulation.
4 rior-posterior symmetry in mammals occurs at gastrulation.
5 N factors and the morphogenetic movements of gastrulation.
6 n directed mesenchymal cell migration during gastrulation.
7 P), WNT, and NODAL pathways is necessary for gastrulation.
8 se cell-fate maps from fertilization through gastrulation.
9 vern the cell-fate decisions associated with gastrulation.
10 dherens junction-cytoskeletal linkage during gastrulation.
11 ified via inhibition of BMP signaling during gastrulation.
12 cise positioning of organs during vertebrate gastrulation.
13 endoderm/mesoderm genes and is essential for gastrulation.
14 d the embryo catastrophically fails early in gastrulation.
15 es specific LPM reporter activity from early gastrulation.
16 t two distinct time points-before and during gastrulation.
17 onstrated by functional perturbations during gastrulation.
18  shell provide additional forces that affect gastrulation.
19             Mesoderm induction begins during gastrulation.
20  pluripotency protein Ventx2 at the onset of gastrulation.
21 internalization of the ventral furrow during gastrulation.
22 ipotent states, before lineage commitment at gastrulation.
23 ess than half of the genomes needed to reach gastrulation.
24 invagination of the mesoderm at the onset of gastrulation.
25 tes mesendoderm development during zebrafish gastrulation.
26 uratus, from the eight-cell stage to late in gastrulation.
27  h post-fertilization, immediately following gastrulation.
28 of early mesoderm formation during mammalian gastrulation.
29  postpone EMT during Drosophila melanogaster gastrulation.
30 he other state is transiently present during gastrulation.
31 iated with pattern formation at the onset of gastrulation.
32 or Wnt signaling activation during embryonic gastrulation.
33 non-canonical Wnt pathways during vertebrate gastrulation.
34 d evolution of similar transitions in animal gastrulation.
35 hogenesis and papc expression during Xenopus gastrulation.
36 pts by Affymetrix GeneChip microarray before gastrulation.
37 arise from basal posterior progenitors after gastrulation.
38  spatiotemporal pattern starting during late gastrulation.
39 that drive initial cell shape changes during gastrulation.
40  the conditions for successful pregnancy and gastrulation.
41 l, whose function is required for vertebrate gastrulation.
42 in pigment cells, and its inhibition impairs gastrulation.
43  during germ layer formation at the onset of gastrulation.
44  several aspects of embryogenesis, including gastrulation.
45 enous strain during a critical period around gastrulation.
46 f Smad2/3 binding and gene expression during gastrulation.
47 vergence and extension cell behaviors during gastrulation.
48 ibits the repression of lambda-olt 2-1 after gastrulation.
49 dination of embryo growth, morphogenesis and gastrulation.
50 ity and cell blebbing, eventually abrogating gastrulation.
51 niche, and germ line commitment occurs after gastrulation.
52 rocess of apical constriction during Xenopus gastrulation.
53 in convergent extension movements in Xenopus gastrulation.
54  blastopore closure throughout the course of gastrulation.
55 ndent epiblast populations, specified before gastrulation.
56  constriction during Drosophila melanogaster gastrulation.
57 ession of individual cells start well before gastrulation.
58 y modulation and tissue morphogenesis during gastrulation.
59  (YSL) secretes a ventralizing signal during gastrulation.
60 e development, from the two-cell stage up to gastrulation.
61 stic and can form multiple individuals until gastrulation.
62 er emerging from the primitive streak during gastrulation.
63 rs of endoderm, mesoderm and ectoderm during gastrulation.
64 TGFbeta) signal expressed posteriorly before gastrulation.
65 remodelling facilitates embryo growth before gastrulation.
66 BMP and Wnt signal activity during zebrafish gastrulation.
67 anterior mesoderm lineage development during gastrulation.
68 t of the extensive cell movements that drive gastrulation.
69 E-cadherin, cellular adhesion, and embryonic gastrulation.
70 e from the ooze of primary mesenchyme during gastrulation.
71 ly superseded by a secondary yolk sac during gastrulation.
72 hanges within the initial conceptus prior to gastrulation.
73 mesendoderm-differentiation genes that drive gastrulation.
74 s and, at least in mice, to the induction of gastrulation.
75 rom dorsal mesoderm formed during vertebrate gastrulation.
76  lineage-specific epigenetic patterns during gastrulation.
77 esults in an additional nuclear cycle before gastrulation.
78 ient of the morphogen Nodal during zebrafish gastrulation.
79 ells induced by a diffusing morphogen during gastrulation.
80 per understanding of tissue formation during gastrulation.
