ライフサイエンスコーパス: gene copy number

1 ellular components such as enzyme levels and gene-copy numbers).

2 hore production and that this was not due to gene copy number.

3 showed large increases in bacterial 16S rRNA gene copy number.

4 for SLE risk associated with reduced FCGR3B gene copy number.

5 smodium codon bias is not correlated to tRNA gene copy number.

6 reby generating haplotypes with variation in gene copy number.

7 by allelic differences in catalytic rate and gene copy number.

8 in lysate array, was tightly correlated with gene copy number.

9 ing Rht-D1b allele, caused by an increase in gene copy number.

10 FR) protein expression and/or with high EGFR gene copy number.

11 omplished, at least in part, through altered gene copy number.

12 and Gossypioides kirkii was correlated with gene copy number.

13 bstitutions and, finally, contraction of the gene copy number.

14 the liver tumor transcriptome was changes in gene copy number.

15 adjusted for the covariates of age and MYCN gene copy number.

16 hanges that correspond to protein levels and gene copy number.

17 of 134 isolates correlated with plasmepsin 2 gene copy number.

18 e of a complex genomic region that varies in gene copy number.

19 w lower-than-expected expression compared to gene copy number.

20 content and amyloid precursor protein (APP) gene copy number.

21 t produces local rearrangements with altered gene copy numbers.

22 tio of telomere repeat copy number to single gene copy number 0.23, 0.09-0.59, p=0.002).

23 rity of gefitinib in patients with high EGFR-gene-copy number (85 vs 89 patients) was not proven (72

24 mia-initiating cells have uncovered multiple gene copy number aberrations and have yielded new insigh

25 d the clinicopathological relevance of SPAG5 gene copy number aberrations, mRNA transcript expression

26 tion protocol to calculate the relative TLR7 gene copy number according to the comparative 2(-DeltaDe

27 Comparison of the relative gene copy numbers according to the presence or absence o

28 types can lead to increases or decreases in gene copy number along chromosomes.

29 Human gene copy number alteration data, microarray expression

30 gnostic value of frequently detected somatic gene copy number alterations (CNAs) in mantle cell lymph

31 than average mRNA-protein correlations, and gene copy number alterations are dampened at the protein

32 In a screen for gene copy number alterations in mouse mammary tumors ini

33 is are highly similar at the level of global gene copy number alterations, loss of heterozygosity and

34 er (LA-HNC) and correlate outcomes with EGFR gene copy number alterations.

35 indings underscore the overall importance of gene copy number amplification as a flexible and fast ev

36 This study reveals how rapid bouts of gene copy number amplification during accrual of distant

37 tumor suppressors, for example, by altering gene copy number amplitude.

38 stent link observed between salivary amylase gene copy number (AMY1 CN) and weight management is like

39 s cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors.

40 EGFR and K-ras mutation analyses and EGFR gene copy number analyses were performed on DNA from pre

41 Using laser capture microdissection and gene copy number analyses, we found that the frequency o

42 Here we perform gene copy number analysis (n=54), genome/exome (n=44) an

43 atory strategies and adaptive potential when gene copy number and allelic frequency are no longer con

44 vating mutations of the EGFR gene, increased gene copy number and certain clinical and pathological f

45 hypermethylation is associated with reduced gene copy number and chromosome 17 aneusomy as observed

46 Mucorales, and the correlation between CotH gene copy number and clinical prevalence, are consistent

47 In this study, we investigated gene copy number and CpG methylation status in CRPC to g

48 cells showed a significant increase in HER-2 gene copy number and expression.

49 re must necessarily be a correlation between gene copy number and gene expression level (transcript a

50 IIalpha (TOP2A) is commonly altered at both gene copy number and gene expression level in cancer cel

51 of these genes show good correlation between gene copy number and gene expression, and are thought to

52 ir data revealed a tight correlation between gene copy number and gene expression.

53 mprove our understanding of the evolution of gene copy number and gene structure.

54 We reasoned that the low luciferase gene copy number and genome insertion locations likely c

55 We analyzed the variation in NLR gene copy number and identified plants with a low number

56 ation, strain background, integration locus, gene copy number and intermodule compatibility.

