ライフサイエンスコーパス: gene amplification

1 increased copy number of a genomic segment (gene amplification).

2 programs: the mitotic cycle, endocycle, and gene amplification.

3 3 lose G1/S checkpoint and are permissive to gene amplification.

4 DNA replication, endoreplication and chorion gene amplification.

5 and KRAS mutations, MET expression, and MET gene amplification.

6 nse observed in osteosarcoma cells with MDM2 gene amplification.

7 d to breast cancers that do not display HER2 gene amplification.

8 tion in a process that does not require HER2 gene amplification.

9 vIII expression even in the presence of high gene amplification.

10 nd treatment of cancers displaying miR-17-92 gene amplification.

11 ssion of GATA6 is found in EACs that contain gene amplification.

12 ll-cycle arrest and in this setting promotes gene amplification.

13 ses, elevated TRIB2 expression resulted from gene amplification.

14 ration of biological diversification without gene amplification.

15 have gone through ruminant lineage-specific gene amplification.

16 c assay occurs either by 'point' mutation or gene amplification.

17 e-stage metastatic cancers in the absence of gene amplification.

18 tein expression in the absence of true ERBB2 gene amplification.

19 ts, including chromosomal translocations and gene amplification.

20 I unless compensated by adaptive mutation or gene amplification.

21 There was also no delta-catenin gene amplification.

22 29% of triple-negative BC had PIP5K1A gene amplification.

23 xpression and for HER2/topoisomerase IIalpha gene amplification.

24 in human prostate and breast cancers due to gene amplification.

25 at least in part to aberrant methylation or gene amplification.

26 mcitabine-resistant tumor cells by reversing gene amplification.

27 through mutations, alternative splicing, and gene amplification.

28 r progesterone receptor expression and ERBB2 gene amplification.

29 tastases of prostate cancer independently of gene amplification.

30 25% of ovarian cancers characterized by PAK1 gene amplification.

31 mall percentage of breast cancers with PHGDH gene amplification.

32 to methodological challenges in detection of gene amplification.

33 e the process of antibiotic pressure-induced gene amplification.

34 ecurrences are frequently dependent upon Met gene amplification.

35 eplication in the new host without requiring gene amplification.

36 ipt may be a passenger aberration related to gene amplification.

37 None of the equivocal cases showed gene amplification.

38 is much broader than that explored by single-gene amplifications.

39 2 gene mutations, ALK gene fusions, or FGFR1 gene amplifications.

40 plication has been implicated as a source of gene amplifications.

41 ranscripts, of which 69% are associated with gene amplifications.

42 e mechanism proposed to initiate palindromic gene amplification, a common feature of cancer cells.

43 ogene at 17q12 is susceptible to palindromic gene amplification, a mechanism characterized by the inv

44 Gene amplification, a process that increases the copy nu

45 c-MET activation can be caused by MET gene amplification, activating mutations, and auto- or p

46 investigated the occurrence and frequency of gene amplification affecting genes mapping to ch13q34 in

47 icle cells, which begin synchronized chorion gene amplification after three rounds of endocycle, prov

48 o the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency al

49 Activation occurs through gene amplification and activating mutations.

50 ion by quantitative and qualitative 16S rRNA gene amplification and amplicon sequencing.

51 using a culture-independent method (16S rRNA gene amplification and clone library analyses).

52 This method can be applied to studies of gene amplification and copy number variation among speci

53 mation on somatic mutations in cancer genes, gene amplification and deletion, tissue type and transcr

54 ic detection methods require gene isolation, gene amplification and detection with a fluorescent-tagg

55 New enzymes often evolve by gene amplification and divergence.

56 Moreover, gene amplification and EGFR mutations have been identifi

57 EGFR gene amplification and EGFRvIII are associated with GBM

58 Here, we focus on the gene amplification and expression of cyclin E in these l

59 dataset had frequent (44%) instances of YAP gene amplification and genetic inactivation of Hippo pat

60 cycle is a mutational process that produces gene amplification and genome instability.

