ライフサイエンスコーパス: gene deletion

1 nsense, missense, splice site, and one whole gene deletion).

2 in mice bearing the Asah1 podocyte-specific gene deletion.

3 e expression was influenced by the RNase III gene deletion.

4 exercise training or skeletal myofiber VEGF gene deletion.

5 ptomes of the same four cell types upon FMR1 gene deletion.

6 ffectiveness of this method of adult cardiac gene deletion.

7 id metabolome and its response to systematic gene deletion.

8 sted this in two mouse models using loxP-Cre gene deletion.

9 and the vessels leaked upon ANG2 blockade or gene deletion.

10 ed null mutants in each of these proteins by gene deletion.

11 isolate (0.9%; 1/113) potentially has pfhrp2 gene deletion.

12 bnormalities attributed to the same targeted gene deletion.

13 ncestral genes and the other sustaining more gene deletions.

14 e most significantly disrupted by coincident gene deletions.

15 ic targets in cancers with tumour-suppressor gene deletions.

16 or double (Trp53(-/-);Brca2(-/-)) suppressor gene deletions.

17 eration and independently acquired focal B2M gene deletions.

18 selectivity of the response to the targeted gene deletions.

19 mice with global or tissue-restricted SOAT2 gene deletions.

20 evant drug-resistant markers, including full gene deletions.

21 variants were de novo, 2 of which were whole gene deletions.

22 homozygotes and 7/8(87.5%) had alpha globin gene deletions.

23 of P. falciparum isolates to identify these gene deletions.

24 6]) and often segregate for null alleles and gene deletions [3, 4, 7, 8].

25 PPP2CA de novo mutations included a partial gene deletion, a frameshift, three nonsense mutations, a

26 dentical high BP, endothelial-specific Epas1 gene deletion accentuated albuminuria with severe podocy

27 These results show that Scn2a gene deletion acts as protective genetic modifier of SUD

28 The results provide insights into the pfhrp2 gene deletion amongst P. falciparum population from Suda

29 of Candida-optimized Cas9-based plasmids for gene deletion, an efficient transformation protocol usin

30 Gene deletion analyses confirmed that the enoyl-CoA hydr

31 Gene deletion analysis indicated that only the cel3B gen

32 essential genes that cannot be evaluated by gene deletion analysis.

33 Using somatic gene deletion and a pharmacological inhibitor, we found

34 Conditional gene deletion and adeno-associated virus-mediated gene d

35 Using gene deletion and adenoviral rescue, we demonstrate that

36 the utility of CRISPR/Cas9 for rapid serial gene deletion and also suggest that additional models ar

37 r neoplasm has been associated with both FXR gene deletion and BA-mediated metabolic abnormalities af

38 Genome resequencing, gene deletion and complementation, gene expression analy

39 erformed two kinds of PSIP1 knockouts: whole-gene deletion and deletion of the integrase binding doma

40 Through targeted gene deletion and functional complementation in Malassez

41 ated genome engineering induces the targeted gene deletion and inversion in situ We found the inverte

42 fifth of the newly sequenced members share a gene deletion and one-third exhibit homopolymeric frames

43 thanosarcina acetivorans, enabling efficient gene deletion and replacement.

44 he broad use of the Gfi1(Cre) mice, both for gene deletion and reporter gene activation, these data a

45 enetic approaches, including tissue-specific gene deletion and the use of various inflammatory trigge

46 number alterations resulting in interspersed gene deletions and extrachromosomal DNA amplification ev

47 ed by combinatorially editing the genome via gene deletions and promoter replacements and by tuning t

48 To determine the evolutionary timing of the gene deletions and the genomic locations of the various

49 Using mice with different Trim2 gene deletions and TRIM2 mutant constructs, we demonstra

50 Gene-deletion and growth experiments in Methanosarcina a

51 ardiac and muscle function in mice with Dmpk gene deletion, and studied post-maturity knockdown using

52 t shRNA essentiality profiles and homozygous gene deletions, and recapitulate mutant-specific mechani

53 used a modified galactose kinase markerless gene deletion approach and found that F. nucleatum invad

54 We used targeted gene deletion approaches and pharmacologic interventions

55 Importantly, NOX4 gene deletions are frequent in HCC patients, correlating

56 MCPH1 deep gene deletions are seen in 5-15% of human cancers, depen

57 iparum strains lacking PfHRP2, due to pfhrp2 gene deletions, are an emerging threat to malaria contro