81  PAE immediately following the completion of gastrulation.
82 ent DNA regions, changing dramatically after gastrulation.
83 , cell cycle elongation, Chk1 activation and gastrulation.
84 nsion movements of the trunk mesoderm during gastrulation.
85 most of its segments form sequentially after gastrulation.
86 ning, and results in developmental arrest at gastrulation.
87 to a diploblastic epithelial body plan after gastrulation [2, 3].
88  acquire location-specific cell fates during gastrulation(2-5).
89 ene regulatory network (GRN) at the onset of gastrulation (24 h postfertilization) in N. vectensis Su
90 ex mutant phenotypes that often emerge after gastrulation(3,4).
91                                        Early gastrulation (6 hpf) assessed by goosecoid expression wa
92 go a reduction in bleb protrusions near late gastrulation accompanied by a VANGL planar cell polarity
93 ation and t48, which in the evolution of fly gastrulation acted as a likely switch from an ingression
94                            During Drosophila gastrulation, actomyosin contraction in ventral cells ge
95 lian embryo is shaped through the process of gastrulation, an early developmental event that transfor
96 e describe the role of p120-catenin in mouse gastrulation, an EMT that can be imaged at cellular reso
97 remain receptive to extracellular cues after gastrulation and continue to make basic germ layer decis
98 ot required for force production during late gastrulation and early neurulation.
99 s with substantial tissue specificity during gastrulation and early organogenesis.
100 t cells initiate dorsal convergence near mid-gastrulation and exhibit non-polarized morphologies, lim
101 and transcriptional activity increase before gastrulation and induce ventral mesoderm formation.
102 s TRPM6 (XTRPM6) is elevated at the onset of gastrulation and is concentrated in the lateral mesoderm
103 yury (T, BRA) is one of the first markers of gastrulation and lineage specification in vertebrates.
104                                          The gastrulation and mitotic phenotypes can be rescued by ei
105                      Loss of XTRPM6 produced gastrulation and neural tube closure defects.
106 at drives key morphogenetic events including gastrulation and neural tube formation.
107 al or cellular defects, including failure of gastrulation and problems with placement and function of
108           Here we identify two genes, folded gastrulation and t48, which in the evolution of fly gast
109 he formation of the three germ layers during gastrulation and the differentiation of adult stem cells
110  delamination of mesendodermal precursors at gastrulation and the proper specification of the neural
111 epression of endogenous Bmp signaling during gastrulation and this enables mesodermal progenitors to
112                    They are activated during gastrulation and undergo a dynamic shift from a transcri
113 ion of the transcription factor Gata2 during gastrulation, and Gata2 is required in both ectodermal a
114 r in many developmental processes, including gastrulation, anterior-posterior axis specification, org
115 olds and that the morphogenetic movements of gastrulation are robust to a 3-fold variation in the pos
116             Developmental stages surrounding gastrulation are very sensitive to ethanol exposure.
117                              Using zebrafish gastrulation as a model for collective cell migration, w
118             Knockout embryos did not undergo gastrulation, as demonstrated by the absence of mesoderm
119 n their differentiation propensities along a gastrulation associable and neuralization associable axi
120 ion of Nodal correlated with expression of a gastrulation-associated gene profile, and Nodal down-reg
121 emerge as the cell cycle slows just prior to gastrulation at a major embryonic transition known as th
122 g several annotated in an existing scRNA-seq gastrulation atlas, and use this approach to guide ESC d
123 itially arises in the developing skin during gastrulation, based on the appearance of polarized apica
124                   Treatment with SB43 during gastrulation blocks anterior PMC positioning and the for
125 tively along a fibronectin (FN) substrate at gastrulation, but how the adhesive and mechanical forces
126  epithelial-mesenchymal transition (EMT) and gastrulation, but its role in self-renewal, pluripotency
127 els in cell aggregates and during vertebrate gastrulation, but the role of differential Cdh activity
128 ansfated from notochord to somite fate after gastrulation by ectopic expression of msgn1, a master re
129  developmental delay and failure to initiate gastrulation by embryonic day 7.5.
130 ential for primitive-streak extension during gastrulation by rendering the basement membrane of the p
131 ctions with the extracellular proteins Short gastrulation/Chordin (Chd) and Twisted gastrulation (Tsg
132 sient overactivation of BMP signaling during gastrulation concomitantly blocked mouth formation and c
133                                              Gastrulation constitutes a fundamental yet diverse morph
134 ing, required for hypochord induction during gastrulation, continues to act in the tailbud to specify
135                            During vertebrate gastrulation, convergence and extension (C and E) of the
136             As the primary driving forces of gastrulation, convergence and extension (C&E) movements
137                            During vertebrate gastrulation, convergence and extension movements elonga
138 tion events occurring prior to completion of gastrulation coordinate the morphogenetic movements unde
139 s embryos was sufficient to fully rescue the gastrulation defect caused by loss of hepatocystin.
