ライフサイエンスコーパス: gene transfer vector

1 small packaging capacity limits its use as a gene transfer vector.

2 s to the therapeutic gene product and to the gene transfer vector.

3 dihydrofolate reductase (DHFR) gene into the gene transfer vector.

4 ment (RRE) combination for expression of the gene transfer vector.

5 of both the packaging plasmid as well as the gene transfer vector.

6 applicable adenovirus serotype for use as a gene transfer vector.

7 example of a non-subgroup C E1A- adenovirus gene transfer vector.

8 d by analyzing their properties as AAV/HBoV1 gene transfer vectors.

9 ent of antiviral therapeutics, vaccines, and gene transfer vectors.

10 d unwanted harmful immune responses to viral gene transfer vectors.

11 transfer system using modified SIN-based LV gene transfer vectors.

12 d viruses (AAVs) have proven to be effective gene transfer vectors.

13 iruses facilitated the assembly of the first gene transfer vectors.

14 ion of species B Ads as in vivo and in vitro gene transfer vectors.

15 se the delivery of pharmacological agents or gene transfer vectors.

16 the paracellular flux of dextrans as well as gene transfer vectors.

17 tantly provides avenues to improve AAV/HBoV1 gene transfer vectors.

18 ficient purification of papillomavirus-based gene transfer vectors.

19 transgenes introduced into vascular cells by gene transfer vectors.

20 results may influence the design of new HAC gene transfer vectors.

21 icable to studies of integrating viruses and gene transfer vectors.

22 nown how other rAAV serotypes perform as CNS gene transfer vectors.

23 inant role of TNF-alpha in elimination of Ad gene transfer vectors.

24 basis of the knowledge that adenovirus (Ad) gene-transfer vectors act as adjuvants in eliciting host

25 he piggyBac (PB) transposase is an efficient gene transfer vector active in a variety of cell types a

26 a replication-defective serotype 5 human Ad gene transfer vector (AdalphaV).

27 or producing high-titer papillomavirus-based gene transfer vectors (also known as pseudoviruses) in m

28 e that uses human papillomavirus (HPV)-based gene transfer vectors, also called pseudovirions (PsVs),

29 Intensive effort has been made in optimizing gene transfer vectors and methods.

30 be used to rationally improve bacteriophage gene transfer vectors and shows it may be possible to en

31 y overcome limitations associated with viral gene transfer vectors and transient nonviral gene delive

32 Recombinant adenovirus (Ad) gene transfer vectors are effective at transferring exog

33 ted to the coronary circulation, and current gene transfer vectors are ill-suited for safe and effect

34 Adenovirus (Ad) gene transfer vectors are rapidly cleared from infected

35 amples serve to highlight the power of viral gene transfer vectors as tools for understanding metabol

36 We reasoned that gene transfer vectors based on Ad2E4ORF6 would have a re

37 Gene transfer vectors based on adeno-associated virus (A

38 at72])- and full-length Tat (Tat86)-encoding gene transfer vectors based on human immunodeficiency vi

39 Gene transfer vectors based on lentiviruses can transduc

40 Gene transfer vectors based on recombinant adeno-associa

41 p fibers have become increasingly popular as gene transfer vectors because they efficiently transduce

42 ted virus (rAAV) vectors are promising human gene transfer vectors, because they mediate long-term ge

43 that the capsid proteins of adenovirus (Ad) gene transfer vectors can be genetically manipulated to

44 Adenovirus (Ad) gene transfer vectors can be used to transfer and expres

45 er gene expression, rendering it a promising gene transfer vector candidate for use in humans.

46 acellular production of papillomaviral-based gene transfer vectors carrying reporter plasmids.

47 Because the gene transfer vector commonly retains only the AAV termi

48 Gene transfer vectors containing adenovirus (Ad) serotyp

49 used a disrupted serotype 5 adenovirus (Ad) gene transfer vector coupled to a third-generation cocai

50 ion of shRNA and TuD in a single bicistronic gene transfer vector derived from Adeno-associated virus

51 omic DNA for gene transfer and of adenoviral gene transfer vectors devoid of all viral coding sequenc

52 n-defective herpes simplex virus (HSV)-1 tat gene transfer vector, dSTat, was used to transiently exp

53 administration of a replication-defective Ad gene-transfer vector encoding the Y. pestis V antigen (A

54 ivery to muscle of an adeno-associated virus gene transfer vector expressing antibodies or antibody-l

55 Next, adeno-associated virus (AAV) gene transfer vectors expressing hFIX were injected into

56 We used novel targeted viral gene transfer vectors expressing redox-sensitive GFP fus

57 tegy that used an E1(-)E3(-) adenovirus (Ad) gene-transfer vector expressing human vascular endotheli

58 These observations suggest that an Ad gene-transfer vector expressing V antigen is a candidate

59 be a good candidate for the development of a gene transfer vector for CF lung disease.

