ライフサイエンスコーパス: gene loci

1 orchestrates the chromatin landscape of SASP gene loci.

2 ding of repressive heterochromatin into SASP gene loci.

3 combine their TCR beta-chain and gamma-chain gene loci.

4 aBp65 was bound on both miR-155 and miR-146a gene loci.

5 n of chromosome translocations of endogenous gene loci.

6 ere, centromere, G-rich telomere, and coding gene loci.

7 r of nascent mRNAs synthesized at individual gene loci.

8 q datasets using different methods to define gene loci.

9 tion including changes at many key cartilage gene loci.

10 lified by their actions at the Runx2 and Sp7 gene loci.

11 lecithin cholesterol acyltransferase (LCAT) gene loci.

12 3100, JQ1 disrupted AR recruitment to target gene loci.

13 was developed that identified ~69,000 lncRNA gene loci.

14 covered in numerous T cell lineage-expressed gene loci.

15 g forms or boundary element function at tRNA gene loci.

16 d the generality of this finding to numerous gene loci.

17 -3 on histone 4 (H3K4me3) at flower MADS box gene loci.

18 domains spliced from adjacent SH3BP1 and CIN gene loci.

19 e loss of tumor suppressors p53 and cadherin gene loci.

20 interaction with specific regions of U snRNA gene loci.

21 marks and increases H3K4me3 marks on target gene loci.

22 approximately 20% were antisense to the host gene loci.

23 training mixed set consisting of 50% of the gene loci.

24 nkage analysis identified potential modifier-gene loci.

25 ne, we find evidence for at least three vasa gene loci.

26 of H3.3 incorporation at activity-dependent gene loci.

27 ements within the globin and other erythroid gene loci.

28 Egr1 in promoter regions of many cholesterol gene loci.

29 f modified cytosines to cytosines at several gene loci.

30 associated with transcriptional activity at gene loci.

31 tem/progenitor enhancers in the FLI1 and ERG gene loci.

32 ng enzyme interaction and remodeling at late-gene loci.

33 nomic DNA surrounding the DHFR, Hsp70, or MT gene loci.

34 om, as many of them are associated with tRNA gene loci.

35 t can be readily adapted to include multiple gene loci.

36 d DNA integration into transgenic and native gene loci.

37 sing of transcripts originating from histone gene loci.

38 d MBD10 in the large-scale silencing of rRNA gene loci.

39 o 1000-times increased in tri-partite immune gene loci.

40 orphisms at the FcgammaRIIa and FcgammaRIIIa gene loci.

41 erformed using probes to the four functional gene loci.

42 tion of stable epigenetic histone 'marks' at gene loci.

43 has been limited to proximal regions around gene loci.

44 immunoglobulin (Ig) and T cell receptor (TR) gene loci.

45 enrichment of long-lived variants at silent gene loci.

46 ing inhibitory histone trimethylation at Th2 gene loci.

47 t tumors had multiple alterations at the KIR gene loci.

48 and phosphorylate Pol II along the myogenic gene loci.

49 atin acetylation at cholesterol-biosynthesis gene loci.

50 nd Pol II loading to enzalutamide-responsive gene loci.

51 tial for H3K9me2 demethylation at cell cycle gene loci.

52 he unrearranged human H chain and L chain Ig gene loci.

53 II (MHC II) in mice containing the human TCR gene loci.

54 ngle-base mutations are achieved in multiple gene loci.

55 tion drives spatial organization at specific gene loci.

56 scription factors modulated enhancers at FGF gene loci.

57 rmation of stable Polycomb domains at target gene loci.

58 the presence of allelic polymorphisms in few gene loci.

59 ms of known genes and 3% correspond to novel gene loci.

60 ging variants were characterized in ASD risk genes/loci.

61 involving a total of 53 polymorphisms in 28 genes/loci.

62 oring highly methylated and silenced mir-124 gene loci, 5-azacytidine treatment allowed miR-124 re-ex

63 e we investigate genetic variation of 12 PAI gene loci (7 on T-PAI and 5 on S-PAI) in 96 worldwide is

64 Similarly, half of heat shock-induced gene loci already preposition very close to nuclear spec

65 by reduced H3K27me3 levels at the respective gene loci and accumulation of novel metabolites.

