コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 activation of the corresponding biosynthetic gene cluster.
2 nzyme BotCYP from a bottromycin biosynthetic gene cluster.
3 recently been linked to the bmp biosynthetic gene cluster.
4 pes of beta-hydroxylases in the biosynthetic gene cluster.
5 epends upon its relative position within the gene cluster.
6 orphisms in the fatty acid desaturase (FADS) gene cluster.
7 f a local cis-acting enhancer in the class I gene cluster.
8 , which is encoded in the hydrazine synthase gene cluster.
9 tructural heterogeneity of the protocadherin gene cluster.
10 final unaccounted enzymes in the colibactin gene cluster.
11 ic bacteria and archaea possessing the hgcAB gene cluster.
12 d upregulation of the characteristic MAA mys gene cluster.
13 aeruginosa lacks a pelX homologue in its pel gene cluster.
14 oleamine-2,3-dioxygenase NanC encoded in the gene cluster.
15 ed with an increase in expression of the mal gene cluster.
16 iVir proposed secondary metabolite synthesis gene cluster.
17 a previously defined steroidal glycoalkaloid gene cluster.
18 ruptor bescii lacking a functional pectinase gene cluster.
19 correlates with chromatin looping within the gene cluster.
20 cing of NRRL 8095 identified the acrophiarin gene cluster.
21 uce small molecules inspired by biosynthetic gene clusters.
22 d two major strategies regulate beta-keratin gene clusters.
23 ive type VI secretion system (T6SS)-encoding gene clusters.
24 onse composed of large, oppositely regulated gene clusters.
25 versity comparable to that observed for some gene clusters.
26 ated with class I lanthipeptide biosynthetic gene clusters.
27 ing, which consequently created co-regulated gene clusters.
28 s reveal that mcrA regulates at least ten SM gene clusters.
29 e to lead to erroneous and/or over-confident gene clusters.
30 nd/or repair after the breakage of ancestral gene clusters.
31 natural product structures from biosynthetic gene clusters.
32 50 enzymes associated with RiPP biosynthetic gene clusters.
33 g comparisons across CREs within and between gene clusters.
34 ols the expression of many ectoine catabolic genes clusters.
35 ring of the centromeres and lacked virulence gene clustering.
38 rmicapyridines which are encoded by the same gene cluster and are structurally and biosynthetically r
39 ication of the quinolactacin A2 biosynthetic gene cluster and elucidate the enzymatic basis for the f
40 characterize a RaS enzyme from one such RiPP gene cluster and find that it installs an aliphatic ethe
41 cted the evolutionary events leading to this gene cluster and found that its phylogenetic distributio
42 trobacter braakii We refactored the citrocin gene cluster and heterologously expressed it in Escheric
44 o-localizes with a tomato steroidal alkaloid gene cluster and is syntenic to a chromosome 12 region c
46 e of new enzymology and based on patterns of gene cluster and precursor peptide conservation across s
48 and the ITS1 region of the fungal ribosomal gene cluster and sequenced using the Illumina NGS platfo
52 ites and H3K4me3-positive loci at the Hoxa/b gene clusters and Meis1 in ChIP-seq, together with NMR a
54 de hundreds of newly identified biosynthetic gene clusters and possess a distinctive functional capac
55 derstanding of both the activation of silent gene clusters and the ecological function of the produce
56 etermining genes - epsC and epsD- in its eps gene cluster, and produces two times more EPS in sucrose
57 t jointly infers pseudotemporal ordering and gene clusters, and quantifies the uncertainty in both.
