ライフサイエンスコーパス: gene regulation

1 ynamic and highly context-specific nature of gene regulation.

2 suggesting non-redundant roles in circadian gene regulation.

3 ranging from RNA metabolism to signalling to gene regulation.

4 s is central to Polycomb system function and gene regulation.

5 e important for light sensing and downstream gene regulation.

6 equence remains a major goal in the field of gene regulation.

7 he genome and are therefore likely to impact gene regulation.

8 of transcription factors (TF) is critical to gene regulation.

9 s co-transcriptionally, and is important for gene regulation.

10 rmations of downstream sequences, leading to gene regulation.

11 ear roles include pathogenesis response (PR) gene regulation.

12 ary to develop complex, predictive models of gene regulation.

13 dynamic conditions, to model their impact on gene regulation.

14 of the identified variants likely influence gene regulation.

15 moter and enhancer interactions critical for gene regulation.

16 s) creating a hidden and unexplored layer of gene regulation.

17 cal to deepening our understanding of proper gene regulation.

18 nctional links between chromatin folding and gene regulation.

19 ing of the role of structures in controlling gene regulation.

20 sses such as transcription, translation, and gene regulation.

21 us to understand precisely how p53 controls gene regulation.

22 ed with ADHD and ASD that likely act through gene regulation.

23 s the prevailing cue that controlled diurnal gene regulation.

24 analyzed for inflammation and kinome-related gene regulation.

25 l and temporal chromatin organization during gene regulation.

26 ndirect mechanisms through which p53 affects gene regulation.

27 contribute to both chromosomal structure and gene regulation.

28 developing a comprehensive understanding of gene regulation.

29 its pioneer-like role, and how this affects gene regulation.

30 obtaining a better understanding of dynamic gene regulation.

31 potential limits of murine models of globin gene regulation.

32 E insertions to structural mutation and host-gene regulation.

33 e assembly is spatially constrained, such as gene regulation.

34 tely define its role within the hierarchy of gene regulation.

35 dular nature for its coactivator function in gene regulation.

36 is likely to have important implications for gene regulation.

37 bal perspective on the architecture of human gene regulation.

38 uct an improved biophysical understanding of gene regulation.

39 s is an important mechanism for evolution of gene regulation.

40 an important role in genome architecture and gene regulation.

41 otide long) involved in post-transcriptional gene regulation.

42 histone H3 tail and promotes KLF9/6-mediated gene regulation.

43 ysfunction and the underlying alterations in gene regulation.

44 en new vistas on the primary architecture of gene regulation.

45 led essential roles of non-coding regions in gene regulation.

46 the role of MDV U(S)3 in viral and cellular gene regulation.

47 RNA binding proteins (RBPs) is essential for gene regulation.

48 f MEF2A and into its role in B cell-specific gene regulation.

49 understanding the role of DNA methylation in gene regulation.

50 ylated cytosine is an effector of epigenetic gene regulation.

51 lass can be a critical mode of developmental gene regulation.

52 annels, exocytosis, homeostasis, and insulin gene regulation.

53 e of CTCF binding sites at TAD boundaries in gene regulation.

54 state and accessibility during developmental gene regulation.

55 is one of the determining factors in global gene regulation.

56 at only a minority play significant roles in gene regulation.

57 and groups of TFs ("TF-TF modules") in Th17 gene regulation.

58 clear periphery for nuclear organization and gene regulation.

59 they have been used to identify new modes of gene regulation.

60 d possibly fulfills CTD related functions in gene regulation.

61 e between the OFF and ON states in bacterial gene regulation.

62 e emerging as an important area of bacterial gene regulation.

63 s) play critical roles in cell type-specific gene regulation.

64 ulting in an incomplete portrait of cytokine gene regulation.

65 tein diversity and shaping various layers of gene regulation.

66 ular processes ranging from transcription to gene regulation.

67 provides a generic alternative to canonical gene regulation.

68 c REs potentially involved in pacemaker cell gene regulation.

69 erimental studies on signal transduction and gene regulation.

70 logy and in affecting cellular functions and gene regulation.

71 nriched in functional annotations related to gene regulation.

72 enhancer silencing could be a common mode of gene regulation.

73 s that dominate our current view of parasite gene regulation.

74 tified with unknown function in inflammatory gene regulation.

75 membraneless nuclear organelles involved in gene regulation.

76 s important to understand condition-specific gene regulation.

77 e drivers of disease-relevant alterations in gene regulation.

