ライフサイエンスコーパス: genetic counseling

1 d 119 second-degree relatives), 60% attended genetic counseling.

2 ted care pathways, and enabled more accurate genetic counseling.

3 to enhance the accuracy of the prognosis and genetic counseling.

4 lications for recurrence risk estimation and genetic counseling.

5 s finding would carry clear implications for genetic counseling.

6 mes provides improved treatment and accurate genetic counseling.

7 y significant variants, which may complicate genetic counseling.

8 hich also must be addressed in the course of genetic counseling.

9 Our results are important for prognosis and genetic counseling.

10 ven implications for prognosis, therapy, and genetic counseling.

11 SCO2 mutations is particularly important for genetic counseling.

12 s, appropriate molecular genetic testing and genetic counseling.

13 l for a definitive diagnosis, prognosis, and genetic counseling.

14 ossible, which is important for clinical and genetic counseling.

15 ugh gamete donation, prenatal diagnosis, and genetic counseling.

16 ropriate management, long-term guidance, and genetic counseling.

17 erest for molecular genetic research and for genetic counseling.

18 acilitate definitive molecular diagnosis and genetic counseling.

19 s that have instituted carrier screening and genetic counseling.

20 of gene defects is essential for informative genetic counseling.

21 ificantly less often than colonoscopy before genetic counseling.

22 investigation for appropriate diagnosis and genetic counseling.

23 east cancer syndromes should be referred for genetic counseling.

24 cer with age and derived its implication for genetic counseling.

25 nto the study and 50% of enrollees completed genetic counseling.

26 sociated significantly with participation in genetic counseling.

27 tion of molecular findings for diagnosis and genetic counseling.

28 rral, study enrollment, and participation in genetic counseling.

29 nown, thus creating significant problems for genetic counseling.

30 p or palate is an important consideration in genetic counseling.

31 d mutations, with important implications for genetic counseling.

32 irmation allowing appropriate prognostic and genetic counseling.

33 eived their DNA test results in concert with genetic counseling.

34 genetic make-up remains a core principle of genetic counseling.

35 peptide pyridinoline cross-links (ICTP), and genetic counseling.

36 rently pursuing appropriate medical care and genetic counseling.

37 tive surgery were provided in the context of genetic counseling.

38 e opportunity for disease prevention through genetic counseling.

39 d not be done without first providing formal genetic counseling.

40 ations, particularly for supportive care and genetic counseling.

41 ting in families affected with PH2 to aid in genetic counseling.

42 establish an etiologic diagnosis and affect genetic counseling.

43 drial genetics that complicate diagnosis and genetic counseling.

44 rmonogenesis, which is familial and requires genetic counseling.

45 Family education and individual genetic counseling.

46 etween nondirectiveness and directiveness in genetic counseling.

47 portant in the differential diagnosis and in genetic counseling.

48 nd process of pretest education and posttest genetic counseling.

49 G mutation received results and were offered genetic counseling.

50 ER1 syndrome phenotype, natural history, and genetic counseling.

51 rtant applications for clinical genetics and genetic counseling.

52 provides a basis for risk stratification and genetic counseling.

53 may be relevant background data in clinical genetic counseling.

54 ul for pre-symptomatic disease detection and genetic counseling.

55 identifies risk factors to be considered in genetic counseling.

56 with abatacept, a CTLA-4 mimetic, and inform genetic counseling.

57 the identification of disease modifiers, and genetic counseling.

58 of 226) herein, and should be considered in genetic counseling.

59 I disorders to ensure accurate diagnosis and genetic counseling.

60 ill have immediate impact on diagnostics and genetic counseling.

61 e professionals, and lowering thresholds for genetic counseling.

62 and transcriptome (tumor RNA) sequencing and genetic counseling.

63 y percent of laboratories provided access to genetic counseling, 69% had a confidentiality policy, an

64 Genetic counseling about the potential risks and benefit

65 ate discrimination to support individualized genetic counseling, although discrimination varies acros

66 on surgical decision-making of pretreatment genetic counseling and BRCA1/BRCA2 testing among breast

67 s, differential access to and utilization of genetic counseling and cancer predisposition testing amo

68 osis colorectal cancer) is critical for both genetic counseling and cancer prevention.

69 l to genetic professionals for gene testing, genetic counseling and cancer risk management; and could

70 cology clinic and were prospectively offered genetic counseling and clinical genetics risk assessment

71 Genetic counseling and clinical presentation confirmed t

72 Traditional genetic counseling and disease education were provided i

73 founder mutation provides an opportunity for genetic counseling and early diagnosis of XP.

