ライフサイエンスコーパス: gatekeeper

1 iologist as service provider, consultant, or gatekeeper.

2 blic institutions are children's nutritional gatekeepers.

3 kinases, while methionine is the predominant gatekeeper (39%).

4 We propose GateKeeper, a new hardware accelerator that functions as

5 from NSAID-induced damages by initiating the gatekeeper action of cell membranes, subsequent to anti-

6 ranscription factors, is emerging as a major gatekeeper against oxidative stress.

7 ranscription factors, is emerging as a major gatekeeper against oxidative stress.

8 r microenvironment likely serve as important gatekeepers against cancer progression and metastasis.

9 analogue inhibitor reveals that a glutamate gatekeeper and a sterically constricted active site conf

10 light a dual role for WEE1 as both a mitotic gatekeeper and a surveyor of chromatin synthesis, provid

11 plicating this domain as the major catalytic gatekeeper and highlighting its value as a target for pr

12 ofreading subunit of the replisome acts as a gatekeeper and influences replication fidelity during th

13 he structure to demonstrate that BioH is the gatekeeper and its physiological substrate is pimeloyl-A

14 ukemia, where miR-150 functions as a pivotal gatekeeper and its repression is required for leukemogen

15 te-of-the-art pre-alignment filters, Shouji, GateKeeper, and SHD.

16 If the metabolic gatekeepers are compromised, influx of additional glucos

17 The addition of GateKeeper as a pre-alignment step can reduce the verifi

18 cancer resistance protein (BCRP) are 2 major gatekeepers at the blood-brain barrier (BBB) that restri

19 ription factor of Borrelia burgdorferi is a 'gatekeeper' because it activates genes required for spir

20 secondary structure, to serve as a principal gatekeeper between a native metastable folded state and

21 uggests a cell-autonomous function of T as a gatekeeper between paraxial mesoderm production and the

22 genetic hierarchy, with Pax3 emerging as the gatekeeper between the presomitic mesoderm and the myoge

23 functionality of Asp-168, which acts like a gatekeeper by altering the width of the heme cavity acce

24 transcription factors function as metabolic gatekeepers by limiting the amount of cellular ATP to le

25 dify water conductance and gradients at key "gatekeeper" cell layers that impact on whole plant water

26 ting T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission.

27 substitution of two amino acids that act as gatekeepers, changing active-site accessibility and prev

28 ensity to aggregate, including enrichment of gatekeeper charged residues at the flanks of hydrophobic

29 Removal of gatekeeper control in the E292A mutant resulted in a sel

30 These findings suggest that two separate gatekeepers control neuronal conversion and maturation a

31 me, led us to ask whether EsMIF might be the gatekeeper controlling the periodic movement of the hemo

32 These results identify a role for Erg as a gatekeeper controlling vascular inflammation, thus provi

33 Thus, Aquarius and HRDE-1 act as gatekeepers coordinating gene expression and genome defe

34 ts of students-and has long been viewed as a gatekeeper course for those interested in pursuing a car

35 inding event, which serves as an allosteric "gatekeeper" defining the extent to which the system is w

36 ce networks demonstrates that the removal of gatekeepers disproportionately contributed to network fr

37 bition and activation, CBD-B functions as a "gatekeeper" domain that modulates the control exerted by

38 ent of type II hybrid inhibitors to overcome gatekeeper drug-resistant mutations in cSrc-T338M, as we

39 aturation and consecutively overcoming these gatekeepers enables deterministic reprogramming of HAFs

40 ndings reveal that CD45 acts as a signaling "gatekeeper," enabling graded signaling outputs while fil

41 and suggest that this enzyme functions as a gatekeeper enzyme to prevent the vast majority of O-mann

42 Due to its function as an inflammatory gatekeeper, expression and activation of NLRP3 need to b

43 The gatekeeper feature is conserved across membrane-associat

44 results implicate that Munc18-1 may act as a gatekeeper for both binary and ternary SNARE complex for

45 Thus, we conclude that IL1R1 is a gatekeeper for celastrol's metabolic actions.

46 APC is considered a gatekeeper for colorectal cancer (CRC).

47 n neocortical development as a translational gatekeeper for functionally related mRNA subgroups and p

48 nt elevation myocardial infarction is a safe gatekeeper for ICA.

