ライフサイエンスコーパス: genetic determinant

1 dox) points to the concomitant importance of genetic determinants.

2 al variability, which is explained partly by genetic determinants.

3 OPD) is linked to both cigarette smoking and genetic determinants.

4 1 and FGF23 concentrations to identify their genetic determinants.

5 x thrombotic disorder with environmental and genetic determinants.

6 apping QTLs and identifying their underlying genetic determinants.

7 size, lipid composition, gene expression and genetic determinants.

8 bout global variation in translation and its genetic determinants.

9 rol virus infection, perhaps because of host genetic determinants.

10 agnoses within families suggests overlapping genetic determinants across psychoses.

11 The same genetic determinant also affects the sensitivity of thes

12 Previous studies have revealed shared genetic determinants among different inflammatory disord

13 evels of lipids and lipoproteins have strong genetic determinants and are recognized as key risk fact

14 minative models which integrate knowledge of genetic determinants and biologic processes governing bo

15 ve as a complementary phenotype to study the genetic determinants and clinical relevance of brain str

16 To identify genetic determinants and mechanisms underlying MetS, an

17 have been long hypothesized to share common genetic determinants and mechanisms.

18 tand its epidemiology, antibiotic resistance genetic determinants and potential virulence factors.

19 The underlying genetic determinants are beginning to emerge and are int

20 a significant cause of mortality(1), yet its genetic determinants are incompletely defined.

21 However, the underlying genetic determinants are largely unknown.

22 ma and during cardiovascular stress, yet the genetic determinants are poorly understood.

23 n the nose, numerous signaling molecules and genetic determinants are required in concert to generate

24 However, the underlying genetic determinants are unclear.

25 The identification of genetic determinants associated with changes in glycemia

26 The aim of this study is to identify genetic determinants associated with leisure sedentary b

27 t hippocampal subfields have partly distinct genetic determinants associated with specific biological

28 l factors the search continues not only into genetic determinants but also extrinsic influences and t

29 nce have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heter

30 To identify genetic determinants conferring salinity tolerance in co

31 that support cancer pathophysiology, but the genetic determinants conferring sensitivity to NAE inhib

32 re is a void in the literature regarding the genetic determinants contributing to the variability obs

33 ion and functional characterization of viral genetic determinants dictating JUNV virulence or attenua

34 inflammation due to a complex interaction of genetic determinants, disruption of mucosal barriers, ab

35 an independent familial trait, and may have genetic determinants distinct from the determinants of p

36 the gam-cII region of phage Phi8 might carry genetic determinants downregulating the transcription of

37 ed that this gene is a potentially important genetic determinant for ALL susceptibility.

38 OE) 4 genotype is the most important, common genetic determinant for Alzheimer disease (AD), and fema

39 l-pump gene Heavy Metal ATPase4 as the major genetic determinant for Cd tolerance.

40 ded nonstructural 2 (NS2) protein as a viral genetic determinant for initiating RSV-induced distal ai

41 These data reveal sex-specific genetic determinants for aortic pulse wave velocity and

42 Genetic determinants for challenge-proven peanut allergy

43 17q21 gene variants are the strongest known genetic determinants for childhood asthma and have been

44 ng and can be potentially useful to identify genetic determinants for complex disorders.

45 This is the first identification of genetic determinants for E. faecalis commensal and patho

46 Xenosphere CCICs retained the genetic determinants for EGFR therapeutic response in vi

47 summary, we identified multiple independent genetic determinants for Lp(a)-cholesterol.

48 Genetic determinants for poor outcomes are unknown.

49 This study defines the minimal genetic determinants for the formation of the key precur

50 Nisin P is a natural nisin variant, the genetic determinants for which were previously identifie

51 In primary microcephaly the genetic determinants frequently involve mutations that c

52 PMD is highly heritable, but few genetic determinants have been identified.

53 While some genetic determinants have been reported, the etiology of

54 d Lpl rpoD enables the identification of Lpl genetic determinants imparting strong ethanol tolerance

55 atment of arrhythmias was described, whereas genetic determinants important to the optimal treatment

56 6-phosphate phosphatase gene, OsTPP7, as the genetic determinant in qAG-9-2, a major quantitative tra

57 In this study, we identify a genetic determinant in the viral envelope (N173) that in

58 These findings provide further insight into genetic determinants in NP and M1 involved in PR8 IAV ad

59 ental risk factors, coagulation factors, and genetic determinants in patients with plaster casts lead

60 orporate biological knowledge on the role of genetic determinants in predicting an outcome.

61 et little is known about its heritability or genetic determinants in the general population.

