ライフサイエンスコーパス: genetic background

1 neuronal and functional deficits on a human genetic background.

2 s such as age, comorbidities, exposures, and genetic background.

3 outer segments when bred into a GCAPs (-/-) genetic background.

4 due, at least in part, to subtle effects of genetic background.

5 ifestyle, but also reflecting differences in genetic background.

6 trains confirmed the recipient mitochondrial genetic background.

7 ized muMT recipients of MD4 B2 cells on each genetic background.

8 sex distorter I-PpoI into the A. arabiensis genetic background.

9 ent human pathogens under the bovine-adapted genetic background.

10 eprints" of neurons that, in part, relate to genetic background.

11 neurologic phenotypes that are sensitive to genetic background.

12 l to clinical symptom levels share a similar genetic background.

13 of a given mutation can be influenced by the genetic background.

14 function pathologies or have a heterogeneous genetic background.

15 mplex disease subtypes influenced by sex and genetic background.

16 rent neurological outcomes depending on host genetic background.

17 served retained universality with respect to genetic background.

18 acy in mice expressing SOD1(G93A) on a mixed genetic background.

19 DiCre-expressing P. falciparum lines in any genetic background.

20 ferential effect on the 2 sexes, acting on a genetic background.

21 ietary factors are acting upon a preexisting genetic background.

22 that the extent of protection may depend on genetic background.

23 anner, and its function is dependent on host genetic background.

24 a would show adaptation to a particular host genetic background.

25 otypic features in Scn2a(Q54) mice depend on genetic background.

26 dontitis in young patients with predisposing genetic background.

27 rol of effects from other covariates such as genetic background.

28 sorder (MDD) have high morbidity and share a genetic background.

29 es embryonic lethality in mice with a hybrid genetic background.

30 some test parameters dependent on gender and genetic background.

31 largely by the number of founders and their genetic background.

32 -like disease in mice with an IL-6-deficient genetic background.

33 tially affect bacterial fitness depending on genetic background.

34 ities, whereas LV progression is modified by genetic background.

35 ncerous, and metastatic cells, with the same genetic background.

36 alleles and expressing them in a common null genetic background.

37 y affected than null homozygotes on the same genetic background.

38 nd highlight the significant contribution of genetic background.

39 ubject to epistatic influences of the global genetic background.

40 n fail upon change in the environment or the genetic background.

41 ypes are more likely to co-occur on the same genetic background.

42 patients with or without knowledge of their genetic background.

43 nly about 20% despite their shared identical genetic background.

44 ongly depend on the particular cell line and genetic background.

45 erferon signaling depend on cell type and/or genetic background.

46 cient strains; however, it is lethal in this genetic background.

47 atric disorders that account for a patient's genetic background.

48 availability and are restricted to a single genetic background.

49 brain, independently from the APOE4 or APOE3 genetic background.

50 cell environment, which depends on the host genetic background.

51 op Saccharum is available due to its complex genetic background.

52 GRN and other dementia mutations on diverse genetic backgrounds.

53 election after validating them in additional genetic backgrounds.

54 vestigial resonator morphology under varied genetic backgrounds.

55 under multiple environmental conditions and genetic backgrounds.

56 misplacement of the division site in certain genetic backgrounds.

57 Kentucky ST198 displayed MDR and virulent genetic backgrounds.

58 the ancestral populations that make up their genetic backgrounds.

59 predispositions can improve learning across genetic backgrounds.

60 A, obviating confounding effects of variable genetic backgrounds.

61 nhancer loss on gene expression in different genetic backgrounds.

62 in multiple SqCLC models with diverse cancer genetic backgrounds.

63 a-prone transgenic progeny across seventy CC genetic backgrounds.

64 mutations arising independently in distinct genetic backgrounds.

65 ill even highly resistant B-ALL with diverse genetic backgrounds.

66 o act on genes that have evolved in multiple genetic backgrounds.

67 he phenotypic outcomes in various sensitized genetic backgrounds.

68 across diverse environmental conditions and genetic backgrounds.

69 ermination in both early- and late-flowering genetic backgrounds.

70 observed even among patients from different genetic backgrounds.

71 mouse strains and mutations placed on inbred genetic backgrounds.

72 ows the apomictic allele to spread onto many genetic backgrounds.

73 ould be selected in individuals with diverse genetic backgrounds.

74 TC phenotype of lpa1 common beans with three genetic backgrounds.

75 substitutions on specificity in hundreds of genetic backgrounds.

76 phylogeny, suggesting they belong to various genetic backgrounds.

77 nserved insertion hotspots between different genetic backgrounds.

