ライフサイエンスコーパス: gating property

1 wed significant changes in voltage-dependent gating properties.

2 events were responsible for variant-specific gating properties.

3 electrical activity derives from its unusual gating properties.

4 nal A-type K+ channels without any change in gating properties.

5 are known to be regulators of the channels' gating properties.

6 in LCC density with similar conductance and gating properties.

7 potassium (Kv1-Kv4) channels in assembly and gating properties.

8 vivo generates a protein with unique voltage gating properties.

9 el because of its distinct voltage-dependent gating properties.

10 ls but resembled P-type Ca channels in their gating properties.

11 a2+ channel current without altering channel gating properties.

12 an embryonic kidney-293 cells revealed novel gating properties.

13 onents of the expression system modulate its gating properties.

14 d sulfonylurea sensitivity and ATP-dependent gating properties.

15 mal current kinetics with minimal changes in gating properties.

16 tion expressed HERG current but with altered gating properties.

17 eference to the modulation of single-channel gating properties.

18 ng anion-selective channels that lacked GABA-gating properties.

19 ch beta-subunit and even MPZ imparted unique gating properties.

20 owever, they exert opposing effects on TRPM8 gating properties.

21 in the dynamic regulation of Cav3.2 channel gating properties.

22 tigated the effects of pH variations on VDAC gating properties.

23 of function because of the modifications in gating properties.

24 n of KATP channels without affecting channel gating properties.

25 allosteric modulator compounds, and controls gating properties.

26 pk1 activation is the result of Ppk1 channel gating properties.

27 urther diversify Nematostella Shaker channel gating properties.

28 ashout was needed to reestablish the initial gating properties.

29 lion-derived cell line, without changing its gating properties.

30 eir current densities without altering their gating properties.

31 largely retaining the characteristic Nav1.9-gating properties.

32 ce complexes with diverse ion-conducting and gating properties.

33 hat play a major role in determining channel-gating properties.

34 at have been engineered to exhibit different gating properties.

35 ted channel, substantially influencing their gating properties.

36 has been correlated with changes in channel-gating properties.

37 sue-specific manner, modifying the channel's gating properties.

38 r cell surface expression and single-channel gating properties.

39 of coupling, and exhibited unaltered voltage-gating properties.

40 nt amplitude, without a detectable effect on gating properties.

41 regulates its intracellular distribution and gating properties.

42 and beta2e are required to stabilize Cav2.3 gating properties allowing sustained Cav2.3 availability

43 We conclude that TWIK-1 displays unique SF gating properties among the family of K2P channels.

44 rdomain interaction in vitro and altered the gating properties and calmodulin sensitivity of expresse

45 The gating properties and current amplitudes of mammalian vo

46 glutamate receptors (AMPA-Rs) with distinct gating properties and exhibit different transmission dyn

47 ype must be conferred entirely by changes in gating properties and is not remedied by coexpression wi

48 1 channels exhibit altered voltage-dependent gating properties and lack the bulk of the phosphorylati

49 also that families of Ca2+ channels display gating properties and neurotransmitter modulation that d

50 rtners of AMPARs that modulate AMPAR channel gating properties and pharmacology, as well as their bio

51 rming CaV alpha1 subunit to modulate channel gating properties and promote cell surface trafficking.

52 alylation, of Kv1.1 affected its macroscopic gating properties and slowed activation and C-type inact

53 ular beta auxiliary subunit, which alter the gating properties and trafficking of the calcium channel

54 -diverse NTDs determine subunit arrangement, gating properties and ultimately synaptic signalling eff

55 opic and single-channel conductance, voltage-gating properties, and kinetics; pH gating sensitivity w

56 region form functional channels with altered gating properties, and we show that NPAS is a general me

57 AMPA receptor surface expression and channel gating properties; and (2) trans-synaptic organizing mol

58 Their ion-gating properties are consistent with those of AChR isot

59 ypes of voltage-gated calcium channel, their gating properties are key for the precise control of neu

60 erefore unnecessary to invoke exotic channel-gating properties as an explanation.