140                                              Gastrulation defects are not rescued by a Kif2a mutated
141 ants, but not their WT counterparts, induced gastrulation defects indicative of aberrant cell migrati
142 ethanol-induced gene expression, epiboly and gastrulation defects.
143 defects that lead to invagination defects at gastrulation, demonstrating a previously uncharacterized
144             These variations observed during gastrulation depend fully on maternal factors.
145 n and monkey in vitro models simulating peri-gastrulation development to show the conserved principle
146  inhibition of jagn just before the start of gastrulation disrupts this asymmetric division of the ER
147 patterning, and an elevated BMP level during gastrulation drives pronounced morphological changes rem
148 m-like properties of the epiblast of the pre-gastrulation embryo and for cellular and physiological h
149                                     Although gastrulation EMT coincides with loss of epiblast pluripo
150                              In mouse embryo gastrulation, epiblast cells delaminate at the primitive
151 c processes, including the cell movements of gastrulation, epiboly and dorsal convergence.
152 disrupts migration of the mesoderm after the gastrulation epithelial-to-mesenchymal transition (EMT).
153 fish tailbud is not a simple continuation of gastrulation events.
154 ions that limit the feasibility of observing gastrulation ex vivo(2).
155 s a model, we show that regulation of folded gastrulation expression by the Fork head transcription f
156 n a self-organized stem cell model for human gastrulation, expression of these genes follows rapid ch
157 eractive Nodal signalling contributes to the gastrulation failure of Tet mutants.
158                 Loss of Zfp568, which causes gastrulation failure, or mutation of the ZFP568-binding
159 e morphogen signal gradients and direct peri-gastrulation fate stratification of human pluripotent st
160                                       During gastrulation, Fog induces apical cell constrictions that
161 ranscriptome analyses show similarity to pre-gastrulation formative epiblast.
162 og signaling is specific to the fast mode of gastrulation found in some flies.
163   Altogether, our data establish that during gastrulation, FOXF1 marks all posterior primitive streak
164 one of the three germ layers produced during gastrulation from which muscle, bones, kidneys, and the
165                                              Gastrulation generates three layers of cells (ectoderm,
166                             During mammalian gastrulation, germ layers arise and are shaped into the
167 ll intercalations of epithelial cells during gastrulation has, in several organisms, been shown to be
168 velopmental heterochronies that occur during gastrulation have impacted morphological brain change du
169 nd spreading of the animal hemisphere during gastrulation, here we provide evidence that radial inter
170 in WNT and NODAL underlies patterning during gastrulation; however, the activities of these pathways
171 -dependent specification of cell fate during gastrulation illustrates the insights gleaned by placing
172               PZR was required for zebrafish gastrulation in a manner dependent upon PZR tyrosyl phos
173 astula transition, and re-established during gastrulation in all embryonic layers.
174 ishment of anterior-posterior patterning and gastrulation in an in vitro system.
175                           Around the time of gastrulation in higher vertebrate embryos, inductive int
176 into this process, we know very little about gastrulation in humans, owing to the difficulty of obtai
177       This protocol describes how to observe gastrulation in living mouse embryos by using light-shee
178     The transition from peri-implantation to gastrulation in mammals entails the specification and or
179 static and developmental contexts, including gastrulation in many organisms and neural tube formation
180 ation and RNA expression during the onset of gastrulation in mouse embryos.
181 ates that mesoderm induction continues after gastrulation in neuromesodermal progenitors (NMPs) withi
182 progression from preimplantation epiblast to gastrulation in rodents.
183 ng primitive streak formation and subsequent gastrulation in the mammalian embryo.
184 NODAL ligands are expressed near the site of gastrulation in the posterior of the embryo, and knockou
185 rs systemically must be established prior to gastrulation in the very early embryo and, because it is
186  fly (Drosophila melanogaster) suggests that gastrulation in this organism also relies on adhesion be
187 ns were unable to complement TMTC3 rescue of gastrulation in Xenopus embryo development.
188 required for anterior neural development and gastrulation in Xenopus embryos.
189 rotocol for applying this technique to study gastrulation in Xenopus laevis (African clawed frog) emb
190 mbryos form extraembryonic mesoderm prior to gastrulation, in contrast to mouse.
191 ulates CE, and Wnts regulate many aspects of gastrulation including CE and EMT.