61 ad relatively mild effects on origins during gene amplification and genomic replication compared with

62 on in HER2-positive breast cancers with HER2 gene amplification and HER2-low or HER2-negative breast

63 Here we show that NOTCH1 gene amplification and increased expression in CAFs are

64 SHH/GLI1 activation is the result of SHH gene amplification and is further mediated by NPM-ALK th

65 ases, increased AR expression occurs without gene amplification and may be due to altered transcripti

66 ost shift of M. persicae to tobacco and that gene amplification and microsatellite polymorphism are e

67 breast cancer cell lines to investigate HER2 gene amplification and modelled a range of different CNV

68 EGFR gene amplification and mutation are common in glioblasto

69 tic alterations, such as EGF receptor (EGFR) gene amplification and mutation, plays a major role in g

70 Epidermal growth factor receptor (EGFR) gene amplification and mutations are the most common onc

71 uently found in human cancers, mainly due to gene amplification and Myc-mediated transcriptional upre

72 IGF2BP1 was also associated with MYCN gene amplification and MYCN mRNA abundance.

73 the species Zaire Ebola virus using partial gene amplification and nanopore sequencing backed up the

74 nes, EBC-1 and H1993, showed significant Met gene amplification and overexpressed Met receptors which

75 Accumulating evidence has demonstrated that gene amplification and overexpression of Aurora A are li

76 somal alterations, with heterogeneous NOTCH1 gene amplification and overexpression that also occur, t

77 nhibition in ovarian cancer cells with Rsf-1 gene amplification and overexpression, but not in those

78 Notch3 gene amplification and pathway activation have been repo

79 t that mammary tumors that contain both HER2 gene amplification and PIK3CA mutations should be treate

80 and prognostic impact of heterogeneous HER2 gene amplification and polysomy 17 in patients with esop

81 eptor 2 (HER2)-positive breast cancer, GSDMB gene amplification and protein overexpression indicate a

82 Gene amplification and protein overexpression of cMET dr

83 We used 16S rRNA gene amplification and pyrosequencing to characterize, f

84 h no impairment of cancer genes, but massive gene amplification and rearrangements.

85 der (R/F) variants were determined by single-gene amplification and sequencing of viral RNA or DNA fr

86 lts obtained by universal bacterial 16S rRNA gene amplification and sequencing.

87 ESBL and pAmpC genes were detected by gene amplification and sequencing.

88 Our gene amplification and somatic mutation analysis of brea

89 nomic sequencing has revealed recurrent ACK1 gene amplification and somatic mutations in a variety of

90 tains TRIM5 identified different patterns of gene amplification and the independent birth of CypA gen

91 ts of breast cancers with heterogeneous HER2 gene amplification and to define the repertoire of poten

92 Analysis for AAK gene amplification and total AAK protein revealed no dif

93 n prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most

94 NA replication within the context of chorion gene amplification and transcriptional regulation of a w

95 yc expression in cancers can result from MYC gene amplification and translocation but also from alter

96 on by exposure of cell lines harboring FGFR3 gene amplification and translocation to the selective FG

97 Although MYC gene amplification and translocations have been observed

98 Target gene amplification and unknown mechanisms also contribut

99 verexpression by immunohistochemistry (IHC), gene amplification and/or elevated serum Her-2/neu, no p

100 growth factor (EGF) receptor (EGFR) through gene amplification and/or mutation resulting in excessiv

101 ion frequencies and the occurrence of cancer gene amplifications and homozygous deletions.

102 ducting the first comprehensive screening of gene amplifications and polymorphisms associated with in

103 1, MIR17HG, TERT, MYC, and MYCN), generating gene amplifications and remodeling regulatory regions.

104 ancers via protein overexpression, mutation, gene amplification, and also paracrine or autocrine up-r

105 gy was associated with increased DNA damage, gene amplification, and aneuploidy, and this genomic ins

106 ounds exhibit weak mutagenic activity, cause gene amplification, and disrupt cellular epigenetic home

107 DNA extraction, rpoB gene amplification, and DNA sequencing analysis were per

108 at gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene

109 uroblastoma, MYCN is frequently activated by gene amplification, and reducing its expression by RNA i

110 stream applications, such as cDNA synthesis, gene amplification, and RT-qPCR.