58 lates with histidine-rich protein 2 (pfhrp2) gene deletion as one of the possible factors contributin

59 The success of each multiple-gene deletion attempt could only be partially predicted

60 Macrophage depletion and C1qa gene deletion attenuated the hypertension-induced beta-c

61 In conclusion, CMKLR1 gene deletion attenuates the effects of chronic DHT trea

62 The virus with the gene deletion, BeninDeltaDP148R, caused mild clinical si

63 We compared major gene deletions between African and Arabian strains of th

64 that transient receptor potential A1 (TRPA1) gene deletion blocks CQ-induced scratching.

65 Furthermore, Traf3ip2 gene deletion blunts adverse remodeling 12 weeks post-I/

66 acapsular strain of C. gattii through CAP59 gene deletion by homologous integration.

67 Mouse cells in which MLL2 gene deletion can be induced display elevated levels of

68 nhibition, by either polymorphic mutation or gene deletion, can lead to the development of tumorigene

69 f future experimental interventions, such as gene deletions, can be improved by using our statistical

70 Local gene deletion caused selective reduction of inhibitory n

71 Consistent with our previous results using gene deletions, Cdk12/Ctk1 is the predominant kinase res

72 ng a non-essential Schizosaccharomyces pombe gene deletion collection, we identify deleted loci that

73 t was introduced into the yeast nonessential gene deletion collection.

74 oryzae strains lacking NDK1 through targeted gene deletion, compared to WT.

75 Targeted gene deletion confirmed that (i) genes encoding methioni

76 Targeted gene deletion confirmed that isogenic mutant strains Del

77 dy-resistant strains arising through further gene deletion could compromise such a strategy.

78 ctivation, transcriptional interference, and gene deletion (CRISPR-AID) in the yeast Saccharomyces ce

79 mples analyzed, we found a total of 15 whole-gene deletions, deleterious or presumably deleterious mu

80 eurons, expression diminished thereafter and gene deletion did not alter brainstem NE neuron numbers.

81 ter cardiorespiratory arrest; and (iii) Aqp4 gene deletion did not impair transport of fluorescent so

82 own adipose tissue (iBAT) of ppHF dams, Ucp1 gene deletion did not restore blood TG concentrations in

83 gous in Jacobsen syndrome, an 11q contiguous gene deletion disorder involving thrombocytopenia, facia

84 We have now shown that mice with a Gnas gene deletion disrupting Gsalpha expression on the mater

85 arasite Plasmodium is refractory to targeted gene deletion during blood infection in the mammalian ho

86 er evidence for this model using conditional gene deletion during the regeneration of airway epitheli

87 This gene deletion efficiently suppressed a key step in autop

88 SNAIL1 gene deletion either during the premalignant phase or af

89 NgR1 gene deletion enhances anatomical changes of inhibitory

90 s, although many genes may be lost by single-gene deletion events, some may be lost in groups of cons

91 results also explain why patients with NFU1 gene deletions exhibit phenotypes that are indicative of

92 In contrast, C57BL/6 mice with BChE gene deletion exhibited increased ghrelin and fought mor

93 itional mutant mice die within 6 mo of Myocd gene deletion, exhibiting profound derangements in the s

94 ithout significant off-target effects of the gene deletion experimental platform per se.

95 Subsequent gene deletion experiments and in vitro characterization

96 In this work, we employ gene deletion experiments and in vitro enzyme studies to

97 f the thiofuranose ring appears according to gene deletion experiments to be mediated by AbmJ, which

98 studies, heterologous pathway expression and gene deletion experiments we are able to show that the N

99 nthetic gene cluster and the use of targeted-gene deletion experiments.

100 stmodification steps were mapped by targeted-gene-deletion experiments and the structural elucidation

101 PCRs in developing and adult beta cells, and gene-deletion experiments identified ADRA2A as a key Gi-

102 We performed targeted gene deletion, expression analysis, biochemistry and pat

103 Conversely, enhanced ERK activity via Nf1 gene deletion extends the response and rescues both neur

104 anges in gene expression compared with whole-gene deletions for these COMPASS members.