78 panded via soft selective sweeps on multiple genetic backgrounds.

79 has not been rigorously tested in different genetic backgrounds.

80 cise isogenic comparisons of variants across genetic backgrounds.

81 ighly variant C57BL/6J (B6) and PWD/Ph (PWD) genetic backgrounds.

82 tic patient-derived virus in mice of diverse genetic backgrounds.

83 change as little as possible across adjacent genetic backgrounds.

84 pression stability of the 5A2 QTL in various genetic backgrounds.

85 ffects on viral fitness depend on the entire genetic background, a phenomenon called 'epistasis'.

86 dual lines, and utilise heterogeneity in the genetic background across individuals to map hundreds of

87 how that both pneumococcal serotype and host genetic background affect the development of disease and

88 Host genetic background affects red blood cell structure, for

89 atocyte-like cells, with a given or modified genetic background, allows investigators to use previous

90 works whose structure and function vary with genetic background and argue that these effects can be e

91 e of NFS2 in symbiosis is contingent on host genetic background and can be counteracted by other gene

92 rd chemotherapy, the predictive value of the genetic background and co-occurring mutations remains to

93 change after transmission to this different genetic background and concerns that this could lead to

94 Nanophthalmos has a significant genetic background and disease-causing mutations have be

95 respect to geographical point of isolation, genetic background and drug resistance, the patterns for

96 n evolutionary process that is influenced by genetic background and environment.

97 t in the context of identical constitutional genetic background and environmental exposure, different

98 th small effects that can be overshadowed by genetic background and environmental variation.

99 However, tradeoffs depend on genetic background and evolutionary history and can them

100 ssentiality of a gene can depend on both the genetic background and growth condition.

101 population of parasites (1-30%, depending on genetic background and growth conditions).

102 individual ATP7A/B mutations in an invariant genetic background and has the potential to be used to s

103 ription factors (TFs) is highly dependent on genetic background and interactions with cofactors.

104 ce its generation time is brief and both the genetic background and rearing environment can be precis

105 ighly heterogeneous disease both in terms of genetic background and response to chemotherapy.

106 Understanding the genetic background and risk of early-onset is suggestive

107 ies suggest that patients with a susceptible genetic background and some stimulus, such as barrier di

108 ditional gene ablation while controlling for genetic background and tamoxifen effects.

109 ries substantially depending on the specific genetic background and that this idiosyncrasy in epistas

110 ttle systematic analysis to understand their genetic background and the potential impacts on the drug

111 ive influences of environmental temperature, genetic background and their interaction on first-year d

112 e, especially those relevant to selection of genetic background and those that might inadvertently be

113 non-edited cells without the interference of genetic background and thus could detect potential off-t

114 mice up to 2 years of age in three different genetic backgrounds and characterized them with respect

115 xity of HTS-induced responses over different genetic backgrounds and connectivity of adaptive mechani

116 sts that there is an interaction between SCZ genetic backgrounds and environmental risk factors.

117 Phenotypes are rarely consistent across genetic backgrounds and environments, but instead vary i

118 t bacterial population structure streamlined genetic backgrounds and established cross schemes to add

119 eatures and allows the analysis of different genetic backgrounds and mutations during the course of t

120 ichia coli as a model bacterium, we examined genetic backgrounds and plasmid profiles of generic feca

121 ion was maintained across a range of diverse genetic backgrounds and shows the importance of leaf mor

122 (Oryza sativa) were assembled into the same genetic background, and 16 homozygous lines selected as

123 ween traits can change with the environment, genetic background, and cell-cycle position.

124 f the effect depended strongly both on plant genetic background, and complexity of the bioassay envir

125 ot be reliably inferred by studying a single genetic background, and thus constitute a major challeng

126 without macrocephaly and with heterogeneous genetic backgrounds, and 6 typically developing control

127 taxin enhances exocytosis in a wide range of genetic backgrounds, and may provide a general means to

128 oughout multiple time points, using multiple genetic backgrounds, and multiple omics approaches (tran

129 C57BL/6J, CD-1, FVB/NCr1, and 129S2/SvPasCrl genetic backgrounds, and of two additional alleles, HttQ

130 al gene expression during disease on the two genetic backgrounds, and that disease diverges by 4 week

131 blast patterning was observed across diverse genetic backgrounds, and the analysis of genetic pattern

132 ver, many questions remain: which tumors and genetic backgrounds are the most sensitive to autophagy

133 e pairs are more likely to occur on the same genetic background as a results of serotype switching, b

134 d generating the pss1 mutation in the pen1-1 genetic background as well as genetic mapping and charac

135 res TORC1 signaling, and is modulated by the genetic background as well as the vehicle used to delive

136 on, which is, in turn, lower in Al-sensitive genetic backgrounds as a result of lower TF expression a

137 ce pathogenesis when introduced into a clean genetic background, as well as a novel activating mutati

138 nt on growth and photosynthesis in different genetic backgrounds at multiple pH values.

