ライフサイエンスコーパス: gating

1 d studies of the structural basis of channel gating.

2 thermosensing and couples to heat-activated gating.

3 tituting an ideal platform for electrostatic gating.

4 ClC-2 and opens the channel by altering its gating.

5 ies and conformational flexibility determine gating.

6 n terms of protein processing and/or channel gating.

7 lve the effect each interaction has on Na(V) gating.

8 nd binding to the pore domain during channel gating.

9 bute to narrowing of the pore during channel gating.

10 eptide that allosterically modulates channel gating.

11 nsing transmembrane potential and subsequent gating.

12 and cAMP-dependent mechanisms of HCN channel gating.

13 ontrolled proton evolution with ionic liquid gating.

14 cysteine redox sensitivity by electrostatic gating.

15 gain the critical role of PLCdelta1 in TRPC4 gating.

16 er of respiratory and cardiac gates for dual gating.

17 olog of ANKRD26, to orchestrate proper cilia gating.

18 itance of both MoSe(2) and WS(2) layers with gating.

19 f the accessed band structures by electrical gating.

20 ture-sensitive structure is coupled to TRPM8 gating.

21 ltiple residues, including those involved in gating.

22 present a strong response under electrolytic gating.

23 at determines both cation selectivity and pH gating.

24 constraints on TrkH are required for channel gating.

25 vivo without the use of any complicated time-gating algorithms or systems, which existing tools are u

26 ocal microscopy coupled with the use of time-gating allowed the precise DEK1 subcellular localization

27 and suggest a correlation between defective gating and ciliopathy pathogenesis.

28 features in Orai1 that contribute to channel gating and consider how they give rise to the unique bio

29 catalytic triad on structure, conformational gating and dynamics of hMGL by combining kinetics, NMR,

30 and arrhythmia based on frequency-dependent gating and ii) generate an ionic current for termination

31 mino acid substitution strongly slowed ClC-6 gating and increased current amplitudes, particularly at

32 molecular mechanisms underlying the channel gating and inhibition of PANX1 and related large-pore ch

33 on shutter allows significantly improved ion gating and ion accumulation due to improved shielding of

34 s to delineate the molecular determinants of gating and ion permeation.

35 rve as a tool for the studying of GJ channel gating and its effects on the spread of excitation in ne

36 he mechanisms of permeation, selectivity and gating and lay the groundwork for understanding the role

37 Transition fibers (TFs) regulate cilia gating and make the primary cilium a distinct functional

38 l nanopockets are known to affect mechanical gating and may be linked to large variability in tension

39 nformational changes underlying GlyR channel gating and modulation.

40 to understand the interdependence of channel gating and permeation in the context of such restricted

41 non-thermal stimuli including electrostatic gating and photoexcitation.

42 yptamine; however, equilibrium constants for gating and priming were similar for 5-HT and terpenoid a

43 ith published experimental analyses of CLC-2 gating and provide a high-resolution structural model to

44 se results appear incompatible with standard gating and rebound models.

45 des mechanistic insights into the allosteric gating and regulation of CN-gated and nucleotide-modulat

46 due pair in the lower pore is detrimental to gating and selectivity, although this interaction might

47 These helices are important for gating and sensing in MscS but the role of the additiona

48 perature-dependent regulation of ion channel gating and shed light on ancient origins of temperature-

49 and -domain reorientation leading to agonist-gating and subunit-dependent competitive inhibition by p

50 ral biology, yielding insight into substrate gating and trapping the protease in the active state.

51 insights into the molecular basis of channel gating and will facilitate organism-specific drug discov

52 le and lower pore were more likely to affect gating and/or ion selectivity than those in the upper po

53 h on how well CFTR channels work (permeation/gating) and on how many are present at the membrane.

54 as implemented with 3D radial sampling, self-gating, and a compressed-sensing reconstruction.

