ライフサイエンスコーパス: gene conversion

1 requency of intragenic recombination events (gene conversions).

2 n, little is known about non-crossover (NCO) gene conversion.

3 a specific defect in replication-associated gene conversion.

4 es among the four arms that show evidence of gene conversion.

5 0% of recombinants could be accounted for by gene conversion.

6 mplate switching that does not affect simple gene conversion.

7 crossover and discover regions of interlocus gene conversion.

8 , population demographic history, and biased gene conversion.

9 ISPR are substrates for transgene-instructed gene conversion.

10 ing (SDSA) plays a major role in DSB-induced gene conversion.

11 es were attributable to compound mutation or gene conversion.

12 est for meiotic drive and found evidence for gene conversion.

13 an essential role in anti-recombination and gene conversion.

14 influence on GC-content evolution via biased gene conversion.

15 f mutational hotspots or sites of long-range gene conversion.

16 of the previously described coalescent with gene conversion.

17 ylation of the DNA repair products following gene conversion.

18 were derived from the MW gene as a result of gene conversion.

19 n ZIC, and GLI family) that show evidence of gene conversion.

20 are proficient for repair of a 238-bp gap by gene conversion.

21 a quantitatively tractable model system for gene conversion.

22 concentrated to one region and attributed to gene conversion.

23 ation of the deletion in KIR2DP1(F) by micro gene conversion.

24 ut ancestral structure, linked selection, or gene conversion.

25 sequence identity, presumably maintained by gene conversion.

26 that show evidence of ongoing inter-paralog gene conversion.

27 nts in the outer membrane protein Msp2 using gene conversion.

28 and II genes in terms of both selection and gene conversion.

29 cs, comes in two known forms: crossovers and gene conversions.

30 ent roles in DSB-induced proximal and distal gene conversions.

31 l to break linkage drag utilizing widespread gene conversions.

32 of meiotic recombination are crossovers and gene conversions.

33 exhibits high resolution in the detection of gene conversions.

34 gene conversion associated with noncrossover gene conversions.

35 Mto1 promote the repair of an induced DSB by gene conversion, a type of homology-directed repair.

36 hondrial retroprocessing and interorganellar gene conversion across the 2 billion year divide between

37 We also show that recombination and biased gene conversion actively maintain the heterogeneous GC c

38 a substantial reduction in recombination and gene conversion activity as measured by the relative fre

39 closely related sabB and omp27 genes due to gene conversion among 51 North American paediatric H. py

40 nvestigate the extent and characteristics of gene conversion among gene families in nine species of t

41 this haplotype indicates that high levels of gene conversion among ISX elements allow them to 'crowd-

42 ghly significant difference in the amount of gene conversion among species.

43 ying differences in the mechanistic basis of gene conversion among species.

44 The rate of gene conversion among WGD-derived gene pairs declined ov

45 nct alleles due to a history of interparalog gene conversion and alleles of the same functional type

46 re, possibly because of the joint effects of gene conversion and balancing selection.

47 While gene conversion and classical nonhomologous end-joining

48 gion that show sequence conservation through gene conversion and contain genes that are crucial for s

49 identify quantitative trait loci for altered gene conversion and crossover frequency and confirm func

50 mutations, and have extremely high rates of gene conversion and deletion.

51 ne reveals large amounts of gene flux (i.e., gene conversion and double crossovers) even within inver

52 s work extends the paradigms of HDR-mediated gene conversion and establishes guidelines for PGE in hu

53 homologous chromosomes, thus contributing to gene conversion and genetic diversity.

54 ct of loss of heterozygosity that accrues as gene conversion and hemizygous deletion expose preexisti

55 rong substitutions associated with GC-biased gene conversion and increased rates of fixation of trans

56 d controlling for possible effects of biased gene conversion and methylation at CpG sites.

57 We find evidence for both GC-biased gene conversion and mutagenesis around meiotic DSB hotsp

58 strate to simultaneously monitor HR-mediated gene conversion and non-conservative mutation events.

59 les because it is somatically diversified by gene conversion and point mutation.

