ライフサイエンスコーパス: genetic drift

1 ich could be attributed to random mortality (genetic drift).

2 al systems is driven by local adaptation and genetic drift.

3 iven by local climatic conditions and random genetic drift.

4 ynamics that is readily distinguishable from genetic drift.

5 ne tuning but a simple consequence of random genetic drift.

6 d (ii) the efficacy of selection relative to genetic drift.

7 ations, and with high risk of inbreeding and genetic drift.

8 e become fixed within populations because of genetic drift.

9 cies in Sardinians than would be expected by genetic drift.

10 bined activities of mutation, selection, and genetic drift.

11 us has largely been characterized by neutral genetic drift.

12 ukaryotes experiencing high levels of random genetic drift.

13 bution of changes in allele frequency due to genetic drift.

14 of the front shape and amplify the effect of genetic drift.

15 leterious mutations that had become fixed by genetic drift.

16 increasing aphid density and thus weakening genetic drift.

17 as adaptive and non-adaptive forces such as genetic drift.

18 rs them susceptible to mutational erosion by genetic drift.

19 of populations that have experienced recent genetic drift.

20 c regions in migration rates and/or rates of genetic drift.

21 ue to functional redundancy, asexuality, and genetic drift.

22 der selection for increased evolvability and genetic drift.

23 enomenon in continuous models without random genetic drift.

24 Eldon-Wakeley model, despite the presence of genetic drift.

25 istent with huge population sizes and minute genetic drift.

26 ng to alternative phenotypes can be fixed by genetic drift.

27 nward to the lower barrier imposed by random genetic drift.

28 on, or neutral rearrangements resulting from genetic drift.

29 ects the balance of natural selection versus genetic drift.

30 t genomic regions rather than by genome-wide genetic drift.

31 tic adaptation, anterior dental loading, and genetic drift.

32 SI+] are only weakly deleterious relative to genetic drift.

33 iple founders for names, non-paternities and genetic drift.

34 eleterious mutational load, and (iii) random genetic drift.

35 ntations of past histories as null models of genetic drift.

36 se of negative selection rather than neutral genetic drift.

37 e regions than in others-plus the effects of genetic drift.

38 her they were fixed in the population due to genetic drift.

39 y a balance between selection, mutation, and genetic drift.

40 ing fine-mapping resolution, and controlling genetic drift.

41 number were mixed, however, consistent with genetic drift.

42 balance among mutation, weak selection, and genetic drift.

43 populations, thus neglecting the effects of genetic drift.

44 tly exceed previous predictions that ignored genetic drift.

45 ces in the modern human gene pool because of genetic drift.

46 n positive selection or can be due to random genetic drift.

47 ll hypothesis to explain trait divergence is genetic drift.

48 creased fixation of deleterious mutations by genetic drift.

49 ty within populations should decrease due to genetic drift.

50 itochondrial population size, thus affecting genetic drift.

51 leotide substitutions, a hallmark of neutral genetic drift.

52 fragments that accumulate mutations through genetic drift.

53 -reproductive years are influenced by random genetic drift.

54 o selection and was less likely to be due to genetic drift.

55 mics analogous to neutral alleles undergoing genetic drift.

56 well as its potential role as a catalyst of genetic drift.

57 changes that would be expected under random genetic drift.

58 an interaction between natural selection and genetic drift.

59 tochastic lineage birth and death and random genetic drift.

60 indistinguishable from a noisy background of genetic drift.

61 and the low background noise resulting from genetic drift.

62 cteristically large population sizes and low genetic drift.

63 iation patterns compatible with evolution by genetic drift.

64 cantly greater than the null distribution of genetic drift.

65 t can be achieved set by the power of random genetic drift.

66 cer cells and how PSA expression shifts with genetic drift.

67 a do not fit the pattern expected by neutral genetic drift.

68 eassignments the sole result of mutation and genetic drift?

69 length beyond which selection dominates over genetic drift; (2) a characteristic angular correlation

70 molded by differences in the power of random genetic drift across the tree of life; and 3) for any pa

71 estimates for the strengths of selection and genetic drift acting on newly incorporated genetic eleme

72 nucleotide substitution and polymorphism to genetic drift acting on weakly selected mutants, and ass

73 tate invasion, spontaneous cell death due to genetic drift after accumulation of irreversible deleter

74 mately 10(-3)-10(-5) per allele) rather than genetic drift alone (P < 10(-15)).

75 of genetic variation within lineages due to genetic drift alone may explain the observed patterns.

