ライフサイエンスコーパス: gene knockdown

1 LY2228820 dimesylate treatment and by shRNA gene knockdown.

2 were generated through small interfering RNA gene knockdown.

3 n and the pleiotropic effects of EB1 and APC gene knockdown.

4 analysis using antisense morpholino-mediated gene knockdown.

5 ocytes in the brain, resulting in a specific gene knockdown.

6 s the most common LCA mutation, was used for gene knockdown.

7 ipts with altered expression following CLOCK gene knockdown.

8 the cross-linker are critical for efficient gene knockdown.

9 ese cells with double stranded (ds) RNAs for gene knockdown.

10 l molecule treatment and morpholino-mediated gene knockdown.

11 old nanoparticles, we demonstrated a tunable gene knockdown.

12 overexpression and RNA interference-mediated gene knockdown.

13 to observe significant downstream effects of gene knockdown.

14 d allows for a highly controlled approach to gene knockdown.

15 orresponding shRNA treatments and individual gene knockdown.

16 overexpression and by small interfering RNA gene knockdown.

17 d hedgehog signaling were investigated after gene knockdown.

18 logical antagonism, and local viral-mediated gene knockdown.

19 ing roles of RIP1 and RIP3 were confirmed by gene knockdown.

20 ects of multi-gene families via simultaneous gene knockdown.

21 sfection agents and are capable of efficient gene knockdown.

22 mes presents a powerful method for efficient gene knockdown.

23 l analyses, physiology, genetic mapping, and gene knockdowns.

24 notypes seen using morpholino-based targeted gene knockdowns.

25 ormed transgenics to assess the phenotype of gene knockdowns.

26 in breast cancer, and cell line response to gene knockdowns.

27 ypic discrepancies between gene-knockout and gene-knockdown(1,2); however, the underlying molecular m

28 additional genetic approaches including RNAi gene knockdown, a duplicated gene with a nuclear hormone

29 TRPM7 gene knockdown abolished the promotion of bone-related g

30 and industrial bacteria, with >50% of target gene knockdown achieved in 12 bacterial species.

31 th a nephrocyte-specific driver for targeted gene knockdown, allowing the identification of genes req

32 Compound jagged and notch gene knockdowns alter zebrafish biliary, kidney, pancrea

33 ating gene expression with morpholino-driven gene knockdown and capped RNA-mediated rescue, we show t

34 own to be dependent on Akt signaling by both gene knockdown and chemical inhibition methods.

35 fering RNA (siRNA)/short hairpin RNA (shRNA) gene knockdown and clustered regularly interspaced short

36 used molecular genetics methods (siRNA/shRNA gene knockdown and CRISPR-mediated transcriptional activ

37 Furthermore, gene knockdown and deletion experiments performed in K56

38 By using gene knockdown and knockout approaches, we demonstrate t

39 Using in vitro RNAi-based gene knockdown and KO mice, we demonstrated that a stron

40 Through stable gene knockdown and mouse subcutaneous xenograft studies,

41 er, an increase likely related to the target gene knockdown and not a general effect of virus infecti

42 Gene knockdown and overexpression approaches show that r

43 an Th17 cell differentiation using both IRF4 gene knockdown and overexpression experiments.

44 ions of hepatic Atg14, we have performed the gene knockdown and overexpression in the mouse livers.

45 Gene knockdown and overexpression studies indicated that

46 Gene knockdown and overexpression studies suggest that O

47 Furthermore, both gene knockdown and pharmacological inhibition studies sh

48 ibrotic tissue facilitated sequence-specific gene knockdown and prevented fibrosis progression.

49 perplexed mutation and this was confirmed by gene knockdown and pyrimidine rescue experiments.

50 Through gene knockdown and rescue approaches, we also find that

51 Short interfering RNA (siRNA)-directed gene knockdown and rescue of tTLL expression demonstrate

52 A cells, an observation confirmed further by gene knockdown and selective inhibitors.

53 idenced by the results of antisense-mediated gene knockdown and the use of the furin- and PC6-selecti

54 f structure-activity relationships involving gene knockdown and toxicity.

55 tradiol suppressed apoptosis induced by both gene knockdowns and BEZ235 treatment.