60 dromes (from Hi-C data), likely facilitating gene conversion and structural rearrangements.

61 be homogenized in sequence, suggesting that gene conversion and unequal crossovers lead to repeat ho

62 content, suggesting a key role for GC-biased gene conversion and/or repair after the breakage of ance

63 Gene conversions and crossovers were the two most common

64 hod for inference under models with variable gene-conversion and crossing-over rates and demonstrate

65 an length of variants generated by segmental gene conversion, and (iii) antigenic variants were ident

66 (ii) defective in HR-mediated immunoglobulin gene conversion, and (iii) exhibit an increased frequenc

67 sified and matured by somatic hypermutation, gene conversion, and class-switch recombination.

68 DSB formation, gene conversion, and crossing-over were coordinately red

69 t, variable mutation/recombination rates and gene conversion, and efficiently outputs pairwise identi

70 econd-site mutation, original-site mutation, gene conversion, and intragenic crossover.

71 ddition, we identified atypical mutations, a gene conversion, and one missed mutation resulting from

72 ntally across insertion sites by non-allelic gene conversion, and vertically through the population b

73 od for jointly estimating the crossing-over, gene-conversion, and mean tract length parameters from p

74 lized genes indicates that recombination and gene conversion are not inhibited by the DR orientation.

75 rvations regarding meiotic crossing over and gene conversion are readily resolved in a framework that

76 ity that a site is involved in non-crossover gene conversion as 5.99 x 10(-6).

77 findings expand our appreciation of HGT and gene conversion as creative evolutionary forces, establi

78 e rapidly from TEs and implicate non-allelic gene conversion as having an important role in accelerat

79 ed to a hyper-recombination phenotype in the gene conversion assay.

80 a strong transmission bias due to GC-biased gene conversion associated with noncrossover gene conver

81 to resist MMS-induced DNA damage and promote gene conversion at blocked replication forks.

82 ressures may also promote different rates of gene conversion at each class.

83 bA gene copy, sabA and sabB were lost due to gene conversion at similar rates in vitro, suggesting ho

84 To investigate whether gene conversion at the bz locus is polarized, two large

85 thin recombination hotspots, focusing biased gene conversion at their flanks.

86 eases the absolute frequency of 'long-tract' gene conversions at Tus/Ter-stalled forks, an outcome no

87 recent duplicates that may have experienced gene conversion because they may provide false signals o

88 is shared with KIR3DL2 and was introduced by gene conversion before separation of the human and chimp

89 r in patients singly or together, arose from gene conversion between CFH encoding FH and CFHR1 encodi

90 However, gene duplication, coupled with gene conversion between duplicate pairs, can potentially

91 Gene conversion between duplicated genes has been implic

92 genomes revealed that, triggered by frequent gene conversion between duplicates, the evolutionary his

93 SNVs, but also SNVs within a locus at which gene conversion between four genomic paralogs operates,

94 he coupling of Y-linked gene duplication and gene conversion between paralogs can also prove costly b

95 ii and C. dublinensis, including evidence of gene conversion between species.

96 Maintenance of the palindromic structure by gene conversion between the arms has been documented, bu

97 heterogeneity is generated by nonreciprocal gene conversion between the tprK expression site and don

98 te and GC content, supporting both GC-biased gene conversion (BGC) models and selection-driven codon

99 s and its different forms, crossing over and gene conversion both play an important role in shaping g

100 cells had a reduced capacity for HR-mediated gene conversion both spontaneously and in response to I-

101 tion (CSR), somatic hypermutation (SHM), and gene conversion by converting DNA cytosines to uracils a

102 conclude that caffeine treatment can disrupt gene conversion by disrupting Rad51 filaments.

103 Homing endonucleases stimulate gene conversion by generating site-specific DNA double-s

104 ng, characteristics that are consistent with gene conversion by synthesis-dependent strand annealing.

105 ly was broken by the realisation that biased gene conversion can explain phenomena such as mammalian

106 ase (Tyr) gene, to evaluate whether targeted gene conversion can occur when CRISPR-Cas9 is active in

107 eukaryotes, i.e., using the coalescent with gene conversion (CGC).

