ライフサイエンスコーパス: gene ablation

1 t been previously explored in the context of gene ablation.

2 rgone excision to assess the consequences of gene ablation.

3 or gene recapitulates the phenotype of PTHrP gene ablation.

4 poridium infection following individual host gene ablation.

5 tely eliminated in isogenic cells with CASP3 gene ablation.

6 o specifically target dermal condensates for gene ablation.

7 out did not perturb the S phase, unlike Ensa gene ablation.

8 diac BNIP3 and NIX/BNIP3L overexpression and gene ablation.

9 smooth muscle cells (VSMC) using conditional gene ablation.

10 estigate nucleotide biosynthesis by directed gene ablation.

11 ACAT1 gene ablation (A1-) in triple transgenic (i.e., 3XTg-AD)

12 STING gene ablation abolished IFN-alphabeta and IDO induction

13 This study addresses whether RBP gene ablation affects heart development.

14 Thus, Ctip2 gene ablation alters sphingolipid levels and expression

15 erive mice deficient for Klf4 by conditional gene ablation and analyze their vascular phenotype follo

16 00 mg/kg) was severely exacerbated by Gpbar1 gene ablation and attenuated by anti-Cysltr1 small inter

17 We investigated this possibility through gene ablation and biochemical studies.

18 Studies using conditional gene ablation and chemical genetic approaches demonstrat

19 Analysis of brain mRNA confirmed gene ablation and demonstrated no compensatory changes i

20 otential role in powdery mildew infection by gene ablation and overexpression in Arabidopsis.

21 Here, using a combination of gene ablation and pharmacological inhibition techniques,

22 devised a CRISPR-based, mutation-independent gene ablation and replacement (AR) compound therapy carr

23 ntal phenotype depends on the degree of Igf2 gene ablation and the interplay between placental and fe

24 Here we show, using conditional gene ablation and three-dimensional tissue culture, that

25 n mouse line for corneal epithelium-specific gene ablation and to analyze the allelic selection of th

26 Here, we combine conditional gene ablation and transgenic RNA interference to uncover

27 dy used bioinformatics, expression analysis, gene ablation, and specific pharmacologic inhibitors to

28 Here we used a tissue-specific gene ablation approach to assess roles of Noggin (Nog) i

29 ze and contrast data obtained using integrin gene ablation approaches in mice with other experimental

30 n total phospholipid mass was reduced 17% by gene ablation, ascribed to a 27% and 32% reduction in th

31 ild-type genes, and Cre recombinase-mediated gene ablations at the single-cell level in the context o

32 models, we demonstrate that beta-arrestin-2 gene ablation augments beta-agonist-mediated airway smoo

33 HSC development ends before Tie2Cre-mediated gene ablation becomes effective.

34 The first group is heterozygous for betaARK1 gene ablation, betaARK1(+/-), and the second is not only

35 second is not only heterozygous for betaARK1 gene ablation but is also transgenic for cardiac-specifi

36 re, implementing spatiotemporally restricted gene ablation by way of the Cre recombinase/loxP system,

37 (Fra-1) is activated in multiple cancers and gene ablation can suppress the invasive phenotypes of ma

38 Interestingly, ROCK1 gene ablation caused a significant increase in glucose-i

39 Hepatocyte cyclin D1 gene ablation caused markedly increased postprandial liv

40 Although mouse Por gene ablation causes embryonic lethality, POR missense m

41 floxed Alpl allele, allowing for conditional gene ablation (conditional knockout [cKO]) when crossed

42 e Genetics Project, where the treatment is a gene ablation, demonstrates the benefits of the new pipe

43 ylation by conventional or conditional cMLCK gene ablation did not affect troponin-I or myosin-bindin

44 While L-FABP gene ablation did not alter liver LCFA-CoA pool size, LC

45 specific knockout mice and found that Plscr3 gene ablation did not influence kidney function under no

46 intercalated cell mineralocorticoid receptor gene ablation directly reduced pendrin's relative abunda

47 Using conditional gene ablation during a later phase of liver development,

48 These studies demonstrated that GPBAR1 gene ablation enhanced the recruitment of classically ac

49 Here, we found that tubular epithelial ZFP24 gene ablation exacerbated ischemia, rhabdomyolysis, and

50 nctional studies show that RTEC-specific Vgf gene ablation exacerbates ischemia-, cisplatin-, and rha

51 dothelial-specific MAP4K4 gene silencing and gene ablation experiments in Apoe(-/-) mice, we show tha

52 Gene ablation experiments show AtSfh1p nullizygosity com

53 Gene ablation experiments using small interfering RNA de

54 Lineage-specific gene-ablation further indicated that Dvl1/2 function is

55 Constitutive neuroplastin deficiency or Nptn gene ablation in adult mice causes substantial electroph

56 is finding, we conditionally targeted Dicer1 gene ablation in embryonic skin progenitors.

