ライフサイエンスコーパス: gene inactivation

1 e genomic aberrations that can contribute to gene inactivation.

2 ather than a discrete, local coordination of gene inactivation.

3 o one oncogenic mutation or tumor suppressor gene inactivation.

4 ting a classic mechanism of tumor suppressor gene inactivation.

5 cause of Dravet syndrome through functional gene inactivation.

6 ion (Msh2(LoxP)), permitting tissue-specific gene inactivation.

7 an R-band cannot be accounted for by direct gene inactivation.

8 m phenotypes similar to those obtained after gene inactivation.

9 r the Sir4 pathway of telomere tethering and gene inactivation.

10 pearing to be important mechanisms of Cables gene inactivation.

11 t phenotypic consequences than one caused by gene inactivation.

12 oncogene activation and p53 tumor suppressor gene inactivation.

13 entric DNA is related to heterochromatin and gene inactivation.

14 er methylation is the commonest mechanism of gene inactivation.

15 mmary gland development by using conditional gene inactivation.

16 ic consequences of conventional global Clcn3 gene inactivation.

17 rs are characterized by VHL tumor suppressor gene inactivation.

18 with deregulated c-myc for evidence of Ink4 gene inactivation.

19 osphoribosyl transferase locus, resulting in gene inactivation.

20 anges and allelic loss, for tumor suppressor gene inactivation.

21 g for variegated phenotypes, that is, mosaic gene inactivation.

22 thylation equivalent phenomenon resulting in gene inactivation.

23 for cell-mediated gene transfer and targeted gene inactivation.

24 romatin and has been implicated in heritable gene inactivation.

25 irmed in human cells by CRISPR/Cas9-mediated gene inactivation.

26 was also rescued by conditional beta-catenin gene inactivation.

27 , consistent with very strong intolerance to gene inactivation.

28 parable with the effects observed with PDE12 gene inactivation.

29 on activator-like effector nuclease-mediated gene inactivation.

30 ral control of fluorescent cell-labeling and gene inactivation.

31 method to manipulate isoforms independent of gene inactivation.

32 ologous end joining (NHEJ), often leading to gene inactivation.

33 n GRB2 expression was reduced by shRNA or by gene inactivation.

34 sequence is deleted, resulting in F8(F-->KO) gene inactivation.

35 phorylation, the epigenetic event leading to gene inactivation.

36 s been an accepted means of tumor suppressor gene inactivation, activation of otherwise normally repr

37 y tobacco smoke occurs in a series of target gene inactivations/activations in defined modules of a g

38 The pattern of species-specific gene inactivations affecting transcriptional regulators

39 Systematic gene inactivation allowed determination of the precise b

40 xperimentally generated in mice by alpha-TTP gene inactivation (alpha-TTP-KO).

41 studies were designed to assess whether TSC gene inactivation alters excitability.

42 ST) library-based antisense method of random gene inactivation and a phenotypic screen for limitation

43 namics during preimplantation development of gene inactivation and acquisition of repressive histone

44 However, gene inactivation and analysis of the accumulated produc

45 hodobacter sphaeroides, were investigated by gene inactivation and biochemical studies.

46 nts) provide natural in vivo models of human gene inactivation and can be valuable indicators of gene

47 lvement in TTM biosynthesis was confirmed by gene inactivation and complementation experiments.

48 Genome degradation, marked by gene inactivation and deletion, is a key feature of host

49 ct the functional relationship between Cav-1 gene inactivation and ERalpha expression, we isolated pr

50 ncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cance

51 sporadic clear cell RCC samples without VHL gene inactivation and in 13 individuals with familial no

52 that shift the reading frame generally cause gene inactivation and in essential genes cause loss of v

53 By in vivo gene inactivation and in vitro biochemical characterizat

54 n prompted us to examine the effect of Kv1.3 gene inactivation and inhibition on peripheral glucose h

55 l mechanism of self-encoded tumor suppressor gene inactivation and link a relatively common single nu

56 Gene inactivation and loss are particularly apparent in

57 usses the principle underlying M1GS-mediated gene inactivation and methodologies involved in effectiv

58 mA gene in TTM biosynthesis was confirmed by gene inactivation and mutation complementation experimen

