ライフサイエンスコーパス: general transcription factor

1 pends upon promoter recognition by the SNAPC general transcription factor.

2 nal transduction pathway, and by Mediator, a general transcription factor.

3 mode of meiotic recombination control via a general transcription factor.

4 loenzyme-associated regulatory protein and a general transcription factor.

5 etailed biochemical characterization of this general transcription factor.

6 ion complex (PIC), comprising Pol II and the general transcription factors.

7 lamina formation and nuclear import of other general transcription factors.

8 ed in DNA binding and interaction with other general transcription factors.

9 s recruited to promoters by interaction with general transcription factors.

10 roughout the genome, a hallmark attribute of general transcription factors.

11 IC), which consists of RNA polymerase II and general transcription factors.

12 ransactivators, coactivators, mediators, and general transcription factors.

13 evels of RNA polymerase II and corresponding general transcription factors.

14 tion, the latter occurring in the absence of general transcription factors.

15 order of magnitude as RNA polymerase II and general transcription factors.

16 transcriptional repression are controlled by general transcription factors.

17 have led to the current hypothesis that the general transcription factor 2 I family of genes, GTF2I

18 ses pointed to acylglycerol kinase (AGK) and general transcription factor 2-I (GTF2I) as positional a

19 ophobe: amylases 1A, 1B, and 1C; oncocytoma: general transcription factors 2H2, 2B, 2C, and 2D).

20 General transcription factor 3 (GTF3) binds specifically

21 A hallmark of general transcription factor 3 (GTF3) is the presence of

22 ast one-hybrid screen, we isolated cDNAs for general transcription factor 3 (GTF3)/muscle TFII-I repe

23 Polycomb anchoring to DNA, and implicate the general transcription factor ADF1 as a novel PRE compone

24 Thus, RapA acts as a general transcription factor and an integral component o

25 The discovery of germ cell-specific general transcription factor and coactivator variants ha

26 ivation domain is responsible for recruiting general transcription factors and coactivators to IE pro

27 ructural motifs, one of which interacts with general transcription factors and coactivators, and the

28 ate function of this network also depends on general transcription factors and cofactors that are ubi

29 For the former effects, AADs bind general transcription factors and larger coactivator com

30 ng the association of promoter DNA only with general transcription factors and not with the polymeras

31 We also found that subsets of general transcription factors and Pol II can form stable

32 (Pol II) is a complex process that requires general transcription factors and Pol II to assemble on

33 subunits and provides the binding sites for general transcription factors and Pol II.

34 wing stages: assembly of the polymerase with general transcription factors and promoter DNA in a 'clo

35 hanism through which Tax communicates to the general transcription factors and RNA polymerase II has

36 e-4 trimethylation and in the recruitment of general transcription factors and RNA polymerase II in t

37 ther Tax could function directly through the general transcription factors and RNA polymerase II or i

38 The head and middle modules interact with general transcription factors and RNA polymerase II, whe

39 on assays reconstituted with highly purified general transcription factors and RNAPII.

40 nzyme, and is in a position to interact with general transcription factors and the Mediator of transc

41 activation domain of VP16 can associate with general transcription factors and with chromatin-modifyi

42 ons reconstituted with highly purified yeast general transcription factors and, importantly, that the

43 at c-Myc binds to TFIIIB, a pol III-specific general transcription factor, and directly activates pol

44 re used to probe the presence of activators, general transcription factors, and chromatin-modifying c

45 DNA-binding proteins, chromatin regulators, general transcription factors, and elongation factors.

46 s indicates that histone acetyltransferases, general transcription factors, and Mediator subunits are

47 is of an 8 nt RNA, occurs independent of the general transcription factors, and requires under-windin

48 o reconstituted system including pol II, the general transcription factors, and TFIIS.

49 e-step model in which nucleosome remodelers, general transcription factors, and the transcriptional e

50 initiation competent form of RNA pol II and general transcription factors appeared in the daughter n

51 Why certain point mutations in a general transcription factor are associated with specifi

52 reactions reconstituted from highly purified general transcription factors are CTD-independent.

