ライフサイエンスコーパス: genetic loci

1 1 genome-wide-significant associations in 19 genetic loci.

2 , the donor and the acceptor are at distinct genetic loci.

3 its, usually controlled by one or more major genetic loci.

4 unintended mutagenic changes at the targeted genetic loci.

5 controlling gene expression, and visualizing genetic loci.

6 ap (LRC), was constructed and contained 2498 genetic loci.

7 or the 13 drugs studied it was 238 across 18 genetic loci.

8 asis refers to interactions between multiple genetic loci.

9 71 have a known molecular etiology or linked genetic loci.

10 ight in Europeans have identified nearly 180 genetic loci.

11 ts and the variation explained by identified genetic loci.

12 uency changes within a generation at 186,576 genetic loci.

13 y were shown to be able to detect additional genetic loci.

14 disorders (ASD) is attributed to hundreds of genetic loci.

15 s were subsequently performed for identified genetic loci.

16 itively defined subgroups and nominate novel genetic loci.

17 diseases caused by variations in a number of genetic loci.

18 requirements, CRISPR/Cas9 cannot access many genetic loci.

19 We identified 21 common and low-frequency genetic loci (14 novel) associated with maximum PWD, inc

20 omal and mitochondrial DNA sequences of four genetic loci (16S rDNA, 28S rDNA, Cytochrome oxidase I a

21 The dataset constitutes 56 genetic loci, 17,887 zygotes, and 1718 live-born mice, o

22 roticism have identified up to 11 associated genetic loci (3,4) .

23 entified 208 significant associations in 176 genetic loci (53 novel).

24 novel approach to unsupervised screening of genetic loci across RNA-seq cohorts.

25 Many genetic loci affect circulating lipid levels, but it rem

26 At least two genetic loci affect the rate of Abeta-related cognitive

27 While studies have reported genetic loci affecting serum urate (SU) concentrations,

28 100 000 participants, we identified over 200 genetic loci, all but eight novel, significantly associa

29 k in diabetes, and the identification of two genetic loci allowing the selection of patients with typ

30 ary angle closure glaucoma (PACG)-associated genetic loci allows improved detection of PACG, compared

31 Through cross-phenotype analysis, these genetic loci also exhibited pleiotropic effects with myo

32 sociation studies identified 245 significant genetic loci, among which 95 genetically interacted with

33 viduals, in addition to identifying specific genetic loci and a SNP-by-SNP interaction implicated in

34 does it allow for interrelationships between genetic loci and across traits.

35 onstrated an association between 21 distinct genetic loci and BCC risk.

36 us, natural LOF variants inform on essential genetic loci and demonstrate PRDM9 redundancy in humans.

37 ese associations might merely involve shared genetic loci and environmental triggers, including micro

38 pulations, provides a foundation to identify genetic loci and genes controlling micronutrient content

39 ery rate approach, we increased discovery of genetic loci and identified two loci shared between neur

40 iants can pinpoint causal genes within known genetic loci and illustrate that applying the approach s

41 Associations