74 avoidably reshaped the customary practice of genetic counseling and established a new proposed paradi

75 ese findings have important implications for genetic counseling and for understanding patterns of rec

76 Genetic counseling and germline genetic testing of cance

77 iagnosis of thyroid dyshormonogenesis allows genetic counseling and has prognostic value in different

78 5-bp deletion will facilitate more accurate genetic counseling and identification of other branches

79 s somewhat unique to genetic testing include genetic counseling and informed consent for genetic test

80 Facilitated cascade testing with telephone genetic counseling and mailed saliva kits resulted in hi

81 This genetic characterization will aid in genetic counseling and management, critically required t

82 using such an array may, thus, be useful for genetic counseling and may help clinical decision making

83 SCCOHT, which could lead to improvements in genetic counseling and new treatment approaches.

84 These findings have major implications for genetic counseling and patient management as new therape

85 nically challenging, but it is important for genetic counseling and perhaps for helping to select app

86 These findings have implications for genetic counseling and prenatal diagnosis for EBS.

87 arly diagnosis and treatment in newborns and genetic counseling and prenatal diagnosis in subsequent

88 These data have important implications for genetic counseling and prenatal diagnosis of HI, and als

89 This information can be elicited during genetic counseling and prior to genetic testing.

90 for precise clinical diagnosis, appropriate genetic counseling and proper medical management for aud

91 ature-sensitive TGM1 genotypes should aid in genetic counseling and provide insights into the pathoph

92 atients has implications for diagnostics and genetic counseling and provides a rational basis for the

93 Participants were offered free genetic counseling and rapid BRCA1/2 testing.

94 serious consequences regarding treatment and genetic counseling and reinforce the use of next-generat

95 onable incidental genetic findings agreed to genetic counseling and screening.

96 nformation relevant to clinical genetics and genetic counseling and should yield insight into the gen

97 y for family members, including the need for genetic counseling and sometimes particular types of sur

98 in the TYMP gene would be very important for genetic counseling and subsequent early diagnosis and in

99 We assessed the impact of genetic counseling and testing (GCT) on the use of endos

100 We examined patterns and correlates of genetic counseling and testing and the impact of results

101 historically have not sought or been offered genetic counseling and testing and thereby contribute to

102 ic cancer, where there are opportunities for genetic counseling and testing as well as clinical monit

103 (3) Genetic counseling and testing clarify the risk for reti

104 The availability of genetic counseling and testing could serve as a valuable

105 pants were 149 high-risk women who underwent genetic counseling and testing for alterations in the BR

106 pants were 289 high-risk women who underwent genetic counseling and testing for alterations in the BR

107 pants were 279 high-risk women who underwent genetic counseling and testing for alterations in the BR

108 Genetic counseling and testing for HNPCC significantly i

109 tection rates has important implications for genetic counseling and testing in clinical settings.

110 his study provides prospective evidence that genetic counseling and testing increased surveillance an

111 Cancer genetic counseling and testing is probably beneficial in

112 Genetic counseling and testing may aid in the management

113 gh frequency and wide spectrum of mutations, genetic counseling and testing with a multigene panel co

114 esearch on short-term effects of prevention, genetic counseling and testing, and screening activities

115 nvened including key stakeholders to address genetic counseling and testing, PCA screening, and manag

116 inations and imaging studies increased after genetic counseling and testing.

117 r intentions toward preventive surgery after genetic counseling and testing.

118 stratification model that can help post-test genetic counseling and that facilitates the decision-mak

119 An exact molecular diagnosis allows genetic counseling and the identification of asymptomati

120 th positive screening results should receive genetic counseling and, if indicated after counseling, B

121 t on the risk assessment tool should receive genetic counseling and, if indicated after counseling, g

122 of high-risk survivors who may benefit from genetic counseling and/or testing of DRGs, which may fur

123 esity control rooted in studies of 1841, and genetic-counseling and cancer-survivorship studies.

124 cian to give better care, more sophisticated genetic counseling, and a more precise prognosis for the

125 rozygotes, which is essential for diagnosis, genetic counseling, and carrier prediction.

126 various medical specialties, social science, genetic counseling, and consumer advocacy.