59 results suggest that rapid and irreversible gene inactivation and pathway degeneration are associate

60 ions are due to the combinational results of gene inactivation and polar effects caused by intron ins

61 Targeted gene inactivation and protein interaction studies demons

62 Following gene inactivation and replacement in human cells, we dem

63 Gene inactivation and reporter expression is achieved th

64 Gene inactivation and RNAi-mediated knockdown of AtCPT7

65 o function of mouse tankyrase 2 by germ line gene inactivation and show that inactivation of tankyras

66 r proteins have been elucidated by selective gene inactivation and subsequent phenotypic analysis.

67 road utility of the approach for conditional gene inactivation and suggests that this tool could be u

68 Here we demonstrate by both gene inactivation and target protein blockade that a sin

69 the fact that there is often a delay between gene inactivation and the time point of phenotypic analy

70 ture regarding VEGF, von Hippel-Lindau (VHL) gene inactivation and VEGF overexpression in RCC was per

71 that specify this polarity by screening for gene inactivations and mutations that disrupt this norma

72 es in concert with gene sequencing, cloning, gene inactivation, and animal testing offers an efficien

73 by microsomal triglyceride transfer protein gene inactivation, and mice were treated with anti-miR33

74 and therefore complementing the conventional gene inactivation approach to finding mutators.

75 ouse mes/met development using a conditional gene inactivation approach.

76 ss potential limitations in the Cre-mediated gene inactivation approach.

77 any of the phenotypes associated with MAGP-1 gene inactivation are consistent with dysregulation of t

78 demonstration of epigenetic tumor-suppressor gene inactivation associated with promoter methylation,

79 ripheral nerve dysfunction and whether COX-2 gene inactivation attenuates nerve fiber loss in long-te

80 icient and reliable, and permits conditional gene inactivation based on both spatial and temporal cue

81 To facilitate gene inactivation by induction of STOP codons (iSTOP), w

82 n antiestrogen-resistant cells compared with gene inactivation by promoter hypermethylation, revealin

83 Gene inactivation by RNA interference shows that set-1 i

84 es and phase-variable and non-phase-variable gene inactivation by the deletion or insertion of bases.

85 Gene inactivation by transposon insertion or allelic exc

86 Although the role of complete gene inactivation by two loss-of-function mutations inhe

87 e perturbations and suggest that recovery by gene inactivation can lead to rapid divergence in the pa

88 tibody binding demonstrated that as few as 3 gene inactivations can reduce the levels human antibody

89 Gene inactivation causes mice (Kv1.3-/-) exposed to a hi

90 ereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.

91 In mice with Col9a1 gene inactivation (Col9a1(-/-)), osteoarthritis (OA) and

92 ocyte-specific shRNA- and CRISPR/Cas9-driven gene inactivation combined with RNA-seq, ATAC-seq, ChIP-

93 olvement in FDM A biosynthesis was proven by gene inactivation, complementation, and heterologous exp

94 Irrespective of the timing of Pkd1 gene inactivation, cystic kidneys showed enhanced uptake

95 in each locus, strains were constructed with gene inactivation, deletion, and/or reporter gene fusion

96 genetics of chromatin remodeling reveal that gene inactivation depends on the recruitment of enzymes

97 n, per se, does not result in a high rate of gene inactivation, despite greatly accelerated retrotran

98 -allelic somatic (glial progenitor cell) Nf1 gene inactivation develop brain tumors that do not fully

99 mice further demonstrated that B13R or B22R gene inactivation diminishes VV virulence, as measured b

100 isingly, the Nestin-Cre mice used to mediate gene inactivation displayed a phenotype.

101 These gene inactivations disrupt the increased expression of t

102 Some of these gene inactivations dramatically shorten daf-2 mutant lif

103 Many of the gene inactivations enhance exogenous RNAi.

104 tisense EST libraries for global chromosomal gene inactivation, establish the practicality of loss-of

105 ged from a common ancestor after the massive gene inactivation event described previously for M. lepr

106 here will be a crucial tool for conditional gene inactivation exclusively in the anterior heart fiel

107 lls that, as a consequence of shRNA-mediated gene inactivation, exhibited defective agonist-induced d

108 dioxane unit through (13)C labeling studies, gene inactivation experiments and enzymatic synthesis.

