ライフサイエンスコーパス: gelsolin

1 ruption (latrunculin or pipette perfusion of gelsolin).

2 tes the cytoskeleton via an interaction with gelsolin.

3 calcium-dependent manner similar to that of gelsolin.

4 eolytic fragments of mutant (D187N/Y) plasma gelsolin.

5 equivalent to fourth and fifth G domains of gelsolin.

6 to LTA inhibits F-actin depolymerization by gelsolin.

7 aortic endothelial cells was compromised by gelsolin.

8 ish corneal crystallin previously called C/L-gelsolin.

9 ent severing by myosin-induced forces and by gelsolin.

10 th x-ray crystallography data for vertebrate gelsolin.

11 vivo may be mediated or inhibited by plasma gelsolin.

12 ation in astrocytes appears to be blocked by gelsolin.

13 re all consistent with PrABP80 being a plant gelsolin.

14 alpha-actin and decreased the expression of gelsolin.

15 s ability to down-regulate the expression of gelsolin.

16 otoreceptors via the actin-severing protein, gelsolin.

17 , aminopeptidase N, CXCL9, endothelin-1, and gelsolin.

18 mplement 3, collagen II, thymosin beta4, and gelsolin.

19 structural similarities and differences with gelsolin.

20 we made several truncated versions of plasma gelsolin.

21 -H1 abrogated the actin-severing activity of Gelsolin.

22 ation of phagosomes enriched with NMMIIA and gelsolin.

23 binding sequence in the cytoskeletal protein gelsolin.

24 A peptide based on the PPI binding site of gelsolin (160-169) binds purified LTA at the same molecu

25 We document the depletion of plasma gelsolin (25-50% of normal) in murine models of sepsis a

26 ify a physical interaction between N-RAS and gelsolin, a factor that has been shown to promote surviv

27 Here we report that plasma gelsolin, a highly conserved human protein, binds LPS fr

28 Lowering the activity of Gelsolin, a known calcium-activated actin filament-sever

29 Gelsolin, a known target of Atf3 transcriptional activit

30 Gelsolin, a multifunctional actin-binding protein, media

31 We hypothesize that plasma concentrations of gelsolin, a protein that responds to injured tissue, mig

32 s interferes with 5-FU-induced expression of gelsolin, a protein with known antiapoptotic activity.

33 ated genes (P<0.0001) were in the domains of gelsolin (actin cytoskeleton), matrix metallopeptidases

34 eterodimeric capping protein (CP), CapG, and gelsolin-actin complex.

35 sing the NMR structure of villin 14T and the gelsolin-actin/Ca2+ crystal structure, six putative site

36 this RPGR-gelsolin interaction, compromising gelsolin activation.

37 r (beta2AR) optobodies suppressed endogenous gelsolin activity and beta2AR signaling, respectively.

38 ity was negatively affected in parallel with Gelsolin activity, suggesting that Nm23-H1 binding inact

39 Here, we used gelsolin affinity chromatography to purify actin from fi

40 Gelsolin also competes with LPS-binding protein (LBP), a

41 In this study we investigate whether gelsolin also interacts with bacterial wall molecules of

42 rin efficiently accelerates the formation of gelsolin amyloid by enabling intermolecular beta-sheet f

43 issue-selective deposition observed there in gelsolin amyloid disease.

44 ergy nucleus, accelerating 8 and 5 kDa D187N gelsolin amyloidogenesis.

45 ated that heparin is capable of accelerating gelsolin amyloidogenesis.

46 t ECM components are capable of accelerating gelsolin amyloidogenesis.

47 e-selective deposition characteristic of the gelsolin amyloidoses is likely influenced by the extrace

48 milial amyloidosis of Finnish type (FAF), or gelsolin amyloidosis, is a systemic amyloid disease caus

49 k of Atf3 induction suppresses expression of gelsolin, an actin-severing protein, and rescues spine d

50 te the unique and complementary functions of gelsolin and ADF/cofilin in the recycling of actin filam

51 es, and demonstrated that photoactivation of gelsolin and beta2-adrenergic receptor (beta2AR) optobod

52 oll-like receptors (TLRs) are neutralized by gelsolin and by a peptide based on gelsolin residues 160

53 ments, shortened to physiological lengths by gelsolin and cross-linked with recombinant human filamin

54 effects of YopO-mediated phosphorylation on gelsolin and identified its phosphorylation sites by mas

55 n, despite the presence of full-length D187N gelsolin and its 68-kDa cleavage product in blood-demons

56 oflourescence to monitor complexes formed by Gelsolin and Nm23-H1 in living cells, we observed their

57 ease of [Ca(2+)]i, minimal colocalization of gelsolin and NMMIIA in focal adhesions, and minimal intr

58 The Ca(2+) -dependent interaction of gelsolin and NMMIIA in turn enables actin remodeling and

59 ized the F-actin much faster than the native gelsolin and other truncates at the same molar ratios.

