ライフサイエンスコーパス: genetic element

1 ment and instead is a component of a selfish genetic element.

2 ea with programmable immunity against mobile genetic elements.

3 to protect bacteria from invasion by foreign genetic elements.

4 lution of consequential mutations and mobile genetic elements.

5 ea provides adaptive immunity against mobile genetic elements.

6 eave the DNA or RNA of the cognate parasitic genetic elements.

7 genetic diversity including multiple mobile genetic elements.

8 ransferred to bacterial pathogens via mobile genetic elements.

9 genetic position and their linkage to mobile genetic elements.

10 e of autonomously replicating foreign mobile genetic elements.

11 that appear to have been derived from mobile genetic elements.

12 idered to be exceptionally successful mobile genetic elements.

13 ogenous retroviruses as well as other mobile genetic elements.

14 ARGs and their co-occurrence with associated genetic elements.

15 ainst invaders like viruses and other mobile genetic elements.

16 lysis of the 16S rRNA gene and various other genetic elements.

17 olerant DNA endonucleases that act as mobile genetic elements.

18 cloning system used to assemble and combine genetic elements.

19 stem that protects prokaryotes from invading genetic elements.

20 by bacteria and archaea to fend off foreign genetic elements.

21 ae and suggest that they spread as parasitic genetic elements.

22 and determined their association with mobile genetic elements.

23 wide spectrum of viruses and other parasitic genetic elements.

24 erived from bacteriophages and other foreign genetic elements.

25 rsity, accumulation of mutations, and mobile genetic elements.

26 r memory of previous encounters with foreign genetic elements.

27 ovides RNA-mediated protection from invading genetic elements.

28 reness for the global dissemination of these genetic elements.

29 abroad for the dissemination of these mobile genetic elements.

30 r the discovery and functional annotation of genetic elements.

31 man genome that has been colonized by mobile genetic elements.

32 otect germ cells from the activity of mobile genetic elements.

33 n and are present on phages and other mobile genetic elements.

34 protect bacteria and archaea against foreign genetic elements.

35 trons are self-splicing ribozymes and mobile genetic elements.

36 ic adaptive genes, usually located on mobile genetic elements.

37 cal significance and effect size of targeted genetic elements.

38 inst the expression of unwanted or parasitic genetic elements.

39 on the presence of virulence and resistance genetic elements.

40 tion with "Cleave and Rescue" (ClvR) selfish genetic elements.

41 yotes for developing host immunity to mobile genetic elements.

42 replicative autonomy and becoming parasitic genetic elements.

43 proteins for RNA-guided cleavage of foreign genetic elements.

44 dly expanding, in a large part due to mobile genetic elements.

45 rity when challenged by pathogens and mobile genetic elements(1-3).

46 although SCCmec has been designated a mobile genetic element, a mechanism for its transfer has not be

47 ith multiple enzymes disseminating on mobile genetic elements across opportunistic pathogens such as

48 as well as widespread circulation of mobile genetic elements across the bacterial population.

49 mic conflict describes a phenomenon in which genetic elements act 'selfishly' to gain a transmission

50 This genetic element allows for predictable tuning, insulatio

51 nes, especially those associated with mobile genetic element and bacteriocins, showed changes in freq

52 genes involved in DNA metabolism, in mobile genetic elements and defective prophages.

53 nds; evolutionary connections between mobile genetic elements and defense, whereby genes of mobile el

54 They were flanked by multiple mobile genetic elements and highly conserved among IPU-minerali

55 s mediated by a diverse complement of mobile genetic elements and occurs primarily by conjugation or

56 quently attacked by viruses and other mobile genetic elements and rely on dedicated antiviral defense

57 t harmonious interactions between co-evolved genetic elements and result in reduced male fertility, s

58 rokaryotes against bacteriophages and mobile genetic elements and serve as the basis for revolutionar

59 s and replication of naturally occurring RNA genetic elements and suggest a means by which diverse RN

60 We show that CbAgo targets multicopy genetic elements and suppresses the propagation of plasm

61 d valuable data from microsatellites, mobile genetic elements, and accurate divergence time estimates