57 s constitutive expression, due to changes in gene copy number and local sequence effects, and that th

58 The linear correlation between sxtA1 gene copy number and microalgal abundance and between th

59 ficacy with epidermal growth factor receptor gene copy number and other biomarkers.

60 ave elevated Akt3 signaling due to increased gene copy number and PTEN loss.

61 reported that this tight correlation between gene copy number and RNA levels is not observed in recen

62 rend for an association between the relative gene copy number and the autoantibody profile in SLE pat

63 brain metastases is attributed to increased gene copy number and the autoregulation of YTHDF3 cap-in

64 order to study the relationship between Rai1 gene copy number and the Dp(11)17/+ phenotypes.

65 rmine the relationship between mitochondrial gene copy number and transcript abundance in the elongat

66 ers, particularly those corresponding to the gene copy number and transcription rate, cannot be disti

67 ynonymous codon bias is correlated with tRNA gene copy number and with protein expression level in tr

68 gene loss and rearrangements further affect gene copy numbers and fractionate ancestral gene linkage

69 igital array enables accurate measurement of gene copy numbers and is of significant value in CNV stu

70 s of Metallosphaera yellowstonensis 16S rRNA gene copy numbers and mRNA expression of haem Cu oxidase

71 ter understanding of how polysomy 17 affects gene-copy number and protein expression will help to sel

72 Integration effects of transgene insertion, gene copy number, and expression variation, as well as d

73 SCC with prominent overexpression, increased gene copy number, and mutations.

74 s with gender, age, response to vaccination, gene copy number, and oral health.

75 d 1,179 controls) for total C4, C4A, and C4B gene copy numbers, and the loss-of-function C4 exon 29 C

76 not previously studied in RM system control--gene copy number--and of a hysteretic response.

77 large differences in gene family content and gene copy number are seen among the sequenced genomes.

78 ific fashion: The regular, discrete jumps in gene-copy number arising from DNA replication during the

79 sequencing of the tyrosine kinase domain and gene copy number assessments were performed.

80 depth among genes, indicating differences in gene copy number between genomes.

81 nt PC3 prostate cancer cells with high ANXA7 gene copy number, but not in PrEC.

82 High EGFR gene copy number by FISH is frequent in HNSCC and is a p

83 uded epidermal growth factor receptor (EGFR) gene copy number by fluorescence in situ hybridization (

84 sion by immunohistochemistry (IHC), and EGFR gene copy number by fluorescent in situ hybridization (F

85 enotyped using Sequenom MassArray and pfmdr1 gene copy number by real-time PCR.

86 situ hybridization (FISH) to determine EGFR gene copy number, by polymerase chain reaction and direc

87 is increasing evidence that the variation in gene copy number can give rise to substantial phenotypic

88 nism of dosage compensation, at the level of gene copy number, can occur when HTA1-HTB1 is deleted.

89 These effects were not due to differences in gene copy number, caused by partially replicated genomes

90 wever, we know little about why the abnormal gene copy number causes disease or why specific features

91 Comparing gene copy number change and RNA expression changes profi

92 ected very little consistent contribution of gene copy number change to RNA expression changes.

93 pluripotent stem cells and induced neurons, gene copy number change within the 15q13.3 microdeletion

94 The process of adaptation relies on gene copy number changes that arise at high rates, inclu

95 We identified 41 miRNA genes with gene copy number changes that were shared among the thre

96 that re-replication may be a contributor to gene copy number changes, which are important in fields

97 n diseases, we will end with a discussion of gene copy-number changes as therapeutic targets.

98 In a screen for gene copy-number changes in mouse mammary tumors, we ide

99 mulation lines of Caenorhabditis elegans for gene copy-number changes with array comparative genomic

100 ccumulation of driver aberrations, including gene copy-number changes, rearrangements and mutations;

101 een the gut microbiome and specific alleles, gene copy number (CN) also varies.

102 stigated the potential relationships between gene copy number (CN) alterations and DNA methylation pr

103 cus which undergo CNV, and to determine FCGR gene copy number (CN).