60 An ideal gene transfer vector for chronic inflammatory diseases s

61 y unique features that make it suitable as a gene transfer vector for the nervous system.

62 FV vectors are attractive gene transfer vectors for hematopoietic stem cell gene t

63 combinant adeno-associated viruses (rAAV) as gene transfer vectors for therapeutic applications.

64 rus (FV) vectors are particularly attractive gene-transfer vectors for stem-cell gene therapy because

65 replication-deficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG)

66 abbage looper Trichoplusia ni was tested for gene transfer vector function as part of a bipartite vec

67 To date, no gene transfer vector has produced prolonged gene express

68 expression in Muller cells after delivery of gene transfer vectors has remained elusive.

69 Gene-addition strategies using gene transfer vectors have been optimized over the past

70 logy and suggest strategies to enhance HBoV1 gene transfer vectors.IMPORTANCE The family of Parvoviri

71 evalence gorilla adenovirus (GAd; GC46) as a gene transfer vector in mice.

72 of vesicular stomatitis virus was used as a gene transfer vector in the dwarf surfclam, Mulinia late

73 stably integrate genetic information through gene transfer vectors in a safe, effective, and economic

74 Recent reports show that HACs are useful gene transfer vectors in expression studies and importan

75 otype 5 (Ad5) have successfully been used as gene transfer vectors in many gene therapy-based approac

76 More recently, they have been used as gene transfer vectors in mice and in human peripheral bl

77 Adenoviruses are commonly used in vitro as gene transfer vectors in multiple applications.

78 ch the lumenal barriers encountered by other gene transfer vectors in the airway, this virus may be a

79 ments to adenovirus necessary for an optimal gene transfer vector include the removal of virus gene e

80 We then present the various gene transfer vectors including plasmid, viral, and cell

81 ourage the rapid introduction of more potent gene transfer vectors into early phase trials.

82 Injection of gene transfer vectors into multiple sites in the mouse b

83 h as cystic fibrosis with this type of viral gene transfer vector is limited by the requirement of ac

84 he main limitation in utilization of Ad as a gene transfer vector is the lack of specificity.

85 -like particles (VLPs), papillomavirus-based gene transfer vectors, known as pseudovirions (PsV), and

86 We have developed a lipidic gene transfer vector, LPDII, where DNA was first complex

87 This novel gene transfer vector may potentially be useful in gene t

88 Increasing the potency of gene transfer vectors may allow improvement of their the

89 mpetent mice in order to study the impact of gene transfer vectors of metabolic, developmental or env

90 , makes it a promising candidate for in vivo gene transfer vector on one hand, and for transduction o

91 8 (AAV8) is currently emerging as a powerful gene transfer vector, owing to its capability to efficie

92 ered to donor lungs in vivo using a nonviral gene-transfer vector, polyethylenimine.

93 disappointing, largely because the available gene-transfer vectors proved to be inadequate.

94 s, and with both the therapeutic and control gene transfer vectors remaining detectable at low levels

95 lonal antibodies (MAbs) with adenovirus (Ad) gene transfer vectors results in rapid, high-level antib

96 e chance of recombination between helper and gene transfer vector sequences by using the constitutive

97 istration of an adeno-associated virus (AAV) gene transfer vector significantly prevented pathology a

98 Most gene transfer vectors so far tested have not provided th

99 a single plasmid-, Tc1-like transposon-based gene transfer vector, termed the Prince Charming vector

100 a single plasmid-, Tc1-like transposon-based gene transfer vector that can be used to generate stable

101 eeping Beauty (SB) transposon is a promising gene transfer vector that integrates nonspecifically int

102 es continue to reveal great potential of new gene transfer vectors that demonstrate increased tropism

103 r the direct comparison of the efficiency of gene transfer vectors that target the liver.

104 uman samples, only one has been studied as a gene transfer vector to date.

105 development and function in vivo, we used a gene transfer vector to transiently overexpress GM-CSF i

106 of first generation (E1(-) E3(-)) Ad5-based gene transfer vectors to different hosts.

107 Using retroviral marking with two different gene transfer vectors, we compared the engraftment poten

108 human immunodeficiency virus type 1 (HIV-1) gene transfer vectors were evaluated in primary canine b

109 Adeno-associated virus (AAV) is a unique gene transfer vector which takes approximately 4 to 6 we