55 tion for capsaicin-mediated TRPV1 activation gating, and reveals multiple ligand-channel interactions

56 m PET raw data is a promising alternative to gating approaches requiring additional hardware (e.g., p

57 g domain 2 (VSD2) and that each of the three gating arginines in VSD2 reduces the activation threshol

58 al Markov state model of CLC-2 "fast" (pore) gating, based on 600 microseconds of molecular dynamics

59 on markers using flow cytometry, traditional gating-based analysis methods and support the data by em

60 ntial, toxins that bind VSD and modulate the gating behavior of K(v) channels exhibit dramatic affini

61 ndings establish p75NTR as a novel regulator gating behavioral response to food scarcity and time-of-

62 onal hardware (e.g., pressure-sensitive belt gating [BG]).

63 h a new dual field switching ion shutter for gating both ion polarities and an X-ray ionization sourc

64 s--an ATP analog that can drive CFTR channel gating but is unsuitable for phosphotransfer by PKA, and

65 trigger Ca(2+)-dependent feedback of channel gating but may support alternate regulatory functions.

66 al-time position management (RPM)-gated), no gating but using only the first 3 min of data (ungated-m

67 (3,8,9), but the mechanistic basis for TASK2 gating by pH is unknown.

68 channel indicating that cold drives channel gating by stabilizing the folded state of the CTD.

69 Thus, the details of single-RyR gating can profoundly affect SR Ca(2+) release even if o

70 These gating changes could be fully reversed by acute CaMKII i

71 ting thermodynamics, as characterized by the gating charge and voltage of equipartitioning, does not

72 The total gating charge displacement associated with this transiti

73 , decreased single-channel open probability, gating charge movement, and its coupling to channel open

74 anonical voltage-gated ion channels, using 2 gating charges found in its fourth transmembrane segment

75 lving the outward or inward translocation of gating charges(1-3), the general determinants of channel

76 learance and synergistic action of all these gating checkpoints are required to allow STIM1 coupling

77 We discovered these gating checkpoints in the middle and cytosolic extended

78 g and require clearance of a series of Orai1 gating checkpoints.

79 , TALP-3 and ANKR-26 form a complex with key gating component DYF-19, the homolog of FBF1.

80 fundamentally from the previously proposed "gating" concept, in which the clock is assumed to suppre

81 Manual biaxial gating confirmed increased frequencies of conventional d

82 Modulation of any part of gating constitutes an entry point for pharmacologically

83 plore here these mechanisms by examining the gating contribution of an interface formed between the V

84 not alter the degree of electrophysiological gating cooperativity between Nav1.5 alpha-subunits.

85 ctivation while having negligible effects on gating currents.

86 is likely to remain constant during the ASIC gating cycle, whereas they may undergo relative movement

87 enting distinct functional states during the gating cycle.

88 ons were performed and compared: data-driven gating (DDG) (we use the term DDG-retro to distinguish t

89 Data-driven gating (DDG) using signals derived from PET raw data is

90 endowed with a good efficacy in rescuing the gating defect of F508del- and G551D-CFTR and a promising

91 ed potentiators, are known to ameliorate the gating defect.

92 SA-born WT mice exhibited sensorimotor gating deficits (males), increased reward preference, le

93 did not exhibit the SZ-related sensorimotor gating deficits, psychostimulant-induced hypersensitivit

94 s was accompanied by increased NMDA receptor gating, dependent on mGluR5 and linked to enhanced Ca(2+

95 teracted with glycine 165, located in loop D gating domains surrounding the intracellular vestibule o

96 o a strengthened donor effect and a weakened gating effect caused by the introduction of MoS(2) layer

97 We propose this dependence is due to the gating effect of a Li-adsorption-generated dipole layer

98 face are predominantly unproductive due to a gating effect of solvation that allows diene protonation

99 The sensing mechanisms (donor and gating effects) of the FET sensor were discussed.

100 f 5-HT(3A), the allosteric regulation of ion gating elements by 5-HT binding is indicative of a preac

101 the later stages of translation initiation, gating entrance into elongation.

102 Functionally, the PSTN is involved in gating feeding behavior, which is conceptually homologou

103 s have shown to exceed performance of manual gating for a limited number of cell subsets.