57 The consequence of pikfyve gene ablation in mammals is unknown.

58 Adipose Phd2 gene ablation in mice enhanced adiposity, with a paralle

59 Dok1 and Dok2 gene ablation in mice induces an NK-cell maturation defe

60 od pressure and sodium balance, in that Drd3 gene ablation in mice results in hypertension and failur

61 ments using dominant negative constructs and gene ablation in mice suggested that two phosphoinositid

62 drives lymphatic morphogenesis through Mmp2-gene ablation in mice, mmp2 knockdown in zebrafish and i

63 s achieved by complete or epithelia-specific gene ablation in mice, results in defective mammary morp

64 Using conditional gene ablation in mice, we demonstrate here that the home

65 RNAi should be more pertinent than gene ablation in modeling disease pathogenesis linked to

66 Here, using spatiotemporal gene ablation in murine hair follicles, we uncover a cri

67 Conditional gene ablation in NCCs results in neonatal lethality beca

68 8 mice provide an improved tool for studying gene ablation in rod photoreceptor cells.

69 estin-CreER(T2)/R26R-YFP mouse for inducible gene ablation in stem cells and their progeny in vivo in

70 We show that mice with Tgfbr2 conditional gene ablation in the CNC have complete cleft secondary p

71 INSM1 gene ablation in the mouse results in the impairment of

72 This notion was tested by conditional gene ablation in transgenic mice.

73 -type-specific and developmentally regulated gene ablation in vivo.

74 CXCR4 gene ablation increased the number of colony-forming uni

75 We noted that FXR gene ablation increases MMP7 expression.

76 Second, L-FABP gene ablation inhibited phytanic acid peroxisomal oxidat

77 Myocd gene ablation is accompanied by dissolution of sarcomeri

78 cisplatin-induced renal injury caused by Vgf gene ablation is partly reversed by TLQP-21, a Vgf-deriv

79 genetic manipulations, such as transgenesis, gene ablation (knockouts) and targeted mutagenesis (knoc

80 in many cases, the phenotype resulting from gene ablation might not provide a complete picture of th

81 This study uses a conditional gene ablation model to further explore the role of AP-2

82 Using an in vivo hematopoietic-specific gene ablation model, we demonstrate that loss of Klf5 fu

83 We used constitutive and neuron-specific gene ablation models targeting an integral subunit of ne

84 in brain development, we generated zebrafish gene ablation models, which recapitulated human-relevant

85 spase 1 into inflammasomes, and consistently gene ablation of ASC abolishes caspase 1 activation and

86 ensation on N-cadherin deletion, SC-specific gene ablation of beta-catenin was generated and characte

87 is required in APC/C function; specifically, gene ablation of CBP by RNA-mediated interference marked

88 First, gene ablation of CD99L2 impairs neutrophil recruitment i

89 Mice with global gene ablation of Colec11 had increased susceptibility to

90 tified all intestinal miRNAs and shown using gene ablation of Dicer1 that miRNAs play a vital role in

91 ta-cell differentiation, we used conditional gene ablation of Foxa2 in mice.

92 Furthermore, gene ablation of G(ialpha1) or antisense oligonucleotide

93 Using alpha cell-specific gene ablation of G6pc2 in mice, we showed that this gene

94 In these cells, gene ablation of Lyn leads to defective B cell receptor

95 e of N-cadherin, mice displaying SC-specific gene ablation of N-cadherin were generated and character

96 T cell-specific gene ablation of Notch1 and Notch2 impaired differentiat

97 n in engulfment of apoptotic cells, although gene ablation of PSR has resulted in a variety of phenot

98 Gene ablation of smpd3 causes a generalized prolongation

99 Paradoxically, gene ablation of the alpha 1A and alpha 1B subtypes in m

100 e we show that pharmacological inhibition or gene ablation of the Ep3 receptor in mice suppresses acc

101 Using conditional gene ablation of the maintenance methyltransferase Dnmt1

102 We show that selective gene ablation of the mouse gimap5 gene impairs the final

103 Antibody blocking or gene ablation of the newly identified complement recepto

104 By using T cell-specific gene ablation of the Notch effector RBP-J or the Notch1

105 We employed gene ablation of the obligatory miRNA-processing enzyme

106 Furthermore, gene ablation of TRAF2 or combined down-regulation of TR

107 We examined the effect of H-FABP gene ablation on brain incorporation of arachidonic ([1-

108 estigated the consequences of PDE4B or PDE4D gene ablation on cAMP signaling at a subcellular level u