104 odel systems that other than loss of RB1 few gene-copy number (CN) alterations are associated with ir

105 components are of unknown function, but low gene copy numbers combined with small genomes make proti

106 Changes in gene copy number contribute to genomic instability, the

107 al amplifications often cause an increase in gene copy number, contributing to the pathogenesis of ca

108 eas neither EGFR protein/mRNA expression nor gene copy number correlated with cetuximab response, exa

109 Increased EGFR gene copy number correlated with LOH-positive status (P

110 determined by the HER2/CEP17 ratio and HER2 gene copy number could significantly predict some benefi

111 rowth factor receptor (EGFR), increased EGFR gene copy number, cyclin D1 polymorphisms, specific gene

112 to more reliably interpret NGS-based cancer gene copy number data in the context of clinical sequenc

113 improved accuracy, relative to unstructured gene copy number data, at predicting tumor state and fut

114 Using this strategy, we integrated gene copy number data, drug exposure data and patient su

115 models of tumor progression from single-cell gene copy number data, including variable rates for diff

116 Mitochondrial gene copy number decreased from 3 to 8-DPA in the develo

117 ndent, additive contributions to Flu(R) in a gene copy number-dependent manner that was not different

118 Epidermal growth factor receptor (EGFR) gene copy number detected by fluorescent in situ hybridi

119 main mutations were not identified, and EGFR gene copy number did not relate to response or PFS, but

120 Additionally, as 16S rRNA gene copy numbers did not provide accurate model fits in

121 progenitor D genome seem to experience more gene copy number divergence than genes from the A genome

122 icularly important in cancer are measures of gene copy number DNA methylation.

123 aling networks by processing DNA sequencing, gene copy number, DNA methylation and RNA-seq data from

124 elongation stages, is a mechanism to change gene copy number during differentiation.

125 d segmental duplication maps and genome-wide gene copy number estimates, we enable future CNV studies

126 ip between maternal tissue expansion and bcd gene copy number expansion in the ovary.

127 gene duplication is a prominent mechanism of gene copy number expansion.

128 We determined beta-defensin gene copy number for 1002 Ethiopian and Tanzanian patien

129 Further, small changes in gene copy number for a 3-gene motif with successive inhi

130 In contrast, the gene copy number for several inflammatory cytokines incr

131 egulation would be due to a reduction in the gene copy number for sst2.

132 g exposure to ALI pulmonary edema fluid, the gene copy number for the major sodium and chloride trans

133 The revamped database also computes average gene copy numbers for any collection of entries selected

134 Gene copy numbers for sst subtypes 1-5 in IMR-32 cells w

135 itial step of gene amplification, increasing gene copy number from one to two or more.

136 ALK gene copy number gain was detected in the vast majority

137 us carcinoma patients is consistent with ALK gene copy number gain, whereas a stromal sarcoma patient

138 represent most of the major lineage-specific gene copy number gains and losses that have occurred in

139 We investigated 67 breakpoint junctions of gene copy number gains in 31 unrelated subjects.

140 gesting enzyme in animals, underwent several gene copy number gains in humans (Perry et al., 2007), d

141 cutoff values for HER2/CEP17 ratio and HER2 gene copy number (GCN) for discriminating positive resul

142 The gene copy number (GCN) varied from 2 to 6 for total C4,

143 thesis postulates that there is selection on gene copy number (gene dosage) to preserve the stoichiom

144 ET, including one with EGFR mutation and MET gene copy number greater than 5.

145 associate with survival, whereas high IGF1R gene copy number harbors positive prognostic value.

146 ce of six retrogenes, accounting for ~13% of gene copy-number heterozygosity.

147 , we demonstrate that complex patterns of AR gene copy number imbalances occur in PCa cell lines, xen

148 th degree of aneuploidy and is partly due to gene copy number imbalances, suggesting that subtle chan

149 Gene copy number impacts on gene expression were detecte

150 We measured amylase gene copy number in 1,000 obese or lean Estonians and in

151 samples; this up-regulation correlates with gene copy number in a subset of melanoma cell lines.