60 dysregulation of the actin-severing protein gelsolin and Pctaire1 (Cdk16) kinase, which cooperates w

61 parison of sequence alignments between human gelsolin and plant villins with x-ray crystallography da

62 These residues are conserved in GSNL-1 and gelsolin and previously implicated in actin-severing act

63 However, the YopO phosphorylation sites on gelsolin and the consequences of YopO-mediated phosphory

64 his is the first direct evidence for a plant gelsolin and the first example of efficient severing by

65 trometry revealed that PrABP80 is related to gelsolin and villin.

66 scinderin (adseverin) gene, and scinla (C/L-gelsolin) and scinlb are novel scinderin-like genes.

67 akage of cell breakdown products (low plasma gelsolin), and possibly altered vitamin K usage or gluco

68 , thrombospondin-2, interleukin-18 receptor, gelsolin, and activated C5.

69 ctin-remodeling complex that includes actin, gelsolin, and EPLIN.

70 ith and activates the actin-severing protein gelsolin, and that gelsolin regulates actin disassembly

71 from bovine cardiac skinned muscle fibres by gelsolin, and the actin filament was reconstituted from

72 g proteins, such as alpha-actinin, vinculin, gelsolin, and tropomyosins (TMs), is considered to contr

73 The presence of misfolding-prone D187N gelsolin appears to exacerbate the age-associated declin

74 Mutations in gelsolin are responsible for a systemic amyloidosis firs

75 ctin-depolymerizing factor (ADF)/cofilin and gelsolin are the two major factors to enhance actin fila

76 High amounts of exogenous gelsolin are, however, required to treat animal models o

77 The related villins and gelsolins are conserved proteins that are constructed fr

78 y, the actin regulatory factors, cofilin and gelsolin, are recruited to BCR clusters in both mAg- and

79 ch, we identified the actin-severing protein Gelsolin as binding partner for Nm23-H1, verifying their

80 , hepatoma-derived growth factor (HDGF), and gelsolin as factors potentially contributing to this act

81 inhibition of the actin binding activity of gelsolin as well as the actin depolymerizing activity of

82 usly identified a gelsolin-like protein (C/L-gelsolin) as a corneal crystallin in zebrafish.

83 nd Ca(2+)-dependent enrichment of NMMIIA and gelsolin at collagen adhesions, and abundant intracellul

84 were collected for full-length human plasma gelsolin at nanomolar to millimolar concentrations of fr

85 long, with a knob-like mass attributable to gelsolin at one end.

86 Gelsolin, at both nanomolar and micromolar Ca(2+) concen

87 he velocity reduction was a direct effect of gelsolin binding to the filament and revealed different

88 ys of actin depolymerizing effects show that gelsolin binds more tightly to LPS than it does to its o

89 [Ca2+]i also blocks the severing activity of gelsolin, but not actin-depolymerizing factor (ADF)/cofi

90 Immunodepletion of gelsolin, but not Xenopus ADF/cofilin, eliminates calciu

91 phosphorylates the actin-remodeling protein gelsolin, but the functional importance of this gelsolin

92 at of the crystal structures solved for Ca2+/gelsolin C-terminal and N-terminal halves+/-monomeric G-

93 f either gelsolin or CapG and does not uncap gelsolin-capped filaments.

94 program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine m

95 s accompanied by upregulation of cytoplasmic gelsolin (cGSN), an abundant actin-severing protein invo

96 y labelled thin filament was attached to the gelsolin-coated surface of a polystyrene bead.

97 to promote survival and show that the N-RAS:gelsolin complex is modulated differently in wild-type a

98 The Ca2+-sensitive actin-severing protein gelsolin concentrates in the Listeria rocket tails at no

99 Plasma gelsolin concentrations were assessed serially on day 0

100 tin, nectin, zyxin, vinculin, laminingamma3, gelsolin, connection43, and N-cadherin.

101 utants suggested that the N-terminal half of gelsolin contained sequences which were responsible for

102 elsolin, providing further support of myosin-gelsolin cooperativity.

