ライフサイエンスコーパス: genetic factor

1 )) and confirmed GRIK3 S310A as a protective genetic factor.

2 changes combine with both environmental and genetic factors.

3 environmental, microbial, immunological, and genetic factors.

4 etrimental effects of both environmental and genetic factors.

5 al curvature appears to be shaped largely by genetic factors.

6 tion is not clear, in particular the role of genetic factors.

7 se disorder (AUD) are strongly determined by genetic factors.

8 viors coaggregate in families largely due to genetic factors.

9 notypic variation in BPH is accounted for by genetic factors.

10 ly be explained by differences in underlying genetic factors.

11 n, and immune responses, in interaction with genetic factors.

12 tic risk of mortality on modification of non-genetic factors.

13 pe 2 diabetes (T2D) and partly determined by genetic factors.

14 raits that are likely to be related to virus genetic factors.

15 se may be linked to certain serovar-specific genetic factors.

16 tion, suggesting the existence of additional genetic factors.

17 ressive periodontitis (AgP) is influenced by genetic factors.

18 nia spectrum disorders could be explained by genetic factors.

19 ic, demographic, cultural, environmental and genetic factors.

20 on based on cell type, external stimuli, and genetic factors.

21 is highly variable and results from multiple genetic factors.

22 y, but its effects vary with tumor stage and genetic factors.

23 re complex interplay between genetic and non-genetic factors.

24 ntiated by yet-unidentified environmental or genetic factors.

25 ontitis variance in the population is due to genetic factors.

26 variants, while accounting for relevant non-genetic factors.

27 ce area in youth is attributable to additive genetic factors.

28 uenced by fetal and maternal genetic and non-genetic factors.

29 of PNES, much less about possible underlying genetic factors.

30 phropathy, calcineurin inhibitors (CNI), and genetic factors.

31 denocarcinoma (EAC) based on genetic and non-genetic factors.

32 which is not fully explained by hormonal or genetic factors.

33 We used gene targeting to validate candidate genetic factors.

34 alant and occupational allergens, as well as genetic factors.

35 es, underscoring the existence of additional genetic factors.

36 s for CHD and other diseases associated with genetic factors.

37 ticularly with regard to the contribution of genetic factors.

38 tiple interactions between environmental and genetic factors.

39 s, and is affected by environmental and host genetic factors.

40 populations, which are mostly driven by non-genetic factors.

41 e phenotypic variance has been attributed to genetic factors.

42 Seventy-five involved human host genetic factors, 36 of which involved analysis of specif

43 d suicide attempts was explained by additive genetic factors (60.7%) and non-shared environment (40.4

44 Similarly, genetic factors accounted for the majority of variation

45 pecific genetic correlation beyond a general genetic factor across psychiatric disorders.

46 Environmental and genetic factors acting at the level of the host species

47 Genetic factors affect adolescent symptom trajectories;

48 These include how host genetic factors affect disease susceptibility and pathog

49 RATIONALE: How host genetic factors affect Mycobacterium tuberculosis (Mtb)

50 Genetic factors affect not only the risk of developing s

51 Our results reveal that genetic factors affect variability in urinary biomarkers

52 ur results reveal technical, biological, and genetic factors affecting circRNA expression variation a

53 ry, suggesting that there might be different genetic factors affecting susceptibility across ancestry

54 Genetic factors, aging, and trauma all contribute to con

55 llenging and population-specific, but use of genetic factors along with a few common population-relev

56 e same time, patients should understand that genetic factors also contribute to diverticulitis risk.

57 we critically review existing evidence that genetic factors alter ME/CFS risk before concluding that

58 Defining genetic factors altering glycosylation may provide a bas

59 DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a

60 A statistical model including additive genetic factors and environmental factors partly shared

61 r, with evidence supporting a combination of genetic factors and environmental insults, including vir

62 Interactions between genetic factors and epigenetic regulatory mechanisms may

63 (V-EoE) would be enriched for early-life and genetic factors and have worse presentation and prognosi

64 orrelation has a significant basis in shared genetic factors and is highly symmetric between left and

65 erstood, but might include both age-specific genetic factors and low-frequency genetic variation.

66 e-gene mutations in patients can help define genetic factors and molecular mechanisms underlying neur

67 attern of cortical atrophy, which relates to genetic factors and motor and cognitive symptoms.