66 ncreased CncC binding at the Jheh and dKeap1 gene loci and activated their transcription, whereas dKe

67 ation requires remodeling of tissue-specific gene loci and activities of key transcriptional regulato

68 oth the juxtaposition of the TMPRSS2 and ERG gene loci and also their recombination.

69 the two RNP delivery methods across multiple gene loci and conclude that electroporation compares ver

70 ronary artery disease in RA signaling target gene loci and correlation between coronary artery diseas

71 lizing induced transcription factors, target gene loci and corresponding transcripts.

72 fically in mouse B cells from BAC-transgenic gene loci and demonstrate that c-Rel protein levels line

73 those responses and on the links between HLA gene loci and EBV-induced disease.

74 ratively hijack this complex to bind at KLFs gene loci and facilitate KLF14 gene expression in lympho

75 atin assembly at retroelements and regulated gene loci and facilitates the formation of constitutive

76 een restricted in size from one to two dozen gene loci and have not decisively resolved the basal bra

77 f folding for proteins encoded at homozygous gene loci and higher concentrations of potentially aggre

78 as identified more than 100 plant resistance gene loci and linked molecular markers used in cultivar

79 fate is determined by Cd4 and Cd8 coreceptor gene loci and not by the specificity of T-cell antigen r

80 insertions into other repetitive sequences, gene loci and other DNA.

81 was associated with the chromatin of target gene loci and physically interacted with histone H3.

82 relation to organization and positioning of gene loci and regulation of chromatin organization throu

83 nates noncoding DNA sequences that interrupt gene loci and reorganizes the remaining fragments by inv

84 ed CncC binding at other xenobiotic response gene loci and suppressed their transcription.

85 imed to characterize the features of the KIR gene loci and their ligands in patients with bile duct c

86 98 and DHX9 bind interdependently to similar gene loci and their transcripts.

87 thylation marks in the context of endogenous gene loci and validate programmable DNA demethylation re

88 STAT3 bound directly to Th2 cell-associated gene loci and was required for the ability of STAT6 to b

89 rd, we found 42 SNP sets that identified 727 gene loci and were significantly associated with one or

90 rd, we found 51 SNP sets that identified 736 gene loci and were significantly associated with tempera

91 ne testing for possible associations between genes, loci and traits of interest by an entire research

92 tylated domains within mammalian beta-globin gene loci, and determined that within the murine locus,

93 esses the accumulation of H3K27me3 at stress gene loci, and maintains the HSR.

94 eta-catenin binds multiple immune-checkpoint gene loci, and targeted DXR treatment inhibited expressi

95 NuRD) complex at the neurogenesis-associated gene loci, and, as a consequence, increasing acetyl hist

96 Association at the histone gene loci appeared to occur through binding of the bromo

97 trate that DNA methylation marks in specific gene loci are associated with asthma and suggest that ep

98 Multiple gene loci are associated with inflammatory bowel disease

99 ing and removing epigenetic histone marks at gene loci are central processes in differentiation.

100 dy or translocations into the immunoglobulin gene loci are considered as initiating events in the pat

101 essibility and transcription of thousands of gene loci are controlled dynamically by CHD4 during earl

102 n structure of Drosophila melanogaster Hsp70 gene loci are dependent on the transcriptional activator

103 e physiological states, while the underlying gene loci are free to diverge.

104 gastritis tissues indicated that the mir-124 gene loci are more heavily methylated in a Colombian pop

105 constitutive and alternative nucleotides in gene loci are nearly identical, their distribution along

106 Since most of the EcREs within early gene loci are situated distantly from promoters, we empl

107 Polymorphisms within HLA gene loci are strongly associated with susceptibility to

108 presence or absence of antibiotic resistance genes/loci are increasingly being developed.

109 wn to occupy AP-1 binding sites within these gene loci, as determined by chromatin immunoprecipitatio

110 dy examines the non-HLA autosomal network of gene loci associated with CD risk in Europe.