103 uh7 cells transfected with plasmids encoding gelsolin deletion mutants suggested that the N-terminal

104 Gelsolin-dependent removal of thin filament proteins als

105 ved only in tissues synthesizing human D187N gelsolin, despite the presence of full-length D187N gels

106 Because the 68 kDa fragment of gelsolin does not form amyloid fibrils in vitro or in a

107 for D6 in D6-HP as in the highly homologous gelsolin domain 6.

108 beit at a lower efficiency than observed for gelsolin domains G1-G3.

109 Gelsolin domains G4-G6 selectively require Ca(2+) to int

110 coding gelsolin-like proteins based on their gelsolin domains in zebrafish: gsna and gsnb group with

111 re constructed from a core of six homologous gelsolin domains.

112 that is related to the actin binding protein gelsolin enhanced estrogen receptor activity, and mutati

113 Gelsolin exhibits tight, Ca(2+)-dependent binding to ful

114 ctin-remodeling protein gelsolin, increasing gelsolin expression and leading to faster glucose-induce

115 We demonstrated that silencing of gelsolin expression by small interfering RNA sensitized

116 lpha-actin; on the other hand, knocking down gelsolin expression enhanced the assembly of alpha-actin

117 apoptosis by demonstrating that silencing of gelsolin expression through RNAi sensitized cells to 5-F

118 t in part through the negative regulation of gelsolin expression.

119 tin cytoskeleton in a depolymerized state by gelsolin facilitates calcium-dependent apical accumulati

120 echanisms that could explain how this unique gelsolin family member might regulate both stable kerati

121 ndicate that GSNL-1 is a novel member of the gelsolin family of actin regulatory proteins and provide

122 The gelsolin family of actin regulatory proteins is activate

123 ke protein-1 (GSNL-1) is a new member of the gelsolin family of actin regulatory proteins.

124 The gelsolin family of proteins is a major class of actin re

125 CapG is the only member of the gelsolin family unable to sever actin filaments.

126 Jak3 and cytoskeletal proteins of the villin/gelsolin family.

127 may maintain an inactive conformation of the gelsolin family.

128 implicated in actin-severing activity of the gelsolin family.

129 seeded with preformed 8 kDa fragment plasma gelsolin fibrils.

130 ains between C. elegans GSNL-1 and mammalian gelsolin for actin regulatory functions.

131 ntaining gelsolin fragments or an N-terminal gelsolin fragment (amino acid residues 1-70) in the pres

132 siRNA reduced the effects of the N-terminal gelsolin fragment and TRAIL.

133 ther, our study suggests that the N-terminal gelsolin fragment enhances TRAIL-induced loss of cell vi

134 e N-terminal region of gelsolin identified a gelsolin fragment in IHH CM.

135 in that promote the 8 kDa disease-associated gelsolin fragments (residues 173-243) generated at the c

136 Gelsolin fragments encompassing N-terminal regions in po

137 Herein, we show that the 8 and 5 kDa gelsolin fragments form amyloid fibrils by a nucleated p

138 autoantibodies generated against N-terminal gelsolin fragments in patients with chronic liver diseas

139 hown that conditioned medium (CM) containing gelsolin fragments or an N-terminal gelsolin fragment (a

140 The apoptotic activity of N-terminal gelsolin fragments was restricted to activated but not q

141 Villins belong to the villin/gelsolin/fragmin superfamily and comprise at least five

142 ently release the actin-capping protein (CP) gelsolin from barbed actin ends in vitro, allowing for e

143 Structural reconstruction of gelsolin from these data provided a striking visual trac

144 esults show a strong effect of LPS on plasma gelsolin function and suggest that some effects of endot

145 itical insight into how YopO disrupts normal gelsolin function to alter host actin dynamics and thus

146 ish: gsna and gsnb group with the vertebrate gelsolin gene, scina and scinb group with the scinderin

147 e for PCR amplification of a fragment of the gelsolin gene.

148 toxemic mice (survival rates were 88% in the gelsolin group vs. 0% in the saline group, p < .001) and

149 llenged mice (survival rates were 30% in the gelsolin group vs. 0% in the saline group, p = .001).

150 ukin-10 levels were 205 +/- 108 pg/mL in the gelsolin group vs. 39 +/- 29 pg/mL in the saline group,

151 e actin-binding proteins villin 1 (VIL1) and gelsolin (GSN) in intestinal epithelial cells (IECs) to

152 Here, we report higher gelsolin (GSN) levels in chemoresistant gynecological ca

153 lpha1-antitrypsin (AAT), hemopexin (HX), and gelsolin (GSN), and tested against catabolic stimulation

154 ed mechanisms, especially its linkage to the gelsolin (GSN)-mediated cell invasion, remain unclear.

