ライフサイエンスコーパス: genetic linkage

1 on from evolutionary histories that resolves genetic linkage.

2 milies showing the strongest evidence of the genetic linkage.

3 estimate variance components and to test for genetic linkage.

4 12 that has numerous independent reports of genetic linkage.

5 been inconsistent for reports of significant genetic linkage.

6 egate within populations and evolve in close genetic linkage.

7 netic colocalization either by pleiotropy or genetic linkage.

8 otypes with other viral functions coupled by genetic linkage.

9 lelic frequency are no longer constrained by genetic linkage.

10 causal variants for single gene disorders is genetic linkage.

11 Here, genetic linkage analyses combined with exome sequencing

12 These findings support the utility of genetic linkage analyses for identification of novel ris

13 15q25-q26 to maximize the informativeness of genetic linkage analyses in a region where they previous

14 Genetic linkage analyses show a TBC1D1 R125W missense va

15 Genetic linkage analyses were performed with the use of

16 er the use of these markers for whole-genome genetic linkage analyses.

17 We performed genetic linkage analysis and candidate gene sequencing o

18 Genetic linkage analysis and complementation data establ

19 festing with calf weakness, we identified by genetic linkage analysis and exome sequencing a heterozy

20 Here we have performed genetic linkage analysis and mapped the disease locus to

21 We applied genetic linkage analysis and next-generation sequencing

22 vary among individuals of a species and that genetic linkage analysis can be used to identify quantit

23 Genetic linkage analysis can provide the means to identi

24 ission in the year following infection using genetic linkage analysis despite apparently increased ri

25 Genetic linkage analysis has identified loss-of-function

26 Genetic linkage analysis has identified regions of the g

27 Genetic linkage analysis identified 14 loci that were as

28 Genetic linkage analysis identified three loci with an L

29 We performed genetic linkage analysis in consanguineous families affe

30 ed in controlling hair texture, we performed genetic linkage analysis in six families of Pakistani or

31 We carried out a genetic linkage analysis in the extended DYT4 family tha

32 Genetic linkage analysis mapped loci with lod scores of

33 Localization of complex traits by genetic linkage analysis may involve exploration of a va

34 mating in Leishmania, opening the way toward genetic linkage analysis of important traits and providi

35 ve gene, NKX2-5, has been identified through genetic linkage analysis of pedigrees with non-syndromic

36 Using genetic linkage analysis of proteoglycan-induced arthrit

37 ine skin model of chemical carcinogenesis in genetic linkage analysis of three independent Mus muscul

38 r describes MLIP, a multiprocessor two-point genetic linkage analysis system that supports statistica

39 , a HSL susceptibility gene), we conducted a genetic linkage analysis that included serotyping and ph

40 Genetic linkage analysis was performed in a family with

41 Two-point genetic linkage analysis was performed with MLINK and mu

42 Genetic linkage analysis was performed with the ALLEGRO

43 In this study, deep sequencing, genetic linkage analysis, and transcriptome data were us

44 Genetic linkage analysis, exome sequencing, tumor studie

45 rted to combine gene expression studies with genetic linkage analysis, leading to a new synergy betwe

46 We performed a genomewide scan and genetic linkage analysis, to identify loci associated wi

47 Using genetic linkage analysis, we earlier identified Dice1 as

48 Using genetic linkage analysis, we mapped a new locus for the

49 sults from the somatic deletion analysis and genetic linkage analysis, we were able to further narrow

50 e analyzed all 49 heritable phenotypes using genetic linkage analysis, with special emphasis on pheno

51 and ordering contigs into pseudomolecules by genetic linkage analysis.

52 and 3 unaffected family members, followed by genetic linkage analysis.

53 g locus in the M. smegmatis chromosome using genetic linkage analysis.