53 Although it is established that some general transcription factors are inactivated at mitosis

54 General transcription factors are required for productiv

55 RNA polymerases (or associated general transcription factors) are hypothesized to reach

56 ires that RNA polymerase II (Pol II) and the general transcription factors assemble on promoter DNA t

57 RNA polymerase II (Pol II) and its general transcription factors assemble on the promoters

58 ional activators and repressors compete with general transcription factors at each step to influence

59 or the proper assembly and activation of the general transcription factors at promoters.

60 ylation of histone H3 and recruitment of the general transcription factors at the HepG2 SNAT2 promote

61 bound to the U6 PSE can recruit the Pol III general transcription factor Bdp1 to form a stable compl

62 nucleosomes are relocated to allow sites of general transcription factor binding and transcription i

63 This stimulation of mediator, Pol II, and general transcription factor binding to promoter DNA cor

64 t bind to AR1 in gel shift experiments, this general transcription factor binds to AR1 in the presenc

65 We propose that TFE and the bacterial general transcription factor CarD, although structurally

66 cription systems reconstituted with purified general transcription factors, cofactor, RNA polymerase

67 On this basis, Mediator is identified as a general transcription factor, comparable in importance t

68 s a striking example of the repurposing of a general transcription factor complex to aid in genome de

69 site at GAL10 by Reb1p activator as well as general transcription factors (e.g., TFIID, TFIIB, and M

70 pended on cross-linking, including Mediator, general transcription factors, elongation factors, ribon

71 eral transcription factor TFIID, is the only general transcription factor encoded by an intronless ge

72 ndicate that a combinatorial regulation of a general transcription factor-encoding gene can be confer

73 The TFIIH general transcription factor facilitates transcription i

74 hows a FRAP that is 100-fold slower than the general transcription factor GFP-TFIIB.

75 We show that GENERAL TRANSCRIPTION FACTOR GROUP E6 (GTE6) regulates d

76 NRC-1, we discoverd subtle differences in a general transcription factor (GTF) binding site motif ac

77 hereas individual RNA polymerase II (pol II)-general transcription factor (GTF) complexes are unstabl

78 TFIIB is an RNA polymerase II general transcription factor (GTF) that has also been im

79 requires the coordinated action of multiple general transcription factors (GTFs) and RNA polymerase

80 ivision in two parts, one containing all the general transcription factors (GTFs) and the other pol I

81 plex (PIC) comprised of Pol II and conserved general transcription factors (GTFs) assembles and opens

82 ment of histone modification enzymes and the general transcription factors (GTFs) by activators.

83 /EBP activators, polymerase II (Pol II), and general transcription factors (GTFs) initially occurred

84 tment of chromatin remodeling activities and general transcription factors (GTFs) to promoters.

85 ion occurs through interactions of HSFs with general transcription factors (GTFs), as has been descri

86 itiation complexes (PICs), which contain the general transcription factors (GTFs), RNA polymerase II

87 ein assemblies in the nucleus, including the General Transcription Factors (GTFs), RNA polymerase II

88 The evolution of tissue-specific general transcription factors (GTFs), such as testis-spe

89 RNA, RNA polymerase II (pol II) dissociates general transcription factors (GTFs; TFIIA, TFIIB, TBP,

90 While general transcription factors have been extensively stud

91 a heteroduplex DNA template do not depend on general transcription factors; however, transcriptional

92 pen reading frame and is the only intronless general transcription factor identified so far.

93 The general transcription factor II B (TFIIB) plays a centra

94 The general transcription factor II H (TFIIH) is a major act

95 When associated with the general transcription factor II H (TFIIH) it activates R

96 ed association with the transcription factor general transcription factor II-I (TFII-I).