49 raphic angiography (CTA) may serve as a safe gatekeeper for ICA.

50 ant coronary artery disease and can act as a gatekeeper for invasive revascularization.

51 suggest that during WNV infection, Ccr7 is a gatekeeper for nonspecific viral transference to the bra

52 circadian clock has emerged as an important gatekeeper for reducing immunity-associated costs, which

53 teric hindrance, thus serving as a molecular gatekeeper for substrate binding and catalysis.

54 The enzyme serving as the gatekeeper for the genome, RNA polymerase (RNAP), is amo

55 that extracellular loop 3 (ECL3) serves as a gatekeeper for the interaction between the tethered liga

56 t the nuclear pore complex (NPC) is the sole gatekeeper for transit of cellular material in and out o

57 ARIalpha to the lysosome, where it acts as a gatekeeper for two-pore channel-mediated triggering of g

58 e use of micro- and nanometre-sized pores as gatekeepers for controlling the movement of fluids, vapo

59 onstrating that cadherins-6, -9, and -10 are gatekeepers for high-magnitude LTP.

60 placed Groucho/TLE1 from TCF-4 and served as gatekeepers for K49 acetylation on beta-CATENIN, which i

61 mbranes that envelop the brain, as potential gatekeepers for modulating brain inflammation and pathol

62 phase ranges of cortical oscillations act as gatekeepers for perception.

63 o and out of land plants and are, therefore, gatekeepers for photosynthesis and transpiration.

64 Microorganisms have a role as gatekeepers for terrestrial carbon fluxes, either causin

65 e two strands of actin filaments that act as gatekeepers for the binding of other actin-binding prote

66 e role of plasmodesmata as both conduits and gatekeepers for the propagation of rapid cell-to-cell si

67 te that intestinal epithelial cells serve as gatekeepers for the supply of AHR ligands to the host an

68 endothelial and epithelial cells as natural gatekeepers for virus-induced sickness behavior, demonst

69 As dietary gatekeepers for young children, parents are often the pr

70 suggested that absence of CAC can act as a "gatekeeper" for further testing among low- and intermedi

71 These data support the role of LpL as the "gatekeeper" for tissue lipid distribution.

72 This is the first evidence for an organelle gatekeeper function at the AIS, which could provide a re

73 Thus, EEPD1 performs a gatekeeper function for replication fork repair by media

74 In summary, our data suggest that the gatekeeper function of Apc consists of two roles, clonal

75 pansion (crypt fission), consistent with the gatekeeper function of Apc.

76 al two-photon microscopy, we demonstrate the gatekeeper function of CNS professional antigen-presenti

77 Our study indicates that the gatekeeper function of omega-3 PUFAs improves GI safety

78 rboxylic acid cycle metabolites bypassed the gatekeeper function of PAX5 and IKZF1 and readily enable

79 with altered ZIP14 function would lack this gatekeeper function of ZIP14 and therefore would be pron

80 of SOD2 activity and ROS by SIRT1 provides a gatekeeper function to reduce PARK2-mediated mitophagy a

81 sts that CBD-B dynamics are critical for its gatekeeper function.

82 ect on actin binding but could determine its gatekeeper function.

83 suppressor genes (TSGs) are a major type of gatekeeper genes in the cell growth.

84 MYD88 expressing WM cells with a mutated HCK gatekeeper greatly increased the half maximal effective

85 cell lines, mutant BRAF bound the ER stress gatekeeper GRP78, which rapidly expanded the ER.

