ライフサイエンスコーパス: gene function

1 fish were used as an in vivo model to assess gene function.

2 to for supporting computational analyses of gene function.

3 ective towards a better understanding of SMN gene function.

4 ving our understanding of cis-regulation and gene function.

5 (RNAi) is a valuable technique to determine gene function.

6 s fill, which can lead to new discoveries in gene function.

7 pleiotropic effects of system-wide losses of gene function.

8 systems biology and for characterizing novel gene function.

9 r to its widespread use to dissect bacterial gene function.

10 R screens enable systematic interrogation of gene function.

11 termination (G-MAD) allows the annotation of gene function.

12 technology for the systematic evaluation of gene function.

13 erable value for the rapid identification of gene function.

14 nes possess all structure necessary for PEBP gene function.

15 s rapid and reversible manipulation to study gene function.

16 e variants but little enrichment in terms of gene function.

17 , hemizygosity, and used mutants, to explore gene function.

18 d transcriptional information can illuminate gene function.

19 iologically relevant and sensitive to detect gene function.

20 o understand the impact of human variants on gene function.

21 ion is necessary to make strong claims about gene function.

22 cs for spatial and/or temporal regulation of gene function.

23 etic variants lead to increased or decreased gene function.

24 for variant interpretation and understanding gene function.

25 traditionally thought to disrupt the entire gene function.

26 tion can be used to inform investigations of gene function.

27 /Cas9 system is a powerful tool for studying gene function.

28 he importance of posterior prevalence in Hox gene function.

29 f-function reagents for the determination of gene function.

30 t DNA, RNA or protein to reduce or to ablate gene function.

31 s the application of the technology to study gene function.

32 accuracy on predicting all three domains of gene function.

33 ontext of expression data and help elucidate gene function.

34 es of selection against heterozygous loss of gene function.

35 cation, are powerful tools for understanding gene function.

36 h 'human knockouts' can provide insight into gene function.

37 ics of archaea that holds promise to unravel gene function.

38 reens are a powerful tool for assessments of gene function.

39 stage suggests some of its significance for gene function.

40 ntegrating in a manner that preserves target gene function.

41 DGAT1-1 gene revealed its regulatory role in gene function.

42 undational for characterization of essential gene function.

43 o improve our fundamental knowledge of coral gene function.

44 into a single cohesive strategy to knock out gene function.

45 notype to genotype and ultimately can assign gene function.

46 ed oil improvement and the identification of gene function.

47 sights into compound mechanism of action and gene function.

48 aired by guides which inefficiently abrogate gene function.

49 cleaved copies-the Rescue-provides essential gene function.

50 gs for tumors that are driven by the loss of gene function.

51 to determine if and how rare variants affect gene function.

52 its detection requires pickpocket 23 (ppk23) gene function.

53 tion of protein-coding genetic variation and gene function.

54 , requiring cis-retinal chromophore and Opn5 gene function.

55 gions and controlling cardiomyocyte-specific gene functions.

56 ntiation, cell signaling pathways, and viral gene functions.

57 el genera with a large repertoire of unknown gene functions.

58 frequently used vocabulary for representing gene functions.

59 for data mining and deeper understanding of gene functions.

60 Transgenic gerbera plants were used to infer gene functions.

61 as well as in studying gene expressions and gene functions.

62 omic studies or rapidly assessing individual gene functions.

63 omosomes is quintessential for understanding gene functions.

64 the type of dataset impacts inferences about gene functions.

65 tion of complex phenotypes, and to attribute gene functions.

66 e in great detail to better understand viral gene functions.

67 dels to (1) strengthen conclusions of single-gene function; (2) model diversity among human populatio

68 ld enable genetic access and perturbation of gene function across mammalian cell types.

69 l be broadly useful to comprehensively study gene function across many contexts.

70 contribute to the evolutionary divergence of gene function across taxa.

71 The loss of rice IAN1 gene function also leads to enhanced heat tolerance, sug

72 ce conservation is commonly used to decipher gene function and assess medical relevance, methods for

73 is based on two linked approaches to impute gene function and bridge genes with biological processes

74 cing defects can have severe consequences on gene function and cause disease.

75 providing tremendous opportunities to study gene function and cell fate in early human development.