139 strophin-deficient mdx mouse on the C57BL/10 genetic background (B10.mdx) is mildly affected, a more

140 Genome-wide association studies identify the genetic background behind a trait by examining associati

141 with antimicrobial resistance identified the genetic background behind rRNA gene mutations causing va

142 separately and jointly, and by comparing the genetic background between them in a total sample of 17,

143 Exploitation of differential p53 genetic backgrounds between human hematopoietic and colo

144 species with populations that share a common genetic background but blood feed in one region and are

145 f function of a gene causes lethality in one genetic background but not another.

146 Mice with identical genetic backgrounds but distinct microbiomes were obtain

147 ourette syndrome (TS) has a well-established genetic background, but its genetic architecture remains

148 iota composition of the recipients and their genetic background, but none of the differences found in

149 These lines share the same genetic background, but show variation in heritable patt

150 rom three experiment groups sharing the same genetic background, but showing highly-divergent growth

151 , we address the importance of the metabolic-genetic background by monitoring transcriptome, proteome

152 argeting of VHL-deficient CC-RCC in multiple genetic backgrounds by clonogenic assays.

153 enic mouse models (FAD) on an APOE4 or APOE3 genetic background, by positron emission tomography and

154 equent in Latino population, suggesting that genetic background can alter its effects on phenotype.

155 Intriguingly, some D. melanogaster nuclear genetic backgrounds can fully rescue COII(G177S) -associ

156 ons were introduced into an oxidative stress genetic background (cat2), the dhar1 dhar2 combination d

157 cy virus (HIV), the relative contribution of genetic background, clinical risk factors, and antiretro

158 Cs from monozygotic twins to investigate how genetic background, clone, and passage number contribute

159 s in the crt gene, which arose on a specific genetic background comprising multiple genomic regions.

160 While the parasite genetic background consistently impacts most of these pa

161 While in the DeltaveA genetic background cpsA deletion restores ST production,

162 the mdx mutation is crossed onto the DBA/2J genetic background (D2.mdx).

163 Thus EGR1, in a genetic background-dependent manner, plays a critical ro

164 e numbers of measurements, such as different genetic backgrounds, disease states and drug perturbatio

165 ns carrying single PWD chromosomes on the B6 genetic background displayed reduced adenoma numbers.

166 number of cigarettes per day has a specific genetic background distinct from those of the other thre

167 In an outbred genetic background, Dnaaf2 homozygotes die after birth a

168 alone and this activation occurs in various genetic backgrounds during spaceflight exposures of week

169 g Tn mutant libraries generated in different genetic backgrounds (e.g. wild-type strain versus knocko

170 texts (e.g., across diverse environments and genetic backgrounds) each genetic change has the potenti

171 Genetic background (ecotype) and thermal regime influenc

172 and allow a global, better interpretation of genetic background effects and a source of naturally def

173 These genetic background effects often result from the action

174 that might explain this variability include genetic background effects, additional rare pathogenic v

175 tion states at TEs are highly susceptible to genetic background effects.

176 Multiple factors, such as genetic background, environmental and luminal factors, a

177 ht to determine whether a tumor with defined genetic background exhibits a stereotypic or heterogeneo

178 for investigating the interplay between the genetic background, exogenous, and endogenous factors wi

179 contributions of environmental factors (E), genetic background (G) and their interaction (G x E) in

180 utants form stomata in the dark, and in this genetic background, GATA expression is sufficient to ind

181 The important effect that genetic background has on the inner ear phenotype of Atp

182 length of the CAG expansion, factors such as genetic background have been shown to contribute to the

183 conditions and show that lines from distinct genetic backgrounds have divergent differentiation capac

184 the type of RET gene mutation and the cancer genetic background (hereditary vs sporadic).

185 ur data indicate that on a defined C57bl/6NJ genetic background, homozygous Dnaaf2 mouse embryos fail

186 e as measured by educational attainment) and genetic background (i.e. TMEM106B polymorphism, rs199062

187 strate the power of CC mice for studying the genetic background impact between comorbidity of t2DM an

188 However, the high variability of genetic background in human populations hampers the repr

189 Although the genetic background in mitochondrial diseases is in eithe

190 Differences in genetic background in model organisms can have complex e

191 maintain a patch of intrinsically maintained genetic background in the south and the mosaic structure

192 ated inflammatory skin disease with a strong genetic background in which activation of IL-17 signalin

193 st Asian-specific haplotype with a different genetic background in which there are no variant alleles

194 of new mutations and their dependency on the genetic background in which they occur.