56 Here, using gene knockdowns and clonogenic survival and cell viabili

57 ations of Caenorhabditis elegans: we induced gene knockdowns and used quantitative genetic methodolog

58 Chitin synthase gene knockdowns and various histochemical experiments in

59 es of splicing events were affected by dnmt3 gene knockdown, and change in two types, exon skipping a

60 dominant negative mutant, genetic knockout, gene knockdown, and chromatin immunoprecipitation approa

61 ion by pathway specific inhibitors, selected gene knockdown, and in vivo tumorigenicity assay.

62 major hurdle in gene therapy or therapeutic gene knockdown, and the development of intelligent and s

63 These methods achieve desirable levels of gene knockdown, and thus can be compared with methods de

64 immunoblotting and fluorescence, siRNA-based gene knockdowns, and FRET-based biosensor reporter assay

65 progenitors, the effect of various reported gene knockdowns, and the reprogramming of pre-B cells in

66 We use a temporally-selective gene knockdown approach to identify endogenous functions

67 In this study, a PURB-specific gene knockdown approach was used in conjunction with bio

68 Using a gene knockdown approach, a genetic framework for PEO dev

69 ion of NF-kappaB signaling events by using a gene knockdown approach: RNA interference through delive

70 Gene knockdown approaches and transgenesis-based lineage

71 Indeed, complementary robo4 gene knockdown approaches in zebrafish embryos show lowe

72 Using a panel of inhibitors and gene knockdown approaches, we identified the upstream ki

73 Eve1 fused to the Gal4 activation domain and gene-knockdown approaches, we investigated the role of e

74 ERbeta gene knockdown, as well as coexpression of the dominant

75 ted by fluorescence colocalization analysis, gene knockdown assay and animal tumor regression.

76 Deletion mutation and gene knockdown assays revealed that formation of a funct

77 Furthermore, we observed that caspase 3 gene knockdown attenuated the growth-stimulating effect

78 deacetylase by small molecule inhibitors or gene knockdown blocks acquisition of BCR-ABL mutations a

79 l-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo.

80 ls capable of both cellular transfection and gene knockdown, but thus far are promiscuous structures,

81 Gene knockdown by RNA interference (RNAi) in Caenorhabdi

82 In addition, Rspo2 and Rspo3 gene knockdown by RNA interference significantly comprom

83 ive or inducible protein expression studies, gene knockdown by RNA interference, or affinity purifica

84 neered a human monocytic cell line for NALP1 gene knockdown by RNA interference.

85 ntagonists were abolished following receptor gene knockdown by siRNA.

86 MCN over-expression using adenovirus or EMCN gene knockdown by siRNA.

87 es performed in mice revealed that myoferlin gene knockdown can attenuate cancer cell proliferation i

88 RNA interference-mediated gene knockdown can be exploited to study the reprogramme

89 We show that RNAi-induced gene knockdown can be generated through introducing smal

90 Overall, the tunable properties and gene-knockdown capabilities of NanoScript enables its ut

91 transfection agents, and demonstrate a high gene knockdown capability in a cell model.

92 in length and have sequence-homology-driven gene-knockdown capability.

93 l, differentiated cells versus stem cells or gene knockdown cells versus wild-type cells) m6A-mediate

94 ression was significantly decreased in PAR-2 gene knockdown cells, whereas no change was detected in

95 024, respectively), and was blocked in PAR-2 gene knockdown cells.

96 lls, whereas no change was detected in PAR-1 gene knockdown cells.

97 tional signatures of drug-like molecules and gene knockdowns, ceSAR combines cheminformatic technique

98 a constitutively active or RNA interference gene knockdown construct, respectively, OsCDPK1 was foun

99 allowing combinatorial gene overexpression, gene knockdown, Cre-mediated gene deletion, or CRISPR/Ca

100 Using HEK293T cells, siRNA-mediated gene knockdown, cytoplasmic and nuclear fractions, RNA-S

101 GSK-3beta inhibition and siRNA gene knockdown decreased bupivacaine induced cell death

102 Following MEGF11 gene knockdown (DeltaMEGF11) or over-expression in MDA-M

103 Specific gene knockdown demonstrates that loss of loxl1 results i

104 1 cell migration as effectively as ST3GALIII-gene knockdown did.

105 ctional studies, but they are ineffective in gene knockdown during oogenesis, an important model syst

106 wns, we characterise functional subgroups of gene knockdowns, each displaying its own typical combina

107 t significantly enhanced cellular uptake and gene knockdown efficiencies in adipose derived mesenchym

108 n vivo biodistribution, larval mortality and gene knockdown efficiency of CS-TPP-dsRNA nanoparticles

109 static interactions, which greatly limit the gene knockdown efficiency.

