ライフサイエンスコーパス: gene structure

1 organization of the proposed 8-intron/9-exon gene structure.

2 in origination with a stepwise formation of gene structure.

3 ing of the evolution of gene copy number and gene structure.

4 ds for genomic coordinates, nomenclature and gene structure.

5 ciate the increasing complexity of mammalian gene structure.

6 esigning and testing potential indicators of gene structure.

7 ron-exon structure, and combines them into a gene structure.

8 ge groups (chromosomes) and determination of gene structure.

9 substrate specificity, tissue expression and gene structure.

10 options and graphic representation of fusion gene structure.

11 d directly sequenced, confirming the genomic gene structure.

12 erver to enhance the analysis and display of gene structure.

13 trategies by identifying genes and improving gene structure.

14 cies to accurately document the evolution of gene structure.

15 still unclear why cells utilize this unusual gene structure.

16 gene events that did not dramatically alter gene structure.

17 ouse CD30 represents the ancestral mammalian gene structure.

18 and categorize binding sites with respect to gene structure.

19 es which are predicted with exactly the same gene structure.

20 and how these combined factors contribute to gene structure.

21 ted with a loss of similarity in intron/exon gene structure.

22 ects that vary by their location relative to gene structure.

23 and to create a mouse with a humanized fpgs gene structure.

24 raints and, where available, knowledge about gene structure.

25 litate rapid visualization and assignment of gene structures.

26 typically biased toward known and predicted gene structures.

27 l in the context of genomic features such as gene structures.

28 e testing on two fungi with vastly different gene structures.

29 e and branchpoint site, confirming predicted gene structures.

30 rkov models to ensure the reliability of the gene structures.

31 ces by sequencing RT-PCR products to confirm gene structures.

32 of splice variants or updates to another 19 gene structures.

33 nd analyzed relative to predicted Drosophila gene structures.

34 ough overlapping sequences to yield accurate gene structures.

35 ne and are biased toward known and predicted gene structures.

36 scripts or counting reads that overlap known gene structures.

37 sequences that lead to the formation of new gene structures.

38 rms iterative training and generates initial gene structures.

39 of alternative splicing in generating novel gene structures.

40 hese, 192 in G089 and 106 in PC346C affected gene structures.

41 support that plant genomes have very complex gene structures.

42 e, GSDraw, for drawing schematic diagrams of gene structures.

43 der to confirm their existence and predicted gene structures, a high-throughput method of rapid ampli

44 of other Drosophila species and have similar gene structure across species despite low levels of sequ

45 t new genes arise by duplication of existing gene structures, after which relaxed selection on the ne

46 The gene structures agreed partially but not completely with

47 similarities among all three FXR proteins in gene structure, amino acid sequence, expression pattern

48 Phylogenetics, synteny and gene structure analyses of H3.3 genes from 32 metazoan g

49 Gene structure analyses revealed that these SPIs contain

50 tion with protein structural predictions and gene-structure analyses on a whole-genome scale to find

51 Together, phylogenetics and gene structure analysis suggests a parsimonious path for

52 ino acid sequence, 3-D protein modeling, and gene structure analysis.

53 s from a genomic database, (ii) characterize gene structure and (iii) perform phylogenetic analysis.

54 increasingly accessible method for studying gene structure and activity on a genome-wide scale.

55 Dramatic changes to NPIP gene structure and altered tissue expression preceded ma

56 mapped more than 120 million reads to define gene structure and alternative splicing events and to qu

57 is study also illustrates how differences in gene structure and alternative splicing present unique p

58 rected acyclic graph (DAG) representation of gene structure and alternative splicing.

59 prehensive, high-quality annotation of their gene structure and boundaries, which is currently lackin

60 has been studied in yeast, the complexity of gene structure and cellular function in metazoan cells h

61 8 subgroups, which was further supported by gene structure and conserved motif analyses.

62 hromosome location, gene duplication status, gene structure and conserved motif analysis, as well as

63 he plant research community for the study of gene structure and evolution.

64 kes another step closer to understanding EBV gene structure and expression and paves a new path for a

65 e nervous system of vertebrates, the galanin gene structure and expression and the consequences of ga

66 ification complexes in regulating heat shock gene structure and expression in Saccharomyces cerevisia

67 In the present study, the gene structure and expression of KSHV ORF56 (primase), O

68 n An. gambiae have considerable variation in gene structure and expression patterns.