62 to the lytic origin of replication (OriLyt) genetic elements, and BET inhibitors prevent viral late

63 ymerase II (RNA Pol II) from core regulatory genetic elements, and eliminates RNA Pol II but not BRD4

64 rous; beta-lactamase genes carried on mobile genetic elements are a key mechanism for the rapid sprea

65 es, but some homologs associated with mobile genetic elements are larger and contain an extra C-termi

66 Mobile genetic elements are ubiquitous.

67 form of CRISPR-based drive system comprising genetic elements arranged in a daisy chain such that eac

68 ermed YeastFab Assembly) to synthesize these genetic elements as standardized biological parts, which

69 three islands are predicted to encode mobile genetic elements as well as virulence factors.

70 and functional characterization of specific genetic elements associated with a phenotype of interest

71 Genetic elements associated with stress survival were pr

72 inland China revealed the presence of mobile genetic elements associated with the expansion of emm12

73 gene transfer permits rapid dissemination of genetic elements between individuals in bacterial popula

74 iruses might descend from primordial selfish genetic elements, bona fide viruses evolved on multiple,

75 Cells benefit from silencing foreign genetic elements but must simultaneously avoid inactivat

76 onal testing of large synthetic libraries of genetic elements, but are limited by the designability,

77 ed (Cas) systems detect and degrade invasive genetic elements by an RNA-guided, RNA-targeting multisu

78 ia and archaea acquire resistance to foreign genetic elements by integrating fragments of foreign DNA

79 e genome is guarded against invading foreign genetic elements by small RNA-dependent gene-silencing p

80 hes, we have designed and introduced a novel genetic element called a ribo-attenuator in Bacteria.

81 two self-copying (or active) guide RNA-only genetic elements, called e-CHACRs and ERACRs.

82 Importantly, our data show that mobile genetic elements can persist within the bacterial popula

83 on a single-celled ciliate reveal how mobile genetic elements can shape a genome, even one which is n

84 fit the guns-for-hire concept whereby mobile genetic elements capture host defense systems and repurp

85 driven by horizontal dissemination of mobile genetic elements carrying blaKPC-2, followed by the intr

86 Here, we describe a chromosomal selfish genetic element, CleaveR [Cleave and Rescue (ClvR)], abl

87 In the first wave of synthetic biology, genetic elements, combined into simple circuits, are use

88 Genetic elements compete for transmission through meiosi

89 de repeated genomic elements, such as mobile genetic elements, compromising our understanding of the

90 These mobile genetic elements confer expression of superantigens SSA

91 Integrons are genetic elements consisting of a functional platform for

92 ates, are characterized by a distinct set of genetic elements controlling their gene expression.

93 lso demonstrate that self-propagating active genetic elements (CopyCat elements) can efficiently dele

94 However, mobile genetic elements counteract Cas12a with inhibitors, nota

95 he replication and segregation of these four genetic elements during polar growth.

96 ngly influenced by the acquisition of mobile genetic elements encoding determinants involved in niche

97 es, and mobile elements, while these foreign genetic elements evolve diverse anti-CRISPR proteins to

98 Although several types of selfish genetic elements exist in nature, few have been successf

99 intact and defective proviruses that contain genetic elements favoring efficient protein expression d

100 lly related to a family of unorthodox homing genetic elements found in Torulaspora and Lachancea yeas

101 Genetic elements found on the assembled genomic fragment

102 n for the horizontal transfer of a "selfish" genetic element from cell to cell via membrane fusion.

103 ogy-directed repair, which copies the active genetic element from the donor to the receiver chromosom

104 of Ewing sarcoma in human cells with defined genetic elements has been challenging.