86 Activity assays demonstrate that the gatekeeper helix is important for directing the substrat

87 ognized element in its C-terminal region, a 'gatekeeper' helix, which extends over the adjacent subun

88 , decreased phosphorylation of the NF-kappaB gatekeeper IkappaBalpha and survival occurred in MYD88 L

89 Conclusion: When PSMA PET is used as the gatekeeper in addition to bone scanning, radionuclide th

90 When PSMA PET is used as the gatekeeper in addition to bone scanning, radionuclide th

91 While emphasizing the role of APC as a gatekeeper in CRC, this study also demonstrates that com

92 show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) wher

93 Our data indicate that NOTCH1 acts as a gatekeeper in human cSCC.

94 otic Bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in can

95 a hormone receptor that acts as a molecular gatekeeper in reproductive decisions.

96 (PP) inhibitors due to the presence of a Gly gatekeeper in the essential calcium dependent protein ki

97 Here, we reveal that Dusp8 is a gatekeeper in the hypothalamic control of glucose homeos

98 SIK pathway functions as a key gluconeogenic gatekeeper in the liver.

99 ferase 1 (UGT1) is a central quality control gatekeeper in the mammalian endoplasmic reticulum (ER).

100 ted substrate flexibility and functions as a gatekeeper in the processing of unnatural substrates.

101 2 of the mitochondrial TIM23 translocon as a gatekeeper in the release of membrane proteins from the

102 ion, which recognizes CX3CR1 as an essential gatekeeper in this scenario.

103 enin signaling components, which are crucial gatekeepers in common forms of intestinal cancer.

104 for such nutrients are therefore ecological gatekeepers in healthy guts, and are attractive candidat

105 This reveals that STRA6 functions as a "gatekeeper" in retinol (vitamin A)-mediated differentiat

106 This pseudo-atomic model of the connector-gatekeeper interaction revealed the existence of a commo

107 GateKeeper is the first design to accelerate pre-alignme

108 This "cellular gatekeeper" is also involved in the control of viral inf

109 This finding suggests the presence of a gatekeeper kinase activity that controls latent HIV-1 in

110 We recently demonstrated the presence of a gatekeeper kinase function that controls latent HIV-1 in

111 therapeutic stimuli that do not target this gatekeeper kinase will likely fail to trigger efficient

112 When implemented on a single FPGA chip, GateKeeper maintains high accuracy (on average >96%) whi

113 Collectively, our data suggest an unexpected gatekeeper mechanism by which RAD52 limits excessive rem

114 d causes receptor degradation, suggesting a "gatekeeper" mechanism that ensures targeting of inactive

115 We target the gatekeeper MET146 of c-Jun N-terminal kinase 3 (JNK3) to

116 id transport triggered expression of the MCU gatekeeper MICU1 but not the MCU core subunit.

117 omponents: the pore-forming MCU protein, the gatekeepers MICU1 and MICU2, and an auxiliary subunit, E

118 Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1).

119 Our Emotional Gatekeeper model demonstrates how this circuit enables f

120 rt in axons and instead suggest an organelle gatekeeper model in which UNC-16 (JIP3/Sunday Driver) se

121 ndings imply a new paradigm for LIN28 - as a gatekeeper molecule that regulates the transition betwee

122 d for renal cancer, as an inhibitor for ABL1 gatekeeper mutant drug-resistant leukaemia patients.

123 The T790M gatekeeper mutant favors activation by stabilizing a hyd

124 What is more the T315I gatekeeper mutant has a significant impact on the bindin

125 ks native and mutated BCR-ABL, including the gatekeeper mutant T315I, which is uniformly resistant to

126 In addition, the same gatekeeper mutants failed to restore proper symbiotic fe

127 unds effectively inhibit clinically relevant gatekeeper mutants of KIT and Abl in biochemical and cel

128 s are conformationally less flexible, target gatekeeper mutated drug-resistant EGFR-L858R/T790M, and

129 new FGFR inhibitors and identify a secondary gatekeeper mutation as a mechanism of acquired resistanc

130 cquired resistance caused by the EGFR(T790M) gatekeeper mutation can occur either by selection of pre

131 As such, the design of gatekeeper mutation resistant kinase inhibitors is a cru

132 ar, the resistance to imatinib caused by the gatekeeper mutation T315I in Bcr-Abl remains a challenge

133 ever, resistance mutations, particularly the gatekeeper mutation T790M, limit this efficacy.