69 amongst other approaches, investigations of gene structure and expression, the role of astrocytes an

70 uropeptides display a marked conservation in gene structure and expression, yet diversity in the gene

71 En masse analysis of gene structure and function by array technologies will h

72 -forming oligonucleotides (TFOs) to modulate gene structure and function has potential as an approach

73 r understanding of the relationships between gene structure and function in Candida albicans.

74 Thus, the hIL10BAC mouse is a model of human gene structure and function revealing tissue-specific re

75 es us with a powerful tool for investigating gene structure and function.

76 nsfer, trans-splicing, and simplification of gene structure and gene content that parallel simplifica

77 ineages, in striking contrast to patterns of gene structure and genome organization, there appears to

78 cific issues such as determination of normal gene structure and identification of abnormal genome str

79 We investigated the gene structure and organization and demonstrated, for th

80 oad applications for analyzing and modifying gene structure and organization of complex genomes.

81 markers and a general lack of information on gene structure and organization.

82 Studies of the gene structure and overlap pattern showed that only a sm

83 pose of this study was thus to elucidate the gene structure and pattern of expression, providing info

84 luding changes in gene content, codon usage, gene structure and post-transcriptional modifications su

85 The gene structure and predicted amino acid sequence of chkI

86 udoobscura and D. virilis and compared their gene structure and predicted amino acid sequences with P

87 The gene structure and primary sequence of prepro-osteocalci

88 Gene structure and protein characteristics show that SCP

89 been identified that extend the known Nanog gene structure and protein coding capacity.

90 The conserved gene structure and protein sequences suggest that the ho

91 ne promoters from ChIP-seq to explore lncRNA gene structure and regulation, as well as lncRNA transcr

92 To understand their gene structure and regulation, we screened a genomic lib

93 t can be divided into four clusters based on gene structure and sequence homology.

94 ThSOS1 shares gene structure and sequence with A. thaliana SOS1 includ

95 compact genome shows conserved gene content, gene structure and synteny in relation to the human and

96 collect a variety of types of evidence about gene structure and synthesize the results, which can the

97 of this study was to characterize the wit3.0 gene structure and the function of its deduced peptide.

98 We clarify gene structure and the murine coding sequence, and we de

99 The conserved gene structure and the similarity in postnatal expressio

100 Here we report the gene structure and transcription regulation of the human

101 ow report work clarifying details of NRXN3's gene structure and variants and documenting association

102 genes coexpressed with their genes, and (6) gene structure and whether genetic mutants exist in thei

103 han 6000 gene annotations including 80 novel gene structures and about 500 translational start sites.

104 Our EST-Genome-Browser can display annotated gene structures and cDNA-genome alignments at scales fro

105 ics statistics in small genomic windows with gene structures and chromatin states yields a rich, high

106 The phylogenetic tree, gene structures and conserved motifs of the correspondin

107 hich contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in

108 locally or on a remote HPC cluster), predict gene structures and gene structure quality, and display

109 s possess unusual features in their inferred gene structures and genome organization.

110 oes not depend on any existing annotation of gene structures and is capable of finding novel splice j

111 rate estimates for gene expression, complete gene structures and new transcript isoforms, as well as

112 ded new insights into the characteristics of gene structures and promoters within this major crop spe

113 ra and Drosophila virilis and compared their gene structures and protein sequences with the rest of t

114 Annotations of gene structures and regulatory elements can inform genom

115 MGI predicts homologies, displays gene structures and supporting information for annotated

116 In this work, we examine gene structures and their relation to the number of tiss

117 ving genome annotation, determining accurate gene structures and their variations, and exploring impo

118 sent novel algorithms, specific to bacterial gene structures and transcriptomes, for analysis of bact

119 resent new algorithms, specific to bacterial gene structures and transcriptomes, for analysis of RNA-

120 erformed forward simulations under realistic gene-structure and selection scenarios to investigate wh

121 Many genes' structures and expression are altered directly by

122 lleles is often laborious, limited by target gene structure, and at times, prone to incomplete condit

123 N sequencing platforms, correctly predicting gene structure, and capturing genes missed by other anno

124 Subsequently, we analyzed the phylogeny, gene structure, and chromosomal distribution of BAHD mem

125 ysis of its amino acid sequence, comparative gene structure, and conserved synteny, chicken DNase II

126 Numerous aspects of genomic architecture, gene structure, and developmental pathways are difficult

127 orrelate well with the nuclear architecture, gene structure, and expression observed in cells, sugges

128 onserved between human and mouse, its locus, gene structure, and function are preserved.

129 features of lncRNAs, including promoter and gene structure, and protein-coding potential.

130 on and dominance of new mutations, arbitrary gene structure, and user-defined recombination maps.