54 Both genetic linkage and allelic association in the IDE regio

55 Together with genetic linkage and allelic association of IDE to Alzhei

56 ipoprotein receptor [VLDLR]) were tested for genetic linkage and allelic association, using two indep

57 Here, we present the results of applying genetic linkage and association analyses to neuropsychol

58 We have previously reported evidence for genetic linkage and association of AD on chromosome 10q2

59 Multiple genetic linkage and association studies identified three

60 ibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1

61 study offers substantial power to carry out genetic linkage and association studies that use specifi

62 on as quantitative phenotypes, and conducted genetic linkage and association studies to map their reg

63 ring, heritability, and statistical power in genetic linkage and association studies.

64 genetic regions have been implicated through genetic linkage and association studies.

65 stimated by the EM algorithm, can be used in genetic linkage and association studies.

66 otype reconstruction is an essential step in genetic linkage and association studies.

67 igators are attempting to characterize using genetic linkage and association.

68 Genetic linkage and candidate gene studies have identifi

69 To enhance its genome studies involving genetic linkage and comparative mapping, a bacterial art

70 GCR provides an explanation for the colinear genetic linkage and expression of individual Hox genes w

71 There was considerable optimism that genetic linkage and genome-wide association (GWA) studie

72 ar population genetics of the interaction of genetic linkage and natural selection.

73 emonstrate a robust strategy for integrating genetic linkage and physical contig maps with mitotic an

74 ical models that emphasize the importance of genetic linkage and pleiotropy in facilitating rapid div

75 y of taste receptor genes, hand in hand with genetic linkage and positional cloning studies, notably

76 to SPG20/spartin gene mutation (excluded by genetic linkage and SPG20/spartin sequence analysis).

77 he host genome, such as those resulting from genetic linkages and environmental stochasticity, have l

78 ies, comparative genomics, prior evidence of genetic linkage, and linkage disequilibrium.

79 The previous genetic linkage approach by microsatellite haplotyping w

80 minants of this variation can be mapped by a genetic-linkage approach.

81 combinations are theoretically possible; (2) genetic linkages are rare; (3) intragenic variability ma

82 iological processes giving rise to them, the genetic linkages associated with transcript abundance af

83 essing deficit found in the disease, by both genetic linkage at 15q14 and biochemical data.

84 is association was supported by family-based genetic linkage at a locus encompassing the DARC gene (g

85 n myogenesis remain unclear, owing partly to genetic linkage at the Myf5/Mrf4 locus and to rapid morp

86 Another important result is that the genetic linkage between a cue locus and modifier loci in

87 In small populations, genetic linkage between a polymorphic neutral locus and

88 Although genetic linkage between CG5762 and a neighboring causati

89 e conclude that our studies provide a direct genetic linkage between GI and chloroplast biogenesis, a

90 lysis of progeny from crosses revealed tight genetic linkage between HaABCC2 and resistance to Cry1Ac

91 et al. and Pergadia et al. find evidence for genetic linkage between major depressive disorder and th

92 a single genetic locus, resulting from tight genetic linkage between multiple functional loci.

93 ation is an effective mechanism to break the genetic linkage between neighboring sequences, thereby r

94 ent mice may explain earlier observations of genetic linkage between R7 family mutations and obesity

95 h mating type, discounting the hypothesis of genetic linkage between the A and B mating-type loci as

96 cted microevolutionary trend is explained by genetic linkage between the causal mutation underlying t

97 riation, yet they remain untapped due to the genetic linkage between the few useful alleles and hundr

98 ve at least one copy of A3H-I despite little genetic linkage between these genes.