127 test requisition forms and during post-test genetic counseling, and genetic ancestry predicted by a

128 STF reviewed the evidence on risk assessment,genetic counseling, and genetic testing for potentially

129 TF reviewed the evidence on risk assessment, genetic counseling, and genetic testing for potentially

130 luated the effectiveness of risk assessment, genetic counseling, and genetic testing in reducing inci

131 , the benefits and harms of risk assessment, genetic counseling, and genetic testing to reduce cancer

132 is with prognostic implications, has refined genetic counseling, and has formed the basis for prenata

133 lopment improves diagnostic capabilities and genetic counseling, and investigators can now turn to th

134 genes may improve premorbid risk assessment, genetic counseling, and management.

135 enotype may aid early diagnosis, appropriate genetic counseling, and monitoring for potential complic

136 Risk assessment, genetic counseling, and mutation testing did not cause a

137 ications for calculation of recurrence risk, genetic counseling, and potential treatment options, and

138 ype and can improve the clinical management, genetic counseling, and risk assessment of patients with

139 ime, making molecular diagnosis, prediction, genetic counseling, and risk management challenging.

140 5 gene will be useful for carrier detection, genetic counseling, and the identification of patients w

141 Individualized screening, genetic counseling, and treatment protocols based on pat

142 ory Improvement Amendments confirmed report, genetic counseling, and treatment recommendations.

143 es has led to improved diagnosis, prognosis, genetic counseling, and, most importantly, new therapies

144 The implications of these results for genetic counseling are discussed.

145 adequately informed or that barriers against genetic counseling are present.

146 vironment interaction, pharmacogenetics, and genetic counseling--are also discussed.

147 89 patients with ovarian cancer referred for genetic counseling at three institutions.

148 There are also important advances in genetic counseling based on results of early fetal diagn

149 scribed here have important implications for genetic counseling, because individuals with CADDS may p

150 , the more complex diagnosis, treatment, and genetic counseling become.

151 A woman who undergoes genetic counseling before testing can be told the probab

152 Each patient in the study underwent formal genetic counseling before testing.

153 Only 18.6 percent (33 of 177) received genetic counseling before the test, and only 16.9 percen

154 Genetic counseling both pretesting and posttesting is es

155 ocess, 82% of women wished to self-refer for genetic counseling, but 63% desired advice and recommend

156 riteria and respondents' report of receiving genetic counseling by a genetics clinician and its assoc

157 DECIPHER enhances genetic counseling by retrieving relevant information fr

158 In these families, genetic counseling can be difficult.

159 Genetic counseling can be effectively and efficiently de

160 ferral of high-risk patients and families to genetic counseling can greatly enhance the care of the p

161 s and prognoses, can improve the accuracy of genetic counseling, can reduce the risk of disease occur

162 Data analyzed were from six high-risk genetic counseling clinics and concern individuals from

163 As the definition of genetic counseling continues to evolve, so does the appl

164 risk assessment tools to guide referrals to genetic counseling demonstrated moderate to high accurac

165 as a genetic basis is important for accurate genetic counseling, early identification of individuals

166 d P.J.W.) to achieve balance in the areas of genetics, counseling, ethics, and public policy, and to

167 We describe our genetic counseling experience with 2 large families pron

168 d up a new field for patient care, including genetic counseling for a severe disease, taking into acc

169 sociated with change in treatment and family genetic counseling for a small proportion of patients.

170 Laboratory diagnosis and genetic counseling for AS are complex, and mutation anal

171 These results support the importance of genetic counseling for both men and women with complex C

172 priate referral of African American women to genetic counseling for BRCA1/2 mutations.

173 Individuals referred to genetic counseling for cancer at two family cancer clini

174 ll enable early genetic diagnosis and better genetic counseling for families with BRA.

175 cilitate discovery of this HSP gene, improve genetic counseling for families with linkage to this loc

176 gnosis based on genetic analysis can lead to genetic counseling for family members of patients.

177 hange in treatment for 14 patients (15%) and genetic counseling for future risk for 9 patients (10%).

178 Genetic counseling for IDC and FDC is also indicated to

179 ter program was more effective than standard genetic counseling for increasing knowledge of breast ca

180 and microarray analysis, to provide improved genetic counseling for phenotypic outcome in the prenata

181 These findings emphasize the importance of genetic counseling for prenatal carrier testing and may

182 A3-associated eye phenotypes can help inform genetic counseling for prognostic estimation of visual l

183 ther identified risk alleles, allows precise genetic counseling for the first time.