110 these kinetoplasts with those obtained after gene knockdowns enabled assignment of proteins to five c

111 yl-1H-pyrazole -3-carboxamide [AM251] or CB1 gene knockdown) enhanced hMMC degranulation and increase

112 siRNA is a highly specific tool for targeted gene knockdown, establishing siRNA-mediated gene silenci

113 Host gene knockdown events did not affect virus antigenicity,

114 ence (RNAi) screen was performed to identify gene knockdown events that enhanced poliovirus replicati

115 Gene knockdown experiments and transplantation assays de

116 dbrain also arise from neural crest, we used gene knockdown experiments in zebrafish to disrupt neura

117 Gene knockdown experiments showed that an expression of

118 Temporally restricted gene knockdown experiments suggest that Lsd1 functions b

119 We then performed small interfering RNA gene knockdown experiments targeting genes encoding prot

120 ized in all RNA interference (RNAi)-mediated gene knockdown experiments to ensure sound conclusions a

121 In siRNA gene knockdown experiments, silencing GP-5, GRN, and MPO

122 nd cooperated in carcinogenesis according to gene knockdown experiments.

123 de transgenic RNAi screen through ubiquitous gene knockdowns, focusing on regulators of adult Drosoph

124 kidney 293T cells undergoing HGPRT-specific gene knockdown followed by influenza virus ribonucleopro

125 properties resulted in an enhanced in vitro gene knockdown for the acid-degradable cationic nanopart

126 n of endogenous Gsc functions in MO-mediated gene knockdown frog and knockout mouse embryos unearthed

127 t repair capacity and the ability to perform gene knockdown in a high-throughput manner.

128 ion, this approach allowed inducible in vivo gene knockdown in any cell type that developed from this

129 of an aptamer fused to an siRNA for targeted gene knockdown in cells bearing an aptamer-binding recep

130 s of their uptake, and significantly greater gene knockdown in cells overexpressing the target antige

131 by evaluating the effect of MKK-4 and MKK-7 gene knockdown in cultured FLS.

132 C8ORF37 in a vertebrate system, we performed gene knockdown in Danio rerio and assessed the cardinal

133 RNAi-mediated gene knockdown in Drosophila melanogaster is a powerful

134 lencing RNA (siRNA) studies that demonstrate gene knockdown in GFP expressing cells.

135 w that lipidoid nanoparticles mediate potent gene knockdown in hepatocytes and immune cell population

136 lockade of GATA3 using small interfering RNA gene knockdown in MCF-7 cells triggered fibroblastic tra

137 our that are broadly functional for targeted gene knockdown in mycobacteria.

138 ods of lentiviral short hairpin RNA-mediated gene knockdown in primary CD4 T cells, we identify inter

139 This capacity, combined with high-throughput gene knockdown in Stentor, enables time-course mechanist

140 erapeutics, which show efficient and durable gene knockdown in the liver, with signs of promising cli

141 he ability to produce a high level of target gene knockdown in the lung with minimal toxicity demonst

142 n vivo by antisense oligonucleotide-mediated gene knockdown in the medial prefrontal cortex, followed

143 2 (Pk2), and a central BBS gene, Bbs7, using gene knockdown in the zebrafish.

144 Finally, we compared transient gene knockdown in tissue culture with results in stable

145 The task of specific gene knockdown in vitro has been facilitated through the

146 mental system enabled induction of efficient gene knockdown in vivo without subsequent manipulation.

147 y to carry out transgenesis in X. laevis and gene knockdown in X. tropicalis, we demonstrate that end

148 Using a combination of in vivo gene knockdown in zebrafish and in vitro assays in human

149 ent fibroblasts, mutant SH-SY5Y cells and by gene knockdown in zebrafish.

150 ome-scale short hairpin RNA (shRNA)-mediated gene knockdowns in KIT-mutant GIST-T1 and GIST882.

151 The efficiency of gene knockdown increased as the number of lipid tails co

152 In contrast, MyoD gene knockdown increases cell survival of wild-type myob

153 To address the question of whether bag3 gene knockdown induces myofibrillar disorganization caus

154 Furthermore, Rsf-1 gene knockdown inhibited cell growth in OVCAR3 cells, wh

155 GABRP gene knockdown inhibited TNBC cell growth and colony for

156 n of the single cell biosensor and transient gene knockdown into the system revealed the formation of

157 RNA interference (RNAi)-mediated gene knockdown is a potent approach for studying gene fu

158 to other CRISPRi systems, dCas9Sth1-mediated gene knockdown is robust when targeted far from the tran

159 a substrate for ABCA3 was performed by shRNA gene knockdown (KD) in THP-1 monocytes.