131 Accurate gene structure annotation is a challenging computational

132 Accurate gene structure annotation is a fundamental but somewhat

133 rovide relevant biological insights into the gene structure annotations being compared.

134 y control, and dissemination of high-quality gene structure annotations challenging.

135 -alone, third-party tool for post-processing gene structure annotations generated by external computa

136 plication for pairwise comparison of sets of gene structure annotations.

137 Furthermore, alterations in CD68 gene structure are associated with failings in mRNA spli

138 Such differences in gene structure are perceived to extend to simpler mechan

139 sEH evolution and gene structure are then discussed before human small nuc

140 ryza sativa), the exon-intron boundaries for gene structures are annotated by spliced alignment of ES

141 reas the orthologous human and mouse SULT2B1 gene structures are identical, the rat SULT2B1 gene stru

142 e annotated as "hypothetical protein," whose gene structures are predicted solely by computer algorit

143 tand the extent to which zebrafish genes and gene structures are related to orthologous human genes.

144 high-resolution map of R-loops and identify gene structure as a critical determinant of R-loop forma

145 (87.2%) but had different overall functional gene structures as revealed by two datasets of 12-day ti

146 conservation of splice-sites as a measure of gene-structure based on multiple alignments across verte

147 annotations that account for differences in gene structure between individuals or strains.

148 Our method does not insist on conserved gene structure between the two sequences, thus making it

149 ormalization obscured tile signal changes at gene structure boundaries.

150 Vega displays only manually annotated gene structures built using transcriptional evidence, wh

151 +/-10) members per genome that share a basic gene structure but show high sequence diversity, primari

152 housands of unordered scaffolds that resolve gene structures, but do not yet permit large-scale analy

153 , JustOrthologs exploits the conservation of gene structure by using the lengths of coding sequence r

154 Unique physiological, functional, and gene structure changes allow Spalax species to survive l

155 This first phylogenetically diverse study of gene structure changes offers insights into the mode and

156 ion was studied by comparing the patterns of gene structure changes, alternative splicing (AS), and c

157 ps transcript annotations onto them, detects gene-structure changes and their possible repercussions,

158 L1A gene on chromosome 15 revealed a complex gene structure comprising at least 28 exons.

159 Analyses of the mouse and rat amelogenin gene structures confirmed that exon 8 arose in a duplica

160 lows visualization of array images, signals, gene structure, conservation, and DNA sequence and motif

161 rexpression phenotype, gene interaction, and gene structure correction.

162 The accumulation of nested gene structures could not be attributed to any obvious f

163 nent of the application contains pre-defined gene structures derived from mRNA transcript sequences f

164 n the cDNA populations with about 38% of the gene structures differing from their predictions.

165 d, evaluate their genome-wide regulation and gene structure, discuss emerging evidence for their mode

166 ne structures are identical, the rat SULT2B1 gene structure diverges.

167 of these algorithms, prediction of complete gene structures, especially for alternatively spliced pr

168 The program generates accurate gene structures, even in the presence of substantial pol

169 se sequencing of the ENCODE regions to study gene structure evolution in mammalian genomes.

170 Reconstruction of parsimonious scenarios of gene structure evolution in paralogous gene families in

171 The gene structure evolution of orthologous gene groups was

172 revious studies have revealed two models for gene structure evolution through the loss of introns: RN

173 of lineage and genome size as predictors of gene structure evolution.

174 nsights into the mode and tempo of mammalian gene structure evolution.

175 It can be a valuable resource for studies of gene structure evolution.

176 Here, we describe the phylogeny, gene structure, evolutionary history, genomic organizati

177 ever, studies on how various ABC transporter gene structures evolved is still absent.

178 sms, and biological relevance with regard to gene structures, expression, and regulation.

179 iced reads, and optionally information about gene structure extracted from cDNA sequence databases.

180 sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined

181 This is an unusual gene structure for Drosophila.

182 that accurately identifies and predicts the gene structure for short peptides with one or two exons.

183 ts to accurately reconstruct the full-length gene structures for most known expressed genes.