76 of N rose to high frequency in Melanesia by genetic drift alone.

77 eviation at 6p22 was unlikely to result from genetic drift alone.

78 e accounted for by the stochastic effects of genetic drift, although significant clustering does occu

79 We discovered an effect similar to genetic drift, amplified by family relationships among c

80 tions of allele frequencies above and beyond genetic drift-an effect known as genetic draft.

81 Modeling is done both using a modified genetic drift analytical treatment and computer simulati

82 Population demography, genetic drift and adaptation to environments over thousa

83 ial groups are necessarily subject to strong genetic drift and at high risk of inbreeding depression.

84 utionary confounding phenomena (for example, genetic drift and demographic history).

85 pattern over time as a consequence of random genetic drift and discuss potential effects of recombina

86 spontaneously emerged as a result of natural genetic drift and drug treatment.

87 eat all loci as equally subject to forces of genetic drift and gene flow.

88 species' ranges due to spatial variation in genetic drift and gene flow.

89 against many H1 strains that have undergone genetic drift and has potential as a "subtype universal"

90 ld prevent differentiation of populations by genetic drift and hinder local adaptation.

91 l breeding, because it measures the rates of genetic drift and inbreeding and affects the efficacy of

92 ios where other evolutionary processes (e.g. genetic drift and introgression) may also be acting.

93 the transition from a stable quasispecies to genetic drift and loss of information can also occur by

94 d mitochondrion, establishing a link between genetic drift and mitochondrial translation.

95 tive power of two nonadaptive forces: random genetic drift and mutation pressure.

96 rent amplifications of the effects of random genetic drift and mutation.

97 n without invoking the nonadaptive forces of genetic drift and mutation.

98 Competition between random genetic drift and natural selection play a central role

99 Because evolutionary processes such as genetic drift and natural selection play a crucial role

100 ation generates the heritable variation that genetic drift and natural selection shape.

101 be acted upon by the twin engines of random genetic drift and natural selection.

102 f a stochastic evolutionary model simulating genetic drift and neoplastic progression.

103 f symbionts, which experience high levels of genetic drift and potential selection for selfish traits

104 N can accelerate extinction by strengthening genetic drift and relaxing selection.

105 aper summarizes simulation studies of random genetic drift and selection in malaria parasites that ta

106 erate the process of evolution beyond simple genetic drift and selection, helping to rapidly generate

107 tions, which may become fixed in a tumor via genetic drift and selection.

108 in evolutionary biology because it controls genetic drift and the response to selection.

109 esult from resampling of finite populations (genetic drift) and the random genetic background of near

110 ms, such as mutation, natural selection, and genetic drift, and also the interactions between genetic

111 by selection for efficient ribosomal usage, genetic drift, and biased mutation.

112 orces of mutation, recombination, and random genetic drift, and drawing from observations on the join

113 rom ~50,000 individuals reveal how mutation, genetic drift, and fitness shape the genetic diversity o

114 of natural selection, population migration, genetic drift, and founder effects have shaped the world

115 determines the amount of genetic variation, genetic drift, and linkage disequilibrium (LD) in popula

116 c factors such as historic population sizes, genetic drift, and mutation can have pronounced effects

117 Although mutation, genetic drift, and natural selection are well establishe

118 has spread to, and in turn on how migration, genetic drift, and natural selection have acted.

119 lies a complex interaction between mutation, genetic drift, and positive selection during duplicate f

120 erge through a combination of recombination, genetic drift, and selection driven by population immuni

121 impacts on the interplay between gene flow, genetic drift, and selection.

122 Through evolution, genetic drift, and speciation, photosynthetic organisms

123 play between recent expansion, gene flow and genetic drift, and their consequences for genetic divers

124 o estimate the contribution of selection and genetic drift, and their interplay, to the evolution of

125 consequent reduction in the power of random genetic drift appears to be sufficient to enable natural

126 its incorporation of a cumulative effect of genetic drift as humans colonized the world.

127 demonstrates a powerful approach to testing genetic drift as the default evolutionary mechanism of t

128 processes known to be in constant operation, genetic drift (as modulated by the demographic history o

129 ect changes in phenotype frequency caused by genetic drift, as well as a simplified simulation of sex

130 despite dramatic nonadaptive genomic shifts (genetic drift) associated with population declines.

131 rifying selection, reversible mutations, and genetic drift, assuming a stationary population size.

132 lose diversity rapidly because of the strong genetic drift at the expansion edge.