105 Horizontal transfer of mobile genetic elements has played a central role in the evolut

106 Here we show that: (1) when selfish genetic elements have a greater impact at the individual

107 , recombinases derived from unrelated mobile genetic elements have essential roles in both prokaryoti

108 Mobile genetic elements have significantly shaped our genomic l

109 Transposable elements (TEs) are mobile genetic elements, highly enriched in heterochromatin, th

110 Integrative genetic elements (IGEs) are mobile multigene DNA units t

111 Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in shapin

112 ibit the replication of HIV and other mobile genetic elements.IMPORTANCE Piwil proteins inhibit the m

113 as successfully used for detection of donkey genetic element in consumable beef sausages preparations

114 vls locus is the most evolutionarily diverse genetic element in Lyme disease-causing borreliae.

115 isolates each had a different insertion of a genetic element in the staphylococcal cassette chromosom

116 and msr(D), were present on chimeric mobile genetic elements in 99.3% of the macrolide-resistant iso

117 eraction between integrative and conjugative genetic elements in a single Gram-negative bacterium wit

118 Cre recombinase mediates precise deletion of genetic elements in a spatially- and temporally-controll

119 rsity of DNA sequences and multiple types of genetic elements in and near centromeres support centrom

120 RNA-based immune system that silences mobile genetic elements in animal germlines.

121 ignifying the potential importance of mobile genetic elements in ARG release from AnMBR systems.

122 some of which were co-localized with mobile genetic elements in assembled metagenomic contigs.

123 Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacterial genomes, but their functio

124 regulate gene expression and suppress mobile genetic elements in eukaryotes(1,2).

125 based adaptive immune system against foreign genetic elements in prokaryotes.

126 em provides adaptive immunity against mobile genetic elements in prokaryotes.

127 e sequence-specific immunity against selfish genetic elements in prokaryotes.

128 izes the custom annotation tracks for mobile genetic elements in public genome browsers.

129 eria and reveal the potential role of mobile genetic elements in shaping the resistome of the rumen m

130 Genetic elements in the bacteriophage lambda immunity re

131 iwil proteins inhibit the movement of mobile genetic elements in the germ line.

132 proteins restrict the replication of mobile genetic elements in the germ line.

133 ans, raising the possibility that additional genetic elements in the locus may have contributed to ev

134 ht on the roles of these recently identified genetic elements in the mechanisms of host resistance an

135 ing frames (uORFs) are ubiquitous repressive genetic elements in vertebrate mRNAs.

136 d genetic drift acting on newly incorporated genetic elements in viral genomes, under conditions of e

137 ultigene deletion; and 3) movement of mobile genetic elements (including prophages) combined with gen

138 since its introduction by exchanging mobile genetic elements, including integrative conjugative elem

139 ssemination of CA-MRSA are carried by mobile genetic elements, including phages and plasmids.

140 the nuclease-dependent degradation of mobile genetic elements, including plasmids and viruses.

141 Beyond genes the system describes other genetic elements, including repeated elements and cis-re

142 itochondria and other maternally transmitted genetic elements, including the role of cytonuclear inco

143 volutionarily connected to capsidless mobile genetic elements, including various plasmids and transpo

144 conjugative transposons) are modular mobile genetic elements integrated into a host genome and are p

145 x arrangement of repeat sequences and mobile genetic elements interspersed among arrays of clustered

146 Furthermore, introduction of this genetic element into strain G27 (hpEurope/type-A and cag

147 tool for standardized assembly of synthetic genetic elements into larger DNA constructs.

148 to catalyse RNA-guided integration of mobile genetic elements into the genome.

149 construction is to manipulate viral proteins/genetic elements involved in antagonizing the host immun

150 ly within various host epithelial cells, the genetic elements involved in the HPT system in S. aureus

151 Through interaction with genetic elements, KChIP2 transcriptionally repressed the

152 In yeast, the cellular extrachromosomal genetic element [KIL-d] alters killer activity of M doub

153 reads more quickly; (2) selection on selfish genetic elements leads them towards a greater impact at

154 HGT events often involve mobile genetic elements like plasmids, which can promote their

155 Central to this exchange are mobile genetic elements like plasmids; yet, the factors shaping

156 teraction of the host genes with surrounding genetic elements, like a convergently overlapped gene an

157 ion and further show the lineage ontogeny of genetic elements linked to diverse human diseases.