134 This gatekeeper mutation therefore identifies a key missing s

135 The BCR-ABL1 kinase domain gatekeeper mutation Thr315Ile (T315I) confers resistance

136 y ROS1(G2032R) mutation and the ROS1(G2026M) gatekeeper mutation.

137 esistance to other TKIs, including the F691L gatekeeper mutation.

138 e kinase domain of ALK, including the L1196M gatekeeper mutation.

139 GIST and the Kit(T669I) (human KIT(T670I)) "gatekeeper" mutation found in imatinib-resistant GIST pa

140 ously sensitive TNBCs, we failed to identify gatekeeper mutations, new driver events or drug pump act

141 Our data point to the importance of such "gatekeeper" mutations in enabling major changes in subst

142 evaluations across the different nutritional gatekeepers need to be integrated.

143 cally demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulator

144 ion is irreversible, indicating PurAH as the gatekeeper of bottromycin biosynthesis.

145 The regulation of Rubisco, the gatekeeper of carbon fixation into the biosphere, by its

146 The Gly gatekeeper of CDPK1 makes it exquisitely sensitive to in

147 GBP1 thus acts as a gatekeeper of cell death pathways, which respond specifi

148 ucleus and the cytoplasm, now doubles as the gatekeeper of cellular identity and aging.

149 tigator of inflammatory agents makes TRPA1 a gatekeeper of chronic inflammatory disorders of the skin

150 d previously unrecognized role of BRCA2 as a gatekeeper of DOX-induced cardiomyocyte apoptosis and su

151 We find that FOXO1 acts as a gatekeeper of endothelial quiescence, which decelerates

152 drogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced

153 Surprisingly for a gatekeeper of glycolysis, no fine control mechanism of b

154 stem regulates DA release and is a canonical gatekeeper of goal-directed behavior.

155 thin a lipophilic pocket past the methionine gatekeeper of group II PAKs approached by these type I 1

156 results reveal that SERPINB1 acts as a vital gatekeeper of inflammation by restraining neutrophil ser

157 signals on eIF4F positions this factor as a gatekeeper of malignant fate.

158 tified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female

159 Here, we demonstrate that the gatekeeper of mitochondrial Ca(2+) uptake, Mitochondrial

160 ed OTX2 as a transcriptional repressor and a gatekeeper of myogenic and neuronal differentiation in m

161 nce for a regulatory role for circFOXP1 as a gatekeeper of pivotal stem cell molecular networks.

162 subunit of the TIM23 complex, functions as a gatekeeper of presequence translocase and thereby mainta

163 the cytosol, KDM8 associates with PKM2, the gatekeeper of pyruvate flux and translocates PKM2 into t

164 ry metabolite regulator), serves as a global gatekeeper of secondary metabolism and a repressor of nu

165 of PLN's inhibitory activity and a critical gatekeeper of SR calcium cycling and contractility in th

166 role of innate leukotriene B4 signaling as a gatekeeper of the hematopoietic niche transition.Hematop

167 as mitochondrial carotenoid scavenger and a gatekeeper of the intrinsic apoptotic pathway.

168 Mechanistically, miR-23a targeted PPIF, gatekeeper of the mitochondria permeability transition p

169 usively present in bacterial TGTs, serves as gatekeeper of the transient subpocket.

170 lytic pathway, revealing how CD44 could be a gatekeeper of the Warburg effect (aerobic glycolysis) in

171 Functioning as a gatekeeper of this developmental signaling transition, t

172 chizosaccharomyces pombe Dcp2 is a conserved gatekeeper of this open-to-closed transition.