97 ion factors that regulate Mkx In particular, general transcription factor II-I repeat domain-containi

98 Here we report the importance of general transcription factor II-I repeat domain-containi

99 The general transcription factor IIA (TFIIA) stimulates RNA

100 In this study, we identified general transcription factor IIA gamma (TFIIA gamma) as

101 We describe a unigenic evolution analysis of general transcription factor IIB (TFIIB) - a protein tha

102 Here, we show that general transcription factor IIB (TFIIB) and cyclin-depe

103 The structure of the general transcription factor IIB (TFIIB) in a complex wi

104 The general transcription factor IIB (TFIIB) is required for

105 but enhanced the interaction of TBP with the general transcription factor IIB (TFIIB).

106 t interaction of the non-coding RNA with the general transcription factor IIB and dissociation of the

107 e cargoes include another PIC component, the general transcription factor IIB or Sua7p, which interac

108 General transcription factor IID (TFIID) is a multisubun

109 The general transcription factor IID (TFIID) plays a central

110 or 1 (TAF1) is an essential component of the general transcription factor IID (TFIID), which nucleate

111 The general transcription factor IIE (TFIIE) is essential fo

112 SNEV, and RAP74 (the largest subunit of the general transcription factor IIF).

113 the core complex of yeast RNA polymerase II general transcription factor IIH (TFIIH) by affinity pur

114 General transcription factor IIH (TFIIH) consists of nin

115 The general transcription factor IIH (TFIIH) is held at prom

116 e nucleotide polymorphism variant within the general transcription factor IIH, polypeptide 4 gene, GT

117 Of the deleted genes, general transcription factor IIi (Gtf2i) has been linked

118 alleling increased histone acetyltransferase general transcription factor IIIC subunit 4 and decrease

119 Although associated general transcription factors impart promoter specificit

120 P-dependent chromatin-remodeling factor by a general transcription factor in vivo.

121 re consistent with Mediator functioning as a general transcription factor in yeast.

122 ing to define positions of RNAP subunits and general transcription factors in an archaeal initiation

123 sed to define positions of RNAP subunits and general transcription factors in bacterial and eukaryal

124 ween E2F binding sites and binding sites for general transcription factors in both normal and tumor c

125 tional diversity of the regulon of the other general transcription factors in E. coli, the functions

126 e mechanism of transcription and the role of general transcription factors in the initiation of the p

127 specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanoso

128 By varying the concentrations of general transcription factors in the reaction mixtures,

129 cal and genetic system to study the roles of general transcription factors in transcription initiatio

130 s known about the dynamic behavior of Pol II general transcription factors in vivo.

131 However, several other general transcription factors, in particular the mediato

132 e suggests that significant changes in these general transcription factors including TFIID, BAF, and

133 pond to the binding sites of Pol II-specific general transcription factors including TFIIF, TFIIH and

134 After inactivation of several general transcription factors, including TBP, TAFs are s

135 One subset of these proteins (general transcription factors) interacts with the TBP.TA

136 cription initiation requires the assembly of general transcription factors into a pre-initiation comp

137 major reservoir of activity where P-TEFb, a general transcription factor key for RNA polymerase II e

138 A elements and directs the assembly of other general transcription factors, leading to binding of RNA

139 tion as to the structure and function of the general transcription factors, little is known about the

140 an example of how regulated activity of the general transcription factors may contribute to inducibl

141 d complexes, including chromatin remodeling, general transcription factor, mediator, and polymerase c

142 anscription requires the late recruitment of general transcription factors, mediator and Pol II not o

143 constituted from homogeneous preparations of general transcription factors, Mediator-associated Pol I

144 tep, probably associated with recruitment of general transcription factors, needed to assemble a tran

145 RfaH, a paralog of the general transcription factor NusG, is recruited to elong

146 cle-dependent kinases (CDKs) associated with general transcription factors of the promoter complex, s

147 nal directionality and selective assembly of general transcription factors on the core sense promoter

148 Families whose members comprise general transcription factor or RNA polymerase subunits

149 yeast TATA-less genes and suggest that other general transcription factors or coactivator subunits ar

150 ducer of cell differentiation, targeting the general transcription factor P-TEFb by HEXIM1/7SK may co

151 The general transcription factor P-TEFb stimulates RNA polym

152 The general transcription factor P-TEFb, a master regulator

153 may result from their dynamic control of the general transcription factor P-TEFb.