158 s, acquisition process, and stability of the genetic elements linked with resistance genes in V. chol

159 r (HGT) relying on bioinformatic analyses of genetic elements maintained on evolutionary timescales o

160 Conjugative plasmids are the principal genetic elements mediating the horizontal transfer of ge

161 Mobile genetic Elements (MEs) are segments of DNA which can cop

162 ; and substantial bla KPC-associated, mobile genetic element (MGE) diversity (50% not within complete

163 To explore the diversity of mobile genetic elements (MGE) associated with archaea of the ph

164 em provides adaptive immunity against mobile genetic elements (MGE) in prokaryotes.

165 erent functional classes of genes and mobile genetic elements (MGE).

166 we reconstructed the precise tempo of mobile genetic elements (MGEs) acquisition events during this p

167 med the conjugation systems, transmit mobile genetic elements (MGEs) among many bacterial species.

168 ndergoing HDT through transmission of mobile genetic elements (MGEs) and genetic transformation.

169 e assembled genomic fragments include mobile genetic elements (MGEs) and metal resistance genes (MRGs

170 Mobile genetic elements (MGEs) are a rich source of new enzymes

171 Fitness costs associated with mobile genetic elements (MGEs) are thought to constrain HGT, bu

172 structure of Escherichia coli and of mobile genetic elements (MGEs) carrying the mcr-1 gene.

173 cteriophages that prey upon them, and mobile genetic elements (MGEs) compete in dynamic environments,

174 Mobile genetic elements (MGEs) contribute to bacterial adaptati

175 Mobile genetic elements (MGEs) encode type IV secretion systems

176 ed linking bacterial taxa to specific mobile genetic elements (MGEs) encoding AR genes.

177 Horizontal gene transfer (HGT) of mobile genetic elements (MGEs) facilitates the spread of antibi

178 ntibiotic-resistance genes (ARGs) and mobile genetic elements (MGEs) in farm environments can potenti

179 eptococcus thermophilus revealed that mobile genetic elements (MGEs) likely contributed to gene acqui

180 Genes and mobile genetic elements (MGEs) previously linked to linuron cat

181 ESBL genes are typically embedded in mobile genetic elements (MGEs) that aid transfer to new plasmid

182 acterial genes known to be carried on mobile genetic elements (MGEs) within avian-borne Escherichia c

183 including viruses and other types of mobile genetic elements (MGEs), and have evolved multiple, dive

184 constant evolutionary battle against mobile genetic elements (MGEs), bacteria have developed several

185 chaea and bacteria is defence against mobile genetic elements (MGEs), including viruses, plasmids and

186 gulating the expression of genes from mobile genetic elements (MGEs), LexA often does so in concert w

187 Mobile genetic elements (MGEs), such as plasmids, promote bacte

188 ge defense systems are often found on mobile genetic elements (MGEs), where they constitutively defen

189 es are hosts to horizontally acquired mobile genetic elements (MGEs), which encode virulence, toxin,

190 CRISPR-Cas systems to combat invading mobile genetic elements (MGEs).

191 s, protecting cells from infection by mobile genetic elements (MGEs).

192 an spread horizontally by residing on mobile genetic elements (MGEs).

193 ls differ in the presence of specific mobile genetic elements (MGEs).

194 y relevant functions, and the role of mobile genetic elements (MGEs).

195 the local wild population can drive a useful genetic element nearly to local fixation for a wide rang

196 lline cellulose efficiently and contains the genetic elements necessary for cellulosome production.

197 ype M28 GAS isolates harbor a 36.3-kb mobile genetic element of apparent group B Streptococcus origin

198 lowed regulatory modulation through inserted genetic elements, on-demand control of the expression/tr

199 ising resilience of this gene to addition of genetic elements or helix substitutions with phylogeneti

200 oorganisms, and assist in identifying mobile genetic elements or lateral gene transfer events.

201 lained solely based on the associated mobile genetic elements or the resistance phenotype.

202 ssential for immunity against diverse mobile genetic elements originating from plasmid and phage.