109 . arenicola circular genome and PCR-targeted gene inactivation experiments identified the 47 kb cyclo

110 Gene inactivation experiments in B. subtilis indicate th

111 Gene inactivation experiments in mice have identified fa

112 cyclomarin A was further illuminated through gene inactivation experiments, which suggest that the tr

113 further supported by the results of in vivo gene inactivation experiments.

114 s, and has been further supported by in vivo gene inactivation experiments.

115 eritable IR genes confer potent and specific gene inactivation for each of these applications.

116 nt test strains were used to filter progeric gene inactivations for specific acceleration of aging.

117 Mice with targeted Piga gene inactivation genetically mimic the human disease an

118 ant lines with differing combinations of NPD gene inactivations had progressively smaller nodules, ea

119 Targeted gene inactivation has demonstrated a crucial role for Ba

120 tudies in mice with liver-specific or global gene inactivation have shown that hypoxia-inducible fact

121 d 2, then elucidated the pathway with target gene inactivation, heterologous reconstitution, and bioc

122 Because of this gene inactivation, humans, apes, and Old World monkeys l

123 mmary, GATA1-Cre causes high-efficiency Piga gene inactivation in a GATA-1-specific pattern.

124 oter CpG islands is a frequent mechanism for gene inactivation in a variety of human cancers, includi

125 s an important mechanism of tumor suppressor gene inactivation in a variety of human cancers.

126 Zinc-finger nucleases (ZFNs) allow targeted gene inactivation in a wide range of model organisms.

127 the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice).

128 Here we show that Nf1 gene inactivation in adult oligodendrocytes (Plp-Nf1 (fl

129 We show further that Adfp gene inactivation in apolipoprotein E-deficient (ApoE(-/

130 th mesenchyme, through neural crest-specific gene inactivation in Bmp4(f/f);Wnt1Cre mice, caused mand

131 hromatin constitutes a frequent mechanism of gene inactivation in cancer.

132 Partial fibrillin 1 gene inactivation in cardiomyocytes was sufficient to pr

133 ene constitutes an alternative mechanism for gene inactivation in colon and other tumors of the gastr

134 In this study we identified as a target for gene inactivation in colon cancer the gene for helicase-

135 However, conditional gene inactivation in diploid cells is still difficult to

136 Jaiswal et al. (2015) to perform conditional gene inactivation in Drosophila.

137 ly demonstrated that astrocyte-specific Tsc1 gene inactivation in mice (Tsc1 cKO mice) results in pro

138 In contrast, Sorl1 gene inactivation in mice accelerated breakdown of triac

139 Hcrt gene inactivation in mice leads to behavioral state inst

140 Plekhg5 gene inactivation in mice results in a late-onset motone

141 We show that PDE4D gene inactivation in mice results in a progressive cardi

142 Hematopoietic-specific gene inactivation in mice revealed Hippo kinase loss to

143 Using cell type-specific gene inactivation in mice, we show that CCM3 has both ce

144 s been used for conditional and conventional gene inactivation in mice.

145 enes with a novel floxed Eln allele to focus gene inactivation in mice.

146 Acute Krit1 gene inactivation in mouse brain microvascular endotheli

147 ic mice, to enable tamoxifen-inducible Hif1a gene inactivation in nestin-expressing NSCs within the a

148 ird, in contrast to the GFAP-Cre strain, Nf1 gene inactivation in NG2+ cells is not sufficient for op

149 used a conditional knock-out approach to BiP gene inactivation in oligodendrocytes during development

150 When BiP gene inactivation in oligodendrocytes was initiated in a

151 lt in a reduction of three major pathways of gene inactivation in our model system.

152 Distinct patterns of gene inactivation in the four near-complete sequences sh

153 or biochemical analysis; and (iii) effective gene inactivation in the nervous system.

154 To enable in vivo CRISPR/Cas9-mediated gene inactivation in the pancreas, we generated a Cre-re

155 a mechanistic account of the role of RASSF1A gene inactivation in tumor initiation is lacking.