59 lizer fungi showed many secondary metabolite gene clusters are anchored by iterative polyketide synth
61 ergent evolutionary lineages of echinocandin gene clusters are descendants from a common ancestral pr
62 aliana Our analyses reveal that biosynthetic gene clusters are embedded in local hot spots of 3D cont
64 uences predicted to arise from cadaside-like gene clusters are predominantly found in soils containin
65 The fellutamide gene cluster and related gene clusters are recognized as relatives of the echinoc
68 We discovered a putative VdCmr1-dependent gene cluster associated with secondary metabolism and st
70 rized suppressor of copper sensitivity (scs) gene cluster, associated with increased tolerance to cop
71 e secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosph
72 ic operational taxonomic units (OTUs, 16S-V4 gene clusters at 97% similarity), a commonly used measur
74 tively, the data from the transfer of 12 nif gene clusters between 15 diverse species (including Esch
77 xchange of secondary metabolite biosynthetic gene clusters (BGCs) among closely related bacteria is a
78 b genome size with 42 predicted biosynthetic gene clusters (BGCs) and 56 putative clusters representi
79 microbiomes encode thousands of biosynthetic gene clusters (BGCs) and represent a new frontier in nat
82 tive prioritization of specific biosynthetic gene clusters (BGCs) for drug development and targeting
84 sessing the capability of their biosynthetic gene clusters (BGCs) for secondary metabolite production
88 fungi, prompting the search for biosynthetic gene clusters (BGCs) of structurally similar perylenequi
90 s uncovered the large number of biosynthetic gene clusters (BGCs) that encode for novel natural produ
91 computational identification of biosynthetic gene clusters (BGCs) that encode ribosomally synthesized
92 asing number of natural product biosynthetic gene clusters (BGCs) to which no known bacterial metabol
93 omodules from monomodular T1PKS biosynthetic gene clusters (BGCs) were experimentally confirmed to be
98 genomes harbor an abundance of biosynthetic gene clusters, but most are expressed at low levels and
99 eveals an untapped reservoir of biosynthetic gene clusters, but prioritization is required to predict
100 ng, we demonstrate that functionally related genes cluster by morphotypic similarity and that this in
101 s our understanding of how regulation of big gene clusters can set up a two-dimensional body surface
102 hat hemizygosity of the GABRB3-GABRA5-GABRG3 gene cluster causes abnormal theta and beta EEG oscillat
103 t overexpression or deletion of the let-7adf gene cluster causes altered IL-6 induction both in tissu
104 eq), we identified two predicted siderophore gene clusters (cbs and sch) that were regulated by iron.
105 ed polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the alpha5, alpha3, and beta4 n
106 number variations in the human CFHR-Factor H gene cluster comprising the complement genes CFHR1, CFHR
107 d Cladosporium phlei, respectively, based on gene cluster conservation with the CTB and hypocrellin B
108 synthetases in uncharacterized biosynthetic gene clusters conserved in >90 different strains of Noca
109 ted through the expression of a subtelomeric gene cluster containing genes that alter the hyphal surf
110 ght differences in the transfer of favorable gene clusters controlling key traits during selection br
111 iG (Minimum Information about a Biosynthetic Gene Cluster) Data Standard and Repository was establish
113 omics revealed four distinct versions of the gene cluster distributed among 19 of the 101 Pseudoalter
114 Strain DHT3 genome contains a polycistronic gene cluster, emtABCD, differentially transcribed under
115 ly identified and widely prevalent prokaryal gene cluster encodes a suite of enzymes with imputed rol
119 utation of a single gene in the biosynthetic gene cluster encoding an antibiotic biosynthesis monooxy
120 SPR/Cas9-mediated deletion of an Arabidopsis gene cluster encoding eight kinases supports their immun
122 ight, shows that three genes of the four mys gene cluster encoding up to mycosporine-glycine are also
124 of many Enterobacteriaceae contain conserved gene clusters encoding putative T4aP assembly systems.
125 and the genome typically carries 20 or more gene clusters encoding the biosynthesis of antibiotics a
126 inase genes and various unknown biosynthetic gene clusters encoding the production of nonribosomal pe
127 cteria allows identification of biosynthetic gene clusters encoding unusual combinations of enzymes t
128 ER, we show that previously undescribed RiPP gene clusters encoding YcaO and TfuA proteins are widesp
130 rk reveals insights into the dynamics behind gene cluster evolution and cell-type specific metabolite
131 ost of the predicted proteins of acrophiarin gene cluster exhibited higher similarity to the predicte
135 We also identify a putative biosynthetic gene cluster for this molecule, which has the four biosy
136 vel species Clostridium porci, and prevalent gene clusters for biosynthesis of sactipeptide-like pept
138 tegy, we recently identified an abundance of gene clusters for ribosomally synthesized and post-trans
141 aled that a previously unidentified NRPS-PKS gene cluster from Flavobacterium was essential for disea
142 e identified the Brevianamide A biosynthetic gene cluster from Penicillium brevicompactum NRRL 864 an
143 methyltransferase OlvS(A) encoded in the olv gene cluster from Streptomyces olivaceus NRRL B-3009 cat
144 ir progenitors shows that olfactory receptor gene clusters from 18 chromosomes make specific and robu