78 that effector binding can be uncoupled from gene regulation.

79 viously unrecognized complexity of virulence gene regulation.

80 romatin modulation, and post-transcriptional gene regulation.

81 noncoding RNA (ncRNA) molecules involved in gene regulation.

82 ocesses including cell wall biosynthesis and gene regulation.

83 intervening at the level of interactomes and gene-regulation.

84 that involve various signaling cascades and gene regulations.

85 fy the metastasis-initiating microRNA-target gene regulations.

86 DNA-binding proteins that have key roles in gene regulation(1,2).

87 s toward more effective investigation of how gene regulation affects human disease.

88 However, accounting for pesticide-triggered gene regulation allows improved performance in capturing

89 onsidering the importance of RNA splicing in gene regulation, alterations in this pathway have been i

90 We discuss how gene regulation analyses have advanced our understanding

91 protein removal is, therefore, essential for gene regulation and accounts for the short half-life of

92 ing RNAs (lncRNAs) play an important role in gene regulation and are increasingly being recognized as

93 tal role in psychostimulant-induced neuronal gene regulation and behavioral adaptation, including loc

94 dissection of cell type-specific long-range gene regulation and can accelerate the identification of

95 ensional genome organization is critical for gene regulation and can malfunction in diseases like can

96 on timescales that are similar to canonical gene regulation and can respond to rapid environmental c

97 hysical properties of protein condensates in gene regulation and cancer.

98 Chromatin interactions are important for gene regulation and cellular specialization.

99 metabolic processes by time-dependent target gene regulation and controls circulating glucose and tri

100 ghlight the unique role of eRNAs in neuronal gene regulation and demonstrate that eRNAs can be used t

101 ma metabolome, especially lipidome, reflects gene regulation and dietary exposures, heralding the dev

102 allow us to better understand mechanisms of gene regulation and disease etiology.

103 pact of the 3D organization of the genome in gene regulation and disease pathogenesis.

104 ons further reveal telomere length-dependent gene regulation and epigenetic modifications at sites sp

105 l of understanding how structures may affect gene regulation and expression.

106 er understanding of chromatin state-mediated gene regulation and facilitate the identification of nov

107 ance of noncoding variants for cell-specific gene regulation and for disease association beyond conve

108 inside the cell nucleus plays a key role in gene regulation and genome replication, as well as maint

109 lar development and stress responses through gene regulation and genome stability control.

110 s on the molecular basis for R-loop-mediated gene regulation and genomic instability and briefly disc

111 c acid sequences have revealed principles of gene regulation and guided genetic variation analysis.

112 idely used in nanotechnology, play a part in gene regulation and have been detected in human nuclei.

113 as potential to enhance our understanding of gene regulation and interactions of cell signalling netw

114 l regulators are important for understanding gene regulation and its effects on diverse biological pr

115 ors, and nuclear architecture in controlling gene regulation and life cycle progression in Plasmodium

116 uman cortex and advance our understanding of gene regulation and lineage specification during this cr

117 ducible gene expression, the coordination of gene regulation and metabolism, and the influence of the

118 essfully applied to the engineering of plant gene regulation and metabolism.

119 nce, linking lifelong protein persistence to gene regulation and nuclear integrity.

120 s surging, because they provide insight into gene regulation and organismal phenotypes (e.g., genes u

121 ified through bulk and single-cell methods), gene regulation and other molecular quantitative trait s

122 The impact on gene regulation and phenotype of the respective mouse li

123 Based on transcriptional level gene regulation and physiological responses to N or P li

124 important organizing principles of bacterial gene regulation and presents a conceptual and computatio

125 k for detecting genomic features involved in gene regulation and prioritizing genomic variation to ex

126 provides resources for functional studies of gene regulation and QDR molecular mechanisms across the

127 by protein machinery play essential role in gene regulation and refine global polymeric folding of t

128 tion of the nucleolus, with implications for gene regulation and ribonucleoprotein particle assembly

129 They are the cornerstone of gene regulation and the most pervasive constituents of t

130 -characterized roles in post-transcriptional gene regulation and transposon repression.

131 links between genetic variation, epigenetic gene regulation, and atrial function.

132 Unique genomic features, patterns of gene regulation, and defence systems in millipedes, not

133 rate investigations of cell-type definition, gene regulation, and disease states.

134 al roles in RNA polymerase (RNAP) recycling, gene regulation, and genomic stability in most bacteria.