76 tic marks such as DNA methylation can affect gene function and change in response to environmental co

77 offers a fast-track approach for perturbing gene function and circumvents certain limitations of sta

78 paramount in decoding the molecular basis of gene function and designing tools to modulate its downst

79 sposon system should facilitate the study of gene function and directed differentiation in human stem

80 al disorders and provided insights into both gene function and disease biology.

81 an excellent vertebrate model for evaluating gene function and disease pathogenesis, especially becau

82 ering plants have resulted in differences in gene function and expression patterns, contributing to d

83 a valuable tool for both genetic analysis of gene function and for synthetic biology applications.

84 screens enable the exploration of mammalian gene function and genetic regulatory networks.

85 pretation for obtaining insights into cancer gene function and genetic tumor evolution.

86 rain development provides vital insight into gene function and identifies critical sensitive periods

87 oanoflagellates has hampered direct tests of gene function and impeded the establishment of choanofla

88 le strategy for globally interrogating miRNA gene function and miRNA-based therapeutic intervention.

89 ive toolbox that allows for interrogation of gene function and modulation of the cellular behaviors.

90 miR-29 biomarkers were selected based on gene function and mRNA expression using quantitative rev

91 not only to the study of human hematopoietic gene function and networks, but also to perform sophisti

92 'phase' of variants can significantly impact gene function and phenotype.

93 hat such relationship might be essential for gene function and regulation.

94 ng remaining challenges, such as discovering gene function and the evolution of GRNs.

95 activation and can be valuable indicators of gene function and the potential toxicity of therapeutic

96 xpression analysis is widely used to predict gene function and to identify functionally related gene

97 genes and are important tools in predicting gene function and understanding disease mechanisms.

98 ation with curated phenotypes, cell-specific gene functions and a multiscale model.

99 een built to allow users to browse and query gene functions and analyze large-scale experimental data

100 ve as a powerful tool for dissecting in vivo gene functions and biological processes in a temporal ma

101 to predict isoform functions from annotated gene functions and expression data, but their performanc

102 gain-of-function approach for interrogating gene functions and for manipulating biological traits.

103 r genomes reveal conserved symbiosis-related gene functions and high sequence divergence.

104 m is a useful tool for the study of specific gene functions and may allow the identification of antig

105 proteomics data yield specific hypotheses on gene functions and metabolic capabilities; and provide s

106 on of fungal proteome and revealed important gene functions and proteome dynamics.

107 is has provided new and global insights into gene functions and roles.

108 , aiming to bridge the gap between genomics, gene functions and traits.

109 f-function studies are key for investigating gene function, and CRISPR technology has made genome edi

110 titative trait loci, have helped to identify genes, functions, and mechanisms of prime importance for

111 techniques enabling conditional analysis of gene function are limited.

112 existing VIGS vectors for revealing monocot gene functions are described and potential new vectors a

113 ecipitation (ChIP-seq) revealed BAZ1B target gene functions are enriched for neurogenesis, neuron dif

114 Although gene functions are relevant to tissue context, most exis

115 New gene functions arise within existing gene families as a

116 we show that BEX1 is a heart failure-induced gene functioning as an mRNA-associated protein that enha

117 First, Hox genes function as activators, modifiers, and suppressors

118 ycle during the transition, whereas epilepsy genes function as downstream effectors in the same proce

119 We propose that the Aux/IAA genes function as hubs that integrate genetic and enviro

120 ction could be used to predict the timing of gene function, as mRNA abundance was found to correlate

121 Combining high-throughput gene function assays with mechanistic models of the impa

122 that Y-linked genes have evolved convergent gene functions associated with testis expression.

123 on intrinsic or extrinsic noises and reveal gene function-associated noise trends implicating the ac

124 st, especially in the context of discovering gene function at scale.

125 ave resulted in new powerful screens to test gene functions at the genomic scale.

126 Thus, the library of gene functions available to the community, rather than t

127 viding a resource for further association of gene function based on co-expression patterns.

128 ant mice, arguing for strong conservation of gene function between these two species.