104 de that confidence shapes a selective neural gating for choice-consistent information, reducing the l

105 ents/s) to quantify live bacterial cells, by gating for their characteristic electrophysiology versus

106 ent aspects of Ca(V) channel trafficking and gating for this purpose.

107 size have long been sought due to their time-gating-free high-contrast multiplexing imaging.

108 present a single frequency-resolved optical gating (FROG) system capable of self-referenced characte

109 al periods in the development of its sensory gating functions.

110 filter, with excess protons shared with the gating glutamate E148.

111 Repeat-A did not restore pressure-dependent gating, hence the sensing module must exist between resi

112 observed in the PCP animal model of sensory gating impairment of schizophrenia, as well as a signifi

113 Our results suggest that gating in Hv1 is tuned by extensive VSD-VSD interactions

114 cture provides a framework for understanding gating in ligand-gated channels and how mutations in the

115 A data-driven method for respiratory gating in PET has recently been commercially developed.

116 egions required for channel formation and pH gating in planar lipid bilayers.

117 trical signalling and control cell volume by gating in response to membrane depolarization or hyperpo

118 ant for H(+) transport and voltage-dependent gating in the CLC exchangers.

119 tions that may be responsible for allosteric gating in these channels.

120 These interactions exert a strong effect on gating, in particular on the stability of the open state

121 M and P1090Q) have distinct effects on TRPM3 gating, including increased basal activity, higher sensi

122 a Get2/CAML cytoplasmic helix that forms a "gating" interaction with Get3/TRC40 important for TA ins

123 e (PDMS) cross connector working in the flow-gating interface regime.

124 into the separation capillary through a flow-gating interface.

125 of an osmoticant agent suggest that channel gating involves a change in solute-inaccessible volume i

126 Extracellular gating involves arginine protonation on the channel surf

127 Intracellular gating involves lysine protonation on inner helices and

128 and fundamental aspects of channel assembly, gating, ion selectivity and pharmacology remain obscure.

129 ese studies provide the structural basis for gating, ion selectivity, and single-channel conductance

130 K channels are voltage independent and their gating is controlled by intracellular [Ca(2+) ] in a bip

131 sensor domain (VSD), and the cNMP-dependent gating is mediated by the intracellular cyclic nucleotid

132 chanistic model explaining potassium channel gating is of a conformational change that alternately di

133 the enthalpy change associated with channel gating is proportional to the length of the CTD.

134 Respiratory gating is the standard to prevent respiration effects fr

135 lpha9alpha10 cholinergic nicotinic receptors gating kinetics ("gain of function" nAChRs).

136 ity of the I (Ks) channel and shifts channel gating kinetics toward more negative potentials.

137 lation of trafficking to shaping ion channel gating kinetics.

138 repeat and charged residues in the flexible gating loop of the catalytic domain distinctively influe

139 ineage interneurons previously implicated in gating mechanical pain and itch.

140 onformational excursions during this dynamic gating mechanism and are likely evolutionarily conserved

141 onent Ca(2+)-uptake machinery and reveal the gating mechanism by which MICUs control uniporter activi

142 This two-stage hand-and-elbow gating mechanism elucidates distinct tissue-specific mod

143 lectron microscopy to identify the molecular gating mechanism in calcium-activated potassium channels

144 An attention-gating mechanism is incorporated into a discriminator ne

145 gest a unifying mechanism that describes the gating mechanism of both CLC subtypes.

146 nel gating, suggest either an entropy-driven gating mechanism or a role for enthalpy-entropy compensa

147 This particular anion channel gating mechanism predicts the existence of mutant transp

148 ests the possibility of a unified mechanical gating mechanism stemming from membrane deformation indu

149 We reveal a gating mechanism that involves two ion-conducting pathwa

150 These data taken together support a gating mechanism that regulates acyl-ACP binding and sub

151 nnel Na(+) currents to quantify the receptor gating mechanism while simultaneously monitoring ionomyc

152 y membrane depolarization via an SF-mediated gating mechanism, but we found here that only very stron

153 The theory is used to predict the gating mechanism, the pathway for backward stepping, and

154 nt conformational changes, suggesting a dual gating mechanism.

