ライフサイエンスコーパス: generation

1 lay between brain state physiology and spasm generation.

2 he effect on algae growth and bioelectricity generation.

3 order to ensure continuous electron current generation.

4 eal how the oxidation of BP influences power generation.

5 s and rejuvenation of the germline with each generation.

6 ormation, cell spreading, and traction-force generation.

7 sted since each is essential for SW and tone generation.

8 ased MAPK pathway activation and thromboxane generation.

9 d to keep up with the global demands of data generation.

10 ot synthetic approach for catalytic hydrogen generation.

11 ng in enhanced reactive oxygen species (ROS) generation.

12 NEP rather than ACE2 being essential for its generation.

13 ved after THC injection or in the subsequent generation.

14 anodic membrane side, is crucial for (1)O(2) generation.

15 are standardized and can be reproduced over generations.

16 y respond to elevated [CO(2) ] over multiple generations.

17 ically have short half-lives of two to three generations.

18 s expansion across a landscape over multiple generations.

19 its faithfully across mammalian somatic cell generations.

20 ansmission of nongenetic information between generations.

21 fected status of individuals across multiple generations.

22 telomere fusions, and propagate for multiple generations.

23 phenotype that tends to wane over successive generations.

24 ing TFE/c-C(3)F(6)/homologous perfluoroanion generation, (13)C/(2)H KIEs, LFERs, CF(2) transfer effic

25 y through the process of high-order harmonic generation(4-7).

26 idant drug conjugated to hydroxyl terminated generation-4 PAMAM dendrimer (D-Sino) as a potential the

27 ccumulate cultural innovations over multiple generations, a phenomenon termed 'cumulative cultural ev

28 ylethylene (DPPTPE) with high singlet-oxygen-generation ability both in dichloromethane and water.

29 e on four key affordance dimensions: benefit-generation ability, benefit-generation willingness, cost

30 nd lifestyle factors in the second and third generations accounted for all of the inter-generational

31 trials using approved drugs that target the generation (ACEIs) and actions (ARBs) of Ang II.

32 at systematic drug level monitoring of newer generation AEDs does not bring tangible benefits in the

33 Here, we show that a second-generation amino-acyl tRNA synthetase (aaRS)/tRNA(CUA) p

34 rting of adverse events, methods of sequence generation and allocation concealment.

35 g macrocyclic cores for in silico-based lead generation and also inspire the design of future macrocy

36 (Thys) are specifically damaged upon (1)O(2) generation and associate with plastoglobules (PGs).

37 The reproducible generation and characterization of attosecond waveforms

38 These findings present a strategy for the generation and control of color perception along the blu

39 based implementation is ideal for hypothesis generation and education in research and large-classroom

40 Herein, the generation and evaluation of multiple machine learning m

41 te research due to their potential for light generation and for stabilisation of their 3D counterpart

42 egalovirus-specific T cells, and through the generation and in vivo monitoring of defined TCR reperto

43 Here, we describe the generation and mapping of 55 new mutations.

44 -1) h(-1) with near-unity selectivity for CO generation and meanwhile excellent stability.

45 tion, a complicated process involving charge generation and recombination in the time domain and carr

46 n the construction of multifunctional energy generation and storage systems that can be twisted and f

47 regation of pale-green seedlings in the M(3) generation, and a subset of these was identified to be d

48 ence on "hot spots", large photothermal heat generation, and easy oxidization.

49 -activation of TCR kinases, second-messenger generation, and JAK/STAT or NFAT transcriptional respons

50 d effector generation, long-lived CD4 memory generation, and robust generation of Ab-producing B cell

51 2B6 enzyme activity, significant HMM species generation, and ubiquitination of CYP2B6 protein but did

52 ,557 human cells continuously traced over 15 generations, and use it for benchmarking phylogenetic in

53 wer Dissipation, also called Minimum Entropy Generation; and the Variational Principle.