62 e identification and characterization of key genetic determinants in the investigation of biological

63 h a worse prognosis in patients with IA, and genetic determinants in this subset of patients have not

64 (referred to here as APOE4), as well as non-genetic determinants including ageing.

65 way for comparative analyses to identify new genetic determinants involved in biocontrol, plant-growt

66 This study was aimed at identifying the genetic determinants involved in coaggregation between t

67 ging pathogen, and little is known about the genetic determinants involved in its pathogenesis.

68 Here, we globally map the host genetic determinants involved in resistance to 14 phylog

69 ation of Lp(a) is highly heritable, with its genetic determinants located in the apo(a) locus and reg

70 entrations are similar between the 2 groups, genetic determinants may be ethnicity specific.

71 In hypothesizing that additional genetic determinants might direct use of these drugs, we

72 We investigated whether distinct or shared genetic determinants might underlie susceptibility to ar

73 Other genetic determinants must therefore contribute independe

74 ults define RHPN2 amplification as a central genetic determinant of a highly aggressive phenotype tha

75 lusion, we identified rs41314453 as the main genetic determinant of ADAMTS13 activity, and we present

76 is association and indicates that Nr2f2 is a genetic determinant of blood pressure (BP).

77 ariation in FTO is the most important common genetic determinant of body weight.

78 We tested the effects of a genetic determinant of branched-chain amino acid/aromati

79 Overall, this study identifies a unique genetic determinant of Cd tolerance in the metal hyperac

80 is study, we aimed to identify the strongest genetic determinant of circulating DMG concentration and

81 demonstrate FBW7 mutational status as a key genetic determinant of CRC response to targeted therapie

82 Furthermore, mutation type may serve as a genetic determinant of deafness, but not cardiac express

83 Our work identifies NPC1 as a genetic determinant of filovirus susceptibility in bats,

84 The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of

85 TGFB1 genetic variation may be an important genetic determinant of mammographic density measure that

86 e, confirming that mecA remains the dominant genetic determinant of MRSA in East London.

87 AROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C(30) apocar

88 first evidence, to our knowledge, of a host genetic determinant of NTS disease in African children,

89 in both mice and humans, identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and su

90 These findings identify MPO as a genetic determinant of pustular skin disease and neutrop

91 ts implicates the vacuolar ATP synthase as a genetic determinant of resistance to TAPs.

92 ify FOXN1 haploinsufficiency as an important genetic determinant of T cell lymphopenia at birth.

93 wn previously that the viral envelope is the genetic determinant of the differential T cell tropism i

94 identified rhophilin 2 (RHPN2) as a central genetic determinant of the mesenchymal phenotype of huma

95 cohort, thus representing the most frequent genetic determinant of the subtype.

96 than does subtype C, and we identify a major genetic determinant of these differences.

97 ariation within TCF7L2 remains the strongest genetic determinant of type 2 diabetes risk in humans.

98 R Cas9 genome-wide mutagenesis to screen for genetic determinants of 2-OG levels, we uncover a redox

99 e-wide association study (GWAS) in search of genetic determinants of a variation in plasma plasminoge

100 The genetic determinants of ADAMTS13 activity remain unclear

101 ve efforts have been devoted to the study of genetic determinants of AF.

102 have proven instrumental in the discovery of genetic determinants of aging, and the fission yeast Sch

103 Understanding of genetic determinants of allergic disease may lead to nov

104 obal public health and the identification of genetic determinants of AMR is a critical component to e

105 to whole-genome sequencing data to identify genetic determinants of antimicrobial resistance (AMR),

106 taxonomic classification, such as profiling genetic determinants of antimicrobial resistance, intera

107 This study aimed to identify novel genetic determinants of AOS.

108 Genetic determinants of arrhythmia susceptibility (such

109 h high heritability, although the underlying genetic determinants of ASDs remain largely unknown.

110 We hypothesize that the genetic determinants of ASFV variability are potential h

111 A better understanding of the viral genetic determinants of attenuation will improve our und

112 To further investigate the genetic determinants of autoantibody positivity, we perf

113 While genetic determinants of barrier function are important,

114 Even after decades of investigation, the genetic determinants of BAV and its complications remain

115 Genetic determinants of biofilm formation differ between

116 squitoes is driven, at least in part, by the genetic determinants of bite reaction size.Our findings

117 coffee consumption and obesity were primary genetic determinants of bitter and sweet beverage consum

118 organism Caenorhabditis elegans to identify genetic determinants of bleomycin-response differences b