135 egated state of the genome can contribute to gene regulation, and highlight experimental challenges f

136 ON/OFF switching, including unusual modes of gene regulation, and highlighting an underappreciation o

137 er via direct interference or indirectly via gene regulation, and may suggest evolutionary outcomes o

138 es in adipogenesis, insulin sensitivity, and gene regulation, and mutations in these genes cause lipo

139 Chromatin looping is important for gene regulation, and studies of 3D chromatin structure a

140 ts of RNA silencing and post-transcriptional gene regulation, and they interact with messenger RNAs (

141 hotoreceptor (PRC) membrane organization and gene regulation are critical to understanding sight and

142 der chromosome structures and their roles in gene regulation are elusive.

143 The conceptual basis for understanding such gene regulation arose from pioneering biophysical studie

144 sical mechanisms that connect metabolism and gene regulation as cells navigate their growth, prolifer

145 The growing understanding of epigenetic gene regulation as it relates to both the stability and

146 This suggests that changes in gene regulation associated with AD are linked to changes

147 important aspects of genome architecture and gene regulation at a higher resolution than previously p

148 hly controlled process that involves complex gene regulation at both transcriptional and post-transcr

149 Studies on KSHV gene regulation at the individual cell level would allow

150 lts indicate a rich layer of tissue-specific gene regulation at the level of alternative splicing in

151 ances enabled the field to begin elucidating gene regulation at the single-locus level.

152 esses that shape the observed differences in gene regulation between individuals in humans or any oth

153 tated by chromatin loops, play a key role in gene regulation but their relevance in senescence remain

154 eart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic ins

155 luable insights into genome organization and gene regulation, but can include spurious interactions t

156 IR is not merely a mechanism of gene regulation, but rather it can mediate cancer pathog

157 omes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA

158 Our results provide new insights into gene regulation by a critical neuronal RNA-BP in human n

159 ay have also contributed to the evolution of gene regulation by adopting enhancer function.

160 ns in personal cancer genomes, which perturb gene regulation by altering chromatin architecture.

161 To gain further molecular insights into gene regulation by CHD7, we performed a protein-protein

162 t demonstrate ROS as signaling molecules for gene regulation by combining two emergent properties of

163 Gene regulation by control of transcription initiation i

164 neered as versatile and innovative tools for gene regulation by external application of their ligand

165 cribe studies in which the mechanism of Lcn2 gene regulation by MALP-2 and mycoplasma infection was i

166 -expression information to model genome-wide gene regulation by miRNAs.

167 ve infection, indicating that Mn sensing and gene regulation by MtsR are critical processes during S.

168 evidence that inter-individual variation in gene regulation can be genetically controlled, and that

169 Thermodynamic models of gene regulation can predict transcriptional regulation i

170 M fungus Pisolithus microcarpus, in terms of gene regulation, carbon metabolism and growth, and inter

171 icing of mRNA precursors is a key process in gene regulation, contributing to the diversity of proteo

172 Together, these studies unravel unexpected gene regulation directly mediated by rRNA and how riboso

173 edox switches in proteins, thereby affecting gene regulation, DNA damage, ion transport, intermediary

174 ill enable the single-cell deconstruction of gene regulation during CAR-T therapy, leading to the dis

175 tochasticity, are critical for understanding gene regulation during cell fate decisions, inflammation

176 hromatin remodeling plays important roles in gene regulation during development, differentiation and

177 ationship between chromatin architecture and gene regulation during development.

178 enome maps provide a resource for studies of gene regulation during tissue or organ progression, and

179 actions mediated by N(6)-mA is essential for gene regulation during trophoblast development in cell c

180 d as a graphical user interface and can mine gene regulations, either by applying a dynamic Bayesian

181 that each mutant had a deleterious effect on gene regulation, even when compensatory changes were inc

182 consistent conceptual framework of bacterial gene regulation, focusing on transcription initiation.

183 adaptation-utilization of random changes in gene regulation for adaptive benefits-was recently propo

184 d genes, biochemical regions associated with gene regulation (for example, transcription factor bindi

185 mulations we propose that altered sex-biased gene regulation from standing genetic variation, rather

186 A sequence, a process that requires units of gene regulation (gates) that are simple to connect and b

187 studies, classic definitions for concepts of gene regulation have evolved as the number of characteri

188 ut the roles of other Integrator subunits in gene regulation have yet to be elucidated.

189 egion that link genetic variation and target gene regulation, helping to focus future investigations.