155 so open undamaged DNA, suggesting a 'kinetic gating' mechanism whereby lesion discrimination relied o

156 common core architecture but show different gating mechanisms and fine-tuned conductive properties.

157 tigating the structural basis of TRP channel gating mechanisms and pharmacology, and, despite the lar

158 hyte ACRs, indicating differences in channel gating mechanisms between the two ACR families.

159 his has broad implications for understanding gating mechanisms of EAG and related ERG and ELK K(+) ch

160 for understanding toxin-VSD interaction and gating mechanisms of K(v) channels in membranes.

161 annels, predicting novel ion-selectivity and gating mechanisms.

162 These observations describe a mechanism for gating membrane fusion.

163 were very similar to the traditional manual gating method.

164 etween CMR-FT and the three echocardiography gating methods (p > 0.05 for all).

165 Several automated gating methods have shown to exceed performance of manua

166 e model analysis to investigate how SF-level gating modalities control selective cation transport in

167 In line with mutagenesis studies, these gating modalities resulted from dynamic interaction netw

168 ilizes an increased channel open probability gating mode by a mechanism that requires an intact rigid

169 We used a six-state gating model combined with intrinsic and Ca(2+)/Mg(2+)-d

170 R clusters that utilize the multiexponential gating model produce infrequent Ca(2+) release events wi

171 bilities: the commonly used two-state Markov gating model, one that utilizes multiple exponentials to

172 Huwentoxin-IV (HwTx-IV) is a gating modifier peptide toxin from spiders that has weak

173 As some gating modifier toxins have affinity for model lipid bil

174 id bilayers, a tripartite relationship among gating modifier toxins, voltage-gated ion channels, and

175 ignals and are frequently targeted by deadly gating-modifier neurotoxins, including tarantula toxins,

176 We also use the sensor to drive an inducible gating module for selective gene expression in non-divid

177 c61gamma C terminus is juxtaposed to the key gating module of Sec61p/Sec61alpha, and we hypothesize i

178 /Sec61gamma is an essential component of the gating module of the ER translocase and is required to m

179 formations in the apo state but to undergo a gating motion and assume a more defined conformation upo

180 evidence that the loops undergo significant gating motions upon the binding of substrate.

181 We show how gating naturally leads to transfer learning and robust m

182 .e., nitrogen magneto-ionics) by electrolyte-gating of a CoN film.

183 However, when AAA4 is bound to ATP, the gating of AAA1 by AAA3 prevails and dynein motion can oc

184 r very short XFEL pulses is relieved through gating of Bragg diffraction by loss of crystalline order

185 ocess and a key residue D171 relevant to the gating of calcium are identified.

186 synthetic devices to enable light-inducible gating of calcium channels, conformational switch, dynam

187 Voltage gating of GJs could play a physiological role, particula

188 ns affected both voltage- and cAMP-dependent gating of HCN2 channels.

189 out how subunit-selective ligands affect the gating of heteromeric iGluRs, namely their activation an

190 ignature sequence in the U-type inactivation gating of hKv2.1 and hKv3.1.

191 the M101 gate latch, which is essential for gating of human Orai1 channels via its sulfur-aromatic i

192 ons evoke neuronal responses via nonspecific gating of ion channels.

193 rt in biological channels and in hydrophobic gating of ion channels.

194 E-M coupling mechanism in voltage-dependent gating of K(V)7.1 as triggered by VSD activations to the

195 gan size by morphogen range and the hormonal gating of morphogen action.

196 Gating of positron emission tomography images has been s

197 a are traditionally analyzed by (subjective) gating of subpopulations on two-dimensional plots.