145 ell annotated and putative NRPS biosynthetic gene clusters from 39 232 bacterial genomes and establis
148 P. falciparum, the heterochromatic virulence gene cluster had a strong repressive effect on the surro
151 irs encoded on one large and three auxiliary gene clusters have been characterized from largely clona
152 ription initiation of specialized metabolite gene clusters have been identified, those affecting tran
154 stone genes often reside in tandemly arrayed gene clusters, hindering systematic loss-of-function ana
155 These systems are regulated by separate gene clusters; however, there is a high degree of struct
156 ed with the AHBA spatial expression of three gene clusters: (i) neuronal morphogenesis and synaptic t
157 re we investigated an enigmatic biosynthetic gene cluster identified previously in the human gut symb
158 gin of bioluminescence and the corresponding gene cluster in a diverse group of enigmatic fungal spec
161 genome-mined discovery of a new biosynthetic gene cluster in extremotolerant Streptomyces huasconensi
162 eered to express a bacterial bioluminescence gene cluster in plastids have not been widely adopted be
163 port the discovery of a new LAP biosynthetic gene cluster in the genome of Rhizobium Pop5, which enco
165 RNA sequencing, we discovered a biosynthetic gene cluster in tomato (Solanum lycopersicum) required f
166 collinear PKS/NRPS system encoded by a 90 kb gene cluster in which an upstream PKS cassette interacts
168 homologous eukaryotic genes and suggest that gene clustering in the one-dimensional chromosome is acc
169 identified new missense variants in the WNK1 gene clustering in the short conserved acidic motif know
170 The majority of natural product biosynthetic gene clusters in bacteria are silent under standard labo
171 nzymes across >50,000 candidate biosynthetic gene clusters in bacterial, fungal, and plant genomes.
172 nce of acquired interbacterial defence (AID) gene clusters in Bacteroidales species that reside withi
173 briae, we focused on the two AAF/II fimbrial gene clusters in EAEC 042 (afaB-aafCB and aafDA) and ide
174 present an approach to isolate and sequence gene clusters in metagenomic samples using microfluidic
177 xpression during ageing, with the associated genes clustered in consistent trajectory groups with coh
181 ed PMMs, encoded in conserved coaBC-dut-algC gene clusters, in a variety of gammaproteobacteria, eith
183 over two-thirds of phosphonate biosynthetic gene clusters, including direct fusions to ~60% of Ppm e
185 ensive phylogenetic analysis of echinocandin gene clusters indicated the divergent evolutionary linea
186 pathogens, and deletion of its biosynthetic gene cluster inhibits virulence in an invertebrate anima
189 A network analysis shows that 63% of the genes cluster into the functional categories of transcri
193 Expression of the corresponding biosynthesis gene cluster is driven by one promoter element (P(cap) )
195 hat the cercosporin toxin biosynthesis (CTB) gene cluster is present in several other phytopathogenic
198 d vertebrates studied to date, one of the HB gene clusters is linked to the widely expressed NPRL3 ge
199 in a recently discovered opiate biosynthetic gene cluster led to the discovery of a family of nine ho
200 erologous expression of the cde biosynthetic gene cluster led to the production of cadasides A (1) an
201 n wheat, is part of a complex resistance (R) gene cluster located in a distal region of chromosome 7A
204 o natural product scaffolds via biosynthetic gene cluster manipulation, total synthesis, semisynthesi
206 prioritization is required to predict which gene clusters may yield promising new chemical matter(2)
210 valuation Online (RODEO 2.0), a biosynthetic gene cluster mining algorithm, we bioinformatically mapp
211 uencing, specialized metabolite biosynthetic gene cluster mining and metabolite analysis revealed an
213 than a thousand uncharacterized biosynthetic gene clusters, most of which originate from low frequenc
214 atrisome network, including type II cystatin gene cluster, mucin 5, and cathepsin loci, via enhancer
215 sis of both components is encoded by a large gene cluster, named cwps In this study, using a CRISPR/C
217 ified a B. cenocepacia O-glycosylation (ogc) gene cluster necessary for synthesis, assembly, and memb
218 fication of an as-yet uncharacterized silent gene cluster of the fungus Aspergillus fumigatus, which
219 o the predicted proteins of the pneumocandin gene cluster of the Leotiomycete Glarea lozoyensis than
222 us knockout mice lacking one of two KRAB-ZFP gene clusters on chromosome 2 and chromosome 4 were none
224 t directed genome mining methods, antibiotic gene cluster predictions and 'essential gene screening'
225 region that is syntenic to human HSA4q21, a gene cluster previously associated with hypertension in
227 unctional organization of the multicopy rRNA gene clusters (rDNA) in the nucleolus is less well under
228 ynthesis of secondary metabolic biosynthetic gene clusters reflect a wealth of previously untapped en
234 ed in the Wood-Ljungdahl pathway and of a 10 gene cluster responsible for increased branched chain am
235 raensis genome library that contains the for gene cluster responsible for the biosynthesis of formyci
239 entification of the responsible biosynthetic gene clusters revealed an unexpected biosynthetic route
241 d syn-BNP-based explorations of biosynthetic gene clusters should allow for more rapid identification
244 revealed a rich source of novel biosynthetic gene clusters, some of which were unique to individual s
245 which in S. denitrificans is encoded in two gene clusters: soxABXY (1) Z (1) and soxCDY (2) Z (2) .