68 We identified IR-genetic factors and selected lifestyles to generate risk

69 Genetic factors and socioeconomic status (SES) inequalit

70 Maternal diabetes, genetic factors and some teratogens have been shown to b

71 Genetic factors and steatosis predispose to hepatocellul

72 trait governed by interactions between host genetic factors and the environment.

73 ur understanding of the interactions between genetic factors and the gut microbiome, and challenges t

74 However, maternal and fetal genetic factors and the molecular mechanisms remain uncl

75 studies improved our understanding of these genetic factors and the molecular mechanisms underlying

76 mGWAS) investigated the relationship between genetic factors and the urine metabolome in kidney disea

77 tability of AD was estimated to be 57.0% for genetic factors, and 3.1% and 40.0% for shared and nonsh

78 been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all o

79 uenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated wi

80 oimaging and cerebrospinal fluid biomarkers, genetic factors, and measures of cognitive resilience) f

81 eated regional effects of clinical symptoms, genetic factors, and medication that may explain progres

82 This study reveals that non-genetic factors, and to a lesser extent, genetic factors

83 non-genetic factors, and to a lesser extent, genetic factors appear to influence mutual eye gaze in a

84 is strongly influenced by cigarette smoking, genetic factors are also important determinants of COPD.

85 This umbrella review investigates which genetic factors are associated with drug-related movemen

86 results suggest that both environmental and genetic factors are associated with structural brain agi

87 Both social environment and genetic factors are critical for smoking initiation and

88 hat spatially complex and temporally dynamic genetic factors are influencing cerebral surface area in

89 sidering traditional measures, we found that genetic factors are largely responsible for most of leaf

90 Genetic factors are likely to be important in determinin

91 isorders in individuals with PNES shows that genetic factors are likely to play a role in PNES or its

92 Mitochondrial genetic factors are now emerging as determinants of raci

93 ontology analysis revealed that a number of genetic factors are related to the metabolic pathway of

94 Genetic factors are surprisingly relevant: PTSD has been

95 ades suggest that environmental, rather than genetic factors are the driving force behind the increas

96 Both environmental and genetic factors are thought to contribute to colon infla

97 ing evidence that environmental, rather than genetic, factors are the major causes of most chronic di

98 bination of sensory, neurophysiological, and genetic factors as potential determinants of obesity.

99 Genetic factors, as well as alterations in colonic neuro

100 This study establishes AMY1-CN as a genetic factor associated with microbiome composition an

101 analysis (GWAS), and fine-mapping to examine genetic factors associated with 15-year cognitive trajec

102 rea and obesity-related traits, and identify genetic factors associated with adipocyte cell size.

103 The identification of genetic factors associated with kidney disease has the p

104 and to examine demographic, immunologic, and genetic factors associated with period of symptom onset.

105 Our study identifies multiple genetic factors associated with rifampicin tolerance in

106 e used to identify and quantify clinical and genetic factors associated with SCD.

107 evere illness in high-risk populations, host genetic factors associated with severe disease are large

108 the levels of lipoprotein(a) and associated genetic factors between individuals that were ascertaine

109 HbA(1c) is influenced by environmental and genetic factors both in people with and in people withou

110 outcome after stroke has been attributed to genetic factors but no locus has been consistently assoc

111 autism spectrum disorder (ASD) share common genetic factors but seem to have specific patterns of ps

112 between a large number of environmental and genetic factors but the comprehensive analysis of contri

113 nt viral load attributable to viral or human genetic factors by using joint host/pathogen genetic dat

114 Non-genetic factors can cause individual cells to fluctuate

115 family history of the disease attributed to genetic factors, common exposures, or both.

116 to be influenced by numerous genetic and non-genetic factors, complicating their analysis.

117 d two-thirds of the variance attributable to genetic factors, consistent with an oligogenic architect

118 Although genetic factors contribute to almost half of all cases o

119 Twin studies suggest that genetic factors contribute to continuity in mental healt

120 This suggests that unknown genetic factors contribute to disease pathogenesis.

121 Although genetic factors contribute to interindividual and interp

122 Despite evidence that genetic factors contribute to the duration of gestation

123 Genetic factors contribute to the risk of thrombotic dis

124 However, environmental rather than genetic factors contributed most to those correlations.

125 ociation was due to a significant overlap in genetic factors contributing to each phenotype (genetic

126 rbor a substantial genetic component but the genetic factors contributing to overall diabetes mortali

127 The genetic factors contributing to the combination of sympt

128 isparities, and none have assessed potential genetic factors contributing to this outcome.