156 c deletion are two predominant mechanisms of gene inactivation in tumorigenesis, but the extent to wh

157 that this is a viable platform for heritable gene inactivation in vertebrates.

158 activation in cultured ECs, and its targeted gene inactivation in vivo alters Notch-dependent vascula

159 -mediated knockdown in vitro and conditional gene inactivation in vivo to study the role of the G(12/

160 Loss of YFP(+) NSCs following Hif1a gene inactivation in vivo was likely an indirect consequ

161 ovides a resource to allow targeted germline gene inactivation in zebrafish and highlights the benefi

162 mbly-based approach for ZFN construction and gene inactivation in zebrafish.

163 ell-based gene transfer approach to targeted gene inactivation in zebrafish.

164 ISPR-based vector system for tissue-specific gene inactivation in zebrafish.

165 Analysis of the fat-reducing gene inactivations in insulin, serotonin and tubby signa

166 osynthetic pathway, using systematic in vivo gene inactivation, in vitro biochemical assays, and tota

167 erations, including disparate roles for MEN1 gene inactivation, indicate that markedly different mole

168 In addition, Cav-1 gene inactivation induces the accumulation of a cell pop

169 Caveolin-1 (Cav-1) gene inactivation interferes with caveolae formation and

170 Tumor suppressor gene inactivation is a crucial event in oncogenesis.

171 Gene inactivation is a powerful approach for functional

172 7(Kip1) is cell-autonomous because biallelic gene inactivation is absent from tumors arising in p27(K

173 Specifically, we demonstrated that gene inactivation is an important mechanism for altering

174 and decreased particle/PFU ratios.IMPORTANCE Gene inactivation is considered to be an important drive

175 re, we found that robustness to heterozygous gene inactivation is not due to dosage compensation.

176 Von Hippel-Lindau gene inactivation is observed in most clear cell renal c

177 ation or deletion (genetic) tumor suppressor gene inactivation is that epigenetic inactivation can be

178 Biallelic RB1 gene inactivation is the initiating genetic lesion in re

179 Similar to the effects of Cdk5 gene inactivation, knockdown of nestin in agrin-deficien

180 Out of 50 C. elegans gene inactivations known to mediate mitochondrial defens

181 TSC gene inactivation leads to hyperactivation of the mammal

182 In principal cells in the kidney, TWIK1 gene inactivation leads to the loss of a nonselective ca

183 Constitutive SOS expression by lexA gene inactivation (lexA71::Tn5) and recA gene mutation (

184 Transposon (Tn) gene-inactivation libraries were generated in three C. j

185 mitochondrial surveillance defects of other gene inactivations, mapping these gene activities upstre

186 led quantitative analysis of the three major gene inactivation mechanisms for a model gene at two dif

187 Gene inactivation mechanisms include events resulting in

188 To study the interaction of these gene-inactivation mechanisms in primary brain tumors, we

189 e show a new molecular mechanism of ER-alpha gene inactivation mediated by pRb2/p130 in ER-negative b

190 tion, we describe the development of a novel gene inactivation methodology to target B. burgdorferi f

191 Here we show using cell-specific gene inactivation models that gamma-carboxylation of OCN

192 GIM(3)E (Gene Inactivation Moderated by Metabolism, Metabolomics

193 e Golgi by N-acetylglucosaminyltransferase I gene inactivation nor PNGase F deglycosylation of fully

194 s of mammalian erythropoiesis include global gene inactivation, nuclear condensation, and enucleation

195 order to understand the specific patterns of gene inactivation observed in different subtypes of lung

196 ent, we recently generated mice in which Nf1 gene inactivation occurs in neuroglial progenitor cells

197 von Hippel-Lindau (VHL) gene inactivation occurs in von Hippel-Lindau (VHL) dise

198 long-established concept, we show here that gene inactivation of activating paired immunoglobulin-li

199 Targeted gene inactivation of Bbcal1 did not appear to affect spo

200 ciple studies and tested the hypothesis that gene inactivation of Ccr2 or Ccr5 will ameliorate experi

201 Gene inactivation of components of the cytosolic chapero

202 autoimmune encephalomyelitis, and show that gene inactivation of cortactin, an actin binding protein

203 Likewise, gene inactivation of each of the 2 receptors in neutroph

204 om mutant strains constructed by insertional gene inactivation of either of these two genes.