190 The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression re

191 Promoters play a central role in controlling gene regulation; however, a small set of promoters is us

192 esearch that implements a unifying inherited gene regulation (IGR) approach to studies of 'non-geneti

193 partially, be related to the loss of E2 host gene regulation.IMPORTANCE Human papillomavirus 16 (HPV1

194 cription factors to regulatory DNA underpins gene regulation in all organisms.

195 tion of ARGONAUTE1 (AGO1) to hypoxia-induced gene regulation in Arabidopsis (Arabidopsis thaliana).

196 e to understanding the mechanisms underlying gene regulation in B. burgdorferi has been the lack of a

197 ntered graduate school in 1964, and to study gene regulation in bacteriophage lambda when I was there

198 of immense discovery for novel sRNA-mediated gene regulation in cardiometabolic diseases.

199 Detailed mechanisms for the role of pMEIs in gene regulation in different tissues will be an importan

200 esource for the exploration of in vivo human gene regulation in diverse tissues and cell types.

201 Gene regulation in eukaryotes requires the controlled ac

202 script by spliceosome (SPL) is a hallmark of gene regulation in eukaryotes.

203 eciate the importance of posttranscriptional gene regulation in glycemic control.

204 s a resource for decoding neurodevelopmental gene regulation in health and disease.

205 ing of the role noncoding variation plays in gene regulation in human health and disease.

206 elektroscirrha does not alter monarch immune gene regulation in larvae, corroborating that monarchs r

207 ch will enable unique studies of TF-mediated gene regulation in live animal models.

208 profoundly shapes the clonal composition and gene regulation in malignant gliomas.

209 (TET) family of enzymes is indispensable for gene regulation in mammals.

210 phage Q beta) is key for posttranscriptional gene regulation in many bacteria.

211 ) are short non-coding sequences involved in gene regulation in many biological processes and disease

212 Widespread APA affects post-transcriptional gene regulation in mRNA translation, stability, and loca

213 regions of genes, suggesting a key role for gene regulation in patients with EoE, which is consisten

214 all RNAs (sRNAs) are important molecules for gene regulation in plants and play an essential role in

215 nsive comparative transcriptomic analysis of gene regulation in regenerating rat livers temporally sp

216 ransferase SETDB1 as a common denominator of gene regulation in several cancer types.

217 initiated the field of modern research into gene regulation in the cardiovascular system.

218 have relevance for identifying mechanisms of gene regulation in the CNS, elucidating the function of

219 has important implications for Hox and Gli3 gene regulation in the context of development and evolut

220 Gene regulation in the germline ensures the production o

221 Our findings support a role for altered gene regulation in the prenatal brain in susceptibility

222 facilitate studies of microRNA function and gene regulation in the retina and other tissues.

223 erstood, and discrete enhancers required for gene regulation in the SAN have not been identified.

224 ce elements serve as primary determinants of gene regulation in these organisms; however, few have de

225 existence of common molecular mechanisms for gene regulation in TS and KS that transmit the gene dosa

226 Cell fractionation revealed temporal gene regulation, in which early lytic gene expression wa

227 tion are regulated across multiple layers of gene regulation, including modulation of gene expression

228 esults highlight the dramatic alterations in gene regulation induced by invasive surgery, primarily r

229 icroRNA arm switching-providing differential gene regulation is also obtained.

230 Gene regulation is chiefly determined at the level of in

231 Our views of how gene regulation is coordinated are dramatically changing

232 The study of gene regulation is dominated by a focus on the control o

233 Gene regulation is important for cells and tissues to fu

234 hanistic understanding of PR-DUB function in gene regulation is limited.

235 ating when and how this post-transcriptional gene regulation is mediated in the induction of LTM.

236 between genome structure and its function in gene regulation is not completely understood.

237 Spatiotemporal gene regulation is often driven by RNA-binding proteins

238 How long-range gene regulation is physically achieved, especially withi

239 he comparable analysis for understanding how gene regulation is shaped through evolution.

240 Thus, in human ASCs growth factor-like gene regulation is transiently imposed by niche signals

241 and certain cancers however, its role in EMT gene regulation is unknown.

242 Our findings provide crucial insights into gene regulation kinetics inside the crowded cellular mil

243 Future analysis of BRD4 D1 gene regulation may shed light on differential BET bromo

244 stigate and repurpose a ubiquitous, indirect gene regulation mechanism from nature, which uses decoy

245 RNA silencing is an essential gene-regulation mechanism in eukaryotic organisms.

246 ression pathways that may be associated with gene regulation mechanisms and with response to treatmen

247 several organ systems through poorly defined gene regulation mechanisms.