155 However, unlike gelsolin, GSNL-1 remained bound to the side of F-actin w

156 for sepsis-induced cell injury, that plasma gelsolin has a crucial protective role in sepsis, and th

157 lity to rapidly depolymerize F-actin, plasma gelsolin has emerged as a therapeutic molecule in differ

158 Gelsolin has six homologous gelsolin-like domains (G1-G6

159 ylated gelsolin in the linker region between gelsolin homology domains G3 and G4, which, in the absen

160 r B-cell epitope in the N-terminal region of gelsolin identified a gelsolin fragment in IHH CM.

161 We ascertained the role of gelsolin in 5-FU-induced apoptosis by demonstrating that

162 We examined the role of plasma gelsolin in animal models of sepsis.

163 -induced apoptosis and that re-expression of gelsolin in cells harboring mutant Ras protected cells f

164 The various functions of gelsolin in extracellular compartments are not yet clear

165 that ADF/cofilin and AIP1 are distinct from gelsolin in modulating filament elongation.

166 Depletion of plasma gelsolin in systemic inflammation may contribute to adve

167 SNL-1 has properties different from those of gelsolin in that it remains bound to F-actin and does no

168 , low pH has also been suggested to activate gelsolin in the absence of Ca(2+) ions, although no stru

169 eptides derived from mutant (D187Y/N) plasma gelsolin in the extracellular matrix (ECM).

170 YopO phosphorylated gelsolin in the linker region between gelsolin homology

171 the splicing of the actin-remodeling protein gelsolin, increasing gelsolin expression and leading to

172 show that clear cells express high levels of gelsolin, indicating a potential role in the functional

173 ults corroborate cooperative effects between gelsolin-induced alterations in the actin filaments and

174 Overexpression of gelsolin inhibited TGF-beta-induced assembly of smooth m

175 ase-causing RPGR mutations perturb this RPGR-gelsolin interaction, compromising gelsolin activation.

176 Gelsolin is a calcium-regulated actin filament severing,

177 Plasma gelsolin is a circulating actin-binding protein that ser

178 Gelsolin is a key actin cytoskeleton-modulating protein

179 Plasma gelsolin is a potential prognostic biomarker for critica

180 Gelsolin is a six-domain (G1-G6) protein activated by ca

181 These data suggest that extracellular gelsolin is involved in the host immune recognition of L

182 Out of these, gelsolin is one of the most potent for filament severing

183 Gelsolin is present in other cell types that express the

184 ng in vivo, and the actin disassembly factor gelsolin is required for normal wrapping.

185 We conclude that gelsolin is the primary Ca2+-sensitive actin filament re

186 Both RPGR and Gelsolin knockout mice show abnormalities of actin polym

187 YopO-mediated phosphorylation activates host gelsolin, leading to severed actin filaments and disturb

188 Repletion of plasma gelsolin leads to solubilization of circulating actin ag

189 Plasma gelsolin levels lower than 61 mg/L predicted longer ICU

190 Low plasma gelsolin levels were associated with increased risk of d

191 elated proteins have three or six repeats of gelsolin-like (G) domain, and each domain plays a distin

192 ventional gelsolin-related protein with four gelsolin-like (G) domains (G1-G4), unlike typical gelsol

193 n F-actin regulating, modular protein with a gelsolin-like core and a distinct C-terminal "headpiece"

194 f villin, D6-HP, which consists of the sixth gelsolin-like domain of villin (D6) and the headpiece (H

195 ) and c.2933A>C (p.Gln978Pro, located in the gelsolin-like domain).

196 lsolin-like protein-1 (GSNL-1) has only four gelsolin-like domains (G1-G4) and still exhibits Ca(2+)-

197 Gelsolin has six homologous gelsolin-like domains (G1-G6), and Ca(2+)-dependent conf

198 Purified FliI containing gelsolin-like domains (GLDs) 1-6 capped actin filaments

199 h FliI mutants, the LRR of FliI, but not its gelsolin-like domains, mediated association with cdc42,

200 gher calcium concentrations, is capable of a gelsolin-like F-actin severing.

201 We have previously identified a gelsolin-like protein (C/L-gelsolin) as a corneal crysta

202 e observed up-regulation of an actin-binding gelsolin-like protein in hypertrophic chondrocytes.