111 tion of genetic alterations (gene mutations, gene amplification, and so on) and epigenetic alteration

112 itro and in mammary tumors in vivo, promoted gene amplification, and synergized with defective apopto

113 hat lineage-specific X-Y coevolution through gene amplification, and the selfish forces underlying th

114 Viral titer estimation, nucleocapsid gene amplification, and viral antinucleocapsid staining

115 enty-seven percent of NSCLCs exhibited SRC-3 gene amplification, and we found that lung cancer cell l

116 We detected PEL-specific miRNA gene amplifications, and concordant changes in pre-miRNA

117 y mutation, transcriptional up-regulation or gene amplification appears required for lymphoid transfo

118 enings indicate that tumors displaying c-MET gene amplification are "addicted" to MET signaling and t

119 MDMX overexpression and gene amplification are implicated in p53 inactivation an

120 These re-replication-induced gene amplifications are mediated by nonallelic homologou

121 c analyses that identified cyclin E1 (CCNE1) gene amplification as a candidate oncogenic driver in hi

122 cetylation, yielding important insights into gene amplification as a metazoan replication model.

123 This occurrence of gene amplification as an herbicide resistance mechanism

124 action (PCR) and RT loop-mediated isothermal gene amplification assays.

125 st these cyclic peptides evolved by internal gene amplification associated with recruitment of AEP fo

126 CNV analysis identified 41 gene amplifications associated with resistance, most aff

127 However, SOX2 overexpression and gene amplification associates with favorable outcome in

128 as cooperating oncogenes activated by way of gene amplification at chromosome 14q13 in lung cancer.

129 Moreover, in fancg cells gene amplification at the CAD and dhfr loci is elevated,

130 eased, suggesting that resistance was due to gene amplification at the chr11 p15.5 locus.

131 s with high copy number due to polyploidy or gene amplification because frameshifts in all alleles ca

132 se in HER2 protein expression was not due to gene amplification but rather was mediated by receptor a

133 ficient for Chiffon have a defect in chorion gene amplification but still undergo endocycling.

134 activated by kinase domain mutations and/or gene amplification, but the interaction between the two

135 sion by immunohistochemistry (n = 478), MDM2 gene amplification by fluorescence in situ hybridization

136 ysis of EGFR, KRAS, and PIK3CA mutations and gene amplification by fluorescence in situ hybridization

137 lts indicate that the MRN complex suppresses gene amplification by stabilizing replication forks and

138 Thus, gene amplification can be acquired and expanded through

139 se cases, heterogeneous distribution of HER2 gene amplification can be found, which creates clinicall

140 These data suggest that gene amplification can improve viral replication in a re

141 y evolve new and essential functions and how gene amplification can increase sex chromosome transmiss

142 ven driver genetic alterations, such as HER2 gene amplification, can be heterogeneously distributed w

143 r-tagged RARalpha-containing proteins to the gene-amplification chromosomal region by lac operator re

144 carcinogenesis, usually as a consequence of gene amplification, chromosomal translocations, or postt

145 This is the first report of tandem target gene amplification conferring field-evolved herbicide re

146 lified in breast tumors, the extent to which gene amplification contributes to ANO1 overexpression, a

147 in patient's plasma samples, acquired LMTK3 gene amplification (copy number variation) was associate

148 pression levels of FGFR-2 and FGFR-3 through gene amplification correlate with treatment response and

149 ectively, this study demonstrates that FGF19 gene amplification corresponds with an increased depende

150 erties determine rate and fitness effects of gene amplification, deletions, and mutations compromisin

151 adjacent nonmalignant mucosa due in part to gene amplification determined by Southern blotting.

152 y was to determine whether the level of HER2 gene amplification determined by the HER2/CEP17 ratio an

153 Here, we report a mechanism of gene amplification due to a translocatable unit (TU) exc

154 elicase in regulating SCR and SCR associated gene amplification/duplications and imply that these fun

155 lates the origins that mediate developmental gene amplification during Drosophila oogenesis.