173 sh/CK1gamma as a novel regulator of Rho1 and gatekeeper of tissue homeostasis whose activity is compr

174 nt and ILC1 conversion solidified c-Maf as a gatekeeper of type 1 regulatory transformation and a con

175 ophils, in cooperation with serum, are vital gatekeepers of a host's microbiome and frontline defende

176 of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new tre

177 IAPs are therefore, not only gatekeepers of cell death, but are probably also involve

178 vertebral LVs add to skull meningeal LVs as gatekeepers of CNS immunity and may be potential targets

179 repression and highlight Ovol1 and Ovol2 as gatekeepers of epithelial adhesion and differentiation b

180 we identified bone lining cells as important gatekeepers of estrogen-controlled bone resorption.

181 r results further indicate that ET cells are gatekeepers of glomerular output and prime determinants

182 s striatal interneuron subclass as important gatekeepers of goal-directed learning.

183 Thus, our results point to ECs as gatekeepers of HSPC trafficking and identify a CD26-medi

184 "Master" transcription factors are the gatekeepers of lineage identity.

185 ts were enriched at promoters and may act as gatekeepers of monoallelic mRNA expression.

186 ough taxonomists have traditionally acted as gatekeepers of order, the numbers of, and speed at which

187 w that stimulatory peptides are the ultimate gatekeepers of puberty.

188 l occupancy, suggesting that nucleosomes are gatekeepers of TF binding sites.

189 ber of tropomyosin (Tm) isoforms function as gatekeepers of the actin filament, controlling the spati

190 We identify macrophages as gatekeepers of the cancer-host cell interaction: deprivi

191 mily proteins BAX and BAK serve as essential gatekeepers of the intrinsic apoptotic pathway and, when

192 Identifying the gatekeepers of the various phenotypic states arrayed alo

193 hemostatic plug but also act individually as gatekeepers of the vascular wall to help preserve vascul

194 re increasingly recognized as organ-specific gatekeepers of their microenvironment.

195 ls, pointing to the endothelial cells as the gatekeepers of this hyperaggressive host immune response

196 These studies identify DCs as metabolic gatekeepers of thymic egress.

197 ctokinase-1 (PFK1), which is considered the "gatekeeper" of glycolysis because it catalyzes the step

198 2 (also known as MAP2K1 and MAP2K2) are the "gatekeepers" of the ERK signaling output with redundant

199 at tumor-reactive CD4(+) T cells act as the "gatekeepers" of the host antitumor immunity in the postc

200 Phosphofructokinase-1 (PFK1), the 'gatekeeper' of glycolysis, catalyses the committed step

201 vel findings demonstrate that the glycolysis gatekeeper PDK1 has a critical role in BCSC reprogrammin

202 Substitution of the FLT3 "gatekeeper" phenylalanine with leucine (F691L) conferred

203 Thus, gatekeeper phosphorylation is critical for synchronizing

204 Since gatekeeper phosphorylation was not necessary for activit

205 n especially prevalent T315I mutation at the gatekeeper position of the kinase domain.

206 Mutations in the catalytic domain at the gatekeeper position represent the most prominent drug-re

207 ic regulator of male germ cell fate and as a gatekeeper preventing initiation of TGCTs.

208 a lead us to propose that the SAC is a major gatekeeper preventing the progression of oocytes harbour

209 Synthetic polymer scaffolds may serve as gatekeepers preventing the adhesion of biomacromolecules

210 nknown how the portal protein functions as a gatekeeper, preventing DNA slippage, whilst allowing its

211 y the primary cilium as an important lineage gatekeeper, preventing HH-to-Ras/MAPK pathway switching.

212 paB, the needle itself and the intracellular gatekeeper protein MxiC.

213 e protein classes is mediated by a conserved gatekeeper protein, MxiC, in Shigella As its molecular m

214 Membrane transporters are key gatekeeper proteins at cellular membranes that closely c

215 threaded models of gp8 (connector) and gp11 (gatekeeper) proteins, which were docked into the corresp

216 ressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signal

217 be employed in multivalent systems to act as gatekeepers regulating post-translational modification.