129 In addition, our analyses suggest that genetic factors controlling circadian rhythm and pigment

130 rence of comorbid depression, such as shared genetic factors, converging biological pathways, social

131 esting that besides environmental variables, genetics factors could control bioaccessibility of pheno

132 cohorts with controlled behavioral states or genetic factors, could provide helpful investigative lea

133 Thus, environmental and genetic factors directly affect developmental mechanisms

134 Genetic factors do not fully account for the relatively

135 depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val(158)met, DAT, BD

136 ed in the etiopathogenesis of ASD, including genetic factors, environmental toxins and stressors, imp

137 Genetic factors explain a major proportion of human heig

138 del incorporating connectomic, cellular, and genetic factors explained 58% of the variance in glioma

139 Additive genetic factors explained between 49.1% and 62.7% of var

140 Genetic factors explained the major part of individual d

141 Vitamin D receptor (VDR) is a key genetic factor for shaping the host microbiome.

142 ay improve statistical power to detect novel genetic factors for cerebral small vessel disease, eluci

143 However, genetic factors for lung cancer have not been fully iden

144 s provided novel understanding regarding the genetic factors for overweight and obesity risks on syst

145 Using both genetic and non-genetic factors, four machine learning models have close

146 ual human brain regions and environmental or genetic factors have been investigated, how brain age is

147 Genetic factors have been postulated to be involved in t

148 Genetic factors have been shown to play an important rol

149 l process corresponding to environmental and genetic factors (here treated together as a unit called

150 to molecular levels and, in combination with genetic factors, holds the key to understanding the phen

151 dies have attempted to identify predisposing genetic factors; however, reproducible findings have not

152 Shared genetic factors impact risk for dermatological autoimmun

153 re studies can explore the identity of these genetic factors, improving our understanding of how they

154 traits the magnitude of the contribution of genetic factors in adolescents remains unclear.

155 for WC; P < 0.001 for both), largely due to genetic factors in common (bivariate h2 > 70%).

156 While the role of host genetic factors in facilitating elite control is well kn

157 ions is central to understanding the role of genetic factors in health and disease.

158 general assumptions which are based on known genetic factors in NAFLD to build a systems biology pred

159 Here, we investigated the effect of host genetic factors in shaping the bacterial species composi

160 ical thickness, were primarily influenced by genetic factors in TD twins; however, mean curvature app

161 Over the past two decades, the importance of genetic factors in the development of FSGS has become in

162 esults provide 1) improved quantification of genetic factors in the etiology of caries and 2) new dat

163 er socio-cultural, psychosocial context, and genetic factors in which risk and resilience are embedde

164 ic correlations (covariability due to shared genetic factors) in interregional cortical thickness, an

165 and mortality; however, the extent to which genetic factors increase risk for PAD is largely unknown

166 Genetic factors increase risk of dementia, but the exten

167 mechanism by which high- and low-penetrance genetic factors increase thyroid cancer risk.

168 d antiretroviral agents on adipocyte health, genetic factors, increased microbial translocation, chan

169 ions share common genetics, that overlapping genetic factors influence both area and thickness in you

170 This study demonstrates that genetic factors influence breast cancer risk after chest

171 uman superior frontal cortex, that heritable genetic factors influence SERPING1 gene expression level

172 A controversial hypothesis is that genetic factors influence vulnerability to depression fo

173 past several years, our understanding of the genetic factors influencing alcohol use and abuse has pr

174 he age at onset of motor symptoms in HD, but genetic factors influencing cognitive and psychiatric pr

175 unprecedented opportunities to elucidate the genetic factors influencing complex traits related to he

176 indicate the potential for the discovery of genetic factors influencing haemodynamic traits in large

177 s that there is a substantial overlap in the genetic factors influencing skin pigmentation and tannin

178 Understanding the genetic factors influencing smoking-related traits facil

179 The genetic factors influencing these clusters were only par

180 l enable the identification of genotypes and genetic factors influencing these traits in blueberry.

181 hat mGWAS hold promise for identifying novel genetic factors involved in adsorption, distribution, me

182 eening provides a powerful means to discover genetic factors involved in cellular processes in a high

183 Understanding of genetic factors involved in NPC and how they contribute

184 ay allow for the identification of potential genetic factors involved in the development of Covid-19.