156 replication stress and gained substrates for gene amplification during replication, as evidenced by t

157 n excellent model for study of the endocycle/gene amplification (E/A) switch.

158 tein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL).

159 to automated dual in situ hybridization for gene amplification evaluation.

160 ns unclear that how the cells with different gene amplification events contribute to disease propagat

161 e results raise a novel possibility that the gene amplification events near the IS1236 elements arise

162 tion of cell-cycle progression contribute to gene amplification events that can drive cancer.

163 reporter allowed the selection of low-order gene amplification events, going from one copy to two co

164 In some isolates, subsequent or coincident gene-amplification events augment resistance.

165 on (immunohistochemical analysis [IHC]), and gene amplification (fluorescent in situ hybridization or

166 Gene amplification followed by functional diversificatio

167 uct analysis and 16S ribosomal RNA bacterial gene amplification for bacterial taxa identification.

168 They include activating mutations or gene amplification for c-Met and constitutively active s

169 chanism, a complex rearrangement followed by gene amplification, for the simultaneous formation of an

170 cence reporter that allows us to distinguish gene amplifications from other up-mutations, we track in

171 that examined the fitness effects of single-gene amplifications genome-wide, we found that a small n

172 The fleeting nature of gene amplifications gives rise to a generic population-l

173 Cyclin E1 (CCNE1) gene amplification has been reported to occur independen

174 Notch3 gene amplification has recently been identified in ovari

175 MET overexpression, with or without gene amplification, has been reported in a variety of hu

176 Elevated YAP protein levels and gene amplification have been implicated in human cancer.

177 tial amplification of CCNE1 (cells with this gene amplification have been reported to be sensitive to

178 The origins of gene amplifications have remained elusive; however, DNA

179 evidence of protein overexpression (IHC) or gene amplification (HER2 copy number or HER2/CEP17 ratio

180 defined according to consensus guidelines as gene amplification (HER2/CEP17 ratio >/= 2.0) in more th

181 In breast cancer cells with HER2 gene amplification, HER2 receptors exist on the cell sur

182 spite being clinically defined by a specific gene amplification, HER2-positive tumours melt into the

183 ated levels of AURKA protein, few have AURKA gene amplification, implying that posttranscriptional me

184 ks contributes to the generation of GCRs and gene amplification in cancer, and to non-recurrent CNVs

185 vides the first evidence of somatic STAT5A/B gene amplification in clinical PCas.

186 and CTCs provided that acquisition of HER-2 gene amplification in CTCs was taken into account.

187 2 was also overexpressed and associated with gene amplification in distinct CCRCC samples.

188 Here, we use developmental gene amplification in Drosophila ovarian follicle cells

189 ion of origins responsible for developmental gene amplification in Drosophila.

190 In addition to its high frequency of gene amplification in glioblastoma multiforme, SEC61gamm

191 e rearrangement profiles linked to localized gene amplification in human cancers with acquired drug r

192 ctivating mutations in c-Met, as well as MET gene amplification in human cancers, points to c-Met as

193 in brains and imaginal discs, as well as for gene amplification in ovarian follicle cells.

194 k factors (HSFs), have undergone large-scale gene amplification in plants.

195 viously developed system was used to analyze gene amplification in selected mutants.

196 c specimens revealed a mutual exclusivity of gene amplification in the majority of glioblastoma tumor

197 s describe a complex pattern of differential gene amplification in the Trim5 cluster of rodents and i

198 PfRh1, PfRh2a, and PfRh2b, and an absence of gene amplification in these isolates.

199 A causal role of gene amplification in tumorigenesis is well known, where

200 e copies per cell in >/= 40% of the cells or gene amplification) in 59.2%.

201 es existed between tumors with or without AR gene amplification, including a common loss of AR repres

202 n be activated through overexpression due to gene amplification, increased transcription, or changes

203 siae can strongly induce the initial step of gene amplification, increasing gene copy number from one

204 ly acquired higher fitness via recurrent K3L gene amplifications, incurring up to 7%-10% increases in

205 mpromised intra-S phase checkpoints promoted gene amplification independently from mutant p53.