192    However, mutants have specific defects in gastrulation, including a high rate of p53-dependent cel
193 imelines and summarizes key stages following gastrulation, including endoderm patterning, organ speci
194            Cellular migration defects during gastrulation induced by Hh pathway antagonism were mitig
195                                           At gastrulation, interactions between the pair-rule genes l
196 tion of the three primary germ layers during gastrulation is an essential step in the establishment o
197                  Germ-layer formation during gastrulation is both a fundamental step of development a
198  we show that germ-layer patterning in avian gastrulation is ipsilateral despite cells undergoing hig
199 apitulate complex morphogenic events such as gastrulation is limited, possibly due to the limited pot
200 ism in the early Drosophila embryo, in which gastrulation is preceded by 13 sequential nuclear cleava
201 a demonstrate that Alk4/5/7 signaling during gastrulation is required to direct PMCs to the oral hood
202 rrow formation, the first step in Drosophila gastrulation, is a well-studied example of tissue morpho
203               Isolated skin explanted before gastrulation lacks strain and fails to acquire a global
204  a signalling centre to trigger the onset of gastrulation-like events in hPSCs.
205  development of the microfluidic model until gastrulation-like events occur (1-2 d).
206 PSC) lines for their ability to undergo peri-gastrulation-like fate patterning upon bone morphogeneti
207                   describe the generation of gastrulation-like foci of cells within micropatterned co
208 embryo and mediate the self-organization of "gastrulation-like" nodes in cultured hESCs.
209 he spatial patterning of the BMP4-dependent "gastrulation-like" phenotype by enhancing phosphorylatio
210 period between zygotic genome activation and gastrulation many regions maintain stable accessibility,
211 als its abnormal development at the onset of gastrulation, many hours before changes are obvious to t
212 te the position of the head and the onset of gastrulation, marked by T/Brachyury (T/Bra) at the poste
213  in cattle results in ectopic domains of the gastrulation marker, BRACHYURY This phenotype, and incre
214                                      By late gastrulation, mesodermal cells become packed as they eng
215 s, demonstrating that in the early stages of gastrulation most subapical clusters in mesoderm not onl
216 pendent endocytosis are necessary for proper gastrulation, most likely by interfering with Wnt5a/Ror2
217 egulating NMPs and their descendants in post-gastrulation mouse embryos.
218          Although it is well-recognized that gastrulation movements depend on forces that are generat
219 ontrollable, counteracting forces that shape gastrulation movements in insects.
220  post-MBT events such as cellularization and gastrulation movements occurred in these cell cycle-arre
221 he source of this extrinsic force, we mapped gastrulation movements temporally using light sheet micr
222 r of APJ/Apelin receptor signaling, promotes gastrulation movements, and might be the first in a seri
223 fere with Wnt5a/Ror2 signaling to coordinate gastrulation movements.
224 nimal caps are not compliant enough to allow gastrulation movements.
225                                       During gastrulation, neural crest cells are specified at the ne
226 ial roles in developmental processes such as gastrulation, neural tube closure and hearing.
227                   We conclude that perturbed gastrulation not only explains the neurulation defects,
228                                              Gastrulation of the Drosophila embryo is one of the most
229 lls gained the ability to reprogram early in gastrulation only after extended contact with the vegeta
230 layers that provide the structural basis for gastrulation or subsequent developmental events [1].
231 ed zebrafish embryos with ethanol during pre-gastrulation period and examined the transcripts by Affy
232                     The nearly identical pre-gastrulation phenotype observed for many different nucle
233 nd the knockdown of this integrin leads to a gastrulation phenotype that is consistent with complete
234 eletion of Igf2 can completely rescue Zfp568 gastrulation phenotypes through late gestation.
235 tion of all three Tet genes in mice leads to gastrulation phenotypes, including primitive streak patt
236                                       During gastrulation, physical forces reshape the simple embryon
237                       We propose that during gastrulation Pnhd acts in the marginal zone to contribut
238                             During amphibian gastrulation, presumptive endoderm is internalised as pa
239  around the ellipsoidal egg surface during a gastrulation process known as epiboly.
240                     It has been considered a gastrulation process unique to amphibians, but we show t
241 rs known to specify placodal identity during gastrulation promotes the formation of ectopic pineal pr
242                                     Modes of gastrulation range from stochastic translocation of indi
243 hich is distinct from PCP signaling or other gastrulation regulators, including BMP and Nodals.