248 e immune responses rely on rapid and precise gene regulation mediated by accessibility of regulatory

249 ce of PARP family members and ADPRylation in gene regulation, mRNA processing, and protein abundance.

250 dimerization mechanism underlie an intricate gene regulation network at physiological conditions.

251 To determine whether cell-cycle-dependent gene regulation occurs in mycobacteria, we characterized

252 suppressive role of TET1 in the thermogenic gene regulation of beige adipocytes is largely DNA demet

253 Previously, by modeling the gene regulation of cancer metabolism we have reported th

254 breakdown at a global level, we studied the gene regulation of total retinal cells and retinal endot

255 the expression patterns, functions, and Hox gene regulation of trachealess (trh), ventral veinless (

256 Although defective gene regulation often affects oncogenic and tumour-suppr

257 It also supports orthogonal gene regulation on multiple levels.

258 understanding the fundamentals of bacterial gene regulation, our knowledge remains limited when comp

259 To induce cell type-specific forms of gene regulation, pioneer factors open tightly packed, in

260 r the topology of the networks used to model gene regulation primarily impacts accurate drug target i

261 strategy that activates a vasculoprotective gene regulation program in PAECs downstream of dysfuncti

262 are translated into functionally appropriate gene regulation programs.

263 In prokaryotes, thermodynamic models of gene regulation provide a highly quantitative mapping fr

264 at ligand binding does not ensure successful gene regulation, providing new insights into these shape

265 Appropriate developmental gene regulation relies on the capacity of gene promoters

266 e structures might relate to allele-specific gene regulation remain open.

267 (H1 CTD) influences chromatin structure and gene regulation remain unclear.

268 Plasmodium vivax gene regulation remains difficult to study due to the la

269 However, its role in gene regulation remains largely unresolved.

270 However, the scope of its gene regulation remains unexplored.

271 vities are integrated to achieve appropriate gene regulation, remains largely unknown.

272 Understanding genome organization and gene regulation requires insight into RNA transcription,

273 falciparum and opens up exciting avenues for gene regulation research and the development of antimala

274 Epigenetic gene regulation shapes neuronal fate in the embryonic ne

275 llows robust detection of high-quality trans-gene regulation signal.

276 etic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and d

277 ciated with altered epigenetic mechanisms of gene regulation, such as DNA methylation, histone modifi

278 dysregulation, epigenetic changes (including gene regulation), telomere length alterations, and micro

279 To provide insight into gene regulation that accompanies root growth, we generat

280 sociodemographic differences in immune-cell gene regulation that emerge by young adulthood and may h

281 e transcriptome and epigenome, two levels of gene regulation that have the potential to reflect both

282 lays important roles at almost all levels of gene regulation through interacting with RNAs, and contr

283 lso applicable to the detection of (illicit) gene regulation through the identification of catalytica

284 Pan-otic CRE drivers enable gene regulation throughout the otic placode lineage, com

285 applies a probabilistic epigenetic model of gene regulation to a single-cell RNA-seq tissue atlas to

286 and synaptic inputs to the nucleus, enabling gene regulation to be tailored to the type of depolarizi

287 nment can also be needed for estrogen-driven gene regulation to occur.

288 Changes in gene regulation underlie much of phenotypic evolution(1)

289 rected by transcription factors is a primary gene regulation underlying most aspects of the biology o

290 esent additional evidence for miRNA-mediated gene regulation via 5' UTR binding, and raise the possib

291 Gene regulation was observed at lower DNA and protein co

292 ubiquitination of DNA-bound proteins and in gene regulation, we analyzed their subcellular locations

293 Strategies combining biochemical analysis of gene regulation, WGS analysis of the noncoding genome, a

294 ntial to various cellular processes, notably gene regulation, while architecture related alterations,

295 circuits, expanding the current toolkit for gene regulation with broad potential applications.

296 stablish a theoretical framework by coupling gene regulation with metabolic pathways.

297 tin interactions underlie several aspects of gene regulation, with transposable elements and disease-

298 plays a pivotal role in sulfotransferase 1E1 gene regulation within mouse liver.

299 for understanding cellular heterogeneity and gene regulation, yet current approaches suffer from low

300 oral control of 3D genome is fundamental for gene regulation, yet it remains challenging to profile h