206 or PfKelch13 mutations and for Pfplasmepsin2 gene amplification (indicating piperaquine resistance).

207 stemic lupus erythematosus (SLE) and whether gene amplification influences the autoantibody profiles

208 Differential gene amplification, insertions/deletions and inversions

209 aring complex chromosomal translocations and gene amplifications involving Igh and c-myc/pvt1 loci.

210 A critical event initiating gene amplification is a DNA double-strand break (DSB), w

211 utility in cancers where drug resistance by gene amplification is a major obstacle to successful the

212 A critical step of BFB cycles leading to gene amplification is a palindromic fusion of sister chr

213 Gene amplification is a phenotype-causing form of chromo

214 Therefore, an early step of gene amplification is a regulated process that is facili

215 Gene amplification is a tumor-specific event during mali

216 or more of these species, and within-species gene amplification is also evident.

217 Here, we show that gene amplification is an additional evasion mechanism us

218 ntly in human B lymphoid tumors, while N-myc gene amplification is frequent in human neuroblastomas.

219 As a developmental strategy, gene amplification is not the predominant means of achie

220 ver, the mechanism of hyperproduction due to gene amplification is not well understood.

221 Epidermal growth factor receptor (EGFR) gene amplification is the most common genetic alteration

222 stance level provided by point mutations and gene amplification is very low and antibiotic-resistant

223 rge DNA palindromes as a very early event in gene amplification is widely recognized, it is not known

224 Amplification of large chromosomal regions (gene amplification) is a common somatic alteration in hu

225 ll cycle-controlled DNA replication and rDNA gene amplification, is the T. thermophila origin recogni

226 x chromosomal rearrangements with associated gene amplification, known as complicons, characterize ma

227 PvDBP gene amplification leads to increased mRNA levels and pr

228 Subsequently, gene amplification may have resulted via several other m

229 This study supports our hypothesis that gene amplification may provide a "molecular foothold," b

230 panel of nine lung cancer cell lines for Met gene amplification, Met expression, Met pathway activati

231 A multistep process of gene amplification, mutation, and reduction allows poxvi

232 Epidermal growth factor receptor (EGFR) gene amplification, mutations, and/or aberrant activatio

233 on in clinical trials for subjects with FGFR gene amplifications, mutations and translocations.

234 132; 4%), as well as gene fusions (n = 51), gene amplifications (n = 35), genes with missense mutati

235 The Palaearctic gene amplification occurred concurrently with the appear

236 Gene amplification occurs frequently in all organisms an

237 pothesis, we found evidence for selection of gene amplification of core regulators of proliferation i

238 Genotyping of resistant cells identified gene amplification of EGFR, KRAS, and mutant BRAF, as we

239 recq4(23), which specifically reduce chorion gene amplification of follicle cells by 4-5 fold, result

240 We conclude that selective gene amplification of GATA6 during EAC development susta

241 NEPC is associated with overexpression and gene amplification of MYCN (encoding N-Myc).

242 o-assembled 3,780-bp contig was confirmed by gene amplification of overlapping regions over almost th

243 of secondary mutations in the kinase target, gene amplification of the primary oncogene, and upregula

244 exhibit sustained stimulation, mutation, or gene amplification of the receptor tyrosine kinase human

245 Frequent gene amplification of the receptor-activated calcium-dep

246 Subsequent reductions in gene amplifications offset the costs associated with lar

247 We show via a phylogenetic analysis of gene amplification on the mouse sex chromosomes that mul

248 anisms including chromosomal translocations, gene amplification or deletion, point mutations and alte

249 factor receptor-alpha (PDGFRalpha) caused by gene amplification or ligand overexpression maintained p

250 The extent of EGFR gene amplification or mutation of the EGFR tyrosine kina

251 ivated in bladder cancer, either directly by gene amplification or mutation, or indirectly by mutatio

252 ion of the MET pathway, for example, through gene amplification or mutations.