203 jejuni ST-21 and ST-45 complexes identified genetic elements over-represented in clinical isolates t

204 Our analysis also identified genetic elements, particularly HLA, as key drivers of au

205 A different composition of mobile genetic elements (plasmids and phages) or amino acid sub

206 gative elements (ICEs) are ubiquitous mobile genetic elements present as "genomic islands" within bac

207 n single nucleotide polymorphisms and mobile genetic element profiles, suggesting a single L. pneumop

208 CRISPR-Cas immunity against invasive mobile genetic elements, prokaryotes must first integrate fragm

209 idered: descent from primordial, precellular genetic elements, reductive evolution from cellular ance

210 We report genetic elements relevant to its expression, including a

211 odified DNA donor molecule acts as a selfish genetic element, replaces the targeted site and propagat

212 To test for cis genetic elements required for Pxr function, we deleted t

213 h in turn has hampered the identification of genetic elements responsible for this resistance phenoty

214 Analysing our data with exons as 'immobile genetic elements' revealed a similar frequency of unexpe

215 gene, which is carried on a distinct mobile genetic element (SCCmec), the expression of which is con

216 resistance genes via the transfer of mobile genetic elements, selective pressure in vivo resulting i

217 Antagonistic coevolution with selfish genetic elements (SGEs) can drive evolution of host resi

218 ments, it also carries risks such as selfish genetic elements (SGEs).

219 defense and antibiotic selection for mobile genetic elements shapes in vitro E. faecalis populations

220 Selfish genetic elements spread in natural populations and have

221 Mobile genetic elements such as genomic islands (GIs) have been

222 cterial genome rearrangements involve mobile genetic elements such as insertion sequence (IS) element

223 -guided adaptive immunity to fend off mobile genetic elements such as phages and plasmids.

224 t protects the prokaryotes against exogenous genetic elements such as phages.

225 Genetic elements such as sex-chromosome drives can disto

226 e sequence-specific immunity against selfish genetic elements such as viruses and plasmids, by specif

227 ed parallels in other maternally transmitted genetic elements, such as bacterial endosymbionts of art

228 mmune systems that protect them from foreign genetic elements, such as invading viruses.

229 eviously undescribed activity against mobile genetic elements, such as LINE-1, to protect the integri

230 ve immune system that interferes with mobile genetic elements, such as plasmids and phages.

231 I demonstrate that female-biased genetic elements-such as the W and X sex chromosomes-wil

232 Our analysis further suggests that genetic elements supporting productive frameshifting cou

233 Two direct cagA-flanking repeats of a genetic element termed CHA-ud were essential for the mul

234 em can allow for the forced propagation of a genetic element that bypasses Mendelian inheritance whic

235 Here we use an active genetic element that encodes a guide RNA, which is embed

236 ific to multiple-queen colonies is a selfish genetic element that enhances its own transmission by ca

237 odel CRISPR screen data for interrogation of genetic elements that alter reporter gene expression rea

238 nal repeat (LTR) retrotransposons are mobile genetic elements that are closely related to retroviruse

239 Transposons are mobile genetic elements that are found in nearly all organisms,

240 cus aureus pathogenicity islands (SaPIs) are genetic elements that are mobilized by specific helper p

241 Inteins are mobile genetic elements that are spliced out of proteins after

242 hysiological conditions (called flipons) are genetic elements that can encode alternative RNA process

243 roteins produced by viruses and other mobile genetic elements that can potently inhibit CRISPR-Cas sy

244 Transposable elements (TEs) are mobile genetic elements that can profoundly impact the evolutio

245 , there is considerable evidence for selfish genetic elements that change the behaviour of individual

246 slands (PICIs) are a family of highly mobile genetic elements that contribute substantively to horizo

247 e and conjugative elements (ICEs) are mobile genetic elements that contribute to horizontal gene tran

248 lands are integrative and conjugative mobile genetic elements that convert nonsymbiotic rhizobia into

249 However, the genetic elements that distinguish grasses that are sensi

250 Transposons are ubiquitous genetic elements that drive genome rearrangements, evolu

251 Inteins are parasitic genetic elements that excise themselves at the protein l

252 Extrachromosomal (ec) DNAs are genetic elements that exist separately from the genome.

253 d the mechanisms underlying the emergence of genetic elements that facilitate clonal spread of the pa

254 ain carried distinct mutations and accessory genetic elements that impacted genes with roles in metab

255 olution of bacteria, archaea, and the mobile genetic elements that infect them.