185 eening approach to systemically identify the genetic factors involved in the regulation of oxidative

186 atly limiting our understanding of the viral genetic factors involved in this deadly disease.

187 ubcategorizing the phenotypes and underlying genetic factors involved.

188 Unraveling the interplay between these genetic factors is key to the discovery of new biomarker

189 Variance due to genetic factors is largely constant, but its share as a

190 FR posttransplant, the effect size of common genetic factors is limited compared to clinical variable

191 iration and their relationship to underlying genetic factors is still poorly understood.

192 berrant glutamate levels can be explained by genetic factors is unknown, and if glutamate can serve a

193 We found that additive genetic factors largely contributed to dog ownership, wi

194 ive hearing loss involving environmental and genetic factors, leading to a decrease in hearing sensit

195 Genetic factors likely contribute to the observed ethnic

196 Maternal and inherited (ie, case) genetic factors likely contribute to the pathogenesis of

197 Genetic factors likely influence the risk of spread.

198 ral dispersal and weather events, as well as genetic factors linked to shifts in host range.

199 We hypothesized that genetic factors linking laterality features with the eti

200 Genetic factors make less of a contribution in this coho

201 ive disease with a multitude of contributing genetic factors, many of which are related to inflammati

202 Finally, recent data suggest that host genetic factors may also modulate the severity of P. aer

203 ociated CpGs suggesting that genetic and non-genetic factors may drive outcomes and ethnic-associated

204 nce components analyses, and that the common genetic factors may influence beta-carotene and obesity

205 Genetic factors may play a greater role in average 25(OH

206 While genetic factors may predispose for autoimmunity, additio

207 , and better understanding of the regulating genetic factors may provide insights for thrombopoiesis.

208 nate to viral exposure, suggesting that host genetic factors may significantly influence susceptibili

209 ion model including each of the clinical and genetic factors mentioned hereafter, among the clinical

210 complex network of interactions between host genetic factors, microbes, and microbial metabolites gov

211 etic effects and little understanding of how genetic factors might influence caries progression or ca

212 In the present study we tested whether genetic factors, modelled alongside common family enviro

213 ree-step gene discovery strategy to identify genetic factors modifying the risk of both C9ALS and spo

214 Evidence suggests that genetic factors modulate the expression of inflammatory

215 individual strains, suggesting that distinct genetic factors modulate these traits independently and

216 The effect of genetic factors on educational attainment has decreased

217 assess the influence of host genetic and non-genetic factors on virus antibody responses.

218 amilial factors, including environmental and genetic factors, on rapid renal decline in diabetes.

219 Importantly, genetic factors operating at 8 years explained only appr

220 ld be the result of ecological, cultural, or genetic factors or a combination thereof.

221 oked by additional environmental/acquired or genetic factors, or both.

222 Genetic factors, particularly those with environmental i

223 ll described, the relationship between local genetic factors, pathogenesis, and subsequent spread of

224 Genetic factors play a key role in the pathogenesis of a

225 It is believed that genetic factors play a large role in the development of

226 Genetic factors play a major role in the etiology of epi

227 Although genetic factors play a role in the etiology of atopic di

228 of patients treated with lithium, suggesting genetic factors play a role.

229 as undeniable impact, evidence suggests that genetic factors play a significant role in completed sui

230 Genetic factors play an important role in KC pathogenesi

231 Although genetic factors play an important role in the pathogenes

232 er progresses and thus understanding how the genetic factors play roles on the progressive brain QT c

233 embrane 6 superfamily member 2 (TM6SF2) is a genetic factor predisposing to nonalcoholic fatty liver

234 ease in our ability to search the genome for genetic factors predisposing to cardiovascular disease (

235 However, the genetic factors regulating colitis and colon tumorigenes

236 s, 30 involved both human and non-human host genetic factors related to coronavirus, 178 involved stu

237 78 involved study of non-human (animal) host genetic factors related to coronavirus, and 984 involved

238 We reviewed the literature on host genetic factors related to coronaviruses, systematically

239 the PRSs in the model developed based on non-genetic factors resulted in a net reclassification impro

240 oach does not leverage the environmental and genetic factors shared among the multiple phenotypes col

241 sms are based, at least partly, on different genetic factors shared by many other conditions, such as

242 Genetic factors significantly influence susceptibility f

243 A shared global genetic factor strongly influenced large areas of the fr

244 ecognized in an individual are determined by genetic factors such as the MHC molecules the individual

245 nderstanding the interaction between various genetic factors, such as parkin and PINK1, in this disea

246 Genetic factors, such as rare variants in the microglial

247 tween G4C2 repeat-associated toxicity and 18 genetic factors, suggesting their potential association

248 Little is known about genetic factors that affect development of alcohol-relat

249 Yet, little is known about the genetic factors that allow these potentially resilient i

250 long with other clinical, familial, and rare genetic factors that are currently used in personalized

251 esults are a step forward in identifying the genetic factors that contribute to AD risk and add novel

252 familial epilepsies, which are enriched for genetic factors that contribute to epilepsy risk.