246 genes that have been previously mapped to a gene cluster spanning a 3.2 Mb region at the upper end o
247 .01 in NOMAS at rs12587586), and in the five-gene cluster SPATA7-PTPN21-ZC3H14-EML5-TTC8 locus (p = 1
248 cilitates the annotation of hard to assemble gene clusters such as the major histocompatibility compl
249 but several features of acrophiarin and its gene cluster suggest a closer relationship with echinoca
250 or this class of viruses, belongs to a phage gene cluster that contains three homology groups: P22-li
251 2q24.13 (rs10735079, P = 1.65 x 10(-8)) in a gene cluster that encodes antiviral restriction enzyme a
252 tion within the fatty acid desaturase (FADS) gene cluster that is associated with circulating and tis
253 replication fork needs to progress through a gene cluster that is transcribed in the opposite directi
254 synthase (DdTPS8)-cytochrome P450 (CYP521A1) gene cluster that produces a novel C12 trisnorsesquiterp
255 ently identified an array of unexplored RiPP gene clusters that are quorum sensing-regulated and cont
256 Recently, we identified a wide array of RiPP gene clusters that are regulated by quorum sensing and e
257 es the discovery of full-length biosynthetic gene clusters that encode biomedically important natural
260 We have been interested in RiPP biosynthetic gene clusters that encode unusual metalloenzymes, as the
261 ic analysis have identified numerous cryptic gene clusters that have the potential to produce novel n
263 lism is a complex process involving multiple gene clusters, that produce a more diverse metabolite pr
264 The data analysis tools detect and track gene clusters, their size, number, persistence time, and
265 he biosynthetic pathway in vitro to link the gene cluster to the beta-lactone natural product, nocard
266 locate active enhancer regions from the SCPP gene cluster to the region upstream of Nuclear Receptor
267 asing number of natural product biosynthetic gene clusters, to which no known molecules can be assign
268 bineering (LLHR), we directly cloned the skt gene cluster using the Streptomyces site-specific integr
269 ring method that perform best for functional gene clustering using annotation sets of varying complet
270 istic framework for characterizing metabolic gene clusters using context-specific gene expression inf
274 only a 400-kb deletion, including the whole-gene cluster, was eventually able to merge the neighbori
275 n to the previously reported core chemotaxis gene cluster, we identify several other conserved protei
276 ue-specific expression analysis of metabolic gene clusters, we developed METACLUSTER, a probabilistic
280 spired by 96 nonribosomal peptide synthetase gene clusters were synthesized and screened for antibact
281 Hundreds of new sactipeptide biosynthetic gene clusters were uncovered, and a novel sactipeptide "
282 We focused on the Iroquois Homeobox A (IRXA) gene cluster, where hypomethylation in exon 3 of IRX2 in
283 human gut symbiont Ruminococcus gnavus This gene cluster which encodes notably for peptide precursor
284 methoprim elicits an upregulation of the mal gene cluster, which encodes proteins involved in synthes
285 an associate with the C19MC microRNA (miRNA) gene cluster, which suggests a role for CBs in the bioge
286 ermal enhancers located upstream of the HoxC gene cluster, which together regulate Hoxc gene expressi
287 several proteins encoded by the biosynthetic gene cluster, which was found in the genomes of about 45
288 s are identified in siderophore biosynthetic gene clusters, which differ in genomic organization-exis
290 ired to form BMCs are typically organized in gene clusters, which promoted their distribution across
291 e in recovering the true cell order for each gene cluster while requiring substantially less computat
294 ing the reactivity predicted by biosynthetic gene clusters with verified structures, the origin of th
295 logenetic analyses revealed that while a few genes cluster with those of other sauropsid species in a
300 s have uncovered many microbial biosynthetic gene clusters without an associated natural product.