218 from both parasites contains a rare glycine gatekeeper residue adjacent to the ATP-binding pocket.

219 e, the BAZ1A bromodomain has a non-canonical gatekeeper residue and binds relatively weakly to acetyl

220 ce through a secondary T790M mutation at the gatekeeper residue and dose-limiting toxicities from wil

221 identifies a phenyl ring that traverses the gatekeeper residue and positions the thiazole in the bac

222 condary mutations, and mutations of the FLT3 gatekeeper residue are infrequent.

223 en bond between a cap group nitrogen and the gatekeeper residue Glu272 was responsible for potent HDA

224 The presence of a unique glycine gatekeeper residue in TgCDPK1 permits selective inhibiti

225 an kinases by capitalizing on a small serine gatekeeper residue in the active site of the Plasmodium

226 Remarkably, CDPK1 contains a small glycine gatekeeper residue in the ATP binding pocket making it s

227 We demonstrate here that Lys-35 acts as a gatekeeper residue in TTR, strongly decreasing its amylo

228 Instead, mutation of the gatekeeper residue into leucine, alanine, or threonine r

229 We generated an analog-sensitive gatekeeper residue mutant of PKG Ialpha (M438G) that eff

230 succeed in being effective against the T338M gatekeeper residue mutation in the kinase binding site.

231 We find that Dasatinib's impotency against gatekeeper residue mutations arises from a loss of ligan

232 Mutations in the gatekeeper residue of kinases have emerged as a key way

233 dole derivatives reveal the influence of the gatekeeper residue on the orientation of small-molecule

234 ase domain, specifically substitution of the gatekeeper residue threonine-790 with methionine (T790M)

235 y (DFG) motif, the regulatory spine, and the gatekeeper residue to kinase regulation.

236 e presence of a heterozygous mutation at the gatekeeper residue, encoding FGFR3(V555M); consistent wi

237 Although this mutation does not lie at the gatekeeper residue, it confers resistance to ROS1 kinase

238 istance, through a secondary mutation of the gatekeeper residue, means that clinical responses only l

239 of the beta3-alphaC loop and mutation of the gatekeeper residue.

240 3.28) act either as molecular switches or as gatekeeper residues that introduce constraints limiting

241 en properly occupied concomitantly opens the gatekeeper residues within the active site and realigns

242 ng a leukemia with the most common, pan-TKI, gatekeeper resistance mutation, T315I.

243 ecific residue, Ile-145, that might act as a gatekeeper restricting access to the binding site.

244 e for selection by thymic MHC2, suggesting a gatekeeper role for ITK in ensuring that only Tregs sele

245 ing hepatocarcinogenesis and establish a new gatekeeper role for p53 in repressing c-MYC-induced CSC

246 istent with epigenetic alterations playing a gatekeeper role in cancer.

247 r and the transmembrane domains played a key gatekeeper role in the conformational dynamics associate

248 ed MAN1B1 can play a mannosidase-independent gatekeeper role in the proteostasis network of higher eu

249 stroke, we found that the cerebellum plays a gatekeeper role, as lesions of the tonsil, the lobus sem

250 us cytokines, but exerts active "angiocrine" gatekeeper roles, controlling their microenvironment in

251 tes that express a drug-resistant methionine gatekeeper (S147 M) CDPK4 mutant.

252 PTEN functions as a phosphatase of NKX3.1, a gatekeeper suppressor of prostate cancer.

253 nly deleted gene in prostate cancer and is a gatekeeper suppressor.

254 mmonly deleted gene in prostate cancer and a gatekeeper suppressor.

255 The gatekeeper system opens for viral genome exit at the beg

256 inically are the acquisition of a secondary "gatekeeper" T790M EGFR mutation that increases the affin

257 nally, we identify the retromer complex as a gatekeeper, terminating beta-arrestin 1-mediated ERK pho

258 transition zone and are thought to act as a gatekeeper that controls ciliary protein trafficking.