203 The Caenorhabditis elegans gelsolin-like protein-1 (gsnl-1) gene encodes an unconve

204 Caenorhabditis elegans gelsolin-like protein-1 (GSNL-1) has only four gelsolin-

205 Caenorhabditis elegans gelsolin-like protein-1 (GSNL-1) is a new member of the

206 s that there are at least six genes encoding gelsolin-like proteins based on their gelsolin domains i

207 lymerization, is indirectly regulated by the gelsolin-like sequence of g2-g3 linker.

208 One result of gelsolin-LPS binding is inhibition of the actin binding

209 h Ras mutations and/or reduced expression of gelsolin may show enhanced apoptosis in response to 5-FU

210 Conversely, when gelsolin-mediated actin filament elongation was inhibite

211 strength was progressive in homozygous D187N gelsolin mice.

212 solin, but the functional importance of this gelsolin modification has not been clear.

213 Gelsolin modulation of cell death using this fragment in

214 g of the gradual Ca2+-induced opening of the gelsolin molecule and highlighted the critical role play

215 d the maximum linear dimension (Dmax) of the gelsolin molecule increased 55 A, from 100 to 155A.

216 of gyration and maximum linear dimension of gelsolin molecules increased from 30.3 to 34.1 A and fro

217 Using phosphomimetic and phosphodeletion gelsolin mutants, we found that YopO-mediated phosphoryl

218 vasopressin action, including Mal2, Akap12, gelsolin, myosin light chain kinase, annexin-2, and Hsp7

219 ein (WASP) was observed in the actin ring of gelsolin null osteoclast.

220 Although gelsolin null osteoclasts failed to exhibit podosomes, a

221 a tail length is also calcium-insensitive in gelsolin-null mouse embryo fibroblasts.

222 not inhibit the capping activities of either gelsolin or CapG and does not uncap gelsolin-capped fila

223 ure (CLP) were treated with exogenous plasma gelsolin or placebo.

224 In vivo analyses revealed that Gelsolin overexpression increased the metastasis of orth

225 When D187N/Y gelsolin passes through the Golgi, furin endoproteolysis

226 The use of N-terminal gelsolin peptide1-70 alone or in combination with TRAIL,

227 Plasma gelsolin (pGSN) binds actin and bioactive mediators to l

228 Plasma gelsolin (pGSN) is an abundant circulating protein that

229 ially mimics calcium-dependent activation of gelsolin, potentially contributing to a reduction in fil

230 These data therefore demonstrate that gelsolin protects cells from butyrate-induced apoptosis

231 e HMM-propelled filaments in the presence of gelsolin, providing further support of myosin-gelsolin c

232 NMMIIA knockdown retards gelsolin recruitment to adhesions and blocks collagen ph

233 lation of SV and the closely related protein gelsolin reduces invasion through ECM.

234 he actin-severing protein gelsolin, and that gelsolin regulates actin disassembly in the connecting c

235 is postulated that the secretory isoform of gelsolin regulates several biological processes through

236 Gelsolin regulates the dynamic assembly and disassembly

237 tcome of serine/threonine phosphorylation in gelsolin regulation and provides critical insight into h

238 in-1 (gsnl-1) gene encodes an unconventional gelsolin-related protein with four G domains.

239 It is an unconventional gelsolin-related protein with four gelsolin-like (G) dom

240 Typically, gelsolin-related proteins have three or six repeats of g

241 lin-like (G) domains (G1-G4), unlike typical gelsolin-related proteins with three or six G domains.

242 t into functional diversity and evolution of gelsolin-related proteins.

243 Plasma gelsolin replacement may have therapeutic application.

244 crucial protective role in sepsis, and that gelsolin replacement represents a potential therapy for

245 Plasma gelsolin repletion also shifted the cytokine profile of

246 -actin by the homologous proteins villin and gelsolin requires unphysiologically high calcium concent

247 that the F-actin depolymerizing property of gelsolin resides in its N terminus, we made several trun

248 alized by gelsolin and by a peptide based on gelsolin residues 160-169 (GSN160-169) which comprise pa

249 tation (D187N/Y) in domain 2 of human plasma gelsolin, resulting in domain 2 misfolding within the se

250 segment) simultaneously to the sequences of gelsolin results in a mutant, CapG-sev, capable of sever

251 Recombinant human plasma gelsolin (rhu-pGSN), a normally circulating protein, has

252 such as lipoteichoic acid (LTA) and whether gelsolin's interaction with bacterial lipids from Gram-n

253 160-169 (GSN160-169) which comprise part of gelsolin's phosphoinositide binding site.