152 We analyzed gene copy number in combination with microarray and GRO-

153 organ and colleagues identified variation in gene copy number in Drosophila in the 1920s and 1930s an

154 We found that the HER2 gene copy number in liquid biopsy was higher in GC and E

155 of EGFR and HER2 protein expression and the gene copy number in NSCLC tumors may have a prognostic v

156 w qPCR assay for the estimation of the sxtA1 gene copy number in seawater samples during a bloom even

157 1R) protein expression, mRNA expression, and gene copy number in surgically resected non-small-cell l

158 and in Ts65DN mice; however, normalizing APP gene copy number in Ts65Dn mice fails to rescue plastici

159 e also show that the FISH test for the AURKA gene copy number in urine yielded a specificity of 79.7%

160 The EGFR gene copy numbers in 134 HNSCC tumors were determined us

161 We also determined the gene copy numbers in a set of 1060 accessions and experi

162 ssion levels are tightly correlated with its gene copy numbers in human colorectal cancer.

163 ed this result experimentally by quantifying gene copy numbers in selected yeast clones with differin

164 chain reaction yielded similar dioxygenases gene copy numbers in unamended, PAC-, or GAC-amended soi

165 high epidermal growth factor receptor (EGFR)-gene-copy number in the intention-to-treat population.

166 amplified gene fragment, with respect to the gene copy numbers (in the starting DNA), is then establi

167 by conversion to homozygosity and increased gene copy number, in human tumors and tumor cell lines.

168 cluding nuclear shape, texture, context, and gene copy number, in order to rank objects according to

169 his study also revealed natural variation in gene copy number, including a duplication of the functio

170 xhibiting significant differences in CRPC in gene copy number, including gains in androgen receptor (

171 tedly initiate DNA replication, resulting in gene copy number increases at several loci important for

172 ur is by an accordion mechanism in which the gene copy number increases followed by base substitution

173 aired normal tissues and frequently exhibits gene copy number increases in lung cancer.

174 the Ensembl public data, we have generated 'gene' copy number indices that facilitate the search for

175 d a significant, yet temporary impact; while gene copy numbers initially decreased 1-2 orders of magn

176 t have few or many CNAs, which we term CONIM genes (COpy Number Instability Modulators).

177 Finally, ATF3 gene copy number is >2 in approximately 80% of the breas

178 ve used a synthetic RNAi system to show that gene copy number is a key factor controlling RNAi for tr

179 Altering gene dosage through variation in gene copy number is a powerful approach to addressing qu

180 oncogenic activation of genes via increased gene copy number is a predominant mechanism for initiati

181 tRNA gene copy number is a primary determinant of tRNA abunda

182 strains of budding yeast had shown that when gene copy number is altered experimentally, RNA levels g

183 ng mutant and transgenic mice in which Gata3 gene copy number is altered, we show that ILC2 generatio

184 In this article, we demonstrate that gene copy number is an omnipresent parameter that can dr

185 High epidermal growth factor receptor (EGFR) gene copy number is associated with poor prognosis in lu

186 We have also demonstrated that PPP1CA gene copy number is increased in 21% of the OSCC cell li

187 Naturally occurring variation in gene copy number is increasingly recognized as a heritab

188 Variation in gene copy number is increasingly recognized as a source

189 t the fitness penalty associated with excess gene copy number is not the only determinant of haploins

190 AP2, which is mostly caused by its increased gene copy number, is likely to be associated with the de

191 This suggests that, by increasing gene copy number, localized endoreduplication serves as

192 1 cell clones also showed a higher degree of gene copy number loss and loss of heterozygosity in SNP

193 versity in mutant alleles and variability in gene copy number may also contribute to the heterogeneit

194 High EGFR gene copy number may be associated with poor outcome in

195 pstream regions combined with differences in gene copy numbers may be a factor in determining differe

196 tected by immunohistochemistry and increased gene copy number measured by fluorescence in situ hybrid

197 ours with discordant ERBB2-protein and ERBB2 gene copy number measurements.