119 Here, we explored associations of genetic determinants of blood lipid levels, lipoprotein

120 We assess whether the genetic determinants of blood lipids, a major cardiovasc

121 We assessed genetic determinants of BMD as estimated by heel quantit

122 rogress has been made toward elucidating the genetic determinants of BMD, our understanding of the fa

123 R associations persisted after adjusting for genetic determinants of BMI.

124 The genetic determinants of body fat distribution are poorly

125 al insights into the complex relationship of genetic determinants of body weight in the etiology of b

126 nts of variability in mineral retention, the genetic determinants of bone turnover and calcium flux a

127 Our results suggest that genetic determinants of BP act from childhood, develop o

128 studies have been conducted to discover the genetic determinants of BPH risk.

129 ad literacy is too recent to have influenced genetic determinants of brain organization.

130 The genetic determinants of C-reactive protein (CRP), a biom

131 tivity by identifying intrinsic cellular and genetic determinants of cancer cell survival following e

132 major bottleneck in our understanding of the genetic determinants of cancer.

133 y of the heart failure syndrome, identifying genetic determinants of cardiac function and structure m

134 These findings suggest that genetic determinants of childhood bone accretion at the

135 However, the underlying genetic determinants of CHK1 inhibitor sensitivity remai

136 o a paucity of adequately sized studies, the genetic determinants of circulating AMH levels are poorl

137 B12 deficiency but little is known about the genetic determinants of circulating B12 concentrations i

138 role of IL-1RA, this study aimed to identify genetic determinants of circulating IL-1RA concentration

139 enome-wide study to report on the underlying genetic determinants of CK variation in a population of

140 The distinctions between genetic determinants of cluster III expression in vitro

141 Genetic determinants of cognition are poorly characteriz

142 identification of previously uncharacterized genetic determinants of complex phenotypes, particularly

143 clerotic plaques and that there are critical genetic determinants of coronary artery disease (CAD) ri

144 association study was performed to identify genetic determinants of Cp levels and evaluate their ass

145 The major genetic determinants of cutaneous melanoma risk in the g

146 lity, little success was achieved in mapping genetic determinants of depression-related traits by mea

147 Early research aimed at identifying genetic determinants of diabetes complications relied on

148 erns of data, for example, in the search for genetic determinants of disease in genome-wide associati

149 nprecedented opportunities to understand the genetic determinants of disease on a global scale.

150 This review explores phenotypic and genetic determinants of disease progression in ALS, and

151 Our understanding of the genetic determinants of disease risk has greatly advance

152 Host specific genetic determinants of disease severity identified by t

153 We sought to identify genetic determinants of early postnatal eNO levels and s

154 Identifying and understanding the genetic determinants of EF is important to better unders

155 These findings suggest that genetic determinants of eGFR are mediated largely throug

156 enome-wide CRISPR-Cas9 screening to identify genetic determinants of EGFR TKI sensitivity and uncover

157 Genetic determinants of elevated circulating myeloperoxi

158 ide from alpha-1 antitrypsin deficiency, the genetic determinants of emphysema distribution remain la

159 The molecular genetic determinants of essential tremor are unknown.

160 TeL SNPs capture a substantial proportion of genetic determinants of expression variance and we estim

161 We investigated whether genetic determinants of female reproductive lifespan wer

162 The specific functional and genetic determinants of follicular lymphoma transformati

163 The genetic determinants of food allergy have not been syste

164 ysregulated DDR pathways in PDAC to identify genetic determinants of gemcitabine sensitivity, identif

165 dy provided a comprehensive landscape of the genetic determinants of gene expression in different tum

166 s an evolution-guided approach to define the genetic determinants of genome defense and to reveal the

167 alth research is increasingly focused on the genetic determinants of healthy ageing, but there is no

168 The genetic determinants of heart failure (HF) and response

169 wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenu

170 In conclusion, we found that genetic determinants of height appear to increase the ri

171 However, whether genetic determinants of height influence risk is uncerta

172 However, the genetic determinants of host jumps and increased virulen

173 burn HTS is known to depend on race, but the genetic determinants of HTS are unknown.

174 We sought to identify genetic determinants of hypoplastic left heart with late

175 is is genetically stable and correlated with genetic determinants of ICV.

176 The genetic determinants of iMac239's CD4 independence provi

177 These eligible studies have evaluated genetic determinants of immediate reactions (IR) to beta

178 The genetic determinants of individual clinical cases are in

179 The identification of novel genetic determinants of infant eNO levels might implicat

180 present a unique opportunity to reveal human genetic determinants of infection and disease.