154 Thus, in an in vitro assay with general transcription factors, Pol II lacking Gdown1 dis

155 tegrating the ChEA3 libraries, we illuminate general transcription factor properties such as whether

156 ings support a model in which Pol II and the general transcription factors rapidly bind promoter-boun

157 titutively occupied by RNA polymerase II and general transcription factors regardless of p53 activity

158 pulation of the epigenetic state of AEs by a general transcription factor regulates 3D genome folding

159 TBP) and TBP-associated factors (TAFs), is a general transcription factor required for RNA polymerase

160 TFIID is a general transcription factor required for transcription

161 t whole-cell extract with TFIIH, the largest general transcription factor required for transcription

162 TATA-binding protein (TBP) is a key general transcription factor required for transcription

163 lymerase III-transcribed genes have distinct general transcription factor requirements for repression

164 mation, whereas efficient recruitment of the general transcription factors requires the TATA box.

165 h TFIIH for efficient communication with the general transcription factors/RNA polymerase II on the c

166 tivates EHV-1 promoters by interactions with general transcription factor(s).

167 CK2 phosphorylates the general transcription factor small nuclear RNA-activatin

168 scription by RNA polymerase III requires the general transcription factor SNAP(C), which binds to hum

169 enes regulated by Abf1p and those by several general transcription factors such as Mot1p and TAFs (TA

170 For instance, plant general transcription factors such as TFIIB have expande

171 ing fission yeast to study the properties of general transcription factors such as TFIIB in choosing

172 ications associated with the assembly of the general transcription factors, such as histone H3 lysine

173 Typical general transcription factors, such as TATA binding prot

174 s are believed to work in part by recruiting general transcription factors, such as TATA-binding prot

175 sis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by m

176 region and is completely dependent upon the general transcription factor TAF1 (TAF(II)250).

177 s regulate each other indirectly through the general transcription factor TAF7.

178 During this period, the general transcription factor TATA binding protein (TBP)

179 essing HRAS(V12), elevated expression of the general transcription factor TATA-box binding protein (T

180 The archaeal general transcription factors TATA-element-binding prote

181 how that CtIP and CtBP can interact with the general transcription factors, TATA binding protein and

182 ssess two TATA-binding protein homologs, the general transcription factor TBP and a related factor ca

183 ement in cells but also the occupancy of the general transcription factors TBP and TFIIB at the repor

184 ng the flanking blocks influenced binding by general transcription factors TBP and TFIIB.

185 DNA specificities and affinities for the general transcription factors TBP, TFIIA and IIB determi

186 rbors extremely divergent orthologues of the general transcription factors TBP, TFIIA, TFIIB and TFII

187 revisiae RNA polymerase II (RNAP II) and the general transcription factors TBP, TFIIB, and TFIIF on p

188 Our results suggest that CTCF, RAD21, a general transcription factor (TBP) and activating chroma

189 but require the support of only two archaeal general transcription factors, TBP (TATA-box binding pro

190 reventing archaeal TATA-box binding protein, general transcription factor TFB, and RNAP access and th

191 I-like enzyme, and its interactions with the general transcription factor TFE, as well as with the tr

192 Gtf2ird1 encodes a polypeptide related to general transcription factor TFII-I, and it is the mouse

193 uman TATA-element binding protein (TBP) with general transcription factor TFIIA and transcriptional r

194 e1-mediated (TASP1-mediated) cleavage of the general transcription factor TFIIA ensures proper coordi

195 ICP4 has a differential requirement for the general transcription factor TFIIA in vitro.

196 h the transcriptional regulator Mot1 and the general transcription factor TFIIA.

197 criptional coregulator subunits and with the general transcription factor TFIIA.

198 he N-terminal domain (NTD) of the RNA Pol II general transcription factor TFIIA.