108 n incorporates regions of <1 kb, and allelic gene conversion changes the frequency of small regions w

109 les exhibiting a high frequency of germ-line gene conversion consistent with homology-directed repair

110 This regulation allows repair by long tract gene conversion, crossover recombination and break-induc

111 ificantly reduced or abolished meiotic DSBs, gene conversion, crossover recombination and the faithfu

112 crossover frequency, crossover interference, gene conversion, crossover/noncrossover ratios, and chro

113 that only 1-15% of gene trees are misled by gene conversion, depending on the lineage considered.

114 f a chromosomal double-strand break (DSB) by gene conversion depends on the ability of the broken end

115 me expression or maternal homogenization via gene conversion, despite the presence of some non-synony

116 ution through the loss of introns: RNA-based gene conversion, dubbed the Fink model and retroposition

117 The analysis suggests that gene conversion effectively initiates uniformly at any p

118 The findings demonstrate that segmental gene conversion efficiently generates Msp2 antigenic var

119 monoterpene synthase followed by a localized gene conversion event directed by a diterpene synthase g

120 he mismatch repair (MMR) system, producing a gene conversion event.

121 Homeologous gene conversion events (HeGCEs) gradually subsided, decl

122 ssess both a typical HR pathway resulting in gene conversion events as well as an end joining (EJ) pa

123 by incorporating recombination hotspots and gene conversion events at arbitrarily chosen locations a

124 Utilizing this assay system, we find that gene conversion events at the proximal and distal region

125 ination of double-strand break (DSB)-induced gene conversion events at the site of a DSB (proximal re

126 1 gene (CFHR1) that originates by recurrent gene conversion events between the CFH and CFHR1 genes.

127 e instability" (HI) hypothesis suggests that gene conversion events focused on heterozygous sites dur

128 s hypothesis by examining the crossovers and gene conversion events induced by gamma irradiation in G

129 etrovirus amplified by PCR revealed possible gene conversion events occurring at numerous pericentrom

130 ls that they have been subject to nonallelic gene conversion events spanning tens of kilobases.

131 uencing signatures, inverted duplications or gene conversion events that include inverted segmental d

132 Strikingly, the gene conversion events were biased in favour of long-tra

133 ken chromatid is not altered in noncrossover gene conversion events, providing strong evidence that n

134 termediate, does not influence the length of gene conversion events, revealing non-catalytical roles

135 ng simulations to assess our power to detect gene conversion events, we determined rates of conversio

136 cies, suggesting frequent duplication and/or gene conversion events.

137 nctional EFG1 allele via de novo mutation or gene conversion events.

138 sE is continually modified through segmental gene conversion events.

139 The mean tract lengths for gene-conversion events are estimated to be approximately

140 The pattern of gene-conversion events associated with cross-overs sugge

141 himeric promoters that are best explained by gene conversion followed by homologous recombination.

142 mapping populations to assess crossover and gene conversion frequency in the hexaploid genome of whe

143 Gene conversion frequently spares the binding site of th

144 In contrast, in gene conversion gap repair and in break-induced replicat

145 ene G+C content, highlighting the G+C-biased gene conversion (gBGC) effect across Cellulosimicrobium

146 Much evidence indicates that GC-biased gene conversion (gBGC) has a major impact on the evoluti

147 However, the strength of GC-biased gene conversion (gBGC) in human populations and its effe

148 opposing mutation, and shows that GC-biased gene conversion (gBGC) predominates over mutation in the

149 selection were initially invoked, GC-biased gene conversion (gBGC), a recombination-associated proce

150 of non-adaptive phenomena, such as GC-biased gene conversion (gBGC), which favors the fixation of str

151 on that match those of genome-wide GC-biased gene conversion (gBGC).

152 n, via the non-adaptive process of GC-biased gene conversion (gBGC).

153 rather is accompanied by elevated levels of gene conversion (GC) and bi-directional GC tracts specif

154 -homologous tail before completing repair by gene conversion (GC).