61 tilayer-modified membranes showed reversible gating properties as the pH condition of feed solution w

62 , the molecular basis of their uniquely slow gating properties as well as the stoichiometry and inter

63 ine 351 and glutamate 355, that influence pH gating properties, as well as a single residue, aspartat

64 cularly terminal sialylation, affected Kv1.l gating properties both by altering the surface potential

65 cularly terminal sialylation, affected Kv1.1 gating properties both by altering the surface potential

66 ypic channels with distinct permeability and gating properties but do not form functional homomeric/h

67 nonselective channel that has some peculiar gating properties, but also exhibits behavior typically

68 in lysenin result in changing its electrical gating properties by modifying the strength of the dipol

69 Small alterations in gating properties can lead to severe changes in cellular

70 Here, we show that cAMP effects on the gating properties CNGCs persist when protein synthesis i

71 ls with lower current amplitudes and altered gating properties compared with wild type.

72 channels in native smooth muscle demonstrate gating properties consistent with a role in maintaining

73 ereby phosphorylation-induced changes in LCC gating properties contribute to EAD generation.

74 derstood, less is known about how single-RyR gating properties define the RyR group dynamics in an ar

75 In contrast, TipE did not alter these gating properties except for a hyperpolarizing shift in

76 I(Ks) caused by loss of function or altered gating properties explains the prolonged QT interval and

77 rmational dynamics simultaneously with other gating properties for the LQT3 variants.

78 ly recently, and there are no reports on the gating properties for the recombinant receptors.

79 are caused by dysfunction in one or several gating properties, for instance activation or inactivati

80 n bilayers, this channel has conductance and gating properties identical to the in situ channel, pass

81 We characterized the kinetics of these novel gating properties in a series of additional voltage-step

82 ay permit evolutionary changes that tune the gating properties in different species.

83 graine type 3 variants reveal alterations of gating properties in keeping with neuronal hyperexcitabi

84 e channels in liposomes and exhibits voltage-gating properties in planar phospholipid bilayers.

85 re, the model can capture nontrivial voltage gating properties in regions where few mutations are kno

86 drug also caused changes in GABA(A) receptor gating properties in the vHipp with resultant changes in

87 ne type 3 variants induce a larger effect on gating properties, in particular the increase of persist

88 Pyr-R channels also exhibit altered gating properties, including a approximately 13 mV posit

89 GluR-A with alanines produced channels with gating properties indistinguishable from wild type.

90 egration of ion channels with newly designed gating properties into cardiomyocytes.

91 nction as unapposed hemichannels to identify gating properties intrinsic to hemichannels and how they

92 These changes in permeation and gating properties mimic the changes induced by mutations

93 xperiments showed typical pressure-dependent gating properties of a stretch-activated channel with a

94 receptor current amplitudes and altered the gating properties of alpha1beta2 receptor channels by re

95 t alternative splicing did not influence the gating properties of alpha1C and alpha1E subunits.

96 units that regulate both the trafficking and gating properties of AMPA receptors, and different TARP

97 t, we consider the impact of crowding on the gating properties of bacterial mechanosensitive membrane

98 The voltage gating properties of BK channels have been characterized

99 The gating properties of BK(Ca) channels are Ca(2+)-, voltag

100 the beta subunit family can finely tune the gating properties of Ca(2+)- and voltage-dependent BK ch

101 ximal capsaicin concentrations, and that the gating properties of capsaicin activation differ from th

102 concentration of permeant ions modulate the gating properties of cardiac L-type Ca(2+) channels.

103 n addition to controlling the expression and gating properties of Cav1.3 channels, the largely extrac

104 in chicken cone photoreceptors regulate the gating properties of cGMP-gated cationic channels (CNGCs

105 ken retinal cone photoreceptors modulate the gating properties of cGMP-gated channels (CNGCs) such th

106 2 interface), to investigate the binding and gating properties of CMPI at the a4:a4 interface.

107 2 interface), to investigate the binding and gating properties of CMPI at the alpha4:alpha4 interface

108 ding gap junction protein Cx26, which alters gating properties of Cx26 channels in a dominant manner.

109 roup of mutations also conferring changes in gating properties of Cx32 channels.

110 d providing a basis to interpret the altered gating properties of disease-causing variants.

111 nding on the state, unitary conductances and gating properties of each hemichannel.

112 rovides a template to further understand the gating properties of Eag1 and related channels.