99 -synuclein in these disorders is provided by genetic linkage between this gene and familial Parkinson

100 olocalization and fine-scale synteny suggest genetic linkage between traits within species and a cons

101 However, genetic linkage between ubiquilin-1 and AD has not been

102 This approach allowed us to establish genetic linkages between metabolites and genes.

103 ous studies have focused on the technique of genetic linkage, but new technologies and experimental r

104 ese pedigrees were evaluated for evidence of genetic linkage, by the maximum-likelihood parametric me

105 Natural selection and genetic linkage cause DNA segments to have genealogical

106 Genetic linkage causes the fate of new mutations in a po

107 Efficient models for genetic linkage disequilibrium (LD) are needed to enable

108 determining the design features of two-stage genetic linkage disequilibrium studies that minimize the

109 KIR3DS1, in positive genetic linkage disequilibrium with KIR2DS1, had no effe

110 Population genetics, linkage disequilibrium, and association analys

111 Fine mapping further confirmed the genetic linkage effect and narrowed the region likely to

112 ctors in the B6 and C3H mouse model and that genetic linkages exist between body weight and lipoprote

113 ns, we conducted a series of correlation and genetic linkage experiments with eight D. melanogaster n

114 ith IC and their FDRs is consistent with the genetic linkage findings in families with PD.

115 assessed the impact of polarity at onset on genetic linkage findings previously detected in this sam

116 ilistic framework that combines the standard genetic linkage formalism with whole-genome molecular-in

117 um, 217/714 (30.4%) sequences had a putative genetic linkage, forming 77 clusters (size range: 2-8).

118 Two high-density genetic linkage framework maps were constructed of 2,842

119 ype 2 diabetes, based on previous reports of genetic linkage, functional molecular studies, expressio

120 We report on the completion of an autosomal genetic linkage (GL) map of the domestic cat (Felis silv

121 A genetic linkage group on chromosome 2 was selected under

122 romosomes that provide the structure for the genetic linkage groups and allow faithful replication, t

123 The rainbow trout genetic linkage groups have been assigned to specific ch

124 .) cytogenetic map that associates classical genetic linkage groups, molecular linkage groups, and a

125 Once genetic linkage has been identified for a complex diseas

126 ugh coordination of both gene expression and genetic linkage have been offered as genetic mechanisms

127 Positional cloning approaches based on genetic linkage have identified the disease genes in the

128 d the ordered-subset analysis to account for genetic linkage heterogeneity in the family-based data s

129 we conducted a whole genome scan to test for genetic linkage in 53 kindreds in which two or more sibl

130 A genome-wide screen for genetic linkage in a large family with an autosomal domi

131 mosome 20 is suggested by the observation of genetic linkage in several independent SLE family collec

132 inical correlates, familial aggregation, and genetic linkage in subjects with these features.

133 ndicating a prominent role for pleiotropy or genetic linkage in the divergence of this character comp

134 Studies have revealed a strong genetic linkage in the early-onset familial form (<60 ye

135 One titin locus lies within the genetic linkage interval and its expression is significa

136 f interactions between natural selection and genetic linkage is abundant not only in centromere- and

137 Genetic linkage is known to be one such feature, and her

138 This close genetic linkage is likely reflected in the strict correl

139 chromosome 6 (logarithm of the odds favoring genetic linkage [LOD] = 2.4), whereas chromosome 21 cont

140 Potato (Solanum tuberosum) has the densest genetic linkage map and one of the earliest established

141 We constructed a genetic linkage map between two divergent populations of

142 A genetic linkage map composed of 841 SSR, AFLP, and RAPD

143 me and used it, along with an integrated SSR genetic linkage map derived from four independent H. ann

144 We describe the first genetic linkage map for Daphnia pulex using 185 microsat

145 The genetic linkage map for green ash (Fraxinus pennsylvanic

146 nalysis, we have developed a high-resolution genetic linkage map for T.gondii.

147 r tambaqui and constructed a high-resolution genetic linkage map from a full-sib family of 124 indivi

148 ato) synaptonemal complex 1 with a molecular genetic linkage map from the interspecific hybrid S. lyc

149 tion between chromosome size and size of the genetic linkage map in centimorgans for the genetic maps

150 , assembled de novo and then anchored to the genetic linkage map into seven pseudochromosomes.

151 nto channel catfish through introgression, a genetic linkage map is helpful.