259 ntrinsic rheostat of BMP signalling: it is a gatekeeper that governs the transition between stem cell

260 Thus, IL-10 is an essential gatekeeper that maintains immune homeostasis at distal s

261 e data demonstrate that Folliculin acts as a gatekeeper that maintains separation of blood and lympha

262 Ampk is an energy gatekeeper that responds to decreases in ATP by inhibiti

263 We propose that N17 and C38 act as gatekeepers that control the intrinsic heterogeneities o

264 Biological ion channels are molecular gatekeepers that control transport across cell membranes

265 dulate enteroendocrine activity by acting as gatekeepers that limit the bioavailability of GLP-1.

266 Thus, basophils are gatekeepers that link adaptive immunity with innate effe

267 RAS proteins are signal transduction gatekeepers that mediate cell growth, survival, and diff

268 We found evidence of structural gatekeepers that, when mutated, alleviated native strain

269 protease an additional histidine acts as a "gatekeeper" that fine-tunes the sensitivity of the PC1/3

270 ogen and (2) from the sulfonamide N-H to the gatekeeper threonine.

271 ell-known z-factor has been widely used as a gatekeeper to assure assay quality in an HTS study.

272 reatic tumorigenesis, and it appears to be a gatekeeper to cancer progression.

273 lso has chaperone-like properties, acts as a gatekeeper to direct the outcome of this reaction.

274 he circulating blood from the CNS, acts as a gatekeeper to facilitate the selective trafficking of su

275 vate dehydrogenase, the key Ca(2+)-sensitive gatekeeper to glucose oxidation.

276 ncept that CCTA may be used effectively as a gatekeeper to ICA.

277 Consistent with the role of ASPP2 as a gatekeeper to inflammation, ASPP2-deficient brains posse

278 e potential of CCTA to serve as an effective gatekeeper to invasive coronary angiography will depend,

279 bit either role of Ded1, positioning it as a gatekeeper to optimize Ded1 activity to the appropriate

280 Trial integration could serve as an early gatekeeper to plasticity, helping to ensure that longer-

281 eins in central hepatocytes and may act as a gatekeeper to prevent hepatic bile salt overload.

282 sociation of KIR and that His-36 serves as a gatekeeper to prevent unregulated signaling through KIR2

283 f how kinase-substrate recognition acts as a gatekeeper to regulate actin cytoskeletal dynamics.

284 er, our study identifies TRAF6 as a critical gatekeeper to restrict p53 mitochondrial translocation,

285 A-based lesion-specific ischemia will be the gatekeeper to the cardiac catheterization laboratory and

286 Peer review acts as the gatekeeper to these mechanisms.

287 Reviewers thereby act as critical gatekeepers to high-quality research.

288 of the endoplasmic reticulum (ER), acting as gatekeepers to the early secretory pathway, yet little i

289 Cells use membrane proteins as gatekeepers to transport ions and molecules, catalyze re

290 suggests that it may serve as an effective "gatekeeper" to invasive testing in patients needing adju

291 : (1) Question, Persuade, and Refer (QPR), a gatekeeper training module targeting teachers and other

292 ceted suicide prevention programs, including gatekeeper training, education and mental health awarene

293 ches that need further investigation include gatekeeper training, education of physicians, and intern

294 Mutation of the gatekeeper tryptophan abolishes the dynamic behavior of

295 2a alternate reading frame (Arf) serves as a gatekeeper tumor suppressor in mice that prevents PN pro

296 , we reported SYMRK to be phosphorylated on "gatekeeper" Tyr both in vitro as well as in planta.

297 cases been found to function as "structural gatekeepers," which avoid unwanted interactions by negat

298 Herein, we show that substituting gatekeeper with nonphosphorylatable residues like Phe or

299 invite and schedule speakers serve as gender gatekeepers with the power to create or reduce gender di

300 hemistry shows that the FRB domain acts as a gatekeeper, with its rapamycin-binding site interacting