ライフサイエンスコーパス: gene insertion

1 on of homologous recombination to facilitate gene insertion.

2 iliated Hib or to a mutant containing a hifE gene insertion.

3 abitat manner is identified through a unique gene insertion.

4 owing for precise and versatile programmable gene insertion.

5 iting enzymes offer promise for programmable gene insertion.

6 egregation of mutations, edits, and targeted gene insertions.

7 insertion sequence elements or phage-related gene insertions.

8 us), whereas sorghum received two additional gene insertions after its divergence from a common ances

9 The rate of gene insertion and deletion is sufficiently high in thes

10 ilities such as base editing, prime editing, gene insertion and gene regulation, thereby providing a

11 hts into A-clade R2 protein structure during gene insertion and may enable future improvement and ada

12 ci we find ancestral alleles, which lack the gene insertions and exhibit high levels of nucleotide po

13 nces, an apparent plasmid hot spot for toxin gene insertion, and that two IS1151-related sequences ar

14 features of A-clade R2 proteins that support gene insertion are not well characterized.

15 The results suggest that the RSV F and G gene insertions are stable in the PIV5 genome.

16 site, were demonstrated to generate precise gene insertions as well as indel mutations at the target

17 /Cas9 knockin system allows highly efficient gene insertion at the pH11 locus of up to 54% using drug

18 y-directed and homology-independent targeted gene insertion at the ZFN-specified locus.

19 us (AAV) donor vectors enables site-specific gene insertion by homology-directed genome editing.

20 support this by showing that single-stranded gene insertion cassettes are recombinogenic and that the

21 ave rise to sorghum and maize acquired a two-gene insertion (containing the adh locus), whereas sorgh

22 tween homeologous regions with only a single gene insertion/deletion and local tandem duplications di

23 his study tested the hypothesis that the ACE gene insertion/deletion polymorphism associates with AF

24 The angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism influences ACE acti

25 ACE gene insertion/deletion polymorphism was determined by p

26 n Escherichia coli by use of a plasmid-based gene insertion/deletion system.

27 s including not only rearrangements but also gene insertions, deletions and duplications.

28 (MLEs) of the new model reveal fast rates of gene insertions/deletions on recent branches, suggesting

29 irus-based vectors include gene replacement, gene insertion, epitope presentation, use of virus contr

30 -like homologs, suggesting that an ancestral gene insertion event and diversification preceded the ev

31 reduction n AC activity, confirming that the gene insertion event disrupted AC activity and ceramide

32 ctivated by a discrete, approximately 4.7 kb gene insertion event that disrupted the 3' end of the BR

33 where we demonstrate that the efficiency of gene insertion events was increased in cells pre-treated

34 lines was characterized in terms of foreign gene insertion, expression of spinach SPS, production of

35 llow the development of methods for specific gene insertion for precision genetic engineering.

36 f site-specific nucleases yielded consistent gene insertion frequencies of 2-3%, similar to tradition

37 r substitution (Prus to Ptac), and exogenous gene insertion (GFP).

38 rrier proteins can be attributed to a single gene insertion in Acyl Carrier Protein4 (At4g25050).

39 E system offers rapid, efficient and precise gene insertion in ESC and iPSC and is particularly well

40 that the adenovirus platform is suitable for gene insertion in juveniles with inherited disease, sugg

41 Most existing cases of targeted gene insertion in plants have either relied on the prese

42 Frequency of gene insertion increased in a dose-dependent manner, rea

43 estigate whether TnsA-D proteins can mediate gene insertion into comparably conserved sites in eukary

44 l-time tracking of viral infection, reporter gene insertion into IAV typically attenuates viral patho

45 safety considerations regarding transposase gene insertions into host genomes have rarely been addre

46 We also found that the Rdr1 gene insertion is variable among accessions from the nor

47 Thus, Cas9-mediated suicide-gene insertion may be a viable genotype-specific cancer

48 However, the function of the foreign gene insertion may need to be considered when designing

49 eport, we evaluated the spectrum of protease gene insertion mutations in patient isolates and analyze

50 These results demonstrate targeted gene insertion of marker-free DNA in rice using CRISPR-C

51 evealed two mutations in the epsilon-subunit gene: insertion of a thymine after epsilon nucleotide 11

52 simultaneous expression of multiple foreign genes, insertion of noncoding/antisense sequences, and s

53 We studied the association between the ACE gene insertion or deletion polymorphism and changes in b

54 would enable higher efficiencies of precise gene insertion or replacement, we screened the Cpf1 nucl

55 T cells by T cell subset selection, suicide gene insertion or selective allodepletion, and the adopt

56 However, precise gene insertion or sequence replacement remains a major h

57 the frequency of genomic rearrangements and gene insertions or deletions was relatively low.

58 revealed that relative number of luciferase gene insertions per genome in the unstable C4-2B reporte

59 hibition might result from pgk-neor cassette gene insertion rather than enhancer deletion.

60 exhibiting targeted mutagenesis or targeted gene insertion, respectively.

61 This gene insertion results in the synthesis of an exon 3-del

62 work characterizes a flexible and efficient gene insertion system for potential therapeutic use.

63 system by using gene replacement rather than gene insertion technology.

64 s direct selection for gene replacements and gene insertions that can facilitate this process.

65 g the possibility to couple tmIgE with other gene insertions that might enhance the antitumor effect,

66 ibe ObLiGaRe, a new method for site-specific gene insertions that uses the efficient NHEJ pathway and

67 ing future use as a reprogrammable RNA-based gene-insertion tool.

68 facilitate future development of R2-mediated gene insertion tools.

69 An H gene insertion vector has been generated from the Edmons

70 2006 for their capability to induce targeted gene insertion via homology directed repair.

71 We found that VSVs with a double gene insertion were significantly more attenuated than V

72 trotransposon protein can support stable new gene insertion, with major implications for native retro

73 enome editing by allowing large, multiplexed gene insertion without reliance on DNA repair pathways.