155 ticular structure of these exons facilitates gene conversion(GC) events, leading to the generation of

156 distribution of meiotic crossovers (COs) and gene conversions (GCs) is essential for understanding ma

157 ecombination, including crossovers (COs) and gene conversions (GCs), impacts natural variation and is

158 There was no evidence of gene conversion, gene locus duplication, or natural sele

159 We also found that gene conversion had a stronger role in shaping the evolu

160 Nonallelic gene conversion has been proposed as a major force in ho

161 We conclude that gene conversion has had only a small effect on mammalian

162 together, our findings reveal that GC-biased gene conversion has important population genetic and pub

163 n methods, we explicitly show that, although gene conversion has little impact on the probability tha

164 positive (balancing) selection and frequent gene conversion has maintained higher diversity of MHC c

165 he evolution of these gene families and that gene conversion has occurred independently in both prima

166 analyses and synteny evidence, we show that gene conversion has played an important role in the evol

167 In addition, historically high rates of gene conversion have homogenized WGD paralogs, probably

168 the construct, 20 to 33% of reads arose via gene conversion (homologous recombination).

169 sequences, a phenomenon known as interlocus gene conversion (IGC).

170 ghts into mechanisms of genome stability and gene conversion in any organism for which genome sequenc

171 recently observed pattern of tetraploidy and gene conversion in asexual, bdelloid rotifers.

172 en shown to affect AID-mediated mutation and gene conversion in chicken DT40 cells.

173 Whereas gene conversion in crossovers is associated with recipro

174 s typically modeled as statistically akin to gene conversion in eukaryotes, i.e., using the coalescen

175 RI-1 specifically reduces gene conversion in human cells while stimulating single

176 n selective medium were sufficient to obtain gene conversion in initially heterozygous mutants.

177 mbination initiation and which causes biased gene conversion in SNP heterozygotes.

178 en whose VSG lack structures that facilitate gene conversion in T. brucei and mechanisms underlying i

179 rsion model--that integrates HGT and ongoing gene conversion in the context of speciation.

180 rsity, and detect signatures consistent with gene conversion in the human species.

181 We could establish intrachromosomal gene conversion in the male germline as underlying mecha

182 Gene conversion in the OPN1LW/OPN1MW genes has been post

183 D-loops, providing a mechanism for limiting gene conversion in vivo.

184 st gene to be demonstrated to be involved in gene conversion in wheat.

185 epair in Saccharomyces cerevisiae we studied gene conversion in which both strands of DNA are newly s

186 ere we show that caffeine treatment prevents gene conversion in yeast, independently of its inhibitio

187 Here, we estimate rates of crossovers and gene conversions in 22 colonies of the honeybee, Apis me

188 imple inversions, likewise, duplications and gene conversions in direct orientation may be called as

189 n events were biased in favour of long-tract gene conversions in FANCJ depleted cells.

190 mster cells exhibit reduction in the overall gene conversions in response to a site-specific chromoso

191 D-loops resemble crossover gene conversions in size, but their extent is similar in

192 for persistence, A. marginale uses segmental gene conversion, in which oligonucleotide segments from

193 es cerevisiae) are analyzed for disparity in gene conversion, in which one allele is more often favor

194 abA is lost, either by phase variation or by gene conversion, in which the babB paralog recombines in

195 e the unidirectional transfer of information-gene conversion-in both crossovers and noncrossovers.

196 epair template (the transgene) are copied by gene conversion into the genome.

197 We also identified interchromosomal gene conversion involving HR and MMEJ at different ends

198 In conclusion, gene conversion is a mechanism for H. pylori to regulate

199 not have observable mutagenic effects after gene conversion is accounted for and that local gene-con

200 e role of hMLH1 and hMRE11 in the process of gene conversion is complex, and these proteins play diff

201 logous chromosomes through crossing over and gene conversion is highly conserved among eukaryotes, co

202 Gene conversion is impaired even at low concentrations o

203 We demonstrate that gene conversion is more prevalent and covers more of the

204 risingly, loss of babA by phase variation or gene conversion is not dependent on the capacity of BabA

205 Gene conversion is not supported by any published coales

206 Gene conversion is one of the frequent end results of ho

207 We determined that sabB to sabA gene conversion is predominantly the result of intra-gen

208 Unexpectedly, we also find that GC-biased gene conversion is restricted to non-crossover tracts co

209 Gene conversion is the copying of a genetic sequence fro

210 n tracts--are also the cases where detecting gene conversion is the easiest.