105 ns, correlations between profiles of related gene deletions, gene-specific perturbations that reflect

106 Conditional hepatocyte Ext1 gene deletion greatly reduced AAV2 liver transduction fo

107 ntiviral shRNA-mediated GRK2 knockdown, GRK2 gene deletion (GRK2(flox/flox)/cre recombinase) and over

108 , to promote synapse formation; and Top3beta gene deletion has been linked to schizophrenia.

109 Finally, we show that gene deletion has further shaped the SVMP complex within

110 CT also benefitted patients with focal IKZF1 gene deletion (hazard ratio, 0.42).

111 SK3 isozymes yields distinct phenotypes from gene deletion, highlighting the power of the chemical-ge

112 Conversely, Ctrp6 gene deletion improved insulin action and increased meta

113 Here, we report that Bmp9 gene deletion in 129/Ola mice triggers hepatic perisinus

114 r expression of fluorescent proteins and for gene deletion in a model planctomycete, Planctopirus lim

115 METHODS AND Long-term global Vegfr3 gene deletion in adult mice resulted in increased fibrin

116 egulated after cardiac myocyte-directed Drp1 gene deletion in adult mice.

117 Hyperactivation of mTORC1 via TSC1 gene deletion in chondrocytes causes uncoupling of the n

118 Targeted Hrd1 gene deletion in DCs diminished MHC-II expression.

119 and myotonia and we identified a novel PNKD gene deletion in familial hemiplegic migraine.

120 evels resulted from promoter methylation and gene deletion in metastases.

121 Cardiac myocyte-specific CIP4 gene deletion in mice attenuated pressure overload-induc

122 Drawbacks of conditional gene deletion in mice include the need for extensive bre

123 in vivo phenotypes with those apparent upon gene deletion in mice provides insights into the specifi

124 Conditional gene deletion in mice revealed that EphrinB2/EphB4 signa

125 Selective TNF gene deletion in microglia of Cx3cr1creER Tnffl/- mice r

126 Vegfc gene deletion in mouse embryos results in failure of lym

127 myocyte- and fibroblast-specific conditional gene deletion in mouse models.

128 Next, we compared mice with conditional Syk gene deletion in myeloid cells (Syk(My)) versus Syk(f/f)

129 Targeted disruption of the BBSome by Bbs1 gene deletion in POMC or AgRP neurons increases body wei

130 Despite global Lamc1 gene deletion in tamoxifen-induced mutant mice, there wa

131 n) is a rare syndrome caused by a contiguous gene deletion in the 11p13-14 region.

132 Our results show that local gene deletion in the hippocampus can induce two of the m

133 NCS-Rapgef2 gene deletion in the NAc in adult mice, using adeno-asso

134 social and emotional impairments, while the gene deletion in the SST population caused stereotypies

135 Stage-specific gene deletion in trophoblasts reveals that loss of both

136 nced, to date there is no report on targeted gene deletion in U. virens and no molecular studies on g

137 -/-) mice, assessing the impact of Msx1+Msx2 gene deletion in vascular myofibroblast and smooth muscl

138 This is the first reported whole gene deletion in XIAP, the causal gene responsible for X

139 ta, which led us to identify a de novo whole gene deletion in XIAP.

140 a thalassaemia heterozygotes or alpha globin gene deletions in beta thalassaemia homozygotes is a sig

141 pDGS), which is characterized by a number of gene deletions in chromosome 22, including the chicken t

142 ollection, a library of single non-essential gene deletions in E. coli str.

143 re DNA changes in 15 mutants, including full gene deletions in ert-m.40 and ert-m.64.

144 responses in primary cells and in mice with gene deletions in Irf3, Irf5, and Irf7 or in Irf5 alone.

145 say can correctly identify pfhrp2 and pfhrp3 gene deletions in multiple strain co-infections, particu

146 roteome, growth rates were unaffected by the gene deletions in the seven-deletion strain.

147 es TRAF3IP2 expression in the heart, and its gene deletion, in a conditional cardiomyocyte-specific m

148 phospholipid transporters, are refractory to gene deletion, indicative of essential functions.

149 Gene deletion-induced autophagy deficiency leads to neur

150 emia, and the second, carrying a monoallelic gene deletion inducing a haploinsufficiency, presents on

151 the role of Cdk5 in GVHD, as germ line Cdk5 gene deletion is embryonically lethal.