199 terpart of the large (alpha/beta) subunit of general transcription factor TFIIA.

200 General transcription factors TFIIA, -B, -D, -E, -F, -H

201 This study shows that a general transcription factor, TFIIA gamma, facilitates o

202 x and is in competition with binding another general transcription factor, TFIIA.

203 6Me3), as well as reduced recruitment of the general transcription factor TFIIB and increased overall

204 causes abnormal interaction of TBP with the general transcription factor TFIIB and induces neurodege

205 A structure of an RNA polymerase II-general transcription factor TFIIB complex at 4.5 angstr

206 The general transcription factor TFIIB is a highly conserved

207 However, the general transcription factor TFIIB is presumed to be uni

208 The general transcription factor TFIIB is required for accur

209 The general transcription factor TFIIB plays a central role

210 The general transcription factor TFIIB plays a crucial role

211 ical probes positioned on the surface of the general transcription factor TFIIB were used to probe th

212 d, activators physically interacted with the general transcription factor TFIIB when the genes were a

213 nd TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal tr

214 ne step in disassembly is the release of the general transcription factor TFIIB, although the mechani

215 f sequence similarity with the polymerase II general transcription factor TFIIB, but it is the carbox

216 occur in the presence of an antibody to the general transcription factor TFIIB, indicating the trans

217 Here we show that the general transcription factor TFIIB, which is required fo

218 affinity RNA aptamers that bind to the yeast general transcription factor TFIIB.

219 that are resistant to DNase and exclude the general transcription factor TFIIB.

220 the IE protein physically interacts with the general transcription factor TFIIB.

221 of unknown function that interacts with the general transcription factor TFIIB.

222 Moreover, looping is dependent upon the general transcription factor TFIIB: the E62K (glutamic a

223 er-order complexes containing the additional general transcription factors TFIIB and TFIIA.

224 d archaeal Pol requires structurally related general transcription factors TFIIB, Brf1, and TFB, resp

225 iption system reconstituted with recombinant general transcription factors (TFIIB, TBP, TFIIE, TFIIF)

226 n)-associated factors that are components of general transcription factor TFIID (dTAFIIs).

227 AF(II)55) is a component of the multisubunit general transcription factor TFIID and has been shown to

228 The general transcription factor TFIID and its individual su

229 s an integral subunit of both the 15-subunit general transcription factor TFIID and the multisubunit,

230 two transcription regulatory complexes, the general transcription factor TFIID and the Spt-Ada-Gcn5

231 The general transcription factor TFIID comprises the TATA-bo

232 many chromatin remodeling complexes and the general transcription factor TFIID contain bromodomains,

233 The general transcription factor TFIID facilitates recruitme

234 hat acetyl-CoA increased the affinity of the general transcription factor TFIID for promoter DNA in a

235 a concise molecular characterization of the general transcription factor TFIID from S. cerevisiae.

236 The RNA polymerase II general transcription factor TFIID is a complex containi

237 General transcription factor TFIID is a cornerstone of R

238 General transcription factor TFIID is a key component of

239 The general transcription factor TFIID is a multisubunit com

240 The general transcription factor TFIID is composed of the TA

241 The general transcription factor TFIID is composed of the TA

242 The general transcription factor TFIID recognizes specifical

243 The general transcription factor TFIID sets the mRNA start s

244 Human TAF5, a 100-kDa subunit of general transcription factor TFIID, is an essential gene

245 TAF(II)250, the largest subunit of the general transcription factor TFIID, is expressed from th

246 n TAF(II)55 (hTAF(II)55), a component of the general transcription factor TFIID, is the only general

247 Bdf1 interacts with the general transcription factor TFIID, which might promote

248 he recruitment of the SWI/SNF complex by the general transcription factor TFIID.

249 associates with TAFII250, a component of the general transcription factor TFIID.

250 h encodes a subunit of the RNA polymerase II general transcription factor TFIID.

251 more ubiquitously expressed component of the general transcription factor TFIID.