244  regulated switch to late replication during gastrulation, reminiscent of mammalian X Chromosome inac
245                   Across the animal kingdom, gastrulation represents a key developmental event during
246 ergent extension movements during vertebrate gastrulation require a balanced activity of non-canonica
247 t and its conditional ablation, beginning at gastrulation, results in increased apoptosis, growth ret
248 al profiling of Hh-deficient mesoderm during gastrulation revealed disruptions to both transcriptiona
249 bition renders the concentration of dNTPs at gastrulation robust, with respect to large variations in
250 e the expression of the Dl target gene short gastrulation (sog) to better understand how a pioneer fa
251                                Later, during gastrulation, Sox32 restricts Pou5f3-Nanog complexes to
252 t1 in mouse embryos causes death at the post-gastrulation stage; however, the functions of Dnmt1 and
253 s from ES cells develop through intermediate gastrulation stages, which are gradually specified by 'r
254  layers during development from pre- to late-gastrulation stages.
255 d mesodermal cells during cleavage and early gastrulation stages.
256 lutionary distance, and peak at the onset of gastrulation, supporting the hourglass model of phylotyp
257 ntration caused changes in cell movements at gastrulation that also altered the tissue fates of these
258 fication in the sea star from zygote through gastrulation that corresponds to the GRN for sea urchin
259 nase MRCK-1 as a key regulator of C. elegans gastrulation that integrates spatial and developmental p
260 xicanus fish, we found heterochronies during gastrulation that produce organizer and axial mesoderm t
261 te embryos undergo dramatic shape changes at gastrulation that require locally produced and anisotrop
262  in Xenopus laevis embryos caused a delay in gastrulation that was rescued by the addition of human T
263                                           By gastrulation the ectodermal territories of the sea urchi
264                            Immediately after gastrulation, the CB consists of four separate regulator
265                              At the start of gastrulation, the ER divides asymmetrically into a popul
266 namic lineage analysis revealed that, during gastrulation, the forelimb, interlimb, and hindlimb fiel
267               During Drosophila melanogaster gastrulation, the invagination of the prospective mesode
268                                       During gastrulation, the pluripotent epiblast self-organizes in
269                            During Drosophila gastrulation, the ventral mesodermal cells constrict the
270  transcriptome increases from middle to late gastrulation, then falls substantially as cells in the n
271 d CaN signaling opposes BMP signaling during gastrulation, thereby promoting neural induction and the
272                                         Upon gastrulation, this conformation matured into conventiona
273 we examined whether C5a could be involved in gastrulation through cAMP transport.
274 ng is required for mesoderm induction during gastrulation through positive transcriptional regulation
275 els in the embryo blocks force generation at gastrulation through two distinct mechanisms: destabiliz
276 ailbud that make a germ layer decision after gastrulation to form spinal cord and mesoderm.
277 F-beta-receptor signaling is required during gastrulation to pattern the anterior skeleton.
278  upstream of and in parallel with PCP during gastrulation to regulate embryonic axis extension cooper
279 he entirety of development-from the onset of gastrulation to swimming tadpoles-in Ciona intestinalis.
280 ven specific embryonic cell populations from gastrulation to the onset of terminal differentiation.
281 hment, and polar aggregation is analogous to gastrulation; together with evidence of functional cell
282 ure of Cdon mutant embryos to ethanol during gastrulation transiently and partially inhibits Nodal pa
283 Short gastrulation/Chordin (Chd) and Twisted gastrulation (Tsg).
284  a Nodal signalling-dependent switch in peri-gastrulation versus preneurulation-associated fate patte
285 n each germlayer is established during early gastrulation via cell movement characteristics that are
286                                              Gastrulation was arguably the key evolutionary innovatio
287                                  Ipsilateral gastrulation was lost by midline ECM and PCD inhibition
288 ion during zebra finch, chicken, and ostrich gastrulation, we provide evidences that changes in the t
289 oblast in mice leads to reduced induction of gastrulation, we show here that prevention of the loss o
290           In the sea urchin embryo, cells at gastrulation were found to reprogram and replace missing
291 milar in both species until the beginning of gastrulation, when BMP signaling broadens and intensifie
292 of the three major germ layers occurs during gastrulation, when cells ingressing through the primitiv
293 ter is expressed throughout the embryo until gastrulation, when it becomes specifically expressed in
294                                        After gastrulation, when similar muscle cell populations in th
295                Its differentiation starts at gastrulation, when the epiblast generates mesoderm and e
296       These progenitors are specified during gastrulation, when they transiently express Foxa2, a gen
297 h changes broadly regulate translation until gastrulation, when this coupling disappears.
298 Dynamic local methylation was evident during gastrulation, which enabled the identification of putati
299 ) axis elongation are fundamental aspects of gastrulation, which is initiated by formation of the pri
300                               During Xenopus gastrulation, Wnt and FGF signaling pathways cooperate t

 
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