133 tualistic partners to stay together, because genetic drift at the expansion front creates regions of

134 ition between Darwinian selection and random genetic drift at the range margins.

135 dation of the rate of loss of variability by genetic drift at this locus.

136 rms of population genetics processes such as genetic drift, balancing and purifying selection, and th

137 side as chronic infection is established and genetic drift becomes the dominant evolutionary force.

138 anguinity, and with population structure and genetic drift becoming emergent features of the model.

139 in the balance between natural selection and genetic drift between two related lineages.

140 fection, ongoing HCV evolution is not random genetic drift but rather the product of strong pressure

141 ines the opportunity for local selection and genetic drift, but has been well studied in few animal-p

142 gion-specific sexual selection and/or random genetic drift, but not universal sexual selection.

143 ve genomic DNA losses and increased power of genetic drift, but we also suggest that additional evide

144 alytical tools and simulations, we show that genetic drift can generate a sharp margin to a species'

145 Here, it is argued that random genetic drift can impose a strong barrier to the advance

146 These results demonstrate that genetic drift can lead to the evolution of complexity in

147 h small population sizes, where the power of genetic drift can outweigh that of selection.

148 nd Daghestani populations is consistent with genetic drift caused by patrilocal endogamy.

149 ay have developed during intervals of strong genetic drift caused by periodic blooms of a subset of g

150 Paulo/378/82), with there being significant genetic drift compared to earlier circulating viruses wi

151 nce, a phenomenon we call 'geometry-enhanced genetic drift', complementary to the founder effect asso

152 utations in the human genome, suggested that genetic drift could play a role in population dynamics o

153 ment of spatial structure and enhancement of genetic drift, could complement molecular strategies in

154 We furthermore show how genetic drift coupled to inbreeding following the popula

155 understood with influenza viruses, in which genetic drift creates antigenically distinct strains tha

156 less experience radically different forms of genetic drift, depending on the reproductive mechanism,

157 he present, most likely fortuitously through genetic drift despite its systematic elimination by bias

158 When a duplicate locus has recently fixed by genetic drift, diversity in the new gene is expected to

159 Since genetic drift does not lead to temporal covariance, we c

160 lyses is needed to support a primary role of genetic drift driving ancient genome reduction of marine

161 y distance, the divergence of populations by genetic drift due to limited dispersal, is responsible.

162 Although genetic drift due to spatial isolation and bottlenecks s

163 Theory predicts rapid genetic drift during invasions, yet many expanding popul

164 the amount of lost variation is explained by genetic drift during the bottleneck and by natural selec

165 obability of a single mutation fixing due to genetic drift during the recovery experiment, we observe

166 mutualistic range expansions as a result of genetic drift effects preceding local resource depletion

167 ween selection and the stochastic effects of genetic drift, estimating an effective population size o

168 ak or asymmetric mutualism is overwhelmed by genetic drift even when mutualism is still beneficial, s

169 ng that gene frequencies change at random by genetic drift, even in the absence of natural selection,

170 m the joint processes of mutation and random genetic drift, even in the face of constant directional

171 vely neutral, highlighting the importance of genetic drift-even for enhancers underlying conserved ph

172 n ancestors with a larger drift load because genetic drift favours phenotypes which have a larger num

173 ion, subsequently shaped by selection and/or genetic drift, followed by a more recent exotic European

174 ty of these diseases is likely the result of genetic drift following a bottleneck.

175 higher call frequencies is inconsistent with genetic drift for the Hispaniolan population, despite ma

176 s, adapted from the work of Kimura on random genetic drift, for the full mtDNA heteroplasmy distribut

177 The solution could lie in distinguishing genetic drift from 'genetic draft' and in dissecting the

178 act on the detection of clonal selection and genetic drift from both bulk and single-cell sequencing

179 front and show how to distinguish such rapid genetic drift from selective sweeps.

180 city was found to have likely arisen through genetic drift from the ancestral cP.

181 In finite populations, genetic drift generates interference between selected lo

182 In finite populations subject to selection, genetic drift generates negative linkage disequilibrium,

183 tation, and at the population level, such as genetic drift, give rise to neutral patterns that we can

184 lation size decreases, selection weakens and genetic drift grows in importance.

185 ctive population sizes than castes, and that genetic drift has had a higher impact in tribal populati

186 ions declined significantly, suggesting that genetic drift has increased because of a population bott

187 * Our results suggest that genetic drift has played a significant role in the recen

188 es are vulnerable to the negative effects of genetic drift, human-caused mortality and habitat change

189 However, higher aerobic activity and genetic drift impose strong mutation pressure and risk o

190 The impact of genetic drift in a population is largely determined by i

191 ese founder events are the spatial analog of genetic drift in a randomly mating population.