160 multiple experimental strategies [including gene knockdown (KD) mediated by small hairpin RNA and cl

161 nd -4, as well as an additional 49 of the 62 genes, knockdown (KD) in somatic cells had minimal effec

162 omains in the developing mesenteries and use gene knockdown, knockout and inhibitor experiments to de

163 period of at least 3days, leading to target gene knockdown lasting at least 10days.

164 or biotechnology intervention strategies as gene knockdown leads to the repulsion of economically im

165 d significantly enhanced cellular uptake and gene knockdown mediated by Tf-PEI polyplexes in human pr

166 used a lentivirus-mediated short hairpin RNA gene knockdown method to study the role of PTEN in CD34(

167 Antisense and RNAi-based gene-knockdown methods vary in efficacy between differen

168 Our results highlight zebrafish gene knockdown-mRNA rescue as an approach that can be us

169 BbCypE and DeltaBbCyp6) and the simultaneous gene knockdown mutant constructs (SiRNA30).

170 omated imaging and analysis to 263 essential gene knockdown mutants in an arrayed library, we derive

171 Gene knockdown occurred within a few hours of release an

172 Gene knockdown of Bad, Bid, Akt1, Akt2, PKC-mu, PKC-epsi

173 Finally, targeted gene knockdown of cx43 in adult regenerating fins recapi

174 Gene knockdown of different BBS genes in zebrafish shows

175 ebrafish larvae (4 days post-fertilization), gene knockdown of either CBS or CSE using morpholinos at

176 d that knockout or site-specific CRISPR/Cas9 gene knockdown of Gadd45b blocks cocaine conditioned pla

177 Gene knockdown of IR, but not IGF-IR, prevented the char

178 -6 production was significantly reduced upon gene knockdown of myeloid differentiation primary respon

179 Gene knockdown of nlz1 and/or nlz2 in zebrafish leads to

180 RNA (siRNA) technology to produce a targeted gene knockdown of NPY and dopamine-beta-hydroxylase (DBH

181 up-regulated in acute pancreatitis and that gene knockdown of PAP correlated with worsening severity

182 Gene knockdown of potential RI-interacting AKAPs express

183 Gene knockdown of PP5 abolished the estrogen-mediated su

184 Inhibition or gene knockdown of PRL-3 did not reduce ULBP2 shedding, b

185 when the c-Met receptor was deactivated, and gene knockdown of PTP1B increased c-Met activation.

186 f COPII function by oligonucleotide-mediated gene knockdown of sec31a and sec31b or brefeldin A treat

187 Gene knockdown of SLC30A2 in mammary epithelial cells re

188 Conversely, gene knockdown of STAT1 in the metastatic TM40D-MB cells

189 Gene knockdown of TLR3, RIGI, or IRF1 decreased monocyte

190 Using morpholino-mediated gene knockdown of TOR pathway components, we show that t

191 Using temporal gene knockdown of zebrafish samhd1, we observe hindbrain

192 ed for the expression of PTN in macrophages, gene knockdowns of these transcription factors were perf

193 ed for replacement of mutant disease-causing genes, knockdown of dominant disease-causing genes using

194 in luminal tumors expressed basal epithelial genes, knockdown of either K14 or p63 was sufficient to

195 Among these GABP-associated genes, knockdown of GABPalpha expression by RNA interfer

196 Among the human homologs of candidate genes, knockdown of PPP2R1A, a gene encoding a constant

197 Consistent with early expression of these genes, knockdown of syngap1b or shank3a cause common emb

198 ovides preliminary evidence that shmiR-based gene knockdown offers a favorable risk-benefit profile i

199 particles are considerably more effective at gene knockdown on a whole body concentration basis than

200 zebrafish development and the effects of ccp gene knockdown on cilia formation, morphology, and tubul

201 ing screen detected distinct consequences of gene knockdown on neuronal morphology.

202 We also performed targeted gene knockdown on this model by directly infecting expla

203 filing gene function by analyzing effects of gene knockdowns on the architecture of a complex tissue

204 Inhibition of RET either by gene knockdown or by treatment with sunitinib or vandeta

205 bromide] after siRNA (small interfering RNA) gene knockdown or drug treatment.