252 14 TBP-associated factors (TAFs) to form the general transcription factor TFIID.

253 includes RNA polymerase II (Pol II) and the general transcription factors TFIID, TFIIA, TFIIB, TFIIF

254 The general transcription factor, TFIID, consists of the TAT

255 TAF(II)250, a component of the general transcription factor, TFIID, is required for the

256 Human general transcription factor TFIIE consists of two subun

257 sequences of the alpha-subunits of eucaryal general transcription factor TFIIE.

258 t 50% of Pol II is found associated with the general transcription factor TFIIF (Pol II-TFIIF), and a

259 The structure of an RNA polymerase II/general transcription factor TFIIF complex was determine

260 eveal how the Gdown1 protein antagonizes the general transcription factor TFIIF during RNAPII initiat

261 The RNA polymerase (pol) II general transcription factor TFIIF functions at several

262 ivation domain (amino acids 142-485) and the general transcription factor TFIIF.

263 tivity has been shown to be regulated by the general transcription factors TFIIF (RAP74) and TFIIB, p

264 ch constitute the TFIIK kinase subcomplex of general transcription factor TFIIH and to mutations in C

265 ody indicates that the AR interacts with the general transcription factor TFIIH in a physiological co

266 of the large subunit of RNA polymerase II by general transcription factor TFIIH is believed to be an

267 CDK7 is the kinase subunit of the general transcription factor TFIIH that phosphorylates t

268 reatly stimulates the CTD kinase activity of general transcription factor TFIIH, and subsequent CTD p

269 orted to bind to XPB, the largest subunit of general transcription factor TFIIH, and to cause degrada

270 alized with transcription sites and with the general transcription factor TFIIH, but not with the spl

271 otes is orchestrated by the core form of the general transcription factor TFIIH, containing the helic

272 General transcription factor TFIIH, previously described

273 valent modification of XPB, a subunit of the general transcription factor TFIIH.

274 viral nonstructural protein NSs and the host general transcription factor TFIIH.

275 al levels of recruitment and activity of the general transcription factor TFIIH.

276 se, and in transcription, as a module of the general transcription factor TFIIH.

277 a subunit of the RNA polymerase III-specific general transcription factor TFIIIC, comprises an N-term

278 ns (80 polypeptides): RNA polymerase II, six general transcription factors, TFIIS, the Pho4 gene acti

279 from different biological subsystems such as general transcription factors (TFs), cellular growth fac

280 The TATA-binding protein (TBP) is a critical general transcription factor that associates with the co

281 TBP) is a highly conserved RNA polymerase II general transcription factor that binds to the core prom

282 l Mfd ATPase is increasingly recognized as a general transcription factor that participates in the re

283 tivities of these promoters are dependent on general transcription factors that inhibit Pol II elonga

284 increased SNAT2 promoter association of the general transcription factors that make up the preinitia

285 prising an RNAPII-like enzyme as well as two general transcription factors, the TATA-binding protein

286 One of the general transcription factors, then, may be subject to r

287 s for the production of an active TFIIA-like general transcription factor throughout oogenesis.

288 It functions along with the cellular general transcription factors to increase the transcript

289 at integrates regulatory inputs and recruits general transcription factors to initiate transcription.

290 h stimulate binding of mediator, Pol II, and general transcription factors to promoter DNA in extract

291 S(V12) promote proliferation by upregulating general transcription factors to stimulate RNA synthesis

292 Mediator is required for recruitment of the general transcription factors to the core promoter.

293 dered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter.

294 at the enhancers but also the recruitment of general transcription factors to the promoter.

295 rogram of chromatin modifiers/remodelers and general transcription factors to the promoter.

296 atin modifiers/remodelers, coactivators, and general transcription factors to the promoters of target

297 nitiation complex by binding not only to the general transcription factors together with RNA polymera

298 Relative binding affinity for general transcription factors was measured for 12 of the

299 In contrast, Mediator and the general transcription factors were blocked during assemb

300 The c-Myc oncoprotein is a general transcription factor whose target genes dictate