192 ilizes the differences accumulated by random genetic drift in allele count data from single-nucleotid

193 age disequilibrium and substantial levels of genetic drift in comparison with their wild-born counter

194 tions, they do not rule out a major role for genetic drift in driving ancient ecological switches.

195 YSV genotypes further emphasizes the role of genetic drift in modeling the population architecture, e

196 s inferred from European GWASs are biased by genetic drift in other populations even when choosing th

197 gional scale seems too limited to counteract genetic drift in patchily distributed tropical plants.

198 loci were also found, suggesting a role for genetic drift in shaping adaptive variation.

199 cular clock and emphasized the importance of genetic drift in shaping molecular evolution.

200 post-glacial colonization or to contemporary genetic drift in small, peripheral populations.

201 ast, heterogeneity appears to be a result of genetic drift in the absence of the restriction of tick

202 Taken together, these results suggest that genetic drift in the B10.BR strain has significantly imp

203 tleneck, indicating an important role of the genetic drift in the evolution of the virus.

204 Our results show that random genetic drift in the malaria life cycle is more pronounc

205 ty is a non-adaptive property resulting from genetic drift in which constructive neutral evolution pr

206 ole of natural selection, relative to random genetic drift, in governing this process is unclear.

207 icial mutations to fix, and spatially-caused genetic drift increases.

208 in population-genetic settings where random genetic drift is a relatively strong force.

209 nt to which variation in the power of random genetic drift is capable of influencing phylogenetic div

210 erior dental loading are well supported, but genetic drift is consistent with the available evidence.

211 utral divergence resulting from mutation and genetic drift is critical for understanding the evolutio

212 We find that genetic drift is dramatically suppressed when dispersal

213 * In small isolated populations, genetic drift is expected to increase chance fixation of

214 Genetic drift is expected to remove polymorphism from po

215 1.0 x 10(7) to 9.0 x 10(7)) suggesting that genetic drift is of minimal importance during an establi

216 agenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cance

217 rests on a 'standard model' in which random genetic drift is the dominant force, selective sweeps oc

218 lection (i.e., its tendency to dominate over genetic drift) is extremely weak relative to classical m

219 in surface-associated growth because strong genetic drift leads to spatial isolation of donor and re

220 In annual species, genetic drift led to the expansion of nuclear and mitoch

221 We show by simulation that genetic drift, leptokurtosis of mutational effects, and

222 on with varying strength among sites, random genetic drift, linkage, and recombination.

223 city by inducing redundancy and potentiating genetic drift locally while conserving genome architectu

224 er (F(ST) > 0.4) indicating the influence of genetic drift, long isolation (possibly dating from the

225 Recent research has shown that genetic drift may have produced many cranial differences

226 s of selection and that population size (and genetic drift) may be an important determinant of the ev

227 usly published results, which suggested that genetic drift might have occurred within the B10.BR stra

228 pproach we fitted predictions from models of genetic drift, migration, constant selection, heterozygo

229 imary role of neutral evolutionary processes-genetic drift, mutation, and gene flow structured by pop

230 oevolutionary processes, including mutation, genetic drift, natural selection and gene flow, can prov

231 of population genetics is to understand how genetic drift, natural selection, and gene flow shape al

232 Such a resistance contributes to the genetic drift of evolving tumors as well as to their lim

233 Genetic drift of influenza virus genomic sequences occur

234 dditionally, we discovered a more pronounced genetic drift of mitochondrial genetic variants in the g

235 emnants is often assumed to be simply due to genetic drift of neutral mutations that occurred after t

236 patterns in mortality were compared with the genetic drift of the influenza viruses by analyzing hema

237 red to evaluate the effects of selection and genetic drift on phenotypic differentiation.

238 Given the increased effects of genetic drift on reduced population size, theory predict

239 axed selection mainly due to higher rates of genetic drift on the wave front.

240 due to abandonment of unproductive lineages, genetic drift, on-going natural selection, and recent br

241 ected if evolution is driven by mutation and genetic drift only, with an excess of low-frequency poly

242 To minimize false discovery due to genetic drift, only 42 of the candidate selection region

243 er the observed variability is due to random genetic drift or is a result of natural selection.

244 l ancestry associated with migration, random genetic drift or natural selection.