181 The discovery of new genetic determinants of inherited skin disorders has bee

182 el of interferon-stimulated genes as well as genetic determinants of innate immune responses, such as

183 Studying genetic determinants of intermediate phenotypes is a pow

184 accine antigens, we set out to determine the genetic determinants of K. kingae encapsulation.

185 ly-onset COPD would identify additional rare genetic determinants of large effect.

186 Our finding that genetic determinants of long TL increase lung adenocarci

187 This study offers a strategy to explore the genetic determinants of longitudinal phenotypes, provide

188 We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,1

189 ess in this field, little is known about the genetic determinants of m(6)A modification and their rol

190 Genetic determinants of macrolide resistance were evalua

191 To understand genetic determinants of mammalian CNS axon regeneration,

192 Investigation of genetic determinants of Mendelian skin disorders has sub

193 Furthermore, understanding of the genetic determinants of metformin response may lead to t

194 We hypothesized that genetic determinants of myeloperoxidase levels influence

195 ta-analysis sought to gain insights into the genetic determinants of myocardial mass.

196 This is the first study addressing the genetic determinants of N uptake and transport in orchid

197 tiple interspecific populations to elucidate genetic determinants of natural variation.

198 mples of the Finnish DIetary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome (

199 Ds) is influenced by nutritional factors and genetic determinants of one-carbon metabolism.

200 thened by a directional consistent effect of genetic determinants of P wave duration.

201 ecombinant progeny for the identification of genetic determinants of parasite traits and adaptations.

202 uzi life cycle, provides tools to define the genetic determinants of parasite virulence, and reforms

203 knockout and activation screens which reveal genetic determinants of PARPi response in wildtype or BR

204 phenotype association studies which identify genetic determinants of pathogen virulence and drug resi

205 ome editing accelerates the discovery of the genetic determinants of phenotype and the engineering of

206 utagenesis revealed a genome-wide map of the genetic determinants of plant root colonization and offe

207 Thus far, unbiased investigations of the genetic determinants of plasma fetuin-A concentrations h

208 ociation study design, we searched for human genetic determinants of plasma levels of intestinal fatt

209 The goal of this study was to identify genetic determinants of plasma N-terminal proatrial natr

210 The genetic determinants of post-burn hypertrophic scarring

211 Identifying genetic determinants of postnatal eNO levels might aid i

212 We identified dozens of novel genetic determinants of proteins associated with the Fra

213 We characterised the major genetic and non-genetic determinants of proteome variation across iPSC l

214 d that cluster polygenic scores representing genetic determinants of reduced beta-cell function and a

215 r, these tools require the identification of genetic determinants of resistance to the full range of

216 , sequence type assignment, and detection of genetic determinants of resistance.

217 , mycobacteria, and influenza, together with genetic determinants of response to vaccination.

218 of each of these 156 proteins might identify genetic determinants of risk-associated circulating fact

219 GELnet is able to reveal genetic determinants of sensitivity and resistance for s

220 tumor onset and progression, as well as the genetic determinants of sensitivity or resistance to con

221 The identification of cellular and genetic determinants of sensitivity to (223)Ra may guide

222 Little is known about the genetic determinants of severe asthma exacerbations.

223 Genetic determinants of sleep-disordered breathing (SDB)

224 Our findings support a model whereby genetic determinants of smoking increase type 2 diabetes

225 First, we confirmed that genetic determinants of smoking initiation increased ris

226 a complex interplay between genetic and non-genetic determinants of somatic evolution.

227 m is the targeted identification of specific genetic determinants of stress adaptation that have evol

228 We predicted genetic determinants of stroke would be more prominent i

229 Here, we investigated genetic determinants of SUA level in the Korean populati

230 nonspeech processing has been suggested, the genetic determinants of subcortical speech processing ha

231 We aimed to identify genetic determinants of survival in progressive supranuc

232 The genetic determinants of susceptibility to cutaneous squa

233 Genetic determinants of susceptibility to silver nanopar

234 RNB genera with the aim of identifying novel genetic determinants of symbiotic association and plant

235 We map genetic determinants of testis weight and testis gene ex

236 To better understand this, we identified genetic determinants of testosterone levels and related

237 ficant associations, we demonstrate that the genetic determinants of testosterone levels are substant

238 o allow investigation of the genetic and non-genetic determinants of the diseases of middle and old a

239 Genetic determinants of the early steps of carcinogenesi

240 The genetic determinants of the human innate immune response

241 We tested this framework by identifying the genetic determinants of the mesenchymal subtype of gliob

242 ariants may enhance our understanding of the genetic determinants of the metabolome.