206 eatment of both cell lines with either Flk-1 gene knockdown or Flk-1 kinase inhibitor SU1498 abrogate

207 oligonucleotides designed to mediate either gene knockdown or gene knockout, coupled with next-gener

208 can be applied for inducible and reversible gene knockdown or gene overexpression in many different

209 y developing single-step optimized inducible gene knockdown or knockout (sOPTiKD or sOPTiKO) platform

210 tightly controlled individual or multiplexed gene knockdown or knockout in hPSCs and in a wide variet

211 lia was significantly inhibited by PPARgamma gene knockdown or neutralizing anti-CD36 antibody, where

212 ere enables mosaic screens in the context of gene knockdown or overexpression by automatically genera

213 the ability to accelerate genetic studies by gene knockdown or overexpression, have led to the widesp

214 hibition of beta1 in tumor cells with stable gene knockdown or treatment with OS2966, a neutralizing

215 rs of high-throughput screens categorize how gene knockdowns or small molecules can change clock peri

216 ies reported prevalent lethality among young gene knockdowns, our phylogenomic analyses reveal that y

217 Pharmacologic and gene knockdown/overexpression approaches were used to in

218 siRNAs) is a powerful new tool for analyzing gene knockdown phenotypes in living mammalian cells.

219 I RNA-targeting CRISPR-Cas system as a novel gene knockdown platform to investigate gene function and

220 been widely exploited for sequence-specific gene knockdown, predominantly to investigate gene functi

221 Subsequently, HDAC9 gene knockdown produced dose-dependent gamma-globin gene

222 lar manipulations, including overexpression, gene knockdown, PSD-93 knock-out mice combined with bioc

223 -type calcium channel accessory beta-subunit gene knockdown reduced calcium transient amplitude.

224 In contrast, HO-1 gene knockdown reduced the survival of intramacrophage B

225 ation of histone 3 at lysine 4, whereas TLR8 gene knockdown reduced these effects.

226 owever, the efficacy of exogenous siRNAs for gene knockdown remains hampered by their susceptibility

227 ndicates that using morpholinos for targeted gene knockdowns remains of considerable value for the ra

228 Here, we developed an endogenous gene knockdown/rescue strategy that combines RNAi select

229 This localized gene knockdown resulted in behavioral changes, including

230 or by small interfering RNA (siRNA)-mediated gene knockdown resulted in c-Myc down-regulation, which,

231 Homer1 gene knockdown resulted in increased GnRH-induced FSHbet

232 In contrast, tcf3 gene knockdown results in a reduced mitotic index withou

233 We show that tcf7 gene knockdown results in dorsal patterning defects with

234 Single gene knockdowns reveal that beetle Robos have specialize

235 RNA interference-mediated gene knockdown revealed that osteoinductive BMP activiti

236 Small interfering RNA (siRNA)-mediated gene knockdown revealed that the inflammatory potential

237 Conditional gene knockdown reveals that inhibition of ROCKII promote

238 also been deployed in genome-wide, specific gene-knockdown screens.

239 Inactivation of SYK by inhibitors or gene knockdown sensitized paclitaxel cytotoxicity in vit

240 BXAP) was found to be the only gene in which gene knockdown sensitized tumor cells to paclitaxel.

241 but not 53BP1 heterozygous tumors or partial gene knockdown) sensitizes glioma cells to ionizing radi

242 Gene knockdown showed a role for SOX9 in cell migration

243 logical manipulations and morpholino-induced gene knockdown, shows that ZVQ is robust, allows extract

244 us mRNA during tetracycline-dependent target gene knockdown, significantly enhancing the experimental

245 The phenotypes of the gene knockdowns sorted into five distinct phenotypic cla

246 cultured neuronal cells, we found that SRC-1 gene knockdown specifically in the NTS significantly dim

247 over-expression strains, and a simultaneous gene knockdown strategy using tandem SiRNA.

248 Gene knockdown studies demonstrated that HDAC1 and HDAC2

249 Gene knockdown studies revealed that tumor eradication r

250 Gene knockdown studies showed that the ERAD E3s Rma1 and

251 l cell polarity across tissues, we performed gene knockdown studies to assess the roles of the relate

252 ar system can be extended toward multiplexed gene knockdown studies, as demonstrated in a two color p

253 karyotic parasite Trypanosoma brucei through gene knockdown studies.