184 signed to automate the process of predicting gene structure from multiple sources of evidence, with r

185 s have pervasive differences with respect to gene structure, function, membership in protein complexe

186 circuit design, information processing, and gene-structure-function relationships that are not appar

187 GenPlay displays tracks adapted to summarize gene structure, gene expression, repeat families, CPG is

188 f every plant gene at the level of sequence, gene structure, gene family and genome organization, whi

189 ace sequence enable the detailed analysis of gene structure, gene family organization and phylogeneti

190 at will facilitate accurate determination of gene structures, genome annotation, and exploration of t

191 embl provides an excellent means for storing gene structures, genome features, and sequence, but it d

192 M is used to find the most likely underlying gene structure given a DNA sequence.

193 e-rich-like, late-envelope protein genes) to gene structure, groupings, and chromosomal organization,

194 ue and global impact on gene composition and gene structure has not been observed for any other trans

195 dependent on the positions of R-loops within gene structures (hereafter named "genic position").

196 g the high conservation of the polyubiquitin gene structure in higher plants, the observed enhancemen

197 NDE1 has a different gene structure in human and mouse resulting in the produ

198 swer these questions, we have begun studying gene structure in nematodes related to Caenorhabditis el

199 ides valuable insights into the evolution of gene structure in plant genomes.

200 ides valuable insights into the evolution of gene structure in plant genomes.

201 and focused on the insights they provide for gene structure in the genome of this recently sequenced

202 ns, we carried out a detailed analysis of AR gene structure in the LuCaP 86.2 and CWR-R1 models of CR

203 visually appealing displays of the predicted gene structures in addition to detailed sequence alignme

204 Orthologous gene structures in eight vertebrate species were compare

205 GHMPs can be used to predict complete shared gene structures in multiple primate sequences.

206 The p53 family member p73 has a complex gene structure, including alternative promoters and alte

207 rrect gene annotations, and numerous unusual gene structures, including abundant stop-codon readthrou

208 of the human TBK1 gene (native promoter and gene structure) incorporated into the mouse genome (Tg-T

209 ison of their predicted protein features and gene structures indicated the presence of two distinct s

210 tabase; (iv) a statistical summary of global gene structure information for each species and its comp

211 : confounding of probe sequence content with gene structure (intron/exon) sequence content.

212 akpoints in genes, we identified seven human gene structures involved in signaling pathways (DEPDC4,

213 use and man, a detailed understanding of its gene structure is important for both diagnostic and stru

214 detailed statistical analysis of Arabidopsis gene structure is presented including intron and exon le

215 This unique gene structure is proposed to provide a novel mechanism

216 One hallmark of eukaryotic gene structure is the presence of introns, which are spl

217 Knowing gene structure is vital to understanding gene function,

218 Comparative analysis of gene structures is important for understanding their evo

219 However, species differences in their gene structures mean that mice do not adequately replica

220 exhibit an enhanced rate of small changes in gene structure, non-coding loci show even much larger ch

221 we suggest a new paradigm whereby the unique gene structure of a polycistronic oncomir confers an int

222 ammatory reactions we have characterized the gene structure of human cysteinyl leukotriene receptor t

223 Likewise, gene structure of mouse, chimpanzee, and human BCKD-kina

224 this paper, we present the DNA sequence and gene structure of Mus musculus RNase 6 and examine the e

225 incorporate prior knowledge by 'knowing' the gene structure of one sequence and annotating the other

226 ignature protein sequence of serpins and the gene structure of ov-serpins, with either seven or eight

227 The two-intron gene structure of the Arabidopsis WAK/WAK-Likes is gener

228 The gene structure of the C2-Idf haplotype differs substanti

229 We then determined the gene structures of more than a thousand large intergenic

230 ntion search of 39 protein features based on gene structures of multiple isoforms with different brea

231 The gene structures of the importin alphas provide insight i

232 We further characterized how the gene structures of the oncogene JAK1 and the tumor suppr

233 shown to be effective in shaping functional gene structures of the systems by statistical analyses.

234 However, the gene-structures of loci, that exhibit AD-associated chan

235 pological properties (i.e., sparsity and hub gene structure) of complex networks in the regularized f

236 perfect we demonstrate that conservation of gene structure on top of nucleotide sequence is a valuab

237 mple evolutionary mechanisms can explain var gene structuring on multiple levels and have important i

238 FttA resolves the dichotomy of a prokaryotic gene structure (operons and polarity) and eukaryotic mol

239 ches and a graphical viewer for displaying a gene structure pattern diagram linked to the resulting b

240 PD2/NRPE2, NRPE1, and AGO, were analyzed for gene structures, phylogenetic relationships, and protein

241 phila to man, suggesting that the p53 family gene structure plays an essential role in the multiple a

242 odeling of non-canonical introns can enhance gene structure prediction accuracy.

243 nd/or pipelines, or directly integrated into gene structure prediction software implementations.