111 ive H3K27me3 modifications is a signature of gene loci associated with gene transcription, replicatio

112 Gene loci associated with schizophrenia are significantl

113 For IL6R, IL1RN, and NLRP3 inflammatory gene loci, associations with fibrinogen were concordant

114 howed significant acetylation changes in 187 gene loci at different chromosomal regions including pro

115 somal colocalization of miR-155 and miR-146a gene loci at the stage of endotoxin tolerance, whereas R

116 In summary, the A. thaliana gene loci At3g14390 and At5g11880 encode functional.

117 pend upon coordinated movement of responding gene loci away from the nuclear periphery.

118 and relocation of the keratinocyte-specific gene loci away from the sites of active transcription to

119 e, facilitate the evolutionary relocation of genes loci between euchromatin and heterochromatin.

120 Here, on extracting from thousands of gene loci both their coding nucleotide sequences and tra

121 1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of ne

122 od for directing DNA methylation to specific gene loci by conjugating catalytic domains of DNA methyl

123 including their propensity to acquire novel gene loci by horizontal genetic transfer, as well as the

124 rearrangements at immunoglobulin heavy chain gene loci by transcriptionally activating the Rag1 and R

125 Uracils in the Ig gene loci can be recognized by uracil DNA glycosylase (U

126 components from alphabeta and gammadeltaTCR gene loci can recombine to confer Ag specificity, thus e

127 E2A-PBX1 preferentially binds to a subset of gene loci cobound by RUNX1 and gene-activating machineri

128 have multiple alterations at the KIR and HLA gene loci compared with control individuals.

129 ling reveals methylation changes at numerous gene loci consistent with SAHH modulation by H19.

130 significantly reduced MeCP2 binding to these gene loci, correlating with increased expression.

131 files and nuclear positions at developmental gene loci differ between human somatic cells and hPSCs,

132 specific epigenetic modifications at target gene loci, directly upregulating metastasis-associated g

133 HMGB2 preferentially localizes to SASP gene loci during senescence.

134 endent process, likely occurring at specific gene loci (e.g., c-Fos) in the reward pathway.

135 Teb2 and Teb3 expressed at their endogenous gene loci enabled affinity purifications that revealed t

136 ofiling in preadipocytes, we find that among gene loci encoding adipogenesis regulators, histone meth

137 f development, before B cell maturation, the gene loci encoding the heavy and light chains of immunog

138 ess variable expression; (iii) less variable gene loci evolve under purifying selection against copy

139 and epigentic acetylation signatures at all gene loci examined with certain genes showing inappropri

140 n nuclei, a select number of tissue-specific gene loci exhibit broadly distributed patterns of histon

141 ranscript isoforms expressed from individual gene loci explain translation of the vast majority of OR

142 The co-expression is most prominent when two gene loci fall within 1,000 base pairs from the observed

143 correlated fluctuations in the positions of gene loci, find large genomic compartments and smaller t

144 retention of regulatory machinery on target gene loci for activation and repression.

145 there is an optimal bivalent signature at 32 gene loci for driving endoderm commitment.

146 on study aims to identify the susceptibility gene loci for excessive alcohol consumption by jointly m

147 G9a/GLP complex is targeted to the specific gene loci for H3K9 methylation is unclear.

148 We identify 6 novel gene loci for height, 2 for BMI, and 3 for schizophrenia

149 amp enables targeting to a greater number of gene loci for stronger occupancy and transcription regul

150 single-nucleotide polymorphisms (SNPs) in 6 genes/loci for keratoconus in Whites.

151 tin spreading to allow for exclusion of SASP gene loci from a global heterochromatin environment duri

152 to sweep through the population at selected gene loci (gene-specific sweeps), or the recombination r

153 nt transcription beyond known protein-coding gene loci, generating a variety of RNA classes, most of

154 hat diversification at particular gammadelta gene loci has been favored during primate evolution, sug

155 e configuration and rearrangements of the Ig gene loci has contributed extensively to our understandi

156 cates to the nucleus, but its recruitment to gene loci has not been demonstrated.

157 ia is highly heritable, and to date multiple gene loci have been reported.

158 Moreover, coregulated gene loci have been shown to relocate to the nuclear per

159 The new gene loci identified implicate novel genetic mechanisms

160 ipitation assays analyzing the corresponding gene loci identified unusual STAT5 binding sites compare

161 the risk of RA by dense genotyping of the 25 gene loci in 10,609 RA cases and 35,605 controls.