54 Despite the development of second-generation antiandrogens, acquired resistance to hormone

55 ples was investigated for energy storage and generation applications, in which superior performance w

56 then examines some of the data-driven "next-generation" approaches that are needed for discovery and

57 life cycle greenhouse gases from electricity generation are limited in their capability to estimate e

58 ier tissues, but the cues promoting Trm cell generation are poorly understood.

59 t are designed to assist in novel hypothesis generation, as well as data management, online sharing a

60 However, many next-generation batteries are limited by electrolyte selectio

61 Puerto Rico and Hispaniola in the dozens of generations before the individuals who we analysed lived

62 stic quantum state transfer and entanglement generation between remote nodes with a high fidelity of

63 A series of first-generation bifunctional inhibitors was achieved through

64 rospects for application in medicine as next-generation biomaterials.

65 he efficacy and safety of ibrutinib, a first-generation BTK inhibitor, with zanubrutinib, a novel hig

66 the HIF1a-mediated block in oligodendrocyte generation by restoring Sox10 expression without affecti

67 germinated and were advanced up to four (M4) generations by selfing.

68 This leads to the generation (by the electron transfer reaction, not the l

69 ons adapted to replication stress, over 1000 generations, by acquiring multiple, concerted mutations.

70 l environments alter the phenotype of future generations-can influence how organisms cope with enviro

71 ly, we discuss future opportunities for next-generation cancer nanomedicines.

72 hem new requirements and challenges for next-generation cancer nanomedicines.

73 n 2016 and 2018, 6114 (40%) received a first-generation cephalosporin, 4097 (27%) received a second o

74 porin, 4097 (27%) received a second or third-generation cephalosporin, and 4971 (33%) received Broad-

75 line antibiotics, fluoroquinolones and third generation cephalosporin.

76 1000 PD increase in use of third- and fourth-generation cephalosporins or carbapenems, there was a 2.

77 uoroquinolones, and use of third- and fourth-generation cephalosporins were each associated with decr

78 n-susceptible to fluoroquinolone and any 3rd generation cephalosporins), and fluoroquinolone (FQ) and

79 red transition metal dichalcogenides as next-generation channel materials is discussed.

80 t CYP6P9a-RR genotype was observed after ten generations (chi(2) = 6.6; P = 0.01) suggesting a revers

81 ed binders were tested for function as third generation Chimeric Antigen Receptors (CAR) T cells demo

82 *CO to *CHO, a key intermediate for methane generation, compared to the competing step, C-C coupling

83 s (SWCNTs) are promising candidates for next-generation computing as a result of their superlative el

84 ronic nano-devices and applications in light generation, computing, and sensing.

85 e-driven atmospheric teleconnections on wave-generation cycles.

86 We developed acDrug PK assays for next-generation disulfide-linked ADCs involving immunoaffinit

87 ew DEL synthesis technologies to enable next-generation drug discovery.

88 ocal dynamics and inputs to cortical pattern generation during a prehension task in mice.

89 building cells from the bottom up, and next-generation educational kits.

90 gregation state has more optoacoustic signal generation efficiency than the monomer transition.

91 analogues have shown great promise for next-generation electronic materials as well as potential gam

92 echargeable lithium metal batteries are next generation energy storage devices with high energy densi

93 m climbing perch (Anabas testudineus) for 11 generations (F1-F11).

94 Early drug generations focused largely on symptom control and pain

95 then suggests two strategies to design next-generation fouling-resistant RO membranes via structural

96 Their classic generation from alkyl halides has a severe drawback due

97 fide nanoclusters that catalyse nitric oxide generation from benign sodium nitrite in the presence of

98 ve in contralateral homolog regions for verb generation (from -2.7 +/- 0.54 to -2.5 +/- 0.40; P = .90

99 However, high energy consumption of vapor generation fundamentally restricts practicality of solar

100 Herein, we report the discovery of second-generation GluN2C/D-selective NMDAR-positive allosteric

101 al properties, such as inhibition of plasmin generation, have been attributed to its main structural

102 xicity assessment and mechanistic hypothesis generation, here we present an intuitive webtool allowin

103 ce for cathode material development for next-generation high-energy, cobalt-free Li-ion batteries.

