ライフサイエンスコーパス: gene activation

1 well as increased H3-K4me3 signal (marker of gene activation).

2 ired for patterning decisions before zygotic gene activation.

3 highly susceptible to oxidation and possible gene activation.

4 5hmCG-mediated demethylation) associate with gene activation.

5 phenotype-a program of inflammatory cytokine gene activation.

6 ific super-enhancer, resulting in high-level gene activation.

7 e/DNA demethylation and genome repair during gene activation.

8 r a novel mechanism of TFIID recruitment and gene activation.

9 a critical mechanism for specifying precise gene activation.

10 r-protein complexes with an impact on timely gene activation.

11 specific enhancers and contributes to target gene activation.

12 e in regulating transcription elongation and gene activation.

13 amily members has little effect on early Hox gene activation.

14 the presence of histone marks permissive of gene activation.

15 ion with transcription factors to facilitate gene activation.

16 ons in embryonic stem cells (ESCs), prior to gene activation.

17 ) in gene promoters is a signaling agent for gene activation.

18 erentially recognized by E2 and 4OHT for the gene activation.

19 platforms which both trigger cell death and gene activation.

20 rthogonal STARs that achieve up to 9000-fold gene activation.

21 age specification-requires HDAC activity for gene activation.

22 e potential to modulate the pattern of viral gene activation.

23 Enhancer activation is a critical step for gene activation.

24 ated H3K14 (H3K14ac), is generally linked to gene activation.

25 chromatin, where it mediated transcriptional gene activation.

26 amic response and NF-kappaB-dependent target gene activation.

27 H3 lysine 27 (H3K27), an epigenetic mark of gene activation.

28 pression of proinflammatory and inflammasome gene activation.

29 her variant chromatin plays a direct role in gene activation.

30 preventing transcription factor binding and gene activation.

31 genetic modification that is associated with gene activation.

32 ained differential chromatin remodelling and gene activation.

33 ion between topological domains and aberrant gene activation.

34 complex (SC), thereby enabling TLR3-mediated gene activation.

35 ilencing, whereas H3K4me3 is associated with gene activation.

36 nery contribute to the selectivity of immune gene activation.

37 sease susceptibility and EWSR1-FLI1-mediated gene activation.

38 either BRD2 or BRD4 alone blunted erythroid gene activation.

39 n PTIP, thus inhibiting H3K4 methylation and gene activation.

40 ate regulation of gene repression as well as gene activation.

41 biting histone modifications associated with gene activation.

42 , such as PDX1, leads to enhancer and target gene activation.

43 r:promoter looping, and the resultant coding gene activation.

44 he level of signal-dependent TF binding, and gene activation.

45 d regions of closed chromatin independent of gene activation.

46 responsible for the variability in galactose gene activation.

47 ines the timing and variability of galactose gene activation.

48 methyltransferases strongly associated with gene activation.

49 the role of chromatin regulators during Hox gene activation.

50 exes, is needed for efficient stress-induced gene activation.

51 ac factors, such as Gata4 and Hand1, use for gene activation.

52 ion of IRF5-targeted M1 macrophage signature gene activation.

53 maintenance of cellular identity but not for gene activation.

54 N-beta or ISGs promoters and sharply reduced gene activation.

55 long-range chromatin interactions and target gene activation.

56 l properties and can antagonize TBX5a target gene activation.

57 st to its homologue Chd1, which functions in gene activation.

58 ct as an inhibitor of development-associated gene activation.

59 ansferase complexes normally associated with gene activation.

60 d acinar morphogenesis is essential in EcSOD-gene activation.

61 g both enhancer RNA transcription and target gene activation.

62 inding did not systematically correlate with gene activation.

63 n remodeling are required for functional EDC gene activation.

64 ependent on and obligatorily linked to Bnip3 gene activation.

65 h the BCR and do not show evidence of target gene activation.

66 ocking Pit1-dependent enhancer/coding target gene activation.

67 ct with their target gene promoter following gene activation.

68 egulatory topology for the precise timing of gene activation.

69 y linked to enhanced chromatin occupancy and gene activation.

70 s of editing, including gene-replacement and gene activation.

71 endent on the cell cycle and zygotic histone gene activation.

72 ent or repression but was necessary for full gene activation.

73 ith genome topology alterations and aberrant gene activation.

74 nterestingly, BER/SSBR inhibition suppressed gene activation.

75 and ZBTB24 binding is mostly associated with gene activation.

76 abolic pathways by suppressing TLR4-mediated gene activation.

77 ding to a select set of enhancers for target gene activation.

78 new insight into how PRC1 can be involved in gene activation.