198 This gating of synaptic plasticity in stress by astrocytic me

199 ed profilin-actin delivery and FH2-regulated gating of the barbed end effectively limits the elongati

200 We take advantage of a femtosecond temporal gating of the electron pulse mediated by an infrared las

201 , it has been shown that subcycle, nonlinear gating of the molecular fingerprint signal renders FRS r

202 strikingly, the V990M mutation affected the gating of the non-canonical pore of TRPM3, resulting in

203 ructural elements are capable of controlling gating of the pore, and appear to permit some modulators

204 rface expression and shapes the inactivation gating of these channels.

205 I hair cells results from the interdependent gating of three conductances.

206 r, it is unknown how nucleotides control the gating of TrkH through TrkA.

207 Validation of this pipeline through manual gating of two datasets (murine splenocytes and human who

208 channels that takes into account contingent gating of two series hemichannels and the distribution o

209 Electrostatic gating of two-dimensional (2D) materials with ionic liqu

210 The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca(2+))

211 -linear dependence of T-type calcium channel gating on GABA(B) receptor activity regulates network os

212 However, the mechanism of gating on the cytoplasmic side of the membrane remains a

213 Gating on this single intuitive metric, partially contam

214 is unclear how this process relates to fast gating or if the intracellular and extracellular regions

215 o evidence of H-L-H involvement in either pH gating or ion selectivity.

216 Still, gating or rebound may be possible in other physiological

217 dynamic tunnel lining, with implications for gating or substrate translocation.

218 by changes in basal ganglia activity through gating- or rebound-like mechanisms.

219 mechanisms, allowing accurate inferences on gating/permeation.

220 mechanism for electromechanical coupling and gating polarity in non-domain-swapped K(v) channels on t

221 es(1-3), the general determinants of channel gating polarity remain poorly understood(4).

222 t pore subunit is the primary determinant of gating polarity.

223 cal characteristics of suspended MoS(2) FET, gating potential was applied through an electrolyte on t

224 the last decade has revealed that the Orai1 gating process is highly cooperative and strongly allost

225 DT-MD method enables exploration of the MscL-gating process with different pulling velocities and var

226 d demonstrate the existence of anion channel gating processes outside the EAAT uptake cycle.

227 al ensembles-coupling distant brain regions, gating processing windows, and providing a reference for

228 hough conformational changes associated with gating promote cross-linking for I409C/R410C, which in t

229 We conclude that TWIK-1 displays unique SF gating properties among the family of K2P channels.

230 derstood, less is known about how single-RyR gating properties define the RyR group dynamics in an ar

231 drug also caused changes in GABA(A) receptor gating properties in the vHipp with resultant changes in

232 egration of ion channels with newly designed gating properties into cardiomyocytes.

233 ding gap junction protein Cx26, which alters gating properties of Cx26 channels in a dominant manner.

234 conflicting reports on the permeability and gating properties of TPC2 and they establish a new parad

235 ine 351 and glutamate 355, that influence pH gating properties, as well as a single residue, aspartat

236 nonselective channel that has some peculiar gating properties, but also exhibits behavior typically

237 largely retaining the characteristic Nav1.9-gating properties.

238 This cell cycle gating provides a temporal compartmentalization of feedb

239 on sites undergo large translocations during gating, providing a potential mechanism for pathogenic e

240 mages that can be used for visualization and gating purposes and for motion estimation using image re

241 management, suggesting its essential role in gating radical transport across the protein-protein inte

242 account in extrapolated models used for MscL gating rationalization.

243 nufacturer's product), external device-based gating (real-time position management (RPM)-gated), no g

244 localization at the synapse and by directly gating receptor channel opening.

245 Our efforts delineating the permeation and gating regions within this complex ion channel have impl

246 aI has an extended sensor paddle that during gating relocates relative to the pore concomitant with b

247 the selection of optimal number of gates for gating remains a challenge.

248 lude cognitive deficits and impaired sensory gating represented by P50 inhibition deficits, which app

249 dynamics, and how transmembrane helices and gating residues control the hydration process.

250 s, specifically its conductance and rates of gating response to voltage steps, demonstrates a clear i

251 irst 3 min of data (ungated-matched), and no gating retaining all coincidences (ungated-full).