195 c variability observed in patients by mixing genetic backgrounds in a controlled manner and performin

196 aits, with universal applications under wide genetic backgrounds in crops.

197 Further, in genetic backgrounds in which the leg primordia are absen

198 We introduced individuals from three genetic backgrounds (inbred - outbred) into a novel envi

199 RAA-Mc quantities correlated with an RA-risk genetic background including DERAA-binding HLA-DQ allele

200 cessfully typed 307 individuals from diverse genetic backgrounds including 11 pure breeds, 1 cross br

201 files of E. coli fed to hosts with different genetic backgrounds, including the long-lived daf-2/insu

202 ss, immune-compromised flies resembled their genetic background, indicating that familial transmissio

203 f each group extends well beyond its overall genetic background, indicating unexpectedly weak correla

204 tructurally identical capsular PS, and their genetic backgrounds influence the amount of capsule prod

205 To shed light onto the genetic background influencing susceptibility for GCA, w

206 tions of introduced alien genes in the wheat genetic background is rarely investigated.

207 particularly in patients with different BRAF genetic backgrounds, is unclear.

208 c day 7.5 (E7.5) embryos in the C57BL6 mouse genetic background led to defective fetal erythropoiesis

209 VT serotypes was consistent across different genetic backgrounds (lineages).

210 o inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectivel

211 ive isolation must exist to maintain the two genetic backgrounds locally cohesive.

212 These results establish that genetic background, Lyst genotype, and age significantly

213 compared with age-matched, sex-matched, and genetic background-matched wild-type (WT) C57BL/6J contr

214 D score, individuals with the most favorable genetic background may be protected against CKD.

215 s that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathw

216 tein mutations in progenitor D39 and related genetic backgrounds; nor is GpsB required for StkP local

217 t that higher blood pressure depends on both genetic background (NOS3 deficiency) and uterine environ

218 yping of 186 apple accessions from a diverse genetic background of 17 Malus species combined with the

219 l from diverse sources and assessment of how genetic background of a mouse strain influences the biol

220 The genetic background of Atopic Dermatitis (AD) with chroni

221 ough there is considerable research into the genetic background of autism spectrum disorders, environ

222 romosome segment, defined by markers, in the genetic background of cv. NC 84173, a fresh market inbre

223 ntive interventions by tailoring them to the genetic background of each patient.

224 The genetic background of follicular lymphomas (FLs) diagnos

225 Our findings indicate that the genetic background of hyperglycemia is unrecognized in t

226 Here, we aimed to describe the genetic background of hypouricemia patients using whole-

227 im of this study is to determine whether the genetic background of initial periodontitis and caries c

228 in commercial varieties, and shows distinct genetic background of landraces.

229 To investigate the genetic background of localized-stage FL, patient cohort

230 from Spain to provide further context on the genetic background of Mesolithic Europe.

231 Our study revealed the genetic background of Nunavik Inuit to be distinct from

232 F has tumour suppressor activity in the same genetic background of Pten loss that yields oncogenic ac

233 Moreover, in a similar genetic background of silenced PKM1 or PKM2, the knockin

234 tance of these resistance alleles within the genetic background of tetraploid peanut, an F(2) populat

235 factors in the perinatal environment and the genetic background of the comparison group.

236 xhibit different behaviours depending on the genetic background of the fish they were raised with.

237 Our results give evidence that even if the genetic background of the HLA-G 3'UTR is identical betwe

238 The aim of this study was to determine the genetic background of the OPRM1 region of 118G in four r

239 urvival in heritable retinoblastoma, and the genetic background of the patient influences choice of e

240 beta-carotene concentration reflects on the genetic background of the rice variety and the transgene

241 ota composition, or minor differences in the genetic background of the strains.