162 tions at known DBA-related ribosomal protein gene loci in 17% (9 of 51) of patients without an identi

163 9 and/or K14 of histone H3 at UVR8-regulated gene loci in a UVR8-dependent manner.

164 rase and the acetylation of H3K27 at precise gene loci in cells.

165 stone gene transcripts colocalize at histone gene loci in dedicated subnuclear foci (histone locus bo

166 emble presumed orthologs but also paralogous gene loci in distinct contigs.

167 cated in the coordinated control of multiple gene loci in Epstein-Barr virus (EBV) latency.

168 egulatory DNA elements in the EKLF and Tal-1 gene loci in erythroid cells.

169 ramatically increased locally at hundreds of gene loci in H3.3K27M patient cells.

170 lease at three disease-associated endogenous gene loci in HEK293T cells, HeLa cells, and human induce

171 lencing and often occurs at tumor suppressor gene loci in human cancer.

172 protocol to knock in a GFP cassette into key gene loci in human pluripotent stem cells (hPSCs), and t

173 particular, >30% of the approximately 800 OR gene loci in humans were polymorphic with respect to cop

174 s HBV in TERT and KMT2B (also known as MLL4) gene loci in liver cancer, HPV and BKV in bladder cancer

175 Interestingly, new gene loci in maize represent junctions of ancestral chro

176 shown to stimulate recombination in reporter gene loci in mammalian cells via site-specific binding a

177 ion (H3K27me3) on chromatin at developmental gene loci in mouse embryonic stem cells.

178 e (miRBase 16) contains over 15,000 microRNA gene loci in over 140 species, and over 17,000 distinct

179 The efficacy of selected 'candidate' gene loci in risk algorithms, to improve the predictive

180 distal regulatory regions of Il-17 and Il-10 gene loci in Th17 cells.

181 sequence span varies greatly among different gene loci in the human genome and longer loci have a hig

182 lase inhibitor promotes accessibility at key gene loci in the MG, and allows more effective reprogram

183 ipt, strong depletion of H3K27me3 at escaper gene loci in the present study suggests that histone sta

184 e-dependent pathway for relocating activated gene loci in yeast.

185 evealed significant enrichment of methylated gene-loci in Cell Cycle Regulation, DNA Damage Response,

186 diting of up to three target sites across 11 genes/loci in cynomolgus monkey embryos using CRISPR-bas

187 even the co-location of functionally related gene loci, including early replication start sites and t

188 ecruitment along a number of immediate early gene loci, including EGR1 and ZFP36, with the highest de

189 ced the levels of H3K4me3 at critical B-cell gene loci, including Pax5 and Rag1/2, which are critical

190 o occur in approximately 40% of the detected gene loci, including several involved in isoprenoid/terp

191 ined two strain populations differing at 113 gene loci, including the cag pathogenicity island virule

192 and Yta7 differed markedly among the histone gene loci, including the two H3-H4 histone gene pairs.

193 A3B and EBNA3C binding at multiple regulated gene loci, indicating a requirement for CBF heterodimers

194 hese results provide multilevel evidence for genes/loci influencing EL.

195 This correlates with incorporation of SASP gene loci into SAHF.

196 echanistically, BCL6 bound to the neutrophil gene loci involved in cellular apoptosis in cells specif

197 of NFAT and histone modifications within key gene loci involved in Th17 differentiation.

198 ndings show that hypermethylation of certain gene loci is controlled in part by an underlying suscept

199 We investigated 7 gene loci (KLF15, NR3C1, LEP, DEPTOR, DDIT4, HSD11B2, an

200 or and/or memory CTLs, the majority of these gene loci lose repressive H3K27me3 while retaining the p

201 hly similar genes in the lymphocyte receptor gene loci makes them difficult to investigate, and the d

202 olution and provide evidence that additional gene loci may be amplified in some species.