205 Pharmacological inhibition or gene inactivation of EP1 receptors ameliorates brain inj

206 the two C. elegans enzymes that require B12, gene inactivation of methionine synthase suppressed the

207 ion and can promote HCC cell invasiveness by gene inactivation of multiple invasion-suppressor miRNAs

208 Gene inactivation of nhx-2 by RNAi led to a loss of fat

209 Gene inactivation of opt-2 led to a phenotype resembling

210 , we describe the results of tissue-specific gene inactivation of plexinD1 in Tie2 expressing precurs

211 Gene inactivation of pRB through chromosomal mutations i

212 OR transport is inhibited by conditional gene inactivation of the Hedgehog signal mediator Smooth

213 ow that the lysosomal dysfunction induced by gene inactivations of lysosomal biogenesis or acidificat

214 esis is unique among the known heterochronic genes: inactivation of lin-42 causes the elongating gona

215 e identify a class of highly connected 'hub' genes: inactivation of these genes can enhance the pheno

216 We show that silencing, or gene inactivation, of endothelial Tie-2 results in leak

217 NF2 gene inactivation on chromosome 22 has been shown as an

218 iranda, in order to test competing models of gene inactivation on its newly evolving Y chromosome (th

219 We examined the effects of autophagy gene inactivation on Salmonella enterica Serovar Typhimu

220 for humans, independent mechanisms involving gene inactivation or altered expression of virulence det

221 Strikingly, Bmp5 gene inactivation or BMP signaling inhibition with a sma

222 me cases, the frameshift mutation results in gene inactivation or decay.

223 We hypothesize that metastasis suppressor gene inactivation or down-regulation plays a role in ova

224 ositol hexakisphosphate kinase 1-2 (IP6K1-2) gene inactivation or IP6K inhibitor treatment abolished

225 ve response was not initiated by in vivo Vhl gene inactivation or pharmacological inhibition of proly

226 ular processes by small molecule inhibitors, gene inactivation, or targeted knockdown strategies comb

227 s that influence the relative utilization of gene inactivation pathways are poorly understood.

228 f DNA methylation to these various competing gene inactivation pathways.

229 to determine whether these two mechanisms of gene inactivation play a complimentary role in medullobl

230 Myostatin gene inactivation prevented the severe loss of skeletal

231 Thus, Cav-1 gene inactivation promotes premalignant alterations in m

232 ducing mutated fetuses, the lack of complete gene inactivation resulted in animals with an intact pan

233 ryonic and extra-embryonic tissues, and Cubn gene inactivation results in early embryo lethality most

234 Biallelic NF2 gene inactivation results in the development of central

235 9R, was assigned as a 4-hydroxylase based on gene inactivation results.

236 Multiple time points of gene inactivation reveal that Pax7 is only required up t

237 and was required for rapid repression after gene inactivation, revealing a function for the nuclear

238 gans skr genes were probed by dsRNA-mediated gene inactivation (RNAi).

239 ate tumor suppressors we applied CRISPR/Cas9 gene inactivation screens to a cellular model of early-s

240 To maximize the chance of target gene inactivation, sgRNAs were curated to target both 5

241 Progression to tumorigenicity upon RASSF1A gene inactivation should therefore require collaborating

242 Cells with heterozygous gene inactivation still contained predominantly diphtham

243 provide a valuable complement to conditional gene inactivation strategies.

244 Here, we use a conditional gene inactivation strategy to show a specific requiremen

245 lict with expectations generated by previous gene inactivation studies and suggest a complex regulati

246 Recent systematic gene inactivation studies have confirmed the integral ro

247 n of H1 subtypes in multicellular organisms, gene inactivation studies have failed to reveal essentia

248 Gene inactivation studies have revealed a critical requi

249 ocyte development, and ectopic expression or gene inactivation studies have revealed several potentia

250 f congenital heart disease have emerged from gene inactivation studies in mice and from human genetic

251 An estimate of the timing of gene inactivation suggests that pathway degeneration beg

252 zed, mainly due to the paucity of a nonpolar gene inactivation system.