244 implementations will aid sequence alignment, gene structure prediction, HMM profile training, nanopor

245 s feature allows use of non-cognate ESTs for gene structure prediction, including ESTs derived from d

246 rmatics research such as sequence alignment, gene structure prediction, motif identification, protein

247 ez Gene ID, GO terms, InterPro descriptions, gene structure, protein length, transcript count, and ex

248 ted by the conservation and variation in the gene structure, protein properties, motif patterns, and/

249 atin immunoprecipitation, promoter function, gene structure, pseudogenes, non-protein-coding RNAs, tr

250 te HPC cluster), predict gene structures and gene structure quality, and display output in a public o

251 of AS isoforms, nonsynonymous mutations, and gene structure rearrangements in the wheat lineage, like

252 In wheat, 35% of these gene structure rearrangements resulted in frame-shift mu

253 We describe the gene structure, regulation, signal transduction.

254 y reduced in size and simplified in terms of gene structure relative to those of multicellular eukary

255 e a novel genomic annotation that highlights gene structures, repetitive elements, and chromosome-sca

256 Genome-wide annotation of gene structure requires the integration of numerous comp

257 fferent evolutionary origins, and the mosaic gene structure resulted in confounding phylogenetic sign

258 Analysis of gene structure reveals that these genes diverged prior t

259 Examination of the NKCC gene structure reveals that this dileucine motif is enco

260 CR) and direct sequencing based on predicted gene structures satisfy this need, at least for single-c

261 r, and the two genes evolved differently for gene structure, sequence, and expression pattern.

262 Based on parallels in Msh1 gene structure shared by plants and corals, and their si

263 This unique gene structure, shared by many important miRNA oncogenes

264 derscored by their linked genomic locations, gene structure, shared extracellular domain composition,

265 parative methods employing information about gene structures should be very successful in correctly p

266 In this study, we show that p53 has a gene structure similar to the p73 and p63 genes.

267 ue property of SLAM, namely that it predicts gene structures simultaneously in two organisms, is key

268 lincRNAs, 59% of them novel, with regard to gene structures, species conservation, chromatin accessi

269 Gene structure studies revealed that Cell-1, -3 and -4 a

270 Highly conserved but distinct gene structures suggest that xenopsins and ciliary opsin

271 We analyzed protein sequence, gene structure, synteny, and phylogenetics to identify G

272 of odorant receptors (Ors) with a nine-exon gene structure that have undergone a massive expansion i

273 r identifying possible functional changes in gene structure that may result from sequence variants.

274 The method also keeps 98% of RefSeq gene structures that are correctly predicted by TWINSCAN

275 important and ancient feature of eukaryotic gene structure, the existence of which has likely facili

276 coding transcripts, untranslated regions and gene structures, thus improving the existing genome anno

277 g contigs, while simultaneously allowing the gene structure to be predicted by homology.

278 ily in Arabidopsis, which is more similar in gene structure to CLV3 than the other CLE genes.

279 no reports of using genome-wide analyses of gene structure to investigate this.

280 anging from the mechanisms that generate new gene structures to the presence of new genes in differen

281 one of these tools that can predict complete gene structures together with 5' UTRs.

282 ccess a number of common genome analysis and gene structure tools, preconfigured in a self-contained

283 on for individual OGS gene models, including gene structure, transcript variants, functional descript

284 pression profiles revealed the landscapes of gene structures, untranslated regions, and splicing acti

285 thms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Geno

286 up and study the conservation of exon-intron gene structures using a graphical interface.

287 sifies the location of each peak relative to gene structure, (v) provides information such as the num

288 iants have the potential to disrupt or alter gene structure, variant interpretation efforts stand to

289 Isoprene synthase gene structure was analysed in three poplar species.

290 nduced CysLTR2 expression, the human CysLTR2 gene structure was characterized.

291 Gene structure was improved in over 13% of genes, and 65

292 coding region, a detailed analysis of LMX1B gene structure was undertaken.

293 genes are unified by sequence similarity and gene structure, we believe the Bex nomenclature should p

294 confirmed transcription at 38 loci; 33 novel gene structures were delineated by 5' and 3' RACE.

295 These results show that early eukaryotic gene structures were very complex, and that simplificati

296 e and can provide both accurate and complete gene structures when used with the correct evidence.

297 g oncogenes, mir-17-92 has an unconventional gene structure, where one primary transcript yields six

298 DB researchers can study the correlations of gene structure with the properties of the encoded three-

299 conclude that this procedure for elucidating gene structures with native cDNA sequences is cost-effec

300 the striking differences in Dscam and DSCAM gene structures with their conserved functions in molecu