198 leviation of fitness defects due to abnormal gene copy numbers might be an important function of prot

199 rs to FGFR inhibitors, relationships between gene copy number, mRNA expression and protein expression

200 , in a separate cohort of 69 tumors, IGF2BP1 gene copy number, mRNA, and protein abundance were deter

201 Using real-time monitoring of gene-copy-number mutations in Escherichia coli, we show

202 Then we inferred the changes in gene copy number (N), syntenies, and tuning sites along

203 11 (95% CI, 2.27 to 21.90) and a median HER2 gene copy number of 11.90 (95% CI, 3.30 to 43.80) were f

204 By manipulating the gene copy number of an X-linked transcription factor, gi

205 e-3-phosphate synthase, EPSPS) and increased gene copy number of EPSPS.

206 the mutational status of exons 9 and 20 and gene copy number of PIK3CA using 86 non-small cell lung

207 this report we demonstrate that reducing the gene copy number of Sp1 significantly increases both the

208 ations, including increases in expression or gene copy number of the receptor or ligands as well as d

209 We determined that although the relative gene copy number of TLR7 varied in both SLE patients and

210 In all cases, the gene copy numbers of DNA polymerase were low (<100/100 n

211 g cotton decaploidy has largely just reduced gene copy numbers of some homologous groups.

212 We quantified gene copy numbers of the pyruvate kinase, liver, and red

213 High-throughput measurement of gene copy number on large numbers of samples is a challe

214 gle switch motifs and show that variation in gene copy number, on the order of a single or few copies

215 risk patients with LOH-positive or high-EGFR-gene-copy-number OPLs.

216 high doses did not significantly alter sst2 gene copy numbers or binding of either the diagnostic do

217 erentiating as little as a 15% difference in gene copy number (or between 6 and 7 copies of a target

218 f instances of a particular component (e.g., gene copy number) or by modulating the intrinsic biochem

219 and epidermal growth factor receptor (EGFR) gene copy numbers, or mutated (somatic mutation rate of

220 re also significantly associated with PPP1CA gene copy number (P=0.014).

221 plification but in 0 of 12 without increased gene copy numbers (P = 0.00016).

222 ytical sensitivity of 2.0 x 10 degrees sxtA1 gene copy number per reaction.

223 ccording to HER2 FISH ratio and average HER2 gene copy number per tumor cell: group 1 (in situ hybrid

224 The finding that gene copy number polymorphism predisposes to immunologic

225 expression by incrementally increasing GPCR gene copy number potentiates Galpha coupling of the phar

226 QPCR)-based arrays, we determined changes in gene copy number, pre-miRNA, and mature miRNA levels for

227 ies with transcription pattern, resulting in gene copy number profiles tailored by environment.

228 f 12 HER2 heterogeneous breast cancers using gene copy number profiling and massively parallel sequen

229 tal transition points caused by variation in gene copy number progressed through tissue development a

230 Alteration in gene copy number provides a simple way to change express

231 RNA genes and archaeal ammonia-monooxygenase gene copy number (qPCR) were significantly higher in hyp

232 chromosomes and represent a good example of gene copy number qualitatively altering a polygenic dise

233 An increased gene copy number ranging from 4 to 20 copies was identif

234 Thus, DPH gene copy number reduction does not affect overall dipht

235 a provide evidence that an increase in IGFIR gene copy number results in aberrant expression in the b

236 ions and in strains with a fourfold range in gene copy number revealed regulation at two levels: numb

237 Consideration of KIR allelic variation and gene copy number revealed that the cenA effect was predo

238 ce copy number (T) compared to a single-copy gene copy number (S) using quantitative polymerase chain

239 nalysis of CREB mRNA expression and the CREB gene copy number showed that CREB overexpression occurre

240 to allow database searches based on 16S rRNA gene copy number, specific organisms or taxonomic subset

241 ency of genetic alterations at 1p36 and PER3 gene copy number status were analyzed in 180 lymph node-

242 t although protein levels largely scale with gene copy number, subunits of multi-protein complexes ar

243 ength, telomere repeat copy number to single gene copy number (T/S) ratio and exposure to institution

244 While using gene copy number to regulate gene expression is limited

245 se sublimons allows individual mitochondrial gene copy numbers to vary independently between differen