253 neurons, was silenced by the CRISPR-mediated gene inactivation system.

254 through the use of the one-step chromosomal gene inactivation technique to identify SXT genes involv

255 ong with integrase phylogenetic analysis and gene inactivation tests, revealed 19 new cases of genes

256 ding genes provide an in vivo model of human gene inactivation that complements knockout studies in c

257 ivations that cause reduced body fat and 112 gene inactivations that cause increased fat storage.

258 We identify 305 gene inactivations that cause reduced body fat and 112 g

259 Furthermore, particular gene inactivations that disrupt RNAi reverse the cell li

260 f the DA9 motorneuron was used to screen for gene inactivations that disrupt the DA9 motorneuron pola

261 en of 5,690 Caenorhabditis elegans genes for gene inactivations that increase lifespan.

262 f-2 mutants and identified approximately 200 gene inactivations that shorten daf-2 life span.

263 , Rankin and colleagues show, using targeted gene inactivation, that induction of Epo expression in m

264 Their potential to expand can lead to gene inactivation, the cause of Friedreich's ataxia dise

265 nfluence on cyst formation by spatiotemporal gene inactivation, the genetic context, the metabolic st

266 riven analysis, heterologous expression, and gene inactivation, the legonmycins were also shown to or

267 Upon gene inactivation, these progeny can dedifferentiate and

268 report that demonstrates selective ERalpha-C gene inactivation through CpG methylation pathway in ute

269 her investigated the mechanisms of ERalpha-C gene inactivation through CpG methylation pathways.

270 We used targeted gene inactivation to define the function of Emp during h

271 Here we use complete and cell-specific gene inactivation to identify the roles of the redundant

272 ble Cre/loxP lineage tracing and conditional gene inactivation to the tibialis anterior muscle regene

273 r receptor, and cyclin D1), tumor suppressor gene inactivation (TP53 and p16), and loss of heterozygo

274 Combinatorial gene inactivation using an RNAi library is a powerful ap

275 ction, deletion of redundant genes and acute gene inactivation using short hairpin RNA (shRNA).

276 Acute gene inactivation using short hairpin RNA (shRNA, knockd

277 hematopoiesis we therefore chose conditional gene inactivation using the Cre/loxP system.

278 The extent of gene inactivation varies between different cell types an

279 MNR2 gene inactivation was associated with an increase in bot

280 In addition, p16 gene inactivation was determined by DNA sequence analysi

281 te this prediction, a system for conditional gene inactivation was developed.

282 Evidence for tissue-specific gene inactivation was obtained at DNA, RNA, and protein

283 om B31 MI that were infectious for mice, and gene inactivation was successful in one of these clones.

284 clear staining, a likely result of biallelic gene inactivation, was observed in 25% (22 of 85) of pri

285 ons are an alternative means of glioblastoma gene inactivation, we coupled pharmacological manipulati

286 n cell lineage, in addition to biallelic Nf2 gene inactivation, we generated the first mouse model de

287 Using morpholino-based gene inactivation, we have analyzed the function of fgf2

288 tic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal fro

289 Using tissue-specific gene inactivation, we show that endothelial-specific ina

290 Using conditional gene inactivation, we show that Nr5a2 also plays crucial

291 ion, the phenotypic consequences of temporal gene inactivation were assessed by monitoring animal sur

292 in most cases; however, other mechanisms of gene inactivation were present in some cases.

293 oliferation as demonstrated by Dok1 and Dok2 gene inactivation, which induces a myeloproliferative di

294 ycolylneuraminic acid (Neu5Gc) due to a CMAH gene inactivation, which occurred approximately three mi

295 chimeric URA3 gene, their expansions caused gene inactivation, which was detected on the selective m

296 sters and display species-specific flagellar gene inactivations, which lead to the putative generatio

297 SKO1 was developed by targeted gene inactivation with a replicative plasmid capable of

298 ata point to a novel mechanism of E-cadherin gene inactivation, with CLL cells displaying a higher pr

299 exposure is related to the nature of somatic gene inactivation within crucial pathways, including the

300 e of these mechanisms can pinpoint biallelic gene inactivation without the use of positional cloning.