79 d against DP1 and blocked E2F1-induced KPNA2 gene activation.

80 on, correlating with the strength of initial gene activation.

81 factors to differentially control downstream gene activation.

82 ve function to the offspring, priming future gene activation.

83 pluripotency factor, POU5F1, and pluripotent gene activation.

84 anslocates to the nucleus causing downstream gene activation.

85 6 (H3K36me2), a modification associated with gene activation.

86 generate nucleosome-depleted regions during gene activation(9).

87 studies on these genes indicate that during gene activation a local increase of phospho-S2 CTD nearb

88 he ASXL proteins and FOXK1/2 in facilitating gene activation across the genome.

89 rsal of polycomb repression as a key step in gene activation after injury.

90 as recently been repurposed to enable target gene activation, allowing regulation of endogenous gene

91 ivo, and m(6)A modification abrogates immune gene activation and adjuvant activity.

92 ciency of multiplex gene editing, endogenous gene activation and C-to-T base editing, and we engineer

93 and adaptive immune receptors can result in gene activation and cell death induction by apoptosis an

94 tivated GLI activator (GLIA)-mediated target gene activation and cell differentiation.

95 en-dependent manner leading to TOT-dependent gene activation and cell proliferation of the TOT-resist

96 chromatin-bound BRD4, instigating autophagy gene activation and cell survival.

97 s a new paradigm of DNA methylation-mediated gene activation and chromatin remodeling, and provides a

98 , it also has an uncharacterized function in gene activation and DNA damage responses.

99 the dCas9-SunTag system to engineer targeted gene activation and DNA methylation in Arabidopsis.

100 on and butyrylation, while sustaining direct gene activation and dynamic bromodomain binding, could i

101 gs is involved in their suppression of viral gene activation and expression.

102 defining the functionality necessary for HIV gene activation and for improving in vitro metabolism an

103 ription factors and cofactors in thermogenic gene activation and identified zinc finger and BTB domai

104 nflammatory and rescued M2 anti-inflammatory gene activation and improved the cholesterol efflux defi

105 LUBAC deficiency results in attenuated gene activation and increased cell death, causing pathol

106 Experiments testing EMT gene activation and inhibition with recombinant WISP1 or

107 NX1 requirement for E2A-PBX1-mediated target gene activation and leukemogenesis.

108 Casilio-ME2 and Casilio-ME3 remarkably boost gene activation and methylcytosine demethylation of targ

109 rstanding of the molecular mechanism of Pdr1 gene activation and multidrug resistance inhibition by i

110 se lncRNAs play a key role in regulating var gene activation and mutually exclusive expression.

111 o prevent genomic instability, inappropriate gene activation and other maladaptive processes.

112 icing modulation, non-coding RNA inhibition, gene activation and programmed gene editing.

113 GFAP gene activation and protein induction appear to play a c

114 tablish a function of Nup98 in hematopoietic gene activation and provide mechanistic insight into whi

115 a model in which pre-mRNA evicts PRC2 during gene activation and provides the means to selectively re

116 ead compound (iKIX1) inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glab

117 ome underlying variations in the patterns of gene activation and regeneration pathways.

118 and emphasize the potential significance of gene activation and regulation in cognitive and social f

119 ent chemical inducers that mediate efficient gene activation and repression in mammalian cells.

120 d applications to counteract CRISPR-mediated gene activation and repression of reporter and endogenou

121 including Rowley et al. (2017), suggest that gene activation and repression play fundamentally import

122 riptional effects, including tissue-specific gene activation and repression, are mediated by the gluc

123 interactions, are essential for both normal gene activation and repression, form a chromosome scaffo

124 es is a central player in epigenetics and in gene activation and repression.

125 ulates 5-HT neuron maturation through direct gene activation and repression.

126 mics uncovers ordered sequences of events in gene activation and repression.

127 ing is the single locus illustration of both gene activation and repression.

128 ranscriptional responses, which include both gene activation and repression.

129 f histone modifications associated with both gene activation and repression.

130 R reveal that the RLRs drive distinct immune gene activation and response polarization to mediate an

131 nterfering with R-loop formation can trigger gene activation and reveal a new strategy for upregulati

132 ween nuclear-WASp- and hSWI/SNF-complexes in gene activation and reveals molecular distinctions in TH

133 YRK1A inhibitors, along with CRISPR-mediated gene activation and shRNA knockdown of DYRK1A, we show h

134 ing of the molecular mechanisms underlying R gene activation and signaling, and susceptibility (S) ge

135 ch functions include locus-specific roles in gene activation and silencing, as well as emerging roles

136 velopment is governed by complex programs of gene activation and silencing, including microRNA-depend

137 , and CD8 + T-cells that are related to both gene activation and silencing.