203 lytic transcripts derived from these latency gene loci may have unique, noncoding nuclear functions d

204 Thus, RUNX2 binding to diverse gene loci may support the biological properties of osteo

205 Chromatin architecture at individual genes/loci may remain stable through cell divisions, fro

206 d evidence of association at four additional gene loci: MMEL1-TNFRSF14 (rs3890745, P = 0.0035 replica

207 ntly contains deletions of tumour suppressor gene loci, most notably SMAD4, which is homozygously del

208 osomes (karyotype), number of protein-coding gene loci, number of transcription factors, guanine-cyto

209 ole chromosome territories and their encoded gene loci occupy preferential positions within the nucle

210 asis for serotype 6C, we studied the capsule gene loci of 14 6C isolates from three different contine

211 vestigating the nucleotide diversity at five gene loci of a large sample that represents the entire g

212 a homozygous deletion polymorphism in the M1 gene loci of glutathione S-transferase (GSTM1-null) in a

213 demonstrated that H3K9me3 is erased from the gene loci of myogenic regulatory factors namely MYOD1, M

214 It is thought that many common variant gene loci of weak effect act additively to predispose to

215 ward, it is unclear as to whether particular gene loci on chromosome 21 (HSA21) are sufficient to cau

216 f movement between two fluorescently labeled gene loci on either the same or different budding yeast

217 ffects of linear and spatial organization of gene loci on gene regulation are linked through TAD arch

218 view of the placement of Panzea markers and genes/loci on genetic and physical maps.

219 ganization of the nucleoid, with movement of gene loci out of the bulk of DNA as levels of transcript

220 nsights into nuclear function would arise if gene loci physically interacting with particular subnucl

221 The aim of this study was to identify gene loci predisposing infants to BPD.

222 ee WRKY factors each bound to more than 1000 gene loci predominantly at W-box elements, the known WRK

223 ity) joining [V(D)J] recombination of immune gene loci proceeds in an ordered manner with D to J port

224 osequencing detected transcription of 17,449 gene loci providing very deep coverage of the transcript

225 romatin binding of CaMKII occurs at specific gene loci reactivated during cardiac hypertrophy.

226 e mechanisms underpinning KLF1 action at the gene loci regulating the first 3 steps in this process,

227 omplex molecular changes around their target gene loci remains incompletely understood.

228 The majority of these identified R gene loci reside in poorly or previously unannotated reg

229 receptor, and cognate signaling proteins to gene loci, respectively.

230 in novel transcript models for 3,574 and 561 gene loci, respectively.

231 nt pathogenic point mutations and CNVs in 13 genes/loci responsible for nonsyndromic and syndromic mo

232 ier insulator function in erythroid membrane gene loci results in mild or severe anemia.

233 two proteins, Chp1 and Sap (corresponding to gene loci rv3822 and rv3821), that complete this pathway

234 nd to differentiation signals, developmental gene loci should be structurally and spatially regulated

235 sense transcripts at some of the EBV latency gene loci showed that they are "late" genes, they are nu

236 target genes, and phasiRNA-generating (PHAS) genes/loci showed that the function of miR482/2118 has e

237 Conformation of antigen receptor gene loci spatially juxtaposes rearranging gene segments

238 ion of F8 in hepatocytes at highly expressed gene loci, such as albumin (Alb).

239 Moreover, genetic manipulations of selected gene loci suggest that some enhancers located within HCD

240 ethylated H3K9 modifications at the receptor gene loci, suggesting a mechanism for silencing receptor

241 n ability and MLL1 recruitment to the target gene loci, suggesting that PHD2 negatively regulates MLL

242 The transcription start sites of lncRNA gene loci tend to be close to their nearest protein-codi

243 Coexpressed gene loci tended to colocalize to the same nuclear subdo

244 DMRs are enriched at progesterone-responsive gene loci that are essential for reproductive function.

245 Gene loci that are hypermethylated and repressed in embr

246 of novel KLF1-dependent events at erythroid gene loci that are independent of GATA1 activity.

247 are novel isoforms, including 273 RNAs from gene loci that have not previously been identified.