152 omic substitution line was used to develop a genetic linkage map of 2B, evaluate the genetics of thre

153 In this study, we constructed a low-density genetic linkage map of Arabidopsis lyrata ssp. lyrata (A

154 Here we present a detailed genetic linkage map of ECB using AFLP and microsatellite

155 A first genetic linkage map of green ash was constructed from 90

156 A transcriptome-based genetic linkage map of perennial ryegrass served as a sc

157 A genetic linkage map of the channel catfish genome (N=29)

158 A comprehensive genetic linkage map of the domestic cat X chromosome was

159 We constructed a joint SSR/RAPD genetic linkage map of the Helianthus petiolaris genome

160 To construct a genetic linkage map of the heterothallic yeast, Cryptoco

161 cted group, we constructed a high-resolution genetic linkage map of the homosporous fern model specie

162 A genetic linkage map of the horse consisting of 742 marke

163 udies using rhesus monkeys, we constructed a genetic linkage map of the rhesus genome.

164 combination rate data from a high-resolution genetic linkage map of the zebra finch.

165 A genetic linkage map ordered 1397 genome scaffolds on 12

166 Further, it was found that genetic linkage map regions containing phytochrome and H

167 A framework genetic linkage map was constructed and combined with lo

168 A high-density SNP-based genetic linkage map was constructed and integrated with

169 A genetic linkage map was constructed in a backcross famil

170 A molecular genetic linkage map was constructed using 148 amplified

171 In this project, a genetic linkage map was constructed using amplified frag

172 s mapped on a high-resolution intra-specific genetic linkage map were validated (11.6-27.3% PVE at 5.

173 erto not been possible, due to the lack of a genetic linkage map.

174 8 on the barley cv Dicktoo x barley cv Morex genetic linkage map.

175 A genetic-linkage map for chromosome 3A was developed by m

176 Comparison of the physical maps with the 3A genetic-linkage map localized the QTLs to gene-containin

177 Through genetic linkage mapping and whole-exome sequencing, we i

178 Genetic linkage mapping has identified more than 100 pla

179 High-density genetic linkage mapping is a valuable and effective meth

180 We then performed genetic linkage mapping of male-specific traits importan

181 Genetic linkage mapping of two crosses showed dominance

182 tosomal dominant transmission, and performed genetic linkage mapping using both parametric and non-pa

183 e hundreds of unique recombinant progeny for genetic linkage mapping, bulk segregant analysis, and hi

184 orted previously on the basis of comparative genetic linkage mapping.

185 in aquaporin-2 (Aqp2) in cph mutants through genetic linkage mapping.

186 as expression QTL (eQTL) in two single-tree genetic linkage maps (F(1) hybrid paternal and E. grandi

187 Human genetic linkage maps are based on rates of recombination

188 High density genetic linkage maps are needed for marker assisted bree

189 stical comparison between two whole-genome F genetic linkage maps constructed from experimental inter

190 Construction of genetic linkage maps for nonhuman primate species provid

191 le sequence repeats (SSR)] we have generated genetic linkage maps for Physcomitrella.

192 oid hybrid speciation by generating detailed genetic linkage maps for three hybrid sunflower species,

193 and interactive method for the estimation of genetic linkage maps from DNA markers.

194 a and underscore the continued importance of genetic linkage maps in the post-genome era.

195 The estimation of genetic linkage maps is a key component in plant and ani

196 Construction of genetic linkage maps is an inevitable step for taking ad

197 used to construct comparative, single-tree, genetic linkage maps of an F(1) hybrid individual and tw

198 ject to recent positive selection; the first genetic linkage maps of resistance to malaria in experim

199 Consensus genetic linkage maps provide a genomic framework for qua

200 Comparative genetic linkage maps provide a powerful tool for the stu

201 Genetic linkage maps reveal the order of markers based o

202 The consensus genetic linkage maps were compared with each other and w

203 Improved genetic linkage maps were developed for S-population (Su

204 otyping-by-sequencing approach and generated genetic linkage maps with 6,291 and 3,297 single nucleot

205 difficult because only a few markers connect genetic linkage maps with physical maps.