138 plays a key role in epigenetic regulation of gene activation and silencing.

139 Lat deletion impaired TCR-dependent cytokine gene activation and the ability of DETCs to undergo prol

140 supported a normal pattern of graded target gene activation and the development of adults with norma

141 p65 axis mediated the TNF-alpha-induced MLCK gene activation and the subsequent MLCK increase in inte

142 Cytokine analysis, inflammatory gene activation and tissue histopathology strongly suppo

143 nd allows time-resolved monitoring of target gene activation and transcriptome reorganization.

144 ts with chromatin regulators associated with gene activation and we observed decreased histone acetyl

145 pecification is tightly coupled with zygotic gene activation and, in most metazoans, is dependent upo

146 C2 transfers from chromatin to pre-mRNA upon gene activation, and chromatin-associated G-tract RNA re

147 hormone treatment in juveniles enhanced NR1 gene activation, and GnRHa treatment in adults improved

148 s commonly used by transcription factors for gene activation, and holo-WhiB1 has been proposed to act

149 y mitochondrial dysfunction, proinflammatory gene activation, and mTORC1 signaling, whereas IMs at da

150 : One enhancer is responsible for sequential gene activation, and the other is responsible for freezi

151 script turnover and failure in early zygotic gene activation appeared to associate with the aberrant

152 Using a CRISPR-Cas9 gene activation approach, we showed that the expression

153 Sequence-dependent mechanisms for gene activation are available to OGG1 to induce transcri

154 ghly expressed genes but that other steps in gene activation are more rate-limiting for most other ye

155 he temporal order of histone acetylation and gene activation, as well as the stability of the install

156 ts of receptor-ligand-binding and cell-based gene activation assays tightly correlated with the abili

157 ression of housekeeping genes and a delay in gene activation at inducible loci.

158 ) T-cell infiltration, and attenuated global gene activation at the site of cutaneous VZV antigen cha

159 binding, and in turn H3K27 modifications and gene activation, at a subset of genomic regions, includi

160 domains does not lead to widespread ectopic gene activation but does affect a significant minority o

161 RR phosphorylation is typically required for gene activation, but few studies have addressed how and

162 mmune differentiation and stimulus-dependent gene activation, but only 10-20% directly alter recogniz

163 ey early genes at 6 h and transition to late gene activation by 12 h by both viruses.

164 Compounds 2-75 and 1005 antagonized gene activation by androgen without inducing chromatin a

165 led molecular knowledge of the mechanisms of gene activation by disease-associated transcription acti

166 BNA3C repressed equally efficiently but host gene activation by EBNA3C was impaired.

167 nts a novel mechanism for tamoxifen-specific gene activation by ER, secondary to its TOT preferential

168 e-strand breaks (DSBs), in the genome during gene activation by ligands of the nuclear receptor super

169 Due to viral replication kinetics, innate gene activation by live yellow-fever or varicella-zoster

170 aments, inhibits Nrf2 translocation and Mrp2 gene activation by pB(25)R infection.

171 We investigate the role of lncRNAs in gene activation by profiling the RNA interactome of SMAR

172 es, OCT4 is required for proper enhancer and gene activation by recruiting co-regulators and RAR:RXR

173 onential growth phase and thus enables rapid gene activation by sigma(S) as soon as the cells enter e

174 provide a promising alternative strategy for gene activation by tethering an autonomous transcription

175 d differentiation, a process that depends on gene activation by the TAL1 complex.

176 Gene activation by the targeted acetyltransferase was hi

177 l evidence in vivo for a cofactor, Dot1L, in gene activation by TR during vertebrate development.

178 ion system, overexpression of Dot1L enhances gene activation by TR in the presence of T3.

179 Drosophila, revealing that it is involved in gene activation by transcriptional enhancers and epigene

180 demonstrate that CRISPR/Cas9-mediated target gene activation can be achieved in vivo, leading to meas

181 Transient gene activation can have a lasting effect even in the ab

182 orting Reactive Oxygen Species (ROS) induced gene activation, Cdk12 suppresses genes that support met

183 f H3NT proteolysis impaired osteoclastogenic gene activation concomitant with defective osteoclast di

184 Gata6 is expressed in SMCs and its target genes activation control SMC differentiation.

185 ppearance of sub-megabase domains defined by gene activation, CpG hypermethylation and depletion of P

186 protein immunoprecipitation, CRISPR-mediated gene activation (CRISPRa), and behavioral approaches.