246 re due to variation of (+)-3-carene synthase gene copy number, transcript and protein expression leve

247 In barley, there is evidence that changes in gene copy number underlie important agronomic traits.

248 Chromosomal rearrangements and gene copy number variation (CNV) are two important tools

249 he contribution of classical HLA alleles and gene copy number variation (CNV) at the hypervariable DR

250 We also found that gene copy number variation (CNV) can provide dual benefi

251 Gene copy number variation (CNV) could be detected in th

252 A HP gene copy number variation (CNV) generates HP1 and HP2 a

253 Gene copy number variation (CNV) has been shown to be as

254 We examined tRNA gene copy number variation (tgCNV) in six individuals; t

255 These results show that gene copy number variation affect the parasite's ability

256 A genome-wide survey of gene copy number variation among human and great ape lin

257 Most recently, gene copy number variation and autoimmunity have been as

258 ve evolution by allowing rapid and extensive gene copy number variation and is implicated in the path

259 esion and secretion is affected by epistatic gene copy number variation and it is predictive of patie

260 We have investigated the alpha-tryptase gene copy number variation and its potential association

261 UBE3A gene copy number variation and the resulting overexpress

262 ory capacity, revealing a mechanism by which gene copy number variation can modulate the host immune

263 ome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic p

264 we used genomic approaches to detect insulin gene copy number variation in rodent species and investi

265 Gene copy number variation is a predominant mechanism us

266 We examined the effect of KIR gene copy number variation on the education of human NK

267 Gene copy number variation, a major source of genetic va

268 defensin expression by mucosal cells, due to gene copy number variation, alters the efficacy of recru

269 rse pool of allelic variants, which includes gene copy number variation, pseudogenes, and other polym

270 ipt provides an evolutionary alternative for gene copy number variation.Eukaryotic cells rely on the

271 Interindividual gene copy-number variation (CNV) of complement component

272 ome hybridization (aCGH), we have determined gene copy number variations (CNVs) common to five indust

273 p11.2 microdeletion is among the most common gene copy number variations (CNVs) known to confer risk

274 vity between populations and species include gene copy number variations and single-nucleotide polymo

275 anscript outlier data points with associated gene copy number variations that correlate with patient'

276 aracterized in terms of SNPs, chromosome and gene copy number variations, confirming that they are cl

277 CAFs are significantly correlated with their gene copy number variations.

278 also insertions and deletions, in particular gene copy number variations.

279 o further genome rearrangements and extended gene copy number variations.

280 High EGFR gene copy number was a predictor of a gefitinib-related

281 EGFR gene copy number was a predictor of clinical benefit fro

282 IGF1R gene copy number was assessed by fluorescent in situ hyb

283 EGFR gene copy number was assessed by fluorescent in situ hyb

284 31 patients with available tissue, high EGFR gene copy number was associated with worse overall survi

285 Prognostic value of high IGF1R gene copy number was confirmed in multivariate analysis.

286 or changes in microbiome diversity, mean AMR gene copy number was consistently high, with some AMR ge

287 MET gene copy number was determined in 14 cell lines and 23

288 lysis of genomic DNA confirmed that the rrm1 gene copy number was increased over 10-fold.

289 The EGFR gene copy number was not predictive of erlotinib efficac

290 Increased MET gene copy number was present with >10 copies in 3 of 23

291 The status of EGFR gene copy numbers was analyzed with clinical parameters

292 istry for p16, and fluorescence ISH for EGFR gene copy number were performed on tissue microarrays.

293 Gains in gene copy number were the principal type of mutations in

294 Assignments for gene copy numbers were achieved by relative standard cur

295 ethene concentrations and Geobacter 16S rRNA gene copy numbers were measured.

296 microbial proliferation and Legionella spp. gene copy numbers were often three logs higher than thos

297 angiosarcomas is achieved via increased Hras-gene copy number, which may be favored by a higher mutat

298 geographical area to identify variations in gene copy number, which we confirm by long-read sequenci

299 lic blood pressure in mice with reduced Npr1 gene copy number, which will have important implications

300 me sequencing, gene expression patterns, and gene copy number, will be required to gain a complete un