252 Quiescent-period gating retaining approximately 50% of coincidences was t

253 mperature, with large rocking motions of the gating ring and bending of pore-lining helices.

254 rmations are distinguished by rocking of the gating rings with respect to the transmembrane region, i

255 nesis suggests that this loop is critical in gating secretion and we propose that a series of conform

256 iting OB output neurons, thereby dynamically gating sensory throughput to the cortex.SIGNIFICANCE STA

257 permeates this tunnel and leverages upon the gating side chains triggering the CD loop to furl, which

258 Correlation analyses were performed on both gating signals.

259 and specificity of nuclear RNAi responses by gating small RNAs into specific nuclear Argonautes.

260 rin-15 ectodomain can act as a stiff or soft gating spring.

261 The common dependence on gating state with distinct binding sites raises the poss

262 The gating state-mediated interaction between the compounds

263 cal testing, adoption of alternative initial gating steps, and incorporation of other datasets.

264 Traditional manual gating strategies are often time-intensive, place a high

265 alidated this method with traditional manual gating strategies for 24 subsets of T cells, B cells, NK

266 ucible alternative to labor intensive manual gating strategies.

267 counts between the hybrid method and manual gating strategy of these cell subsets showed results tha

268 R subdomains leads to a remarkably elaborate gating structure as programmed by the amino acid sequenc

269 be a general feature of beta-barrel channel gating, suggest either an entropy-driven gating mechanis

270 e substrate was integrated into a liquid-ion gating system surrounded by pH 7.4 buffer as an electrol

271 ded by an external, device-based respiratory gating system.

272 e "conformational wave" of liganded-receptor gating takes place in the ECD and the interfacial M2-M3

273 with a manually created hierarchically cell gating template implemented, along with a custom develop

274 laser wavelengths and synchronized detection gating that can be tailored and optimized for each FRET

275 previously unaccounted steps in EAG channel gating that could be activated by ligand binding to the

276 sically studied as regulators of ion channel gating that engage the nAChR channel pore.

277 s using simulations with three models of RyR gating that have identical open probabilities: the commo

278 lpha, and we hypothesize it is important for gating the ER translocon.

279 Pg neurons may exert part of their effect by gating the flow of visual information to descending neur

280 By gating the transition from 30S biogenesis to translation

281 Compared with standard gating, the results of our workflow provide new insights

282 ing, interface modulation, and electrostatic gating, there is as of yet no analogue of these effects

283 At the same time, the gating thermodynamics, as characterized by the gating ch

284 horylation site mimics the effect on voltage gating to a lesser extent.

285 al/computational model of GJ channel voltage gating to assess properties of GJ channels that takes in

286 Herein, we use gating to develop a copper-containing single-chain nanop

287 We also used fluorescent gating to examine the effect of ThT on the aggregate siz

288 try measurements include manual or automated gating to identify cell subsets from the cytometry data,

289 ork framework that incorporates hierarchical gating to model the prefrontal cortex's ability to flexi

290 concept that the system can implement logic gating to specifically detect breast cancer cells and ex

291 Previous attempts to simulate gating transitions in MscL by either directly applying s

292 The proton-selective histidine and gating tryptophan in the open BM2 reorient on the micros

293 ion of traditional multicolor flow cytometry gating, unsupervised clustering analysis and BAL superna

294 cy as well as chemical inhibitors on channel gating using a Ca(2+)-sensitive promoter to express a se

295 onsisting of a modified U-Net with attention-gating was implemented to establish a high-throughput an

296 D) flow of the thoracic aorta with navigator gating was performed as a reference comparison.

297 aminations were acquired, with a respiratory gating waveform recorded by an external, device-based re

298 in social approach behavior and sensorimotor gating, whereas MIA offspring with a low inflammatory cy

299 Recently electrolytic gating, which can generate large electric fields and vol

300 1)) that is most efficient in the absence of gating, which represents the first example of antiambipo