211 ugh repair of double-strand breaks (DSBs) by gene conversion is the most accurate way to repair such

212 How the extent of gene conversions is regulated is unknown.

213 Recombination, or rather segmented gene conversion, is fundamental in Trypanosoma brucei fo

214 Our results show that, as expected, gene conversion leads to higher rates of false-positive

215 nes are assembled into functional units by a gene conversion-like mechanism that employs flanking var

216 balance between short- (STGC) and long-tract gene conversion (LTGC) between sister chromatids.

217 omplex, reveal a bias in favor of long-tract gene conversion (LTGC) during SCR.

218 e regulation of short- (STGC) and long-tract gene conversions (LTGC) by FANCJ was dependent on its in

219 cost enables the development of genome-wide gene conversion maps and 'unlocks' many previously inacc

220 nges in recombinational processes, including gene conversion, may be a central force driving the evol

221 The VLRs appear to be diversified by a gene conversion mechanism involving lineage-specific cyt

222 ately 35 bases) engage in a highly efficient gene conversion mechanism.

223 essential for VSG silencing, suppresses VSG gene conversion-mediated switching.

224 model--the duplicative HGT and differential gene conversion model--that integrates HGT and ongoing g

225 onor" region to an "acceptor." In nonallelic gene conversion (NAGC), the donor and the acceptor are a

226 Non-exchange gene conversion (non-crossover, NCO) may facilitate homo

227 Gene conversion, non-reciprocal transfer from one homolo

228 ting-type donor selection and for the biased gene conversion observed during meiosis, where M cells s

229 exhibit HR defects, especially in long-tract gene conversion, occurring downstream of RAD51 loading,

230 Gene conversion occurs between one of the several donor

231 rved 16S ribosomal RNA gene, we suggest that gene conversion occurs in multiple, separated genomic ho

232 Our results indicate that gene conversion occurs more frequently than crossing ove

233 Anaplasma marginale utilizes gene conversion of a repertoire of silent msp2 alleles i

234 break by homologous recombination results in gene conversion of an inactive GFP allele to an active G

235 air mutation that encoded a stop codon or by gene conversion of babA with a duplicate copy of babB, a

236 xpression site, and diversity is achieved by gene conversion of chromosomally encoded msp2 pseudogene

237 permutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxyc

238 hile concerted evolution of IR1 is driven by gene conversion of small regions.

239 rogenital environment by loss of capsule and gene conversion of the Neisseria gonorrheae norB-aniA ca

240 on of these differences is that simultaneous gene conversion on both sides of a recombination-initiat

241 oups, we quantified the effects of GC-biased gene conversion on population genomic data sets.

242 that this result cannot be caused by biased gene conversion or hypermutable CpG sites.

243 le-specific manner, leading to DNA repair by gene conversion or NHEJ.

244 tion is consistent with the effect of biased gene conversion or selection-dependent processes.

245 is known to initiate somatic hypermutation, gene conversion or switch recombination by cytidine deam

246 the JAK2 mutation by mitotic recombination, gene conversion, or deletion was excluded in all wild-ty

247 The gene conversion patterns of G1-irradiated cells (but not

248 cenarios, including recombination hot spots, gene conversion, population size changes, population str

249 rker exchange, corresponding to noncrossover gene conversions, predominate between alleles derived fr

250 mbination VLR are somatically assembled by a gene conversion process.

251 in this experiment allowed for estimates of gene-conversion processes.

252 lection pressure, expression divergence, and gene conversion rate among genomes.