104 d analyzed the data in parallel with three 3-generation human pedigrees (26 individuals).

105 Such 'next generation' implementation includes delivery of combinat

106 ffective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocar

107 Furthermore, inhibiting force generation in cancer cells would increase the T cell act

108 ytes uncouples fatty acid oxidation from ATP generation in mitochondria and promotes energy dissipati

109 nt parental pairs, perduring for at least 10 generations in one pair.

110 hylation in selected genes, across all three generations, indicating epigenetic transfer of effects.

111 is a great need for the development of next generation instrumentation and technologies utilizing en

112 rials are serving as the precursors for next-generation interactive materials.

113 Comparative evidence generation is even sparser for medical devices.

114 Product generation is significantly faster than in traditional b

115 minary pharmacokinetic assessment of a first-generation lead 4a (A91).

116 In order to enable the next-generation lithium-metal batteries, a "fail safe" mechan

117 It stimulated effector generation, long-lived CD4 memory generation, and robust

118 to a single genomic region and, using third generation, long-read sequencing, we identified a 120 kb

119 rized Raman spectroscopy and second-harmonic generation maps of the PdSe(2) flakes.

120 served in this study offer guidance for next generation membranes for sour natural gas separation.

121 e to blood and blood culture specimens, next-generation metagenomics, and gas chromatography mass spe

122 ution environments (TEEs) offered by current-generation microprocessors-in particular, Intel's SGX.

123 terization of a series of light-driven third-generation molecular motors featuring various structural

124 test this hypothesis, we resequenced two 3-4 generation nuclear families (totaling 29 individuals) of

125 tile exsolution, crystallization, and cavity generation occur together.

126 e then assessed whether this would result in generation of "renovascular units" comprising both vesse

127 Here we detail technology for the generation of 'libraries' of clonogenic cells from 1-mm-

128 ped oxygen atom transfer approach allows the generation of 1,3-oxazoles containing a variety of sulfo

129 rge experimental data set, which enabled the generation of a large predicted lipid database with 145,

130 This was achieved by the generation of a library of Cys mutations in Env glycopro

131 in channel catfish and may contribute to the generation of a more efficient system for precise gene i

132 A mechanism involving the generation of a nitrilimine is proposed.

133 Our methodology relies on in situ generation of a uniquely reactive Bi(V) arylating agent

134 long-lived CD4 memory generation, and robust generation of Ab-producing B cells.

135 nation could be a versatile strategy for the generation of adaptive anti-tumour immune responses.

136 Intratumoral generation of ADO depends on the sequential catabolism o

137 ight absorptivity of Eosin Y for a reductive generation of alkyl radicals from N-(acyloxy)phthalimide

138 We describe here an original mode of generation of aneuploidies that could be very common in

139 n is commonly processed in the brain through generation of antagonistic responses to different wavele

140 To enable a new generation of anti-viral vaccines, we designed self-asse

141 the other hand, the method did not allow the generation of benzocyclobutene-1,2-dione from 2-diazo-1,

142 ease-of-use, and allows highly customizable generation of both daily-use and publication-quality fig

143 emia exhibited Ca(2+) overload and increased generation of both spontaneous Ca(2+) waves and delayed

144 R/Cas9 system, that subsequently allowed the generation of cKOs by local viral delivery of the Cre-re

145 This observation suggests that the generation of dG(N1-H)(.) via dG(N2-H)(.) following hydr

146 More recently, a newer generation of diagnostics with immense potential has eme

147 d neighboring mesenchymal cells underpin the generation of different pancreatic cell types.