254 opoisomerase levels as predicted by in vitro gene knockdown studies.

255 ng potent siRNAs and facilitating functional gene knockdown studies.

256 regulated VSMC contractility, based on siRNA gene knockdown studies.

257 Gene-knockdown studies in AsPC-1 and HPAF-2 cell lines c

258 ockade of YKL-40 using small-interfering RNA gene knockdown suppressed tumor angiogenesis in vitro an

259 eported a plasmid-based, tamoxifen-inducible gene knockdown system in cultured cells using a combined

260 diomyocytes and a short hairpin RNA-mediated gene knockdown system of the bag3 gene were performed.

261 contributions to resistance and to identify gene knockdown targets for carbapenem potentiation.

262 tes an underappreciated shortcoming of siRNA gene knockdown technology.

263 Here we identified gene knockdowns that lead to an increase in aneuploidy i

264 Furthermore, Plk1 gene knockdown through Plk1-specific shRNA or its activi

265 Here we used overexpression and gene knockdown to investigate the role in embryonic myog

266 EGS-based approach merits consideration as a gene knockdown tool in archaea.

267 provides both innate immunity and efficient gene-knockdown tools in many eukaryotic species, but cur

268 covered with more GSDCs than those in YKL-40 gene knockdown tumors.

269 ries can now be readily generated to perform gene knockdowns under various conditions, increasing the

270 veral of these technologies such as targeted gene knockdown using antisense morpholinos, small molecu

271 inhibition by 3-O-methyl-sphingomyelin or by gene knockdown using antisense oligonucleotides attenuat

272 In zebrafish, gene knockdown using morpholinos revealed a genetic inte

273 ino-4,5,6,7-tetrabromo-1H-benzimidazole) and gene knockdown using RNA interference, we identified CK2

274 We implement a total of 14 genes knockdowns using multiplex-CRISPRi.

275 PTBP1 gene knockdown was achieved via PTBP1-siRNA; restoration

276 rol siRNA cargos were loaded into hydrogels, gene knockdown was only encountered for hydrogels contai

277 Morpholino-induced transient gene knockdown was performed in zebrafish embryos.

278 iogenesis demonstrated that mirtron-mediated gene knockdown was splicing-dependent, Drosha-independen

279 By targeted gene knockdown we show the significance of this, demonst

280 logical inhibitors and small interfering RNA gene knockdown, we demonstrated that concomitant activat

281 Furthermore, using gene knockdown, we discovered that this activation is in

282 horylation of guide strands correlating with gene knockdown, we employed a peptide-nucleic acid (PNA)

283 Using cell-type specific gene knockdown, we find that both neurons and glia contr

284 is end, using small molecules or conditional gene knockdown, we inhibited proteins controlling G(1) a

285 Using chained amiRNAs for multi-gene knockdown, we show that concatenation of miRNAs tar

286 proliferation and death to a data set of 118 gene knockdowns, we characterise functional subgroups of

287 cal inhibitors/activators and siRNA-mediated gene knockdowns, we correlated channel activity with Rap

288 Using specific inhibitors and gene knockdowns, we show that activation of DNA-PKcs and

289 YWHAE-FAM22 fusion gene knockdowns were performed with shRNAs and siRNAs ta

290 s prompted more extensive studies of MOBKL1B gene knockdowns, which included additional siRNAs and sp

291 These multiple gene knockdowns will not only increase the efficiency of

292 thione levels and (18)F-FASu uptake, whereas gene knockdown with anti-xCT small interfering RNA led t

293 thione levels and (18)F-FASu uptake, whereas gene knockdown with anti-xCT small interfering RNA led t

294 Either MYD88 or TLR8 gene knockdown with relevant siRNA reduced HIV-1 ssRNA-m

295 n determining CD8(+) effector T-cell fate by gene knockdown with RNAi is challenging because naive T

296 n of CSN3 or of icIL-1Ra1 production through gene knockdown with specific small interfering RNA in A4

297 nd demonstrated the feasibility of selective gene knockdown within specific cell types.

298 ivity that enable specific and robust target gene knockdown without altering the genome.

299 lear Cre translocation and equally effective gene knockdown without cardiomyopathy is achievable with

300 enous microRNA machinery to elicit efficient gene knockdown without impeding normal cellular function

301 otransduction in vivo in morpholino-mediated gene knockdown zebrafish.