254 actin-capping and -severing proteins such as gelsolin, scinderin, and severin, are calcium-regulated

255 at the mutation induces a destabilization of gelsolin second domain, without compromising its calcium

256 tightly packed architecture of calcium-free gelsolin, seen from both SAXS and x-ray crystallographic

257 and unphosphorylated actin in complexes with gelsolin segment 1 and profilin.

258 ies based on the similarities of cofilin and gelsolin segment 1 proposed the cleft between subdomains

259 One end of the particles was capped by a gelsolin (segment 1-3)-TnT fusion protein (substituting

260 region encompassing amino acids 1-70 in the gelsolin sequence; antibody directed to an epitope withi

261 extracted (using the actin severing protein gelsolin) showed that the difference in hysteresis betwe

262 essibility and local structural contacts for gelsolin shows a statistically significant agreement bet

263 The structure of an inactive form of gelsolin shows that the equivalent acidic residues are i

264 ation and maturation through the cytoplasmic gelsolin signaling pathway, providing new drug targets f

265 egion (phosphoinositide-binding domain 2) of gelsolin, significant V-ATPase apical membrane mobilizat

266 filin that shares actin-binding domains with gelsolin, significantly increased PC2(iv) channel functi

267 changes that accompany calcium activation of gelsolin, small-angle x-ray scattering (SAXS) data were

268 Gelsolin stimulated PC2(iv) channel function in the pres

269 severin is a member of the calcium-regulated gelsolin superfamily of actin-binding proteins.

270 we found that Flightless-I, a member of the gelsolin superfamily of actin-remodeling proteins, inter

271 an actin binding protein that belongs to the gelsolin superfamily, is expressed almost exclusively in

272 ng a muscle-specific promoter to drive D187N gelsolin synthesis.

273 including SYWC, kallistatin, complement C9, gelsolin, testican-2, and aldolase C, performed well in

274 cal interaction between endogenous N-RAS and gelsolin that correlates with survival.Oncogene advance

275 is uncovered the actin-depolymerizing factor gelsolin, the membrane glycoprotein dysadherin, the cent

276 thin filament was selectively removed using gelsolin (thin filament severing protein), and the actin

277 tivated the actin-depolymerizing function of Gelsolin to inhibit cell motility.

278 addition of purified LTA, and the binding of gelsolin to LTA inhibits F-actin depolymerization by gel

279 increase of alpha-actin and the decrease of gelsolin to promote MSC differentiation.

280 oteins, including the actin-severing protein gelsolin, to disrupt actin filaments and thus impair pha

281 In Gelsolin-transfected cells, coexpression of Nm23-H1 abro

282 Average actin, tropomyosin, and gelsolin-troponin composition indicated one troponin-tro

283 ined the HF phenotype, while spermadhesin-1, gelsolin, tubulins, glyceraldehyde-3-phosphate dehydroge

284 n dynamics by competing with ADF/cofilin and gelsolin, two key proteins that promote the turnover of

285 amyloidogenic fragments from the full-length gelsolin variants and demonstrated that heparin is capab

286 Unlike human plasma gelsolin, VLN1 does not nucleate the assembly of filamen

287 Gelsolin was able to partially inhibit LPS- or LTA-induc

288 Conversely, actin severing by Gelsolin was abrogated by RNA interference-mediated sile

289 Glomerular labeling of ezrin, moesin, and gelsolin was altered at 3 wk, but expression of nestin a

290 The OD of recombinant human plasma gelsolin was found to decrease following the addition of

291 uld induce a shape where the g3-g4 linker of gelsolin was open when we truncated the C-tail latch fro

292 Gelsolin was recently reported to bind endotoxin (LPS) f

293 ase in the molecular mobility of recombinant gelsolin when buffer pH was lowered from 9 to 5.

294 cross-linked actin filaments assembled with gelsolin, whereas soluble macromolecules of the same siz

295 Gelsolin, which maintains an organized actin cytoskeleto

296 fully activate the F-actin-severing shape of gelsolin with micromolar levels of Ca(2+) available.

297 entration ([Ca(2+)]i, and the association of gelsolin with nonmuscle myosin IIA (NMMIIA) at collagen

298 re loosely folded inactive conformation than gelsolin, with a shorter S1-S2 latch.

299 gnificant role for RPGR in the activation of gelsolin, without which abnormalities in actin polymeris

300 ull-length (wt) Jak3 using Jak3-wt or villin/gelsolin-wt as substrate showed that Jak3 autophosphoryl