184 isorder has hindered clinical management and genetic counseling for the many affected individuals in

185 This greatly changes psychiatric genetic counseling for these patients and families.

186 ause ALSP led to more accurate prognosis and genetic counseling for these patients in addition to inc

187 Issues in genetic counseling for this highly variable disease are

188 women but should be used as a supplement to genetic counseling for those at high risk.

189 Only 1334 (36.8%) reported receiving genetic counseling from a genetics clinician prior to te

190 l surgeon regarding appropriate patients for genetic counseling (GC) referral (approach 2).

191 idence that the benefits of risk assessment, genetic counseling, genetic testing, and interventions a

192 e that the overall harms of risk assessment, genetic counseling, genetic testing, and interventions a

193 idence that the benefits of risk assessment, genetic counseling, genetic testing, and interventions a

194 Studies of risk assessment, genetic counseling, genetic testing, and interventions t

195 ions; benefits and harms of risk assessment, genetic counseling, genetic testing, and risk-reducing i

196 or younger should trigger consideration for genetic counseling/germline mutation testing and may ser

197 abnormalities, and will thereby improve the genetic counseling given to individuals with KITLG varia

198 This is important for genetic counseling: given that VWS is rare compared to n

199 r (82.5%) of 114 patients with ACC underwent genetic counseling (group 1).

200 nce useful to assist clinical ascertainment, genetic counseling, guidance of symptomatic monitoring,

201 data can provide accurate diagnoses, improve genetic counseling, help define disease mechanisms, esta

202 Physicians should be prepared to offer genetic counseling if they order genetic tests.

203 has important treatment (ketogenic diet) and genetic counseling implications.

204 ic disease, and a change in treatment beyond genetic counseling in 44%.

205 and facilitates the provision of appropriate genetic counseling in Alport syndrome.

206 Genetic counseling in EPP requires identification of FEC

207 f the gene and raise important questions for genetic counseling in families with these distinctive ph

208 This finding is important to consider in SMA genetic counseling in individuals with black African anc

209 se penetrance estimates should be useful for genetic counseling in multiple-case families.

210 to define criteria for clinical practice and genetic counseling in rare diseases.

211 Most of them (68.6%) attended genetic counseling in the first year.

212 creening/early detection, and risk reduction/genetic counseling in their practices in the next 5 year

213 Formal genetic counseling includes preparation of a family pedi

214 Genetic counseling increased the accuracy of risk percep

215 Education and genetic counseling increased understanding and retention

216 of HAE-C1-INH treatment in female patients, genetic counseling, infertility, abortion, lactation, me

217 as provided crucial information for accurate genetic counseling, inspired a recently proposed functio

218 icious genetic testing, pretest and posttest genetic counseling, interpretation and application of ge

219 The process of genetic counseling is critical both before and after tes

220 counseling before BRCA1/BRCA2 gene testing, genetic counseling is increasingly offered by telephone.

221 Genetic counseling is now routinely offered to individua

222 nts with defined autosomal dominant disease, genetic counseling is of high clinical relevance, also w

223 Genetic counseling is strongly advised for family member

224 A crucial issue in genetic counseling is the recognition of nonallelic gene

225 hildren of their daughters, raises important genetic counseling issues.

226 early and accurate diagnosis, and facilitate genetic counseling, leading to directly benefiting famil

227 sk individuals throughout families who, with genetic counseling, may become candidates for germ-line

228 ple guidelines emphasizing the importance of genetic counseling, most US women undergoing BRCA geneti

229 ific to key questions about risk assessment, genetic counseling, mutation testing, prevention interve

230 Standard one-on-one genetic counseling (n = 105) or education by a computer

231 education by a computer program followed by genetic counseling (n = 106).

232 assigned to in-person (n = 495) or telephone genetic counseling (n = 493).

233 s and will be valuable in the management and genetic counseling of a significant number of individual

234 ndings have important implications regarding genetic counseling of affected individuals who reach rep

235 prognostic value and allows more insightful genetic counseling of couples who opt for assisted repro

236 upports better understanding, diagnosis, and genetic counseling of EV patients.

237 cant implications for medical management and genetic counseling of FA families.

238 d inheritance has important consequences for genetic counseling of families with Fanconi anemia belon

239 osaicism can have important implications for genetic counseling of families with hereditary disorders

240 The results have implications for genetic counseling of families with seemingly sporadic T

241 m in the FBN2 gene is important for accurate genetic counseling of families with sporadic cases of CC

242 HPE and demonstrate how this can inform the genetic counseling of families.

243 important for both analysis of patients and genetic counseling of families.