129 nce is not attributable to acute loss of MMR gene function but might arise during sustained MMR-defic

130 eating a genome- and phenome-wide catalog of gene function by characterizing new knockout-mouse strai

131 titutes state-of-the-art technology to study gene function by facilitating inducible expression in a

132 CRISPR is widely used to disrupt gene function by inducing small insertions and deletions

133 Elucidation of gene function by reverse genetics in animal models frequ

134 pression caused by the perturbation of clock gene function can have large effects on the growth of ad

135 y low in F0 embryos that cell non-autonomous gene functions can be probed effectively and redundant a

136 t size for a habitat suggested four putative gene function categories associated with a habitat in bo

137 The emergence of four gene function categories combined with a lack of paralle

138 Manipulating gene function cell type-specifically is a common experim

139 e conservation of gene expression depends on gene function, cell type and evolutionary distance.

140 fish demonstrate that p.Tyr247Cys attenuates gene function, consistent with protein structural analys

141 PR-Cas nucleases is a powerful tool to study gene function, create disease models and holds promise f

142 acute manipulations more likely reveal basic gene functions, developmental plasticity can be a major

143 l populations provide rapid methods to study gene function directly.

144 Loss of XBAT35 gene function disrupts the plant's ability to defend aga

145 ash-soil community already showed a similar gene function diversity, phylum diversity and overall re

146 Loss of gene function does not appreciably affect endogenous gen

147 iated with conserved RAREs, suggesting these genes function downstream of RA.

148 d minimization of negative impacts on nearby gene function due to precision targeting.

149 AG and STK genes show strong conservation of gene function during poplar catkin development and are p

150 ations that can further our understanding of gene function during postembryonic development and in di

151 e obtained by untangling specific paralogous gene functions during development might not only signifi

152 To validate the gene functions, each candidate gene was silenced by inje

153 also show that the dre-1/F box heterochronic gene functions early in development to control maintenan

154 ene expression is essential to understanding gene function, engineering cellular behaviors, and devel

155 SR, we calculated gene-by-gene correlations, gene function enrichment, and comparison of temporal dyn

156 m genes in parasitoid wasps to study how new gene functions evolve.

157 Mice with altered nAChR gene function exhibit PFC-dependent behavioral deficits,

158 d the choice of dataset, annotation quality, gene function, expression similarity measure, and cluste

159 onally, libraries were created by predicting gene function from RNA-seq co-expression data processed

160 -Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research

161 To predict gene function, Geneshot utilizes gene-gene similarity ma

162 The loss of WRKY1 gene function has marked effects on the light and N resp

163 Although gene functions have been studied extensively, little is

164 Although gene functions have been well studied, little is known a

165 shing early developmental programs, maternal gene functions have remained elusive due to a paucity of

166 m presents an innovative approach to predict gene function, identify novel factors related to differe

167 o enable the discovery of: (i) new leads for gene function, (ii) non-coding RNAs; (iii) genes, pathwa

168 Analyzing gene function in a broad range of research organisms is

169 ty of tissues, allowing detailed analysis of gene function in a multicellular organism.

170 The ability to alter gene function in a targeted manner will unmask the effec

171 l differentiation and the ability to dissect gene function in a temporal manner.

172 d number of genetic tools available to study gene function in ameloblasts.

173 efficient knockdown platform to interrogate gene function in animal embryos.

174 have underpinned comprehensive assessment of gene function in bacteria and eukaryotes.

175 structure and epigenetic mechanisms regulate gene function in both development and disease.

176 uld allow wide-ranging and rigorous tests of gene function in both larval and adult corals.

177 A better understanding of gene function in C4 plants is now needed to inform more

178 Gene function in cancer is often cell type-specific.

179 ies have revolutionized our understanding of gene function in complex biological settings, including

180 reating a platform for systematic screens of gene function in developing and adult flies with unprece

181 ources, which have been key to understanding gene function in diploid model organisms, are missing in

182 s of CRISPR screens to investigate redundant gene function in highly duplicated plant genomes.

183 ity of rare disease genomic studies to parse gene function in human developmental pathways.

184 e marrow delivery system to rapidly evaluate gene function in innate and adaptive immune cells in viv

185 Genetic screens help infer gene function in mammalian cells, but it has remained di

186 Overall, we show that large-scale studies of gene function in model organisms provide a powerful appr

187 xpression analysis has provided insight into gene function in organisms from Arabidopsis to zebrafish

188 lopment of similar methods for interrogating gene function in other marine invertebrates.

189 ossibilities for stably fine-tuning residual gene function in planta.

190 s, and enriched views of gene expression and gene function in plants.