109 The effect of folate transporter gene ablation on colon carcinogenesis was evaluated 8 an

110 disease model, we evaluated the effect of C3 gene ablation on disease development in MRL/lpr-Daf-1(-/

111 on of CD99L2 on peripheral neutrophils, only gene ablation on endothelial cells but not on myeloid ce

112 To address this issue, the effect of L-FABP gene ablation on liver cytosolic LCFA-CoA binding, LCFA-

113 -arrestin-1 or beta-arrestin-2 inhibition or gene ablation on signaling and function of multiple GPCR

114 e aryl hydrocarbon receptor (AHR), either by gene ablation or by in utero exposure to 2,3,7,8-tetrach

115 In contrast, calpain 1 gene ablation or inhibition with calpastatin prevented i

116 abilization with beta-escin was unaltered by gene ablation or overexpression.

117 sm via the analysis of their phenotype after gene ablation or overexpression.

118 e could be induced in WT cells either by Atm gene ablation or persistent chemical inhibition of ATM k

119 hanced by Runx2 deficiency that results from gene ablation or RNA interference, whereas induction of

120 alpha inhibition (with etanercept), TNFalpha gene ablation, or p38 inhibition, prevents atrial struct

121 for 7 days and were abolished by local Bdnf gene ablation, or pretreatment with xestospongin C, an i

122 rotein expression using short hairpin RNA or gene ablation prevented the sensitizing effects of ethan

123 er by spontaneous mutation or by conditional gene ablation, prevented the induction of p21(CIP1) and

124 n sensory neurons is a direct effect of Klf7 gene ablation, rather than a secondary effect of cell de

125 s provided three new insights: First, L-FABP gene ablation reduced maximal, but not initial, uptake o

126 Importantly, Sirt3 gene ablation reduced the brain injury after IR.

127 scence photobleaching recovery, where L-FABP gene ablation reduced the cytoplasmic, but not membrane,

128 Finally, beta1 gene ablation reduced the EC(50) of the U46619 agonist i

129 H-FABP gene ablation reduced total heart fatty acid uptake 40 a

130 L-FABP gene ablation resulted not only in loss of L-FABP but al

131 Finally, L-FABP gene ablation selectively increased the amount of LCFAs

132 H-FABP gene ablation significantly increased PtdIns mass 1.4-fo

133 Here, using temporally controlled gene ablation specifically in beta cells in mice, we ide

134 ically or via complete or conditional NFATc1 gene ablation, stem cells are activated prematurely, res

135 Gene ablation studies confirmed that PPARalpha mediated

136 Hepatocyte-specific gene ablation studies demonstrated that the Mapk9 gene (

137 e transcription factors STAT1 and STAT2, and gene ablation studies have demonstrated that both STAT1

138 Gene ablation studies have shown severe dental defects i

139 Gene ablation studies in mice have revealed roles for ga

140 Recent gene ablation studies in mice have shown that matriptase

141 Here we used gene ablation studies in mice to demonstrate a central r

142 nsation in the animal kingdom, identified by gene ablation studies, has raised questions about whethe

143 Gene-ablation studies have indicated important developme

144 Gene-ablation studies showed that MTP function and chylo

145 ysis ('ChIP-on-chip') and cell type-specific gene ablation that the winged helix transcription factor

146 c DP precursors for labeling, isolation, and gene ablation that will greatly enhance investigations i

147 insulin promoter, has been shown by targeted gene ablation to be required for pancreatic development.

148 We used tissue-specific gene ablation to generate mice lacking Klf4 in their gas

149 rphic Fgf8 allele (Fgf8neo) and Cre-mediated gene ablation to show that Fgf8 is essential for the sur

150 del in vivo, we utilized hepatocyte-specific gene ablation to study the binding of HNF6 to its target

151 We have used conditional gene ablation to uncover a dramatic and unpredicted role

152 is an acidic noncollagenous protein shown by gene ablations to be critical for the proper mineralizat

153 ncluding a model derived using Car6 and CHOP gene ablations, to delineate a role for CAVI-b in ischem

154 Selective gene ablation using CRISPR-Cas9 is achieved by installat

155 se (SOD1), reduction of MMP-9 function using gene ablation, viral gene therapy, or pharmacological in

156 Bmp2 gene ablation was confirmed by real-time PCR analysis in

157 Gene ablation was used to study the function of Ubc13 in

158 Using mice with conditional gene ablation, we analyzed the tissue-specific function

159 conditional murine CD11c Cre-mediated ADAR1 gene ablation, which did not induce general apoptosis in

160 in C3H mice carrying the type I IFN receptor gene ablation, which effectively blocks all autocrine/pa

161 em, enabling tamoxifen inducible conditional gene ablation while controlling for genetic background a

162 Using conditional gene ablation with the Cre-LoxP system in mice, we demon