244 he phenotype, with profound implications for genetic counseling of individuals at risk for recurrence

245 The results are useful for genetic counseling of individuals with partial monosomy

246 ion from the location of mutations, will aid genetic counseling of individuals with TIGR/myocilin var

247 icism should always be considered during the genetic counseling of newly identified families with ret

248 assist physicians in prenatal diagnosis and genetic counseling of parents who are at risk for having

249 morigenesis, direct patient care, and enable genetic counseling of patients and families.

250 s and causes of HPE, and thus to improve the genetic counseling of patients and their families.

251 llele; this is of potential significance for genetic counseling of patients with EPP.

252 ave important public policy implications for genetic counseling of SCT carriers.

253 Genetic counseling of the affected families is an import

254 for patients with colorectal cancer and for genetic counseling of their relatives.

255 s should allow improved risk assessments for genetic counseling of women with premutation or intermed

256 In addition to their utility for improved genetics counseling of patients and their families, the

257 e of endocrine tumors increases, the role of genetic counseling on the multidisciplinary endocrinolog

258 The USPSTF recommends against routine genetic counseling or BRCA testing for women whose famil

259 who received genetic testing did not receive genetic counseling or that the counseling was not effect

260 sociated significantly with participation in genetic counseling (OR = 5.46; 95% CI, 1.44 to 20.60; P

261 recommends against routine risk assessment, genetic counseling, or genetic testing for women whose p

262 recommends against routine risk assessment, genetic counseling, or genetic testing for women whose p

263 that can contribute to current screening and genetic counseling practices in a high-risk population.

264 ications for clinical practice, facilitating genetic counseling, prenatal diagnosis, and evaluation o

265 An optimal approach includes prepregnancy genetic counseling, prenatal diagnostic procedures, and

266 ation of heterozygous carriers, assisting in genetic counseling, prenatal testing, and preimplantatio

267 ety of different genes and investment in the genetic counseling process likely increases the chance t

268 Practical implications of these findings for genetic counseling, prognostication, and even therapy ha

269 and satisfaction among patients who receive genetic counseling provided by a genetics clinician, as

270 A large percentage of cancer genetic counseling providers predicted they would opt fo

271 xamination, review of systems, education and genetic counseling regarding Lynch syndrome (age 21 year

272 RC at age 35 years or younger should receive genetic counseling regardless of their family history an

273 ing African American women to participate in genetic counseling research for BRCA1 and BRCA2 (BRCA1/2

274 Any genetic-counseling service set up for families with deaf

275 Recently mandated coverage of genetic counseling services as a preventive service with

276 tinues to evolve, so does the application of genetic counseling services in all areas of medicine and

277 act on deaf people, in a population for whom genetic-counseling services are relevant.

278 or deafness mean that it is now possible for genetic-counseling services to offer genetic testing for

279 stories using the GREAT, separate from their genetic counseling session.

280 enetic providers was endorsed to address the genetic counseling shortage.

281 and IPAH patients but should be preceded by genetic counseling, since lifetime penetrance is only 10

282 E-driven tumors and valuable information for genetic counseling, surveillance, and immunotherapy for

283 PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed ma

284 rtant for identifying individuals to receive genetic counseling/testing (GC/GT).

285 Beyond diagnosis and genetic counseling, the benefits from studying these dis

286 hies will lead to more precise diagnosis and genetic counseling; therapeutic strategies are being dev

287 risk of etoposide is needed to provide sound genetic counseling to cancer patients treated with this

288 topenia and leukemia predisposition includes genetic counseling, treatment or prevention of excessive

289 with a pathogenic variant, family uptake of genetic counseling was assessed in the first year(s) aft

290 enty-eight studies (n = 8060) indicated that genetic counseling was associated with reduced breast ca

291 However, genetic counseling was more effective than the computer

292 tested whether telephone delivery of BRCA1/2 genetic counseling was noninferior to in-person delivery

293 Attending genetic counseling was observed more frequently in first

294 g, whether informed consent was obtained and genetic counseling was offered before testing, and the i

295 explaining the origin, nature, and goals of genetic counseling, we consider the impact of the Human

296 r adjunct educational methods to traditional genetic counseling will be needed.

297 trial compared 1-year outcomes for telephone genetic counseling with in-person counseling among women

298 y," improves disease management, and fosters genetic counseling with respect to recurrence risks whil

299 -up of 16 years, 60.0% of relatives attended genetic counseling, with 41.0% in the first year.

300 This suggests, therefore, that genetic counseling would benefit from the addition of sp