253 .2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in add

254 hosis, and nonalcoholic fatty liver disease, genetic factors that contribute to the HCC risk remain u

255 al aggregation but little is known about the genetic factors that contribute to these cases.

256 to new areas of inquiry to better understand genetic factors that determine the fate of viral infecti

257 However, the genetic factors that determine their dimensions are uncl

258 d the extremes of such variation to identify genetic factors that differentiate newly resynthesised B

259 xperimentally falsifiable predictions on the genetic factors that drive the formation of individual n

260 istics, supporting our expectation of common genetic factors that drive the synapse formation within

261 ration with other omics data, uncovering the genetic factors that govern stroke recurrence and stroke

262 erns of dementia has led to the discovery of genetic factors that have a role in the pathogenesis of

263 Genetic factors that have been identified include genes

264 daptation to adversity, may be influenced by genetic factors that have remained largely unexplored in

265 ble but still little is known about the host genetic factors that increase or reduce the risk of deve

266 standing question in the field is what other genetic factors that influence GBA-associated risk for d

267 Genetic factors that influence kidney traits have been u

268 variability could result from epigenetic and genetic factors that influence stem cell behavior.

269 have increased our understanding of the host genetic factors that influence WT risk, with sequencing

270 o identify environmental, socioeconomic, and genetic factors that may be responsible for the observed

271 he biology of small HER2-positive tumors and genetic factors that may predispose to paclitaxel-induce

272 We identify multiple genetic factors that mediate susceptibility to rifampici

273 A causative understanding of genetic factors that regulate glioblastoma pathogenesis

274 ors than humans, allow the identification of genetic factors that shape the immune system.

275 s which influence this relationship, such as genetic factors, the use of psychotropic medications dur

276 HD and cannabis use are partly determined by genetic factors; the heritability of ADHD is estimated a

277 by genetic alteration and other clinical and genetic factors to analyze differences in growth rates u

278 e types, consistent with the contribution of genetic factors to disease occurrence.

279 ining tumors by manipulating genetic and non-genetic factors to metastasize, resist treatment, and ma

280 opaminergic modulation, and the potential of genetic factors to stratify patients.

281 ions of environmental, maternal and additive genetic factors to the Lifetime reproductive success (LR

282 The contribution of genetic factors to this risk is unclear.

283 We identified Cyfip2 as a major significant genetic factor underlying binge eating and provide a beh

284 The search for the genetic factors underlying complex neuropsychiatric diso

285 valuable for studying the environmental and genetic factors underlying injury in the developing huma

286 se results yield additional insight into the genetic factors underlying kidney function and progressi

287 Genetic factors underlying leukocyte telomere length (LT

288 nts are instrumental as tools for dissecting genetic factors underlying the mechanisms involved in ch

289 ence genome is essential for identifying the genetic factors underlying traits of interest through li

290 Evidence of shared genetic factors was found between frequent insomnia symp

291 For non-genetic factors, we study the emerging wearable technolo

292 onprogressors had a lower risk category when genetic factors were considered.

293 nal cardiologists consider both clinical and genetic factors when selecting antiplatelet therapy foll

294 romoting effects of obesity are modulated by genetic factors will foster the identification of at-ris

295 e regression, that ALS shares polygenic risk genetic factors with a number of traits and conditions,

296 ntrol during hypoxia at altitude, by linking genetic factors with cardiovascular dynamics, as evaluat

297 ental exposure, as opposed to medications or genetic factors with effects on DNA methylation or gene

298 d associations of BMI and other clinical and genetic factors with glycemic progression defined as req

299 bivariate GWAS meta-analysis to demonstrate genetic factors with pleiotropic effects on bone mineral

300 of periodontitis in the population is due to genetic factors, with higher heritability for more sever