243 s of PR interval seem to be mainly driven by genetic determinants of the PR segment.

244 However, the genetic determinants of the renal handling of Mg(2+), wh

245 We investigated genetic determinants of the size of penumbra in mice sub

246 Little is known about the underlying genetic determinants of thermoregulation in plant-pathog

247 Understanding the molecular and genetic determinants of these metabolic programs is crit

248 urs in distinct pathologic patterns, but the genetic determinants of these patterns are unknown.

249 To explore the genetic determinants of these phenotypic differences, we

250 oviding a basis for new understanding of the genetic determinants of these traits and pulmonary disea

251 aits such as meat quality, information about genetic determinants of these traits is in high demand.

252 y, we sought to determine the prevalence and genetic determinants of this phenomenon in a large refer

253 ity in a subset of treated patients, but the genetic determinants of this susceptibility are poorly u

254 association studies (GWAS), we unveiled the genetic determinants of tocochromanol accumulation in to

255 hough recent mapping efforts have elucidated genetic determinants of transcript levels, mapping of pr

256 this model represent the degree to which the genetic determinants of two phenotypes overlap.

257 We studied genetic determinants of urine 6-bromotryptophan and its

258 We evaluated genetic determinants of urine arsenic metabolites in Ame

259 However, the genetic determinants of variable response to aspirin (al

260 pression quantitative trait loci (eQTL), the genetic determinants of variation in gene expression pat

261 To investigate the genetic determinants of variation in grip strength, we p

262 71 P. acnes genomes, we identified potential genetic determinants of various P. acnes strains in asso

263 Identification of risk-adjusted genetic determinants of virulence may help to improve pr

264 e aimed to increase our understanding of the genetic determinants of vitamin D levels by undertaking

265 bitor treatment, indicating the existence of genetic determinants of Wee1 inhibitor sensitivity other

266 raits are important clinical indicators, the genetic determinants of which have not been fully invest

267 However, the genetic determinants of within-plant movement are unknow

268 The antibiotic resistance genetic determinants on the LAC-4 genome correlate well

269 Multiple biological, behavioural and genetic determinants or correlates of obesity have been

270 stress on productive HSV-1 growth and viral genetic determinants potentially enabling replication un

271 upport the hypothesis that currently unknown genetic determinants, potentially discoverable by whole-

272 se of cardiovascular mortality; however, its genetic determinants remain incompletely defined.

273 h heritability in first-degree relatives, AV genetic determinants remain incompletely understood.

274 y and morbidity risk in humans, although its genetic determinants remain largely unknown.

275 s in developmental pathways, the majority of genetic determinants remain unknown.

276 The 64 mutant analyses revealed all the genetic determinants required for assembly of the SPN3US

277 with high-throughput sequencing, to identify genetic determinants required for P. aeruginosa growth u

278 To identify possible viral genetic determinants responsible for differences in symp

279 To identify chromosomal genetic determinants responsible for E. faecalis biofilm

280 The genetic determinants responsible for this canonical case

281 nto the environment of bacterial species and genetic determinants (RIs) involved in antibiotic resist

282 We have now determined an additional genetic determinant(s) for A3F localization to HIV-1 cor

283 Thus, Satb2 is a genetic determinant that mediates proper circuit develop

284 interplay between environmental factors and genetic determinants that cannot be completely replicate

285 V predispose populations to outbreaks, viral genetic determinants that confer greater fitness for epi

286 ot known whether these strains harbor unique genetic determinants that confer virulence in extra-inte

287 The genetic determinants that control the entrance into the

288 ell-intrinsic response by characterizing the genetic determinants that control the expulsion and deat

289 s, emphasizes the need for identification of genetic determinants that dictate CHIKV virulence in the

290 The viral genetic determinants that dictate the severity of acute

291 In this study, we aim to describe the genetic determinants that modify the FVIII PK profile in

292 In bacteria, recognition typically involves genetic determinants that provide cell surface receptors

293 ogic, without conserved phenotypes and known genetic determinants that rigorously distinguish UTI- an

294 owered flight, but little is known about the genetic determinants that shape their wings.

295 tion, leading to derepression of the key ACT genetic determinant Top2b, and provides new insight into

296 he interaction of T. tabaci and TSWV isolate genetic determinants underlie successful transmission of

297 findings establish and characterize a novel genetic determinant underlying sensitivity to diverse ad

298 Although the genetic determinants underlying disease onset remain unc

299 However, the genetic determinants underlying in planta variation of c

300 In this study, we have identified genetic determinants underlying the genotype displacemen