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1 ures such as particle-mediated DNA delivery (gene gun).
2 and skin by particle-mediated gene transfer (Gene Gun).
3  293 cells and whole brain using a hand-held gene gun.
4 d organotypic brain slices using a hand-held gene gun.
5  DNA vaccines administered intradermally via gene gun.
6 ary vaccine Ags after single immunization by gene gun.
7 s only in sera of mice inoculated by using a gene gun.
8 rabbit Peyer's patches using a helium-driven gene gun.
9 parate plasmid after codelivery into skin by gene gun.
10                         We reasoned that the gene gun administration of CIITA DNA with DNA vaccines e
11 ediated biolistic delivery using a hand-held gene gun, allows non-toxic labeling of multiple cells in
12           An N586-82Q plasmid, delivered via gene gun, also showed ELISA responses, mainly in the zQ1
13 nts were delivered to the skin of a mouse by gene gun and IFN-gamma levels were measured at the skin
14      Two delivery systems, cDNA delivered by gene gun and Venezuelan equine encephalitis virus-like r
15 entation may be more significant in clinical Gene Gun applications than in pre-clinical mouse studies
16        We conclude that transfected cells in gene gun-bombarded skin, but not needle-injected muscle,
17 psy of the skin target site up to 24 h after gene gun bombardment completely abrogated the Ab respons
18  been studied, including liposomal delivery, gene gun bombardment, and picoinjection into single livi
19                                    Following gene gun bombardments of DNA, both were biased towards t
20                    The studies revealed that gene gun bombardments of DNAs expressing secreted Ags st
21                                  Following a gene gun booster, the presence of ASC in the inguinal ly
22 X3C-mut were inoculated into mice by using a gene gun, both plasmids elicited an antibody response de
23 ese formulations into a biolistic format for gene gun by forming fireable dry bullets obtained via ly
24 ression vectors simultaneously delivered via gene gun can significantly augment antitumor effects, ev
25                         Using the Biolistics Gene Gun, cDNA constructs encoding a Kv1 subfamily-speci
26                         Using the Biolistics Gene Gun, cDNA constructs encoding either Kv2.1DN or Kv2
27                          Using the biolistic gene gun, cDNAs encoding a dominant negative mutant Kv4.
28                          Using the biolistic gene gun, cDNAs encoding a mutant Kv4.2 alpha subunit (K
29  was conducted to investigate whether Accell gene gun coadministration of DNA encoding human interleu
30                               The use of the gene gun, combined with the new generation of fluorescen
31 vered by a combination of vaccinia virus and gene gun-delivered DNA were effective against SHIV89.6P
32                                              Gene gun-delivered plasmid encoding the wild-type NY-ESO
33 erologous prime/boost strategy consisting of gene gun-delivered PSCA-cDNA followed by Venezuelan equi
34  IL-4-producing CD4(+) T cells was found for gene gun deliveries of cell-associated Ags.
35 y raised immunoglobulin G2a (IgG2a), whereas gene gun deliveries of DNA predominantly raised IgG1.
36                                              Gene gun deliveries of secreted Ags were used to bias re
37  DNA vaccine efficacy by immunizing mice via gene gun delivery and challenging them with live, virule
38 e data suggested that muscle inoculation and gene gun delivery elicited Th1-like and Th2-like respons
39                        Each regimen included gene gun delivery of a DNA vaccine expressing all SHIV89
40                            Here we show that gene gun delivery of DNA encoding an H5 HA protein confe
41 ually given by intramuscular injection or by gene gun delivery of DNA-coated particles into the epide
42 all, the high levels of protection seen with gene gun delivery of HA-DNA were as good as, if not bett
43                      Immunization of mice by Gene Gun delivery of the 47-kDa domain of SERA elicited
44 e evaluated a physical gene transfer method (gene gun delivery) for its ability to transfect the epid
45 tor-mediated gene transfers were superior to gene-gun delivery of plasmid DNA.
46                Cynos administered vaccine by gene gun developed antibodies to HEV (anti-HEV), whereas
47 response with mostly IgG2a anti-H1 Ab, while gene gun DNA immunization produced a predominantly Th2 r
48 ences in the doses of DNA used in saline and gene gun DNA immunization.
49 on site tissue for i.m. needle and epidermal gene gun DNA immunizations.
50 dy, we combined chemical (GET) and physical (gene gun) DNA delivery systems, and hypothesized the com
51                   Intradermal vaccination by gene gun efficiently delivers DNA vaccines into DCs of t
52                                  In the i.m.-gene gun (g.g.)-g.g. regimen, the mice immunized with gp
53 ersely, intradermal genetic immunization via gene gun (GG) delivered TcPRAC as an immunogen, generati
54           Administration of DNA vaccines via gene gun has emerged as an important form of Ag-specific
55               Single plasmid immunization by gene gun identified a novel vaccine target antigen which
56  when these mice were challenged with OVA by gene gun immunization in the contraction phase of the pr
57                                              Gene gun immunization of dual-expression DNA vaccines in
58 ne injection of DNA into skin or muscle, and gene gun immunization of skin or muscle.
59 hin the epidermis impacts on the efficacy of Gene Gun immunization protocols.