256 This system is also targeted by mobile genetic elements that integrate into chromosomal dif sit

257 R-Cas variants, often associated with mobile genetic elements that lack the nucleases required for in

258 Gene drives are genetic elements that manipulate Mendelian inheritance r

259 etween the host chromosome(s) and the mobile genetic elements that mediate gene exchange.

260 ort tandem repeats (STRs) are highly mutable genetic elements that often reside in regulatory and cod

261 of genomic information, the discovery of the genetic elements that regulate complex traits remains a

262 Genetic elements that replicate extrachromosomally are r

263 mids are stably maintained extra-chromosomal genetic elements that replicate independently from the h

264 Inteins are invasive genetic elements that self-splice at the protein level f

265 Inteins are mobile genetic elements that self-splice at the protein level.

266 e and conjugative elements (ICEs) are mobile genetic elements that transfer from cell to cell by conj

267 Retrotransposons are eukaryotic mobile genetic elements that transpose by reverse transcription

268 DGR systems are remarkable genetic elements that use error-prone reverse transcript

269 Recently, we identified two mobile genetic elements that were closely associated with emm12

270 ogram can be circumvented by a protein-based genetic element, the [GAR(+)] prion, permitting simultan

271 associated with viruses and/or other mobile genetic elements, there is no doubt that the LUCA was a

272 rom viruses and infections with other mobile genetic elements." There is an abundance of genomic data

273 Mobile genetic elements threaten genome integrity in all organi

274 from one microorganism to another by mobile genetic elements, thus transferring resistance to previo

275 ognize diverse targets, ranging from selfish genetic elements to genes essential for gametogenesis.

276 e, reflects the ability of the corresponding genetic elements to maintain mobility and persistence in

277 t our method links plasmids and other mobile genetic elements to their host species in a real microbi

278 ial evolution, reliable assignment of mobile genetic elements to their microbial hosts in natural com

279 meiosis provides an opportunity for selfish genetic elements to violate Mendel's law of segregation

280 evolutionarily conserved function in mobile genetic element (transposons) silencing and maintenance

281 particular interest, as they control mobile genetic elements (transposons) in germ cells and thus ho

282 mes against the deleterious action of mobile genetic elements (transposons).

283 To identify novel genetic elements underling the risk of inhibitor develop

284 scriminating conserved versus taxon-specific genetic elements underlying CHC variation.

285 tic drivers and the diverse mechanisms these genetic elements use to bias their transmission to the n

286 -specific immunity against phages and mobile genetic elements using CRISPR-associated nucleases guide

287 aea employ adaptive immunity against foreign genetic elements using CRISPR-Cas systems.

288 mune system defends microbes against foreign genetic elements via DNA or RNA-DNA interference.

289 uide strands derived from invading or mobile genetic elements, via an unknown pathway, to direct guid

290 outer-membrane vesicles (OMVs) that package genetic elements, virulence factors, and cell-to-cell co

291 Most of the classic selfish genetic elements were discovered through their biasing o

292 DNA (class 2) transposons are mobile genetic elements which move within their 'host' genome t

293 ported transmission of resistance via mobile genetic elements, which demonstrated greater diversity o

294 resent a novel and universal class of mobile genetic elements, which have broad impact on bacterial v

295 Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes r

296 ria and archaea from phages and other mobile genetic elements, which use small anti-CRISPR (Acr) prot

297 lds identified ARGs likely located on mobile genetic elements, with up to 11 ARGs per plasmid-associa

298 portant to identify ecological or functional genetic elements within the maternal or infant nasal mic

299 Moreover, proviruses that lack these genetic elements, yet contain strong donor splice sequen

300 mal rap-phr genes are also present on mobile genetic elements, yet relatively little is known about t