248 We identify a network of such gene loci that increase their association inter-chromoso

249 HIMs), each of which represents a cluster of gene loci that is in spatial contact more frequently tha

250 iations of a total of 1251 alleles of all 40 gene loci that together are known to affect antigens of

251 histone mark at a significant proportion of gene loci that undergo daily transcription, implicating

252 appropriate chromatin remodeling at specific gene loci that underpins appropriate CD8(+) T cell linea

253 hed in non-coding sequences near chondrocyte genes, loci that likely became optimized during knee evo

254 ver tumor nodules and identified at least 16 genes/loci that contribute to accelerated tumor developm

255 We also found SNPs in 10 genes/loci that had a summary P value < 0.05.

256 We also identified an additional 32 CIS genes/loci that may represent modifiers of the Apc(Min)

257 volutionary novel A alleles of the both OXTR gene loci, that the spread of alleles of rs22542298 and

258 lated strains that vary at a small number of gene loci, that this population of strains may already b

259 e to an increase in H3K27me3 marks at stress gene loci, the timing of which is determined by reduced

260 regulating H3K9 demethylation at cell cycle gene loci, thereby representing a key player in oncogene

261 PK may play a role in recruitment of XRN2 to gene loci thus regulating coupling 3'-end pre-mRNA proce

262 repressive chromatin modifications at these gene loci, thus maintaining the potential for expression

263 ave brought the number of IBD susceptibility gene loci to 163.

264 l. used mice with human TCRalphabeta and HLA gene loci to discover CD4+ TCRs of optimal affinity for

265 CDX2 binds to and activates Hnf4 gene loci to elevate HNF4 expression at fetal stages.

266 nce approach to detect resistance-associated gene loci to improve our mechanistic understanding of ho

267 hPSCs from studying the impact of individual gene loci to investigation of multigenic human traits, a

268 e single-molecule quantification of mRNA and gene loci to measure the transcriptional activity of an

269 d to insert various tags and fluorophores at gene loci to study the physiological behavior of protein

270 arch literature to identify and characterise gene loci to the highest standard.

271 itiation and elongation, and localization of gene loci to transcription factories in the nucleus.

272 ctors that contribute to insusceptibility of gene loci to transcriptional silencing remain unknown.

273 teins were inserted into the Rex1 and Oct3/4 gene loci to visualize the expression of these genes.

274 cells into effector cells, specific cytokine gene loci undergo extensive changes in chromatin modific

275 and identify transcription evidence in 4781 gene loci, underlining the importance of these non-refer

276 o transcriptional competence at Th2 cytokine gene loci upon recall activation indicates that linear d

277 No insertion into microRNA gene loci was detected.

278 Correlations between 34 gene loci were identified that showed concordant variati

279 conditions, the regulatory sequences of late gene loci were not in close proximity, and these genes w

280 two enzymes synthesizing GSH, although both gene loci were not refractory to recombination.

281 t the stage of endotoxin tolerance, both miR gene loci were occupied by C/EBPbeta, NFkappaBp50, and t

282 SNPs in the 9p21 and PHACTR1 gene loci were strongly associated with CAC and MI, and

283 Several genes/loci were also found to confer resistance to two o

284 arrays, leading to the identification of 445 gene loci where SF-1-binding regions were located from 1

285 hat SAFB1 acts as a novel AR co-regulator at gene loci where signals from the MST1/Hippo and EZH2 pat

286 over, we also demonstrate that developmental gene loci, which have bivalent histone modifications, te

287 CBs associate with specific gene loci, which impacts expression and provides a platf

288 DNA damage and loss of key tumor suppressor gene loci, which in combination can initiate tumorigenes

289 ethylation of Lys9 of histone H3 at specific gene loci, which is associated with transcriptional repr

290 CBs associate non-randomly with U1 and U2 gene loci, which produce the small nuclear RNA (snRNA) c

291 chromatin-remodeling of both Nanog and Oct4 gene loci, which requires RA receptor-alpha, RIP140 and

292 omeZipper incorporates 4,035 conserved grass gene loci, which were used for the first genome-wide seq

293 hromosomal architecture by linking dispersed gene loci with centromeres.

294 We visualized gene loci with diffraction-limited resolution, chromosom

295 Genes and gene loci with increased expression included CT1087, enc

296 Association and disassociation of gene loci with respect to specific nuclear compartments

297 ition of lncRNA, which excludes those lncRNA gene loci with small open reading frames from being rega

298 g-tagged primers simultaneously probe 16 p53 gene loci, with an abbreviated thermal cycling protocol

299 alls a precise nucleotide change in specific gene loci without causing a double-strand break.

300 correction for 3131 haplotype blocks), four gene loci yielded significant associations.