113 osine phosphorylation is correlated with the gating properties of expressed wild-type and mutant Kv c

114 hese experiments are the first to assess the gating properties of GABA(A)Rs in the presence of an aux

115 The gating properties of GIRK channels (Kir3.1/Kir3.2a) acti

116 eveals that the splice insert alters the key gating properties of GluK1 receptors and their modulatio

117 We examined formation and gating properties of heterotypic gap junction (GJ) chann

118 and two slow gates in series to describe the gating properties of homotypic and heterotypic GJ channe

119 ped a stochastic four-state model describing gating properties of homotypic and heterotypic GJ channe

120 etable mathematical structure to capture the gating properties of human ionotropic receptors (validat

121 The voltage-dependent gating properties of I(to,fast) were, however, not alter

122 membrane and/or by perturbing the intricate gating properties of Kv11.1 channels.

123 Kv6.1 and variants influence expression and gating properties of Kv2.1, and also that coassembly wit

124 Abstract beta1-Subunits enhance the gating properties of large-conductance Ca(2+)-activated

125 We report the first characterization of the gating properties of M34T, which had previously been rep

126 MICUs achieve this by modifying the gating properties of MCU(cx) allowing it to spend more t

127 xiliary subunits differentially regulate the gating properties of Na(v)1.7 channels.

128 that co-expression of TMEM233 modulates the gating properties of Na(V)1.7.

129 Little is known of the gating properties of native SK channels in CNS neurons.

130 fect of S241A and S241L substitutions on the gating properties of Nav1.7.

131 effects on trafficking and voltage-dependent gating properties of recombinant Ca(v)2.1 Ca2+ channel c

132 new methodology to study the permeation and gating properties of recombinant mammalian InsP(3)Rs in

133 on of the localization and voltage-dependent gating properties of the abundant neuronal Kv2.1 channel

134 ysiological mechanism regulating the "short" gating properties of the CaV1.3(43S) variant and positio

135 ar nuclei neurons indicated that the altered gating properties of the Cav3.3 disease variants lower t

136 ssed in Xenopus oocytes, beta1 modulates the gating properties of the channel-forming type IIA alpha

137 shear stress activates ENaC by modifying the gating properties of the channel.

138 ace and brings about profound changes in the gating properties of the channel.

139 arly in the C terminus, drastically modifies gating properties of the channel.

140 ensity that is not accompanied by changes in gating properties of the channel.

141 erpolarizing shifts in the voltage-dependent gating properties of the channel.

142 2.1 monomer did not significantly affect the gating properties of the channel.

143 he binding of IP(3) to the LBD regulates the gating properties of the channel.

144 to connexons, docking with adjacent cells or gating properties of the gap junction.

145 expression of Kv4.2 or Kv4.3 alone, and the gating properties of the heteromeric Kv4.2/Kv4.3 channel

146 ta subunit involved in the modulation of the gating properties of the high voltage-activated calcium

147 We have studied the gating properties of the hSkM1-R669H mutant Na channel e

148 Single-channel recordings reveal improved gating properties of the I507-ATC compared to I507-ATT D

149 we determined macroscopic and single-channel gating properties of the intercellular channels formed.

150 We have investigated the gating properties of the inward rectifier chloride chann

151 Thus the gating properties of the L-type Ca(2+) channels expresse

152 Exploiting the unique charge movement and gating properties of the L382V mutant of Shaker, we show

153 ing/deswelling properties of multilayers and gating properties of the multilayer-modified TEPC membra

154 The gating properties of the Na(+) current through H1 and th

155 -M1 or S2-M4, was dependent on the intrinsic gating properties of the NMDA receptors, being more effe

156 channel and thus providing the transport and gating properties of the NPC.

157 crucial role in the membrane expression and gating properties of the pore-forming alpha(1) subunit.

158 uggest that Ca(v)beta subunits determine the gating properties of the presynaptic Ca(2+) channels wit

159 mino-terminal domain layer without affecting gating properties of the receptor.