152 To better understand how gene deletions lead to altered neuronal activity, we inv

153 Rif1 depletion by RNAi or gene deletion led to increased transcription and increas

154 We generate double-gene deletion libraries to demonstrate this technology,

155 sFRP-1 gene deletion mice were grossly normal with no differenc

156 Genetic mutations (partial gene deletion, missing genes, IS insertion, internal sto

157 Using gene deletion models that eliminate tumor necrosis facto

158 y comparing parental B. pertussis to an rseA gene deletion mutant (PM18), we sought to characterize t

159 Overall, as the first report of targeted gene deletion mutant in U. virens, our results showed th

160 ntial production of 128 proteins in the oxyR gene deletion mutant, indicating its global regulatory r

161 growth phase are elucidated for seven single gene deletion mutants from upper glycolysis, pentose pho

162 We pooled diverse transcriptionally barcoded gene deletion mutants in 11 different environmental cond

163 ng in C. elegans, we utilized the individual gene deletion mutants in E. coli (K12).

164 o molecular analyses using defined virulence gene deletion mutants in that lineage as of yet.

165 lence characteristics, and produced isogenic gene deletion mutants of important CA-MRSA virulence det

166 ilico examination of the inferred fitness of gene deletion mutants suggests that secondary replicons

167 scherichia coli collection and uncovered 244 gene deletion mutants that slow Caenorhabditis elegans d

168 Twelve single gene deletion mutants were under selection in this assay

169 pattern of yeast Pex11 in all non-essential gene deletion mutants, as well as in temperature-sensiti

170 itro assays and in vivo growth phenotypes of gene deletion mutants.

171 Bar-seq) screening of a pooled collection of gene-deletion mutants cultivated as biofilm and plankton

172 accine strategy for Burkholderia, but single-gene-deletion mutants have not provided complete protect

173 physiological role of LdTyrRS in Leishmania, gene deletion mutations were attempted via targeted gene

174 However, neither TNF-alpha gene deletion nor anti-TNF-alpha neutralizing antibodies

175 ts prostate cancer metastases and as neither gene deletions nor inactivating mutations of PPM1A have

176 WWOX gene deletions occur in a variety of human cancer types,

177 Strikingly, gene deletion occurred even when the transferred cells w

178 were left in a naive state, suggesting that gene deletion occurs independent of T cell activation.

179 Renal collecting duct-specific gene deletion of CCN2 significantly reduced cyst growth

180 Systematic gene deletion of conserved ApiAP2 genes in Plasmodium co

181 Individual gene deletion of dynamin 1, a primary dynamin isoform in

182 y in vivo, we generated mice with a targeted gene deletion of Ifi27l2a.

183 uses using cells and animals with a targeted gene deletion of Ifitm3 as well as deficient cells trans

184 litic flavivirus, using mice with a targeted gene deletion of Ifitm3 Based on extensive virological a

185 Gene deletion of intermediates of Wingless-related integ

186 In obstructed kidneys from mice with gene deletion of Mas (Mas(-/-)), apoptosis and macrophag

187 A double gene deletion of RCF2 and RCF3 affects cellular survival

188 Zinc-finger nuclease-mediated targeted gene deletion of the major rat macrophage epoxygenase Cy

189 lation on ventricular repolarization through gene deletion of the sialyltransferase ST3Gal4.

190 Mice with myeloid-specific gene deletion of Traf3ip3 have increased RNA virus-trigg

191 Intriguingly, although gene deletion of TRPC3 or TRPC6 alone did not protect ag

192 published transcript profiles of 1484 single gene deletions of Saccharomyces cerevisiae.

193 optimization of non-structural (NS1 and NS2) genes, deletion of the small hydrophobic (SH) gene, codo

194 Here, we used MMTV-Cre-mediated Cbl gene deletion on a Cbl-b null background, as well as a t

195 se (Alox15) to compare the influence of each gene deletion on beta cell function and survival in resp

196 previous reports, we found no effect of Dmpk gene deletion on cardiac or muscle function, when studie

197 We studied the impact of Sema3E gene deletion on macrophage function during the LPS-indu

198 cell sorting to assess genome-wide impact of gene deletions on membrane protein expression.