187 n factor that can have two distinct roles in gene activation, depending on its location within a prom

188 revealing an unexpected function of Mel18 in gene activation during cardiac differentiation.

189 this stable epigenetic mark works to prevent gene activation during development.

190 Such activity was crucial for gene activation during mammalian neurogenesis.

191 , dynamic changes in genome organization and gene activation during YAP reprogramming is mediated by

192 rthermore, by comparing the dynamics of Hoxb genes activation during zebra finch, chicken, and ostric

193 locus body (HLB) assembles prior to zygotic gene activation early during development and concentrate

194 nthesis known as bursts represent individual gene activation events in which multiple polymerases are

195 In mice, bromodomain inhibition repressed gene-activation events downstream of DNMT3A(R882mut)-ind

196 The sequence of gene activation/expression and receptor editing of these

197 e corresponding TAD may also account for the gene activation function of EZH1, the paralog of EZH2.

198 ible interactions resulted in distinct plant gene activation (> twofold unique transcripts, 335:191:1

199 is of the inhibition and its reversal during gene activation has remained enigmatic.

200 However, modest levels of gene activation have limited potential applications.

201 ion of CRTC2, LSD1-mediated demethylation of gene-activation histone marks H3K4-me2/3, and subsequent

202 The largest proportion of gene activation [i.e., (i) 59%, (ii) 42%, and (iii) 58%]

203 ollaborative mechanisms of mSWI/SNF-mediated gene activation, identifying functions that are co-opted

204 control chromatin structural alterations and gene activation in a cell context dependent manner.

205 s to ensure appropriate target selection and gene activation in each context.

206 p gain insights into the mechanism of silent gene activation in fungal defense.

207 ic Nup, called Nup98, has been implicated in gene activation in healthy cells and has been shown to d

208 onic stem cell reporter cell line to monitor gene activation in individual cells and to show that act

209 postnatal 3' CGI methylation and associated gene activation in intestinal epithelial cells are signi

210 regulatory factors that affect LXR-dependent gene activation in macrophages remain to be elucidated.

211 Gene activation in metazoans is accompanied by the prese

212 the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how th

213 ammalian evolution distinct from its role in gene activation in other organisms.

214 ppaB that drives alterations in enhancer and gene activation in response to chronic TNF-alpha signali

215 d may therefore play a major role in driving gene activation in response to GCs.

216 nd to define the kinetics and selectivity of gene activation in response to microbial ligands; howeve

217 expression, but rather delayed the timing of gene activation in response to specific extracellular si

218 YAP/TAZ target gene activation in response to USP9X knockdown was suppr

219 udy reveals that stress-induced pathological gene activation in the heart requires a previously uncha

220 al hair cell-specific gene deletion/reporter gene activation in the inner ear.

221 method by monitoring the mRNA dynamics upon gene activation in the presence of a splicing inhibitor.

222 gene expression and potentiates stronger GAL gene activation in the presence of Gal1.

223 , while Dnmt1 impedes 2-cell-embryo-specific gene activation in the second step.

224 tern of collective sinusoidal oscillation in gene activation, in multiple dominant frequencies and in

225 ve to the TSS for possible oxidation-induced gene activation include c-MYC, KRAS, c-KIT, HIF-1alpha,

226 onic immune infiltrates and pro-inflammatory gene activation, including NF-kB phosphorylation, were n

227 et of bivalent promoters that resolve toward gene activation, inducing a feto-oncogenic program that

228 Gene activation inside LADs typically causes NL detachme

229 In contrast, Sp7 gene activation involves changes in histone modification

230 Multiplexed endogenous gene activation is a versatile and highly scalable strat

231 MEF2 target gene activation is directly linked to VEGFA-induced rele

232 y, the coupling between inducer identity and gene activation is flexible: the ligand specificity of Z

233 average than non-responsive genes, and rapid gene activation is linked to conditional pause-release.

234 e B cell subpopulations, an order of L chain gene activation is suggested as: sigma-2 followed by kap

235 A key functional event in eukaryotic gene activation is the formation of dynamic protein-prot

236 Although RA-mediated gene activation is well understood, less is known about

237 ation of two distinct domains of coordinated gene activation located at different places in the genom

238 Upon signal-induced gene activation, long-range enhancer contacts at the dom

239 accumulate on chromatin, and is defective in gene activation, maintenance of histone H3 lysine 4 trim

240 ion of histone H3 K27 acetylation (H3K27ac) (gene activation mark) or histone H3 K27 trimethylation (

241 uptake transporter gene Ntcp, and removes a gene-activation marker, trimethylated histone H3 lysine-