206 e groups (genome assembly release Tcas_3.0), genetic linkage maps, the official gene set, Reference S

207 riendly computer program for construction of genetic linkage maps.

208 y were to generate high-density physical and genetic-linkage maps of wheat homoeologous group 3 chrom

209 Genetic linkage may result in the expression of multiple

210 heritability (variance-components methods), genetic linkage (multipoint quantitative trait analyses)

211 Theoretical work predicts genetic linkage of a gamete cell-size regulatory gene(s)

212 Collectively, our data suggest that the genetic linkage of AD in this set of chromosome 10-linke

213 Nonetheless, mounting evidence for genetic linkage of autism to the chromosome 17q11.2 regi

214 Genetic linkage of common complement polymorphisms to di

215 We conclude that the genetic linkage of critical physiological and virulence

216 In this cohort we found genetic linkage of disease (P = 0.00045) to chromosomal

217 The authors tested for genetic linkage of DSM-IV-diagnosed major depressive dis

218 cing (NGS, env region) were used to evaluate genetic linkage of HIV from the 7 seroconverters and the

219 underscores the importance of assessing the genetic linkage of HIV seroconversion events in HIV prev

220 We previously reported genetic linkage of loci controlling age-at-onset in Alzh

221 The overall LOD score for genetic linkage of markers to the region was 3.57.

222 The genetic linkage of rcoM with both aerobic (cox) and anae

223 Given the genetic linkage of the FANCJ-A349P allele to FA, we inve

224 autoimmune diseases and the well-established genetic linkage of these diseases with MHC class II.

225 The reasons for the tight genetic linkage of this receptor-ligand pair remain elus

226 We failed to identify genetic linkage of TNF release when considering each sti

227 Thus, these results demonstrate genetic linkages of hyperglycemia and body weight with S

228 Traditional approaches using genetic linkage or candidate gene analysis have often be

229 hree-factor crosses revealed little, if any, genetic linkage over distances of 500 to 600 bp, and lar

230 addition, evidence obtained from genome-wide/genetic linkage/proteomic/translational approaches revea

231 y prohibits the systematic mapping of entire genetic linkage regions in order to find the polymorphis

232 d 643 arginine/glycine (R/G) occur in strong genetic linkage resulting in two common haplotypes (LSR

233 t mutation screen, we conducted a genomewide genetic linkage scan.

234 s that are derived from (noisy) whole-genome genetic-linkage scans.

235 We have performed a genetic linkage screen in 16 pedigrees with FALS with no

236 hold levels of multiple mtDNA deletions, and genetic linkage, sequencing and expression analysis excl

237 ndicate that population structure and strong genetic linkage shapes within-host HCV evolutionary dyna

238 Mania at onset substantially increased the genetic linkage signal on chromosome 16p (maximum lod sc

239 equilibrium that is required by the current genetic-linkage software.

240 Genetic linkage studies and candidate gene association s

241 Genetic linkage studies and exome sequencing have identi

242 microsatellites as the markers of choice for genetic linkage studies and many other studies of human

243 Previous genetic linkage studies and sequencing of plausible gene

244 Recent genetic linkage studies complement the existing evidence

245 hensive tag SNP maps that will be useful for genetic linkage studies in humans.

246 Genetic linkage studies in informative [C57BL/6JxSM/J]F2

247 Genetic linkage studies indicate that germline variation

248 We report on our initial genetic linkage studies of schizophrenia in the genetica

249 Our objective was to conduct genetic linkage studies of the type of OCD thought to ha

250 dney biopsy is frequently unhelpful, whereas genetic linkage studies or mutations in the UMOD gene ma

251 Genetic linkage studies show that the effects of DNA ris

252 Genetic linkage studies showed that there was a high lev

253 These findings and recent genetic linkage studies strongly implicate NMDA receptor

254 Although genetic linkage studies support a critical underlying ro

255 Multiple genetic linkage studies support the hypothesis that the

256 ays, along with microsatellite analysis, and genetic linkage studies were performed.

