ライフサイエンスコーパス: gene recombination

1 lls, of forming antigen receptors by somatic gene recombination.

2 eus and locus contraction in preparation for gene recombination.

3 tosis during immunoglobulin (Ig) light chain gene recombination.

4 te commitment and immunoglobulin heavy-chain gene recombination.

5 -deficient mice were generated by homologous gene recombination.

6 provides feedback to terminate further V(H) gene recombination.

7 constraints of accessibility to control V(H) gene recombination.

8 but through the control of antigen receptor gene recombination.

9 le, enabling temporal and spatial control of gene recombination.

10 thymus, after TCR-beta but before TCR-alpha gene recombination.

11 proliferative selection and antigen receptor gene recombination.

12 had previously been associated with somatic gene recombination.

13 variable (V), diversity (D) and joining (J) gene recombination.

14 teins important in homology-based chicken Ab gene recombinations.

15 izontal DNA transfer and assortative (entire gene) recombination.

16 protein feeds back to terminate further V(H) gene recombination, a phenomenon also referred to as all

17 TCR-beta gene recombination and allelic exclusion were normal in

18 apid adaptation to novel niches by promoting gene recombination and duplication followed by functiona

19 Igk gene recombination and expression in Kidins220-deficient

20 ble lipids into cultured human cells enables gene recombination and genome editing with efficiencies

21 ns in vivo to stimulate TCRbeta and TCRalpha gene recombination and influence differentiation of alph

22 es a molecular basis for chromatin-dependent gene recombination and presents a single protein domain

23 n, preventing down-regulation of light chain gene recombination and promoting secondary light chain g

24 xpression, as shown by tissue-selective Des1 gene recombination and reduced Des1 catalytic activity,

25 nts in gene therapy by initiating homologous gene recombination and repair.

26 ic gene expression program linked with V(D)J gene recombination and T-cell receptor signaling.

27 status is inherently and inversely linked to gene recombination and that the outcomes of gene recombi

28 of Ku70 was compatible with T cell receptor gene recombination and the development of mature CD4+CD8

29 n is critical for immunoglobulin light chain gene recombination and to prevent malignant transformati

30 growth, transient activation of the WAP-Cre gene, recombination, and constitutive expression of LacZ

31 Internal gene recombination appears to occur among them.

32 Significant gene recombination ( approximately 80%) occurred in the

33 ifferentiation, cell cycle fluctuations, and gene recombination are coincident during normal T cell d

34 definitive process of T cell receptor (TCR) gene recombination, are presently emerging.

35 7R/STAT5 levels promote immunoglobulin kappa gene recombination at the early pro-B cell stage.

36 The highly restricted timing of V to J gene recombination at the pre-B-cell stage is under the

37 which carry CD19(Cre) that initiates floxed gene recombination at the pro-B-cell stage.

38 Following assessment of tissue-specific gene recombination, B-cell architecture, in vitro and in

39 Immunoglobulin gene recombination can result in the assembly of self-re

40 sition, a survival program is initiated, TCR gene recombination ceases, cells migrate into a new thym

41 In yeast genes, recombination (conversion) is polarized, being hi

42 ion and caudal portions of the tongue, where gene recombination did not occur until E14.5.

43 High fidelity in vitro gene recombination ("DNA shuffling") coupled with sequen

44 CR signaling to induce Igl locus opening and gene recombination during B cell development and recepto

45 transition and suppressing antigen receptor gene recombination, ensuring that only one productive Ig

46 Allele KIR3DL1*009 resulted from a gene recombination event between the inhibitory receptor

47 Together, our data suggest that Ig gene recombination events can generate B cells with auto

48 ajor leaps in protein function occur through gene recombination events that connect two or more prote

49 lta and that might function to regulate Tcrd gene recombination events.

50 aining portion of the Ig loci regulate the V gene recombination frequency in a regional manner.

51 odel human genome, including genome editing, gene recombination, gene replacement, gene expression, a

52 ackgrounds suggests that assortative (entire gene) recombination has also contributed to strain diver

53 We propose that the outcome of gene recombination (i.e., TCR expression) may not influe

54 s manipulated to control gene expression and gene recombination in developing thymocytes.

55 Using cell-specific inducible gene recombination in mice we found that, in the postnat

56 ugh intravenous injection, we achieved 8.2 % gene recombination in mouse T lymphocytes.

57 nslocation is the most frequent illegitimate gene recombination in paediatric cancer, occurring in ap

58 hat uses complementary approaches to achieve gene recombination in specific cell populations in the b

59 defect preferentially affects immune system gene recombination in T cells rather than B cells.

60 polymorphism to analyze TCR-alpha and -beta gene recombination in thymically derived gamma delta cel

61 e data indicate a direct role for ATM in TCR gene recombination in vivo that is critical for surface

62 tional protein delivery into mouse brain for gene recombination in vivo.

63 dataset, scFusion detects the invariant TCR gene recombinations in mucosal-associated invariant T ce

64 to establish the configuration within which gene recombination initiates.

65 We found that TCR-beta gene recombination is a frequent occurrence in thymic ga

66 racterized mice in which Phox2b-Cre mediated gene recombination labeled neurons with tdTomato.

67 that ablation of Fmrp in aNSCs by inducible gene recombination leads to reduced hippocampal neurogen

68 Because NK cells lack gene-recombination machinery and are thought to be relat

69 ect the transition between proliferative and gene recombination molecular programs.

70 development is blocked and ongoing antibody gene recombination occurs, which often alters antibody s

71 Random pairwise gene recombination of two positive variants led to a fur

72 variable [V], diversity [D], and joining [J] genes) recombination of their antigen receptor loci to c

73 gests anomalies of evolution such as partial gene recombination or functional constraints.

74 acquired through errors in DNA replication, gene recombination, or extrinsically imposed damage, are

75 ted mutations, although the possibility that gene recombination plays a role cannot be eliminated.

76 gene recombination and that the outcomes of gene recombination regulate developmental progression.

77 disrupted targeting at the tongue tip, where gene recombination removed bdnf by embryonic day 13.5 (E

78 unctional differences in RT-mediated somatic gene recombination/retroinsertion and resulting genomic

79 A new form of somatic gene recombination (SGR) has been identified in the huma

80 Gene recombination-specific enzymes were assessed by PCR

81 s with a lymphoid past were identified in Ig gene recombination substrate reporter mice treated with

82 s of murine immunoglobulin heavy-chain (IgH) gene recombination take place within a chromosomal domai

83 To develop a quantitative assay for pilin gene recombination that is independent of phase variatio

84 We propose that in pre-B cells undergoing Ig gene recombination, the DNA breaks activate a p53/miR-34

85 While the RecA protein is required for pilin gene recombination, the factors which maintain the silen

86 he nucleus and retain its activity to induce gene recombination, this in vitro experiment better exem

87 Within genes, recombination tracts are more likely to terminate

88 Here we report that adipocyte-specific Lpin1 gene recombination unexpectedly resulted in expression o

89 chromatin architecture, gene expression, and gene recombination via compaction of the genome into chr

90 polypurine site situated between the two TK genes, recombination was observed at frequencies in the