160 in II, angiotensin receptors type 1 modulate gating properties of the remaining Kv4.3 channels on the

161 1239H and R1239G have similar effects on the gating properties of the skeletal muscle L-type Ca2+ cha

162 pus oocytes, the beta1 subunit modulates the gating properties of the type IIA alpha subunit, resulti

163 the effect of these three key lipids on the gating properties of the voltage-dependent anion channel

164 so forms an 8-pS chloride channel with mixed gating properties of the wild type and mutant CFTR chann

165 combination of Cx43 and Cx45 on the voltage-gating properties of their channels, we transfected DNA

166 Mimicking the gating properties of these biological structures would b

167 This is due, in large part, to the unique gating properties of these channels, which are character

168 nate (MTS) reagents for their effects on the gating properties of these cysteine mutants in intact Xe

169 of Na(v)1.6 and Na(v)1.8 by pp38, regulates gating properties of this channel but not its current de

170 V(j)-dependent gating properties of this mutant channel were characteri

171 lation of TRPV1 expression and modulated the gating properties of this receptor.

172 conflicting reports on the permeability and gating properties of TPC2 and they establish a new parad

173 The voltage- and calcium-dependent gating properties of two lens gap-junctional hemichannel

174 proposed model can also be used to simulate gating properties of unapposed hemichannels.

175 The purpose of this study was to compare the gating properties of various alpha1 subunit complexes co

176 separate VSDs can realize the characteristic gating properties of voltage-gated cation channels.

177 pable of modulating both the conductance and gating properties of voltage-gated ion channels in hippo

178 The gating properties of voltage-gated potassium channels ar

179 ly that polypeptide toxins that modulate the gating properties of voltage-sensitive cation channels a

180 In mdx mouse cells the intrinsic gating property of fast voltage-sensitive inactivation i

181 gate, the R state results from an intrinsic gating property of the channel filter region.

182 d of the pore, R is most likely an intrinsic gating property of the K(+) filter.

183 The hysteretic gating property of the multilayer-modified TEPC membrane

184 lectrophysiologically and were found to have gating properties only slightly altered from wild-type.

185 ns, which potentially regulate the channel's gating properties over a spectrum of different tissues o

186 the structural determinants for the unusual gating properties remain elusive.

187 ulted in voltage dependence and inactivation-gating properties, respectively, of the T(in) channel th

188 residual conductance state (G(min)) and V(j) gating properties, respectively.

189 Examination of desensitization and gating properties revealed these to be similar in VB and

190 ess constructs generated in this study shows gating properties similar to wild-type BK channel but wi

191 s) were reduced by 30-40%, respectively, and gating properties, such as the voltage of half-maximum a

192 These gating properties suggest a physiological mechanism by w

193 d type-B receptors have strikingly different gating properties that are further modulated by Neto-alp

194 bits substantial time- and voltage-dependent gating properties that may have significance for the phy

195 -type Ca(2+)-currents with voltage-dependent gating properties that suggest modulation by beta2a- and

196 ondition, resulted in current amplitudes and gating properties that were intermediate between wild-ty

197 hanol results from a modification of channel gating properties: the contribution of long openings to

198 r permeability characteristics but different gating properties: the probability of the wild-type chan

199 channel beta subunits modify alpha1 subunit gating properties through direct interactions with intra

200 The distinct gating properties we describe may allow them to subserve

201 Based on its brain distribution and novel gating properties, we suggest that alpha1I plays importa

202 Gating properties were altered modestly in most mutant c

203 formed intercellular channels, although the gating properties were altered.

204 Observed gating properties were consistent with a second gating m

205 The biomimetic ion-gating properties were demonstrated by measuring the pH-

206 l networking, pH-tuning, and electrochemical gating properties were identified between the network fi

207 .1), involved in voltage- and time-dependent gating properties were investigated by heterologous expr

208 RGC subtypes, along with their Na(V) channel-gating properties, were recorded during experimentally i

209 ectifying K(+) (GIRK) channels have distinct gating properties when activated by receptors coupled sp

210 nits formed functional channels with altered gating properties when expressed alone in oocytes.

211 ptophan (W) and examined their corresponding gating properties when expressed in Hek293t cells along

212 increased I(Ca,L) density without changes in gating properties, whereas expression of Cav3-F97C reduc

213 d robust sodium currents, but with different gating properties, whereas the splicing variant with the

214 s findings of the creation of biomimetic ion-gating properties with core-shell nanoparticle network a

215 se-dependent curve, altered Ca(2+)-dependent gating properties with decreased maximal open probabilit