199 This number is based on gene deletions only and represents a lower limit, yet th

200 CX3CR1 gene deletion or anti-Abeta immunotherapy causes expansi

201 tical role of DC-HIL was supported by DC-HIL gene deletion or anti-DC-HIL treatment, which abrogated

202 Absence of ODZ1 by gene deletion or downregulation of ODZ1 by small interfe

203 c B cells with subsequent acute induction of gene deletion or expression, we demonstrate that the con

204 In mice, nNos gene deletion or inhibition shortened atrial APD and inc

205 e liver regeneration using Cre/loxP-mediated gene deletion or intravenous delivery of beta1-integrin

206 weeks and 6 months, who had SMN1 homozygous gene deletion or mutation.

207 used to achieve tooth root formation-related gene deletion or overexpression, as well as strengths an

208 Here we show that DAGL-alpha gene deletion or pharmacological inhibition disrupts LTP

209 Gene deletion or selective drug blockade of TRPC6 or cGM

210 on of cathepsin B expression via CRISPR-Cas9 gene deletion or shRNA knockdown had no effect on the ef

211 DAMTS13 activity resulting from the ADAMTS13 gene deletion or the antibody-mediated inhibition of pla

212 To that end, the effects of various gene deletions or chemical blocking agents were tested b

213 profiles for point mutations crossed against gene deletions or exposed to environmental perturbations

214 Targeted gene deletion, or conditional mutation, of genes encodin

215 overexpression, gene knockdown, Cre-mediated gene deletion, or CRISPR/Cas9-mediated (where CRISPR ind

216 Transgenic gene deletion/over-expression studies have established t

217 Through extensive gene deletion, pathway-targeted molecular networking, qu

218 Using a combination of cell-type-specific gene deletions, pharmacology, and chemogenetics, we foun

219 comparative analysis of bacterial growth and gene deletion phenotypes using hundreds of genome-scale

220 e, IGHJ gene usage is unaffected by the IGHD gene-deletion polymorphisms.

221 a majority of cases whereas a more complete gene deletion predisposes to leukemia.

222 Moreover, endothelial-specific RhoA gene deletion prevents vascular leakage and passive cuta

223 Synapsin II (SynII) gene deletion produces a deficit in inhibitory synaptic

224 In adult mice induction of EC-specific cox10 gene deletion produces no overt phenotype.

225 screen of knockout-mice in a targeted single-gene deletion project.

226 ipoprotein-dependent, and EZH2 inhibition or gene deletion promoted lipoprotein-dependent lipid uptak

227 Inpp5f (Sac2) gene deletion promoted recovery from spinal cord injury

228 The 18 successful multiple-gene deletions ranged in size from 21 to 183 kb and coll

229 Here, we report the construction of a double-gene-deletion recombinant virus, ASFV-G-Delta9GL/DeltaUK

230 Receptor gene deletion reduced tsetse infection, identifying this

231 at YAP regulates CCN2, and YAP inhibition or gene deletion reduces renal fibrosis in Pkd1KO mouse kid

232 ASO therapy, especially since mice with Dmpk gene deletion reportedly show cardiac defects and skelet

233 only used for conditional hair cell-specific gene deletion/reporter gene activation in the inner ear.

234 However, Mif gene deletion restricted to renal tubular epithelial cel

235 In this context, SWI/SNF-specific gene deletion resulted in drug resistance.

236 Shisa7 gene deletion resulted in faster AMPAR currents in CA1 s

237 In murine prostate epithelium, PPARD gene deletion resulted in increased cellularity.

238 We recently reported that Efnb3 gene deletion results in hypertension in female but not

239 t on CRISPR/CAS9 technology-mediated ALX/FPR gene deletion revealed the importance of the lipoxin rec

240 Here we evaluated heterozygous Scn2a gene deletion (Scn2a+/-) as a protective genetic modifie

241 of MAPK signaling, we performed CRISPR-Cas9 gene deletion screens in the setting of BRAF, MEK, EGFR,

242 aploid deletion collection and identified 27 gene deletions sensitive to both low oxygen and cobalt c

243 r basic protein-1/eosinophil peroxidase dual gene deletion) show that eosinophils are required for al

244 Conditional gene deletion showed a cell-intrinsic requirement of CD2

245 Targeted gene deletion showed that FolVam7-mediated vesicle traff

246 Gene deletion showed that sapA is required for the adher

247 se GSK3 inhibition or renal tubular GSK3beta gene deletion significantly increased FoxM1 expression,