257 e immunodeficiency and indicate the value of genetic linkage studies, thereby improving the genetic d

258 pported by many somatic deletion studies and genetic linkage studies.

259 s with 22q11 deletion syndrome (22q11DS) and genetic linkage studies.

260 with gene disruption in animal models or by genetic linkage studies.

261 ts were ascertained for two bipolar disorder genetic linkage studies: the University of Chicago, John

262 sideration of age at onset as a covariate in genetic-linkage studies may reduce genetic heterogeneity

263 for the sample sizes commonly used in human genetics linkage studies, minor QTL effects often go und

264 Together, the combination of our unbiased genetic linkage study and the in silico analysis positio

265 Evidence from a genetic linkage study had suggested a possible syndrome

266 We performed a genetic linkage study in 37 multigenerational human pedi

267 The authors conducted a genetic linkage study of families that have both autism

268 Genetic linkage tests reveal that silencing in the early

269 Here we present a method based on genetic linkage that can prospectively identify function

270 These traits showed genetic linkage to a short segment of chromosome 12p, in

271 Its genetic linkage to a single polymorphism at position 57

272 B) on chromosome 17q21 demonstrates a strong genetic linkage to asthma, but its function in asthma is

273 to shape patterns of adaptive evolution via genetic linkage to beneficial mutations.

274 o a region on chromosome 11q23-24 that shows genetic linkage to BMI and type 2 diabetes in Pima India

275 AD shows genetic linkage to Chromosome 1q21.

276 ies, autoreactive CD4+ and CD8+ T cells, and genetic linkage to disease syntenic to that found in hum

277 a glucose binding protein (GBP) based on its genetic linkage to genes that are homologous to an ATP-b

278 stribution among bacterial species and their genetic linkage to known or predicted cell surface struc

279 e of toxin-associated PAAR-repeat motifs and genetic linkage to members of the valine-glycine repeat

280 er of genetic loci have shown association or genetic linkage to monogenic forms of POAG, the identifi

281 pontaneous swarming suppressors, inadvertent genetic linkage to swarming mutations, and auxotrophy.

282 the BALB.K and B10.BR strains to analyze for genetic linkage to the allogeneic BM engraftment phenoty

283 A number of autoimmune diseases have shown genetic linkage to the CTLA-4 locus.

284 ermatitis (AD) and psoriasis, share distinct genetic linkage to the Epidermal Differentiation Complex

285 , from haplotype structure and long-distance genetic linkage to the generation of new allelic variant

286 ossibly NS) segments, coupled with transient genetic linkage to the internal gene segments.

287 Genetic linkage to the K(ATP) locus was established usin

288 between the 2 genomes, both MAT loci exhibit genetic linkage to their respective centromere during me

289 s characterized for 113 strains via PCR, and genetic linkage was assessed.

290 The genetic linkage was confirmed and defined by microsatell

291 these endophenotypes; in the present study, genetic linkage was evaluated.

292 An apparently similar genetic linkage was observed in the rice genome.

293 ism and genes implicated without significant genetic linkage were excluded from this study.

294 andidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, w

295 that affect brain fiber architecture and its genetic linkage with cognitive function.

296 ttractive antiviral targets because of their genetic linkage with many other positions that we predic

297 ds] scores indicated suggestive evidence for genetic linkage with QTLs influencing urine arsenic meta

298 ily members located within intervals showing genetic linkage with SLE are TNFSF4 (also known as OX40L

299 lternatively spliced form of CTLA-4 that has genetic linkage with type I diabetes in the NOD mice.

300 has been observed across species, including genetic linkages with human cognitive abilities, PFC act