148 nge in the expressed protein, leading to the generation of disease-related multichain PrP assemblies

149 ent F-actin cross-linking, which enables the generation of F-actin bundles required for the sustained

150 For topological reasons, this led to the generation of four defects in the resulting hexosome str

151 G quenches the fluorescence and inhibits ROS generation of G.

152 A direct path to exploit it is the generation of heat, for applications including passive b

153 led metal exchange in soft positions for the generation of heterometallic secondary building units (S

154 the molecular design guidelines for the next generation of high-performance n-type materials for ther

155 This protocol allows generation of homozygous mutant cell lines using an inse

156 in-protein clusters in ProtCID, enabling the generation of hypotheses on the structures of biological

157 cleoprotein (NP) alone is sufficient for the generation of IBs, indicating that it plays an important

158 Our work paves the way to the next generation of integrated exciton optoelectronic nano-dev

159 Cell crawling requires the generation of intracellular forces by the cytoskeleton a

160 wo-phase process by which antigen drives the generation of long-lived plasma cells and memory B cells

161 The generation of MAR-ASD-specific epitope autoantibodies in

162 hile seaweed and shrimp by-product mitigated generation of MDA and HHE in herring PI.

163 t to local tissue deformation leading to the generation of mechanical forces and the deformation of t

164 f the germinal center reaction, limiting the generation of memory B cell and long-lived plasma cell r

165 standing of the microcircuits supporting the generation of memory-related network dynamics.SIGNIFICAN

166 ission peaks from 670 nm to 720 nm, the next generation of miRFPs should become versatile NIR probes

167 ms have fueled hopes to bring about the next generation of more physiologically relevant high-through

168 f three-dimensional (3D) growth, enabled the generation of morphological diversity on land.

169 cation of vascular endothelial cells and the generation of multilineage HSPCs from hemogenic endothel

170 DeGeRing might facilitate the generation of mutant DNA sequences for protein engineeri

171 chanotransduction links diastolic stretch to generation of NADPH oxidase 2 (NOX2)-dependent reactive

172 enetically engineer high HbF include de novo generation of naturally occurring hereditary persistence

173 e loss of ventral identity, resulting in the generation of neurons with the characteristics of dorsal

174 uses (swIAVs) can play a crucial role in the generation of new human pandemic viruses.

175 t-driven cobalt catalysis, which enables the generation of nucleophilic radicals through strain relea

176 ee perovskites novel candidates for the next generation of optoelectronics.

177 In parallel, periodontitis results in generation of oral pathobiont-reactive Th17 cells in the

178 Excessive generation of oxidants by immune cells results in acute

179 Generation of pDCs from bone marrow dendritic cell (DC)

180 This confirmed that OTX2 is required for the generation of photoreceptors, but also for repression of

181 oiety (R = Me, i-Pr) was used to control the generation of planar chirality by lithiation, with the a

182 stand its effect on megakaryopoiesis and the generation of PLPs.

183 ion and control, paving the way for the next generation of POC immunodiagnostics.

184 es nanodisplay of diverse symmetries towards generation of potent vaccines.

185 re on thermal stability of sucralose and the generation of potentially toxic compounds was assessed a

186 hosphates provides multiple pathways for the generation of reactive intermediates, including mixed ca

187 by apoptosis, mitochondrial depolarization, generation of reactive oxygen species, and PARP cleavage

188 ts glyceraldehyde kinase activity and in the generation of riboflavin cyclic 4',5'-phosphate (cyclic

189 density functional theory to reveal how the generation of S-vacancies within MoS(2) nanoparticles an

190 ies and training programs must support a new generation of scientists and clinicians who work in mult

191 ue and long-term societal impact of the next generation of sensor network applications.

192 consumption and small footprint for the next generation of Si-based on-chip optical interconnects.

193 Furthermore, generation of store-operated interactions between PIP(2)

194 The generation of synthesis gas (hydrogen and carbon monoxid

195 es, 65-94% yield) could be achieved with the generation of synthetically important beta-aryl ketone i

196 The continuous generation of the 7-amino-4-methylcoumarin (AMC) from su

197 sion of a 14-alkoxy radical with concomitant generation of the C8-C13 bond.

198 phosphorylation step, resulting in the rapid generation of the more active phosphorylated conformer.

199 -17-producing T(H)17 cells but increased the generation of those producing GM-CSF.

200 We validate this technology with the rapid generation of three BCR KI lines expressing native human

201 structural data retrieving, and the pioneer generation of true hsTYR inhibitors.