248 Ten countries have reported pfhrp2/pfhrp3 gene deletions since the first observation of pfhrp2-del

249 Through targeted gene deletion, small molecule inhibition, and lineage tr

250 an existing collection of viable ADP1 single-gene deletion strains and a new transposon insertion seq

251 and testing autotrophic growth phenotypes of gene deletion strains at ambient CO(2) We find that the

252 nas palustris In vivo metabolite analysis of gene deletion strains demonstrated that this anaerobic M

253 A library of 322 signature-tagged gene deletion strains for 155 C. neoformans TF genes has

254 In gene deletion strains of the modification pathway, prote

255 tion of the respective protein kinase single-gene deletion strains.

256 ort the construction of 264 signature-tagged gene-deletion strains for 129 putative kinases, and exam

257 high-quality library of 322 signature-tagged gene-deletion strains for 155 putative TF genes previous

258 We phenotype gene-deletion strains of fission yeast in 59,350 individ

259 Growth phenotype profiling of genome-wide gene-deletion strains over stress conditions can offer a

260 loarchaeon, including expression vectors and gene-deletion strategies, including CRISPR.

261 Here, we have used a conditional gene deletion strategy in mice to probe the specific rol

262 Gene deletion studies indicate that Leishmania SepSecS i

263 the production of virulence factors based on gene deletion studies of the sae and agr two-component s

264 Conditional gene deletion studies revealed that T-bet expression in

265 Finally, gene deletion studies show thatCjLPMO10A is needed byC.

266 were provided by whole genome sequencing and gene deletion studies, while bioactivity assays showed a

267 Previous gene deletion study revealed a role for PRL2 in spermato

268 y abnormalities were not related to specific gene deletions suggesting a "neighboring effect" of regi

269 Gene deletion suggests that AbmC is involved in peptide

270 dress this, we have implemented an inducible gene deletion system based on a dimerised Cre recombinas

271 with a cardiac and skeletal muscle directed gene deletion system for spatial-temporal control of dys

272 We also established a CRISPR/Cas9 gene deletion system in this NF-kappaB reporter line, en

273 in the group with heterozygous or homozygous gene deletions than in those with no deletion.

274 ong with an additional seven genes and three gene deletions that enhance secondary metabolism.

275 h was identified by a genome-wide screen for gene deletions that impair the fitness of aneuploid yeas

276 Jasplakinolide) or genetic disruption (zyxin gene deletion) that alter actin, and their persistence r

277 Parasites with pfhrp2/3 gene deletions threaten the use of these mRDTs and have

278 ing the central THP core were isolated after gene deletion (tmlF).

279 t/Fzd (OMP-18R5/vantictumab) and conditional gene deletion to test the therapeutic potential of targe

280 Here, we used gene deletions to investigate how the environmental stim

281 The gene deletion tool Osr2Cre removed Hnf4a in developing n

282 hed results and to properly control targeted gene deletions using the lck-cre(+) strain.

283 Targeted gene deletion verified that the F. fujikuroi polyketide

284 Thus, gene deletion via viral co-delivery of CRISPR-Cas9 in pr

285 Snai1 gene deletion was, however, only partial and could there

286 Using targeted gene deletion, we generated a set of 28 isogenic mutants

287 emic effects often associated with embryonic gene deletion, we generated an endothelial-specific and

288 Using conditional, cardiac myocyte-specific gene deletion, we now demonstrate that mAKAPbeta express

289 using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lin

290 Using a series of gene deletions, we show that four of the five genes are

291 Using targeted gene deletions, we verify the importance of a highly exp

292 an instance of uniparental disomy, and whole-gene deletion were identified in nine patients from eigh

293 True pfhrp2/3 gene deletions were confirmed if samples were (1) micros

294 om 3 African countries to determine if these gene deletions were present.

295 In total, 4 exonic, single-gene deletions were validated in schizophrenia cases and

296 allenging genome-editing procedures, such as gene deletion, which is important for inducing a loss of

297 High transgene expression mimicked gene deletion, with failure of lymph node development an

298 Current systems for conditional gene deletion within mouse macrophage lineages are limit

299 proaches, we demonstrate that whereas Gpbar1 gene deletion worsens the severity of liver injury, its

300 However, pfhrp2 gene deletions yielding false-negative RDTs, first repor