242 Despite improved knowledge regarding the genetic background of the tumor and better understanding

243 Kingdom wheat breeding, highlights the wide genetic background of the UK wheat gene pool, and facili

244 ral pathogenesis depend on mouse age and the genetic background of the virus.IMPORTANCE The replicati

245 Thus, the genetic backgrounds of C. heterostrophus and U. botrytis

246 alling networks-and interacts with different genetic backgrounds of co-occurring alterations-in diffe

247 There was a significant difference in the genetic backgrounds of S. aureus colonizing AE cases ver

248 -fold during cellular Mn stress, but only in genetic backgrounds of S. pneumoniae and Bacillus subtil

249 ystem vary in their effects depending on the genetic backgrounds of the pathogen and host, and interp

250 mouse population for studying the impact of genetic background on comorbidity of alveolar bone chang

251 The influence of genetic background on driver mutations is well establish

252 end previous studies comparing the effect of genetic background on the AS phenotype by investigating

253 r results also demonstrated the influence of genetic background on the expression of cold and floweri

254 While the effects of species and genetic background on these phenotypes remain difficult

255 n researchers do not factor in the effect of genetic background on tumor biology.

256 ions in a population to be contingent on the genetic background on which they appear.

257 sting the effects of mutations and different genetic backgrounds on protein stability.

258 These findings indicate the effect of common genetic backgrounds on the Ube3a maternal deletion behav

259 se diseases is often associated with gender, genetic background, or a combination of these and other

260 With a well-controlled genetic background, our data suggest that unbalanced spe

261 Overall, this study shows that genetic background plays a dominant role in driving phen

262 A key result was that host genetic background plays a more important role in shapin

263 microbiome composition is influenced by host genetic background, potentially cariogenic taxa are like

264 tes cues from the environment and the host's genetic background, potentially offering a holistic view

265 icient and vic1 I/LnJ congenic mice on other genetic backgrounds produce antivirus Abs when infected

266 Here, 11 diverse species of yeasts with genetic backgrounds representative of different branches

267 Bay mice on the C57BL/6 and C57BL/6NJ inbred genetic backgrounds, respectively.

268 ession, the Ctss gene was deleted in the mdx genetic background, resulting in protection from muscula

269 endent saddle pattern mutants from different genetic backgrounds revealed independent lesions affecti

270 ed genes between the winter and spring wheat genetic backgrounds showed a striking pattern of biased

271 ies in four melanoma cell lines with various genetic backgrounds showed an increase in the proliferat

272 ies of experiments to examine the effects of genetic background (strain), voluntary exercise (wheel r

273 Genetic background strongly influenced the magnitude and

274 r deleterious effect in rodents of different genetic background, supporting the merit of anti-GRP78 d

275 o For example, mice in the resistant C57BL/6 genetic background that are triple-deficient for TLR3, -

276 l injury that occurs in an individual with a genetic background that permits the development of autoi

277 rnatively activated macrophages on different genetic backgrounds that may contribute to phenotypic va

278 mouse models of DMD, which are on different genetic backgrounds, the C57BL/10ScSn-Dmdmdx (B10-mdx) a

279 rossing this Pkhd1 mutation onto the C57BL/6 genetic background; thus, the NOD genetic background (wh

280 ation of cage ventilation and bedding type), genetic background, time of year, cage location on the r

281 n the Philippines, while also serving as the genetic background to contextualize ongoing local prospe

282 APA in elav/fne double mutant CNS, the first genetic background to largely abrogate this distinct APA

283 an intermediate revertants and may alter the genetic background to render reversion detrimental to fi

284 erated a total of 24 mutants in type 1 and 2 genetic backgrounds to ascertain the functions of noncan

285 Here, we have used three different genetic backgrounds to manipulate spindle shape without

286 hybrids, used to separate Eda genotype from genetic background, to contrasting conditions in semi-na

287 ogressions into tomato, to recover a uniform genetic background, to isolate recombinant sub-lines wit

288 entifies known phenotypes for a diversity of genetic backgrounds under cyclohexamide stress and also

289 Hence, we examine their shared genetic background using a cross-disorder GWAS meta-anal

290 he importance of identifying and controlling genetic background variation.

291 cultivars, which inherit major U.S. soybean genetic backgrounds, was used along with previous mappin

292 ng Prdm9 functional knockouts in an array of genetic backgrounds, we observe a wide range of fertilit

293 se dNTP imbalances are strongly mutagenic in genetic backgrounds where DNA polymerase function or MMR

294 ll types and relies on their shared germline genetic background, whereas adaptive immunity operates t

295 he C57BL/6 genetic background; thus, the NOD genetic background (which promotes autoimmunity) is esse

296 icrobiota readily distinguishable from their genetic background with the introduction and establishme

297 (Lonchura striata domestica) from different genetic backgrounds with synthetic songs in which tempo

298 ) isolates have revealed a wide diversity of genetic backgrounds, with only sporadic occurrence of ST

299 germline MCU deficiency in mice with certain genetic background yields viable pups, and knockout of t

300 We found that, depending on their genetic background, young flies had microbiota of differ