202 uncover the in vivo mechanisms allowing the generation of two opposing apical epithelial surfaces wi

203 is work establishes a clear path to the next generation of two-step VT complexes through incorporatio

204 we demonstrate its feasibility for the next generation of ultra-high-field (UHF) HTS NMR magnets.

205 d d-sulfono-gamma-AApeptides represent a new generation of unnatural helical peptidomimetics, which h

206 n from promoter sequences would enable rapid generation of useful promoters and facilitate synthetic

207 wth of virus stocks for research and for the generation of vaccines.

208 We report the successful generation of various structured light beams including h

209 h myeloid-restricted ZIKV that precluded the generation of viremia and viral dissemination to periphe

210 Third, I describe the next generation of work on gene x environment interaction, wi

211 t of progeny survival when three consecutive generations of animals are exposed to P. vranovensis.

212 lerance and transplant immunology represents generations of scientific inquiry guided by careful obse

213 nsional heterostructures are central to next-generation optical, electronic, and quantum information

214 al optoacoustic tomography (eMSOT) as a next-generation optoacoustic method to impart high accuracy i

215 trol the electronic properties of these next generation organic materials.

216 itage is fundamental for conveying to future generations our culture, traditions, and ways of thinkin

217 of mosquitoes carrying the drive within 5-11 generations over a range of initial release ratios.

218 r an order of magnitude enhancement of power generation (P(gen) ~ 1.25 muWcm(-2)) in our thermo-photo

219 colytic PVs, including development of second-generation parvoviruses with enhanced oncolytic and immu

220 iven particle acceleration, attosecond pulse generation, plasma photonics, high-field physics and lab

221 1 or IL-1beta pathway attenuated platelet EV generation, prevented platelet-neutrophil aggregation, a

222 o be broadly useful for a variety of library generation problems, ranging from protein engineering at

223 electro-optic modulation via a sum-frequency-generation process in high quality factor (Q) whispering

224 pathway genes and those required for energy generation processes, such as oxidative phosphorylation

225 pulations that increased mitochondrial redox generation promoted proline biosynthesis, while reducing

226 ,282 mother-child pairs participating in the Generation R Study, a population-based birth cohort in R

227 irical blood perfusion rates, metabolic heat generation rates reached as high as 2.0E04 W/m(3) for no

228 s reinforced the need for continued evidence generation regarding typhoid epidemiology and TCV impact

229 allows for the target recognition and signal generation regions to be designed independently.

230 e-transition alloys can excel at hot-carrier generation reveals a new material platform for near-infr

231 n adolescent/young adult males, we used next-generation RNA sequencing to investigate the gene expres

232 Higher-affinity next-generation ROS1 TKIs developed to have improved intracra

233 a new means of targeted attenuation for next-generation rotavirus vaccine design.

234 al O(3) chemistry, particularly with the new-generation satellite instruments that offer finer spatia

235 an application and running example, password generation schemas are humanly computable algorithms bas

236 using modified ITT was 70% according to next-generation sequencing (<10-5 sensitivity).

237 tive genomic hybridization and targeted next generation sequencing (48-gene panel).

238 romatin immunoprecipitation followed by next-generation sequencing (ChIP-seq) was used to assess a ra

239 While next-generation sequencing (NGS) has dramatically increased t

240 Next-generation sequencing (NGS) identified the best discrimi

241 sition of T cell receptors (TCRs) using next-generation sequencing (NGS) in neonates, infants, and ch

242 ined by the Hybridization capture-based next-generation sequencing (NGS) platform.

243 can be corrected by the high-quality second-generation sequencing (SGS) short reads, which is referr

244 The error-prone third-generation sequencing (TGS) long reads can be corrected

245 c treatments are lacking.METHODSWe used next-generation sequencing and array-based DNA methylation pr

246 Next-generation sequencing and bioinformatics analysis in the

247 The TCR repertoire was analyzed by next-generation sequencing and cytokine levels were determine

248 This DNA was subjected to deep next-generation sequencing and tested against a custom panel

249 Next-generation sequencing approaches to map RNA-DNA hybrids,

250 Akt and STAT3 signaling in vitro, while next generation sequencing broadly implicates TrkB.T1 in the

251 al inference of CNVs from SNP array and next-generation sequencing data are available.