242 that changes in the timing of collinear Hox gene activation might underlie natural variation in fore

243 PPARgamma binding and gene activation occur via this upstream duplicated site,

244 When gene activation occurred before DNA circularization, coh

245 binding site in the promoter of the TGF-beta gene, activation of STAT6 in splenocytes by NaB, recruit

246 For the rat gene, activation of the Slick promoter was found to be a

247 upregulation of a cohort of cardiac-specific genes, activation of pathways associated with muscle con

248 inactivation with upregulation of CIC target genes, activation of proliferative pathways, inhibition

249 re recombinase-mediated fluorescent reporter gene activation only in Stra8-expressing cells, newly-fo

250 on is dominated by a focus on the control of gene activation or increase in the level of expression.

251 itute a regulatory context leading to either gene activation or repression.

252 iption factors (TFs) to target promoters for gene activation or repression.

253 f histone methylation associated with either gene activation or silencing.

254 A gene-activation or gene-specific ramp-up strategy would

255 ed to) the dynamical characterization of the gene activation patterns ruling cell types and different

256 same hierarchy, indicating that it reflects gene activation per se.

257 Histone acetylation and associated gene activation plays a key role in plasticity and so we

258 Our results suggest a multistep gene activation process during the formation and retriev

259 hout asthma while largely retaining the same gene activation profile for each species.

260 heterochromatin organization for a specific gene activation program.

261 Gene activation requires cooperative assembly of multipr

262 In most cases, Zap1-dependent gene activation results in increased levels of mRNAs and

263 nected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where reg

264 Using a transposon-mediated gene-activation screen in human cells, we identify that

265 sed this approach for a high-coverage pooled gene-activation screen in vivo and discovered previously

266 g enhancers and genes, thereby resisting the gene activation signals during embryonic stem cell diffe

267 However, PIP5K does not interact with the gene activation signature protein H3K4me3.

268 tein levels and decreased betacatenin target gene activation, suggesting IPO11 facilitates betacateni

269 binding of a single TF can be sufficient for gene activation, suggesting that co-binding events do no

270 ted with STAT3, deregulate cytokine-mediated gene activation, suppress an interferon response, and in

271 This gene activation system is multiplexable and easily tuned

272 imuli trigger highly coordinated cascades of gene activation that are precisely calibrated to the nat

273 lation of chromosomal HIF-1alpha turnover in gene activation that bears important implication in canc

274 eeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in

275 elicited oxidative stress and innate immune gene activation that were exacerbated by p38 GOF and Bsk

276 , we will discuss the role of condensates in gene activation; the multivalent features of protein, RN

277 e) mice, both for gene deletion and reporter gene activation, these data are significant and necessar

278 ching between transcriptional repression and gene activation through the auxin-dependent degradation

279 istence of lineage-to-lineage variability in gene activation times and mean RNA production rates, and

280 is not required for either transcription or gene activation to occur.

281 sibilities of chromatin regions and neuronal gene activation to push cells to a neuronal state.

282 Computationally identified gene activation trajectories were experimentally substan

283 ia are significantly associated with altered gene activation, transcription, and DNA damage repair.

284 In addition, we explored tissue-specific gene activation using positive feedback loops.

285 sor for bacterial cdNs, shaping inflammatory gene activation via its effects on STING and NF-kappaB.

286 es showed that although classical p53 target gene activation was maintained, a subset of p53 target g

287 In contrast, a broader effect on MafA/MafB gene activation was observed in mice lacking NCoA6 in is

288 erm memory (LTAM) and identified three major gene activation waves.

289 For one of these regions of coordinate gene activation, we show that regional epigenetic regula

290 in instances where new phenotypes arise via gene activation, we suggest a set of principles: evoluti

291 Transcriptional response and target gene activation were also investigated in PBMCs.

292 ylation without Pol II recruitment or robust gene activation, whereas MyoD induces histone acetylatio

293 : one enhances matrix deposition by fibrotic gene activation, whereas the other slows down matrix deg

294 ver, in some cases, proximity coincides with gene activation, whereas, in others, preformed topologie

295 limitations, we developed a novel system for gene activation, which bypasses native promoters to achi

296 G1 promoter interactions are associated with gene activation, while ARID1A binding is associated with

297 and persistent Ag expression with low innate gene activation, while less potent rAds induced less Ag

298 In addition, we achieve multiplexed gene activation with a crRNA array.

299 these results demonstrate a novel system for gene activation with wide adaptability for studies of tr

300 n factors are emerging as powerful tools for gene activation within a natural chromosomal context, cu