191 rently lack the means to identify and modify gene function in specific subsets of midbrain dopaminerg

192 ereby allowing high-resolution dissection of gene function in the context of bacterial operons.

193 iting is a powerful method for investigating gene function in the context of human development.

194 and the wide range of mechanistic effects on gene function in the context of signalling networks.

195 ificant; it extends our understanding of Dlx gene function in the developing forebrain beyond the reg

196 Moreover, knowledge about gene function in the inherited cancers offers insights t

197 Our data reveal conservation of RAV gene function in the regulation of flowering time in mon

198 rculosis pathogenesis, analysis of essential gene function in this slow-growing pathogen remains diff

199 represents a powerful approach for studying gene function in vivo and in vitro.

200 a conventional genetics approach to identify gene function in vivo.

201 chniques now enables the rapid assessment of gene function in wheat directly.

202 imentary approaches are widely used to study gene function in zebrafish: induction of genetic mutatio

203 ffer insights into the genetic diversity and gene functions in benthic diatoms.

204 tions have enabled researchers to understand gene functions in disease and development, providing a p

205 s are being harnessed to probe combinatorial gene functions in functional genomics studies and have t

206 Plasmodium gene functions in mosquito and liver stages remain poorl

207 ing technique and widely used to investigate gene functions in some biological processes and diseases

208 opens avenues for discovering and analyzing gene functions in the spatial and temporal contexts of p

209 is Primer, I summarise how this multifaceted gene functions in various mammalian tissues and organs,

210 to link primary DNA sequence information to gene functions in vertebrate models.

211 Cas9 as a robust tool to study novel cardiac gene functions in vivo.

212 istasis analysis demonstrated that the three genes function in a common pathway.

213 gly, most of these differentially methylated genes function in cell adhesion and communication pathwa

214 NUT1 downstream target genes function in cell wall biosynthesis, apoptosis, and

215 rray analyses revealed that JMJD1A-dependent genes function in cellular growth, proliferation and sur

216 Syncytium-expressed exocyst genes function in defense while some are under transcrip

217 These genes function in extracellular matrix regulation and tu

218 phenotypic variation that can elucidate how genes function in networks to collectively shape ocular

219 othesized that Dlx1, Dlx2 and Brn3b homeobox genes function in parallel intrinsic pathways to determi

220 even greater decrease, suggesting that both genes function in response to salt and have distinct fun

221 The SERK1/2 genes function in the same genetic pathway as EMS1 in an

222 amk2-specific negative interactors included genes functioning in chromatin silencing and DNA damage

223 gsk3-specific negative interactors included genes functioning in translation and ribosomes.

224 The mutated genes were enriched for genes functioning in transport, protein quality control,

225 ul model for characterizing the evolution of genes functioning in venom and nervous systems.

226 lecture in which he outlined key ideas about gene function, in particular what he called the central

227 show how dTn-Seq can help identify leads for gene function, including those involved in hyper-compete

228 role in extending the repertoire of specific gene functions, including light and oxygen sensing, whic

229 ative splicing events (ASE) that could alter gene function independent of mutations.

230 variants predicted to lead to loss of ACVR1C gene function influence body fat distribution and protec

231 The computational prediction of gene function is a key step in making full use of newly

232 s befalling coral reefs, understanding coral gene function is essential to advance reef conservation.

233 of multicellular organisms, interrogation of gene function is greatly facilitated by methods that all

234 Gene function is mostly characterized through overexpres

235 act of rare variants is under-appreciated as gene function is normally studied in the context of a si

236 rstanding the genetic and molecular bases of gene function is of increasing importance to harness the

237 Loss of gene function is often complete, as F0 embryos closely r

238 GWAS schizophrenia variants whose associated gene function is related to synaptic transmission, and (

239 lend support to the notion that loss of ndh gene function is the first step of plastome degradation

240 The classic model for the evolution of novel gene function is through gene duplication followed by ev

241 Similarity of GO terms and gene functions is quantified with six different scores i

242 provide a valuable foundation for studies of gene function, metabolic engineering, and trait modifica

243 l global impact of AS on the human canonical gene functions, molecular interactions and cellular path

244 cts expression patterns to information about gene function, mouse expression patterns and phenotypes,

245 alleles, transgenic lines, gene expression, gene function, mutant phenotypes, orthology, human disea

246 rast, predictors based on attributes such as gene function, mutation rates, or network features perfo

247 ns has led to ground-breaking discoveries in gene-function, neuronal circuits, and physiological resp

248 ause of the need in many cases to manipulate gene function of neurons in situ.