60                              Carefully timed gene gun immunization studies designed to take advantage
61   We tested the ability of intramuscular and gene gun immunization with DNA expressing influenza viru
62 ed in predominantly IgG2a responses, whereas gene gun immunization yielded a preponderance of IgG1 an
63 ss-presentation in CD8+ T cell priming using gene gun immunization, and indicate that augmentation of
64  in the generation of immune responses after gene gun immunization.
65 of protective responses from those seen with gene gun immunization.
66 .m.) injection or delivered intradermally by Gene Gun immunization.
67                      For the NP DNA, boosted gene gun immunizations of 0.4 microg of DNA and boosted
68 cited to the SERA protein following i.m. and Gene Gun immunizations with SERA plasmid DNA was immunog
69 itro skin organ cultures were developed from gene gun immunized mouse ear specimens to obtain LC.
70        Waning gamma interferon production in gene gun-immunized animals was countered by a marked inc
71                           Particle-mediated (gene gun) in vivo delivery of the murine interleukin 12
72 ata of in vivo transfection in the rabbit by Gene Gun indicate that reporter gene constructs containi
73 d particles to neuronal preparations with a "gene gun," individual neurons and glia whose membranes a
74 ccinations administered to the skin with the gene gun induced and progressively increased p11C, C-->M
75  epidermis using a hand-held, helium-driven "gene gun" induced beta-gal-specific Ab and lytic respons
76 due to cell respiration were monitored, with gene gun injected PEBBLEs, in rat C6 glioma cells.
77 ch remained viable after PEBBLE delivery via gene gun injection.
78 her gp120 or gp140 DNA vaccines delivered by gene gun inoculation followed by recombinant gp120 prote
79 body responses in mice immunized by a single gene gun inoculation of plasmid expressing the influenza
80 mbardment of DNA-coated gold beads by Accell gene gun inoculation.
81                       For the HA DNA, single gene gun inoculations of 0.04 microg and boosted inocula
82                          Three received only gene gun inoculations.
83 lated intravenously, intramuscularly, and by gene gun inoculations.
84  intramuscular, intradermal, and epithelial (gene gun) inoculations.
85 accines were delivered to mice by biolistic (gene gun) intradermal inoculation.
86                                  Peritumoral gene gun introduction of interleukin-12 may be a novel,
87 ry via biolistic methods (such as the Helios gene gun) involve precipitation of nucleic acids onto mi
88 at DNA vaccine with HEV ORF2 administered by gene gun is protective against a heterologous viral chal
89  DNA-based immunizations administered by the gene gun may be an effective method of inducing local im
90 vaccination and demonstrates the efficacy of gene gun-mediated delivery of foreign DNA to a mucosal t
91                                              Gene gun-mediated DNA vaccination stimulates an immune r
92                  These results indicate that gene gun-mediated immunization with papillomavirus early
93                   These results suggest that gene gun-mediated in vivo delivery of IL-12 cDNA should
94               Rabbits were then immunized by gene gun-mediated intracutaneous administration of four
95                                              Gene gun-mediated transfection of mouse inner ear sensor
96                            Here we show that gene gun-mediated vaccination with an epitope-based DNA
97 y at the skin site receiving DNA transfer by gene gun on days 6, 8, 10, and 12 after tumor implantati
98                                The hand-held gene gun provides a rapid and efficient method of incorp
99 radermal administration of nucleic acids via gene gun represents an efficient method for delivering n
100                                     However, gene gun responses are more difficult to categorize beca
101 odes, but not in other lymph nodes, revealed gene gun responses being initiated in the nodes that dra
102 er 4 doses of DNA administered by epidermal (gene gun) route, all guinea pigs developed enzyme-linked
103 munized via the intramuscular and epidermal (gene gun) routes with 100 and 1 micrograms, respectively
104 l combination of GET-gold-DNA carriers using gene gun shows potential as an alternative DNA delivery
105 be easily performed using the Bio-Rad Helios gene gun system.
106                     In addition, the corneal gene gun technique may be generally used to study the in
107  with a model DNA-based antigen delivered by gene gun technology would induce an antibody response de
108                                        Using gene gun technology, we immunized a Wistar rat with an A
109 ow that after immunization of mouse skins by gene gun, the number of antigen-bearing DCs that migrate
110                                              Gene gun therapy with interleukin-12 cDNA into the perit
111 ermally with high expresser plasmid, using a gene gun to administer three doses at 6-wk intervals.
112                                  We used the gene gun to deliver transgenic (tg) Ag to the skin of C5
113 ted with DNA-coated gold micro-projectiles ("Gene Gun") to induce potent cellular and humoral immune
114          In this study, we demonstrated that gene gun transfection and production of semaphorin III i
115 cial role in Purkinje cell development using gene gun transfections within intact murine cerebellar c
116                                              Gene gun treatment markedly augmented (3-fold) LC migrat
117 el this mechanism, we examined the impact of gene gun treatment on LC with respect to their activatio
118 ptor binding domain (S-RBD) was delivered by gene gun using GET bullets.
119 we compared immune responses generated after gene gun vaccination of mice with DNA vaccine plasmids d
120 this model, depigmentation was introduced by gene gun vaccination with eukaryotic expression plasmids
121 nucleoprotein (NP) in C57BL/6 mice following gene gun vaccination.
122                                            A gene gun was used to inoculate vaccines into the epiderm
123 ntrast, cutaneous DC transfected in situ via gene gun were detected in the draining lymph node at a 2
124                Rhesus macaques vaccinated by gene gun with pWRG/AND-M developed remarkably high level

 
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