253 Hyperactive FOXA1 signaling due to gene amplification or overexpression has been reported i

254 This regulation was lost, however, after MET gene amplification or overexpression of a constitutively

255 ive PPAR signaling, either due to PPAR gamma gene amplification or RXRA hot-spot mutation (S427F/Y) d

256 rs that would otherwise not be identified by gene amplification or translocation alone.

257 < 40 min without the need of gene isolation, gene amplification, or expensive fluorescent tag but wit

258 ng: chromosome 7 copy gain, focal MET or HGF gene amplification, or MET kinase domain mutations.

259 adleri RLAT/KE/1957/SKINK-7 showed extensive gene amplifications, pervasive aneuploidy, and fission o

260 e switch from the endoreplication cycle to a gene-amplification phase, during which special genomic r

261 cells harboring either mutation (PIK3CA) or gene amplification (PIK3CB).

262 NOTCH3 gene amplification plays an important role in the progre

263 d patient-derived xenograft models with YES1 gene amplifications presented a high sensitivity to dasa

264 copy number amplification (fCNA) - enabling gene amplification, rapid tumor evolution, and the rewir

265 l substantial evolutionary changes including gene amplifications, rearrangements, loss and fusion.

266 of HER2-blocking agents to tumors with HER2 gene amplification, recent retrospective analyses sugges

267 Recent studies have identified gene amplification, sequence polymorphism, and variant e

268 Thus, palindromic gene amplification shaped the amplified ERBB2 locus.

269 hat first separates the HER2+ tumors using a gene amplification signal for Her2/neu amplicon genes an

270 The level of HER2 gene amplification significantly predicts sensitivity to

271 in the majority (90%) of SCCs regardless of gene amplification status.

272 Renewed interest in gene amplification stems from its importance in evolutio

273 Using a tissue-specific gene amplification strategy, we generated a transgenic m

274 tions occur primarily in the absence of HER2 gene amplification such that most HER2-mutant tumors are

275 populations-but they show elevated rates of gene amplification, suggesting that copy-number variatio

276 ed global transcriptional changes and led to gene amplification, suggesting that the role of RM syste

277 cle switch at stage 6/7 and the endocycle to gene amplification switch at stage10A/10B.

278 dometrial carcinomas manifest recurrent ESR1 gene amplifications that truncate the hormone-binding do

279 We identified a mutant in which, during gene amplification, the replication forks move twice as

280 ce arose from target site mutation or target gene amplification, the resistance mechanism in horsewee

281 Despite the gene amplification, there was comparatively little effec

282 a model in which dosage compensation buffers gene amplification through aneuploidy to provide a natur

283 vely blocks the switch from the endocycle to gene amplification through its regulation of ttk69.

284 MDM2 expression is found to be regulated via gene amplification, transcription, protein translation a

285 ast tumor samples with a focus on regions of gene amplification using mate-pair sequencing of long-in

286 The mechanisms of ERBB2 dosage changes-gene amplification versus chromosome gain and loss-proba

287 tive in situ analysis revealed that STAT5A/B gene amplification was associated with increased STAT5A/

288 Gene amplification was associated with reduced disease-f

289 We have previously shown that Rsf-1 gene amplification was associated with the most aggressi

290 The EPSPS gene amplification was heritable in common waterhemp and

291 EPSPS gene amplification was heritable, correlated with resist

292 present on every chromosome and, therefore, gene amplification was likely not caused by unequal chro

293 STAT5A/B gene amplification was more frequently found in PCas of

294 Gene amplification was performed together with immunohis

295 l to adenocarcinoma though tumour-associated gene amplifications were absent.

296 lian cells become proficient for spontaneous gene amplification when the function of the DSB repair p

297 pro-B lymphomas routinely activate c-myc by gene amplification, whereas Xrcc4/p53-deficient peripher

298 A expression was associated with focal PFGRA gene amplification, which was similarly detected in a sm

299 23) are overexpressed only in the context of gene amplification while two genes (ERMP1 and IL33) are

300 atellite in the promoter region and a recent gene amplification, with some aphid clones carrying up t