249 stablish that human collybistin, the loss of gene function of which causes severe encephalopathy, is

250 ortant because different downstream effector genes function optimally at different expression levels.

251 Cells that entirely lose accessory gene function or plasmid mobility dominate in the long r

252 quencies, and variants having high impact on gene function or provide any other added information or

253 At last, it will help users hypothesize new gene functions or genotype-phenotype associations by an

254 understudied mechanism of evolution for new gene functions, particularly under conditions of rapid e

255 reference data sets related to mouse genes, gene functions, phenotypes, and mouse models of human di

256 Our work has broad impacts on the study of gene functions, phenotypical heterogeneity, and genetic

257 etwork (GCN) can be constructed and used for gene function prediction, candidate gene selection, and

258 ne, GCN analysis has shown great promise for gene function prediction, however, measurable progress i

259 arding cancer gene networks construction and gene function prediction, MFR also obtains the results w

260 ch as drug repurposing, disease modeling and gene function prediction.

261 onnection between xenolog classification and gene function prediction.

262 and human osteoblast expression studies; (2) gene-function prediction; (3) skeletal phenotyping of 12

263 knowledge from experimental ground truth to gene function predictions and annotations?

264 tive phenotype is caused by an alteration in gene function rather than a loss-of-function mutation.

265 ated reprogramming indicating that the PpCSP genes function redundantly in cellular reprogramming.

266 tification strategy enables discovery of new gene functions relevant to disease.

267 Loss of MtMATE67 gene function resulted in accumulation of Fe in the apop

268 This unbiased morphologic map of gene function revealed TRAF2/c-REL negative regulation o

269 he relationship becomes negative for a given gene function (rs approximately -0.13).

270 del may offer unique usefulness for studying gene functions simultaneously in multilineages in the lu

271 CRISPR/Cas9 is a versatile tool for plant gene function studies and crop improvement.

272 ene silencing (VIGS) is used extensively for gene function studies in plants.

273 allel sequencing often require complementary gene function studies to determine if and how rare varia

274 he wider applications of i-GONAD may promote gene function studies using novel murine models.

275 The Cre/loxP system is a powerful tool for gene function study in vivo.

276 efficient approach to investigate essential gene function that may be particularly useful in charact

277 enabled the definition of sets of genes and gene functions that were acquired or lost in specific li

278 To understand gene function, the encoding DNA or mRNA transcript can b

279 itors requires CREB-CBP interaction and Nr4a gene function, these data support the notion that the ba

280 abolite analyses, and direct confirmation of gene function through RNAi.

281 ultiple data types and external knowledge of gene function to detect candidate genes, applied the met

282 lop a new technology for inhibiting maternal gene function to identify the H3K9 methyltransferase nec

283 l links and help researchers to choose which gene functions to investigate in a biological event.

284 technique helps to transfer the knowledge of gene functions to the prediction of isoform functions an

285 he mechanisms by which interferon-stimulated genes function to inhibit viral replication.

286 ated, cross-species approaches to uncovering gene function using functional genomics and other approa

287 l microscopy is a powerful tool for studying gene functions using strain libraries, but it suffers fr

288 Gene function was characterized by down-regulation and o

289 Gene function was characterized by downregulation and ov

290 Gene function was investigated and pathway analysis was

291 ing of bptf in zebrafish to induce a loss of gene function, we observed a significant reduction in he

292 ese "molecular scars" as a guide to discover gene functions, we discovered a vertebrate-specific MIto

293 mbinase system is an essential tool to study gene function when early ablation or overexpression can

294 ClvRs, each targeting a different essential gene, function when located at a common chromosomal posi

295 genes or cause the loss of tumor suppressing gene function which can lead to tumorigenesis by downreg

296 CRISPR-Cas9 system enables global screens of gene function with high sensitivity and specificity, but

297 hat uses a range of approaches for assessing gene function with high-throughput molecular, genetic, a

298 le for understanding the effects SVs have on gene function, with the prospect of identifying novel ag

299 d recessive CHD are associated with distinct gene functions, with cilia-related genes providing a res

300 Our study reveals that a viral latency gene functions within a distinct subset of cells to faci