253 In addition, using previous estimates of the gene conversion rate from Daphnia mutation accumulation

254 sequence, with a corresponding non-crossover gene conversion rate of 8.75 +/- 0.05 x 10(-6) per base

255 present a method for inferring mutation and gene-conversion rates by using the number of sequence di

256 e conversion is accounted for and that local gene-conversion rates reflect recombination rates.

257 High-frequency gene conversion reactions between many silent pilin loci

258 A major route for such VSG switching is gene conversion reactions in which RAD51, a universally

259 nvolvement of hMLH1 and hMRE11 in the distal gene conversion requires both hMSH2 and heteroduplex for

260 Gene conversions resulting from meiotic recombination ar

261 ion vls system, on the lp28-1 plasmid, where gene conversion results in surface expression of the ant

262 Gene conversion results in the nonreciprocal transfer of

263 Substitution types subject to biased gene conversion show no more variation among species tha

264 rn changes (in Siglecs -1, -5, -6, and -11); gene conversion (SIGLEC11); and deletion or pseudogeniza

265 features of paralogous genes correlate with gene conversion, such as intra-/interchromosomal locatio

266 ms, including repeat-mediated inversions and gene conversion, that are most often missed by other met

267 Surprisingly, these isolates had acquired by gene conversion the complete gonococcal denitrification

268 reduces spontaneous mutation accumulation by gene conversion, the freshly mutated copy being correcte

269 nt results from studies of crossing over and gene conversion, the molecular structures of recombinati

270 model that approximates the coalescent with gene conversion: the bacterial sequential Markov coalesc

271 point mutations and templated mutations via gene conversion to diversify their expressed Ig loci, wh

272 alization of the full potential of segmental gene conversion to dramatically expand the variant reper

273 This recruitment is essential to limit gene conversion tract lengths genome-wide, without affec

274 : (1) spontaneous and damage-induced mitotic gene conversion tracts are more than three times larger

275 Gene conversion tracts are mostly unidirectional, with n

276 We found that gene conversion tracts are similar for mouse and human c

277 400,000 boundaries of historic crossovers or gene conversion tracts.

278 rters of the crossovers were associated with gene conversion tracts.

279 med human cells, despite similarities in the gene conversion tracts.

280 n to the adaptive allele, recombination, and gene conversion, under non-equilibrium demographic histo

281 eveal the extent of the impact of interlocus gene conversion upon the spectrum of human inherited dis

282 au) gene in the six green plants was lost by gene conversion using wild-type plastid DNA as template

283 y homologous recombination--specifically, by gene conversion--using a heterochromatic donor, HMLalpha

284 hylated state, which influences the usage of gene conversion versus popout mechanisms.

285 homing endonucleases are capable of inducing gene conversion via homologous recombination.

286 Limited evidence of gene conversion was documented among the X/Y alleles of

287 f unbiased and biased sites, the strength of gene conversion was estimated to be on the order of Nb a

288 Although higher levels of gene conversion were found among young gene duplicates,

289 High levels of nucleotide diversity and gene conversion were found at these genes.

290 , absence of the RecQ helicase Sgs1 promotes gene conversion, whereas deletion of the FANCM-related M

291 s for genotype errors, recent mutations, and gene conversions which disrupt DNA sequence identity wit

292 es of site-specific chromosomal cleavage and gene conversion, which results in the gain of the I-SceI

293 nd gradual erosion of PRDM9-binding sites by gene conversion will alter the recombination landscape o

294 the essential gene resistant to cleavage and gene conversion with cleaved copies-the Rescue-provides

295 and improved gene targeting and chromosomal gene conversion with either double-stranded DNA or singl

296 Such a pattern could be caused by gene conversion with reverse-transcribed mRNA (i.e., ret

297 bsequently lost) or partially overwritten by gene conversion with transiently present foreign DNA.

298 ation-bearing chromosome and could accompany gene conversions with the homologous chromosome.

299 wever, we are first to demonstrate a de novo gene conversion within the lineage of a pedigree.

300 this issue, Lange et al. show that although gene conversion within these arrays maintains their inte