252 Modern genomic research is driven by next-generation sequencing experiments such as ChIP-seq and C

253 Here, using next-generation sequencing of near-full-length single HIV-1 g

254 Targeted next generation sequencing offers the potential for consisten

255 In two independent ongoing next-generation sequencing projects for individuals with holo

256 NV Radar, a software tool that utilizes next-generation sequencing read depth information and variant

257 ch individual DIs were identified using next-generation sequencing techniques.

258 Next-generation sequencing technologies have generated, and c

259 With the reduction in price of next-generation sequencing technologies, gene expression prof

260 ts using conventional genetic tools and next-generation sequencing technologies.

261 Thus, this study aimed to use next-generation sequencing to evaluate the subgingival microb

262 We used next-generation sequencing to study 214 patients with SMM.

263 in 4,649 patients and 4,982 controls by next generation sequencing using molecular inversion probes t

264 Serologic testing, contact-tracing, and next-generation sequencing were used to identify ANDV infecti

265 ry and IgA repertoire was determined by next-generation sequencing.

266 A second-generation series improved on affinity by incorporating

267 excluded owing to their weak second harmonic generation (SHG) response.

268 The feature of 24-h electricity generation shows great potential energy applications of

269 based diagnostics, high-affinity DNA aptamer generation, site-specific labeling of RNAs, semi-synthet

270 on assay with surface-specific sum-frequency generation spectroscopy.

271 ponses change as a function of the number of generations spent in contact with humans under 3 differe

272 rstand the physical mechanisms of earthquake generation, subduction zones worldwide are continuously

273 e from moderate-intensity resistance took 15 generations, supporting at least 2-years interval is nee

274 clude, an outlook on the development of next-generation TE materials in line with these thermodynamic

275 The potential for next-generation technologies to address the current limitatio

276 rimary fibroblasts from DC patients and late generation telomerase knockout mice display lower nicoti

277 We show that kynurenine generation through IDO is markedly induced after MI in m

278 ut with the decisive asset of a much shorter generation time (1.5 months).

279 d up to 50 years and increased with species' generation time.

280 Shorter generation times and lower asymptotic body mass were sel

281 f bacterial physiological state and possible generation times during latent TB infection in humans.

282 roduce TKI resistance, and second- and third-generation TKIs largely mitigate this problem.

283 The anniversary provides a chance for a new generation to take a look back, to see how science has a

284 precursors for homolytic on-protein radical generation; to study enzyme function with natural, unnat

285 tomography and IOP was estimated by the new-generation tonometer Corvis ST.

286 ined time-resolved vibrational sum frequency generation (TR-vSFG) spectroscopy with ab initio DFT-bas

287 est that incorporating such theory into next-generation trait-based terrestrial biosphere models woul

288 carbon sink and should be considered in next-generation vegetation models, particularly in the contex

289 and results as a calibration target for next-generation vegetation models.

290 We present a new strategy for silyl radical generation via electroreduction of readily available chl

291 lifespan and may even be transmitted across generations via epigenetic germline inheritance.

292 Here, we have developed next-generation viscosifiers-organically modified magnesium s

293 Vibrational sum frequency generation (vSFG) measurements performed in the OH stret

294 nderstanding and guide the discovery of next-generation water harvesting materials.

295 ystems and multimaterial assemblies for next generation wearable devices and robotics.

296 d computational design algorithm is molecule generation, where the machine is required to design high

297 hyrins showed decent in vitro singlet oxygen generation, which was supported by the intracellular DCF

298 ensions: benefit-generation ability, benefit-generation willingness, cost-infliction ability, and cos

299 Rationale: Aerosol generation with modes of oxygen therapy such as high-flo

300 ontransitive evolutionary sequence in a 1000-generation yeast evolution experiment.