245 ex chromosomes can be classified in terms of genetic drift or positive selection being the primary me

246 ferentially purged from, or are retained by, genetic drift or positive selection in mammalian genomes

247 g Europeans, either because of extraordinary genetic drift or selective sweeps.

248 rope, consistent with discordant and extreme genetic drifts or adaptive selections after human migrat

249 sland populations, geographic isolation with genetic drift, or a combination of these factors.

250 istance dispersal founding event followed by genetic drift; or the response in an obligate mycorrhiza

251 d therefore evolved primarily as a result of genetic drift, others can be linked to nonstochastic pro

252 lations experienced greater evolution due to genetic drift over the season.

253 rk has shown that hotspots can evolve due to genetic drift overpowering their intrinsic disadvantage.

254 However, genetic drift, particularly due to founder effects, will

255 lated populations lose genetic diversity via genetic drift, phonemes are not subject to drift in the

256 broadly consistent with the hypothesis that genetic drift plays a role in shaping genomic mutation r

257 d how asexual reproduction may interact with genetic drift (population size).

258 is believed to be caused by a combination of genetic drift, population immunity, and recombination, b

259 y understood, and the relative importance of genetic drift, positive selection, and relaxed purifying

260 Second, effective population size and genetic drift profoundly affect the statistical frequenc

261 * Genetic drift promotes fixation of deleterious mutations

262 to a lower limit set by the power of random genetic drift rather than by intrinsic physiological lim

263 uency differences between populations due to genetic drift rather than natural selection.

264 It extends the population dynamics of genetic drift, recasting Kimura's selectively neutral th

265 Thus, random genetic drift, recent changes in mutational tendencies,

266 maintained by mutation-selection balance and genetic drift, recent evidence indicates that intra-locu

267 , likely promoting ecological divergence and genetic drift resulting in a wide range of genome-wide d

268 an implanted xenograft, reverse the initial genetic drift seen after passage on non-humanized mice a

269 pproximately balanced by the power of random genetic drift, such that variation in equilibrium genome

270 f Africa, chromosome X experienced much more genetic drift than is expected from the pattern on the a

271 Withstanding 3.5 billion years of genetic drift, the canonical genetic code remains such a

272 lutionary patterns and processes governed by genetic drift, the small effects of such mutations make

273 In Bacteria, assessing the contribution of genetic drift to genome evolution is problematic because

274 Our genetic drift treatment takes into account that after ge

275 the paradoxical constructive role of random genetic drift, typically mildly deleterious, in fosterin

276 We use Brownian motion to model genetic drift under neutrality, and a deterministic mode

277 We tested a stochastic model of genetic drift using partial envelope sequences sampled l

278 ed by determining the relative importance of genetic drift vs. positive selection in the fixation of

279 es found in the kidney and the rate at which genetic drift was affecting the disseminated populations

280 Little genetic drift was detected in viruses shed by the same s

281 te-occupancy frequency data it appeared that genetic drift was the major force acting on these IS630/

282 explore the antagonism between mutualism and genetic drift, we grew cross-feeding strains of the budd

283 low levels of immigration and high levels of genetic drift, whereas those populations less isolated d

284 eased variance enhances levels of short-term genetic drift which is predicted to inhibit adaptation.

285 Genetic drift, which is particularly effective within sm

286 agonistic selection, recurrent mutation, and genetic drift, which should collectively shape empirical

287 own to sensitively depend on the strength of genetic drift, which varies among strains and environmen

288 a but that both also experienced more recent genetic drift, which was greater in East Asians.

289 However, genetic drift will have a greater influence on small iso

290 that in small island populations of rodents, genetic drift will lead to alleles at multiple genomic l

291 Thus, a history of genetic drift with accumulation of point mutations was n

292 volved populations due to both selection and genetic drift with expectations under drift only.

293 successful samples to forward simulations of genetic drift with natural selection and find that selec

294 rguing against positive selection and toward genetic drift with relaxation of purifying selection.

295 uropean farmers showed that the Kalash share genetic drift with the Paleolithic Siberian hunter-gathe

296 n augmenting genetic differentiation through genetic drift, with isolated northern European breeds sh

297 tain mobility and persistence in the face of genetic drift within potential host target sites.

298 genotype level, there was relatively little genetic drift within the individual gene segments, sugge

299 to reveal possible genomic heterogeneity and genetic drifts within cell lines.

300 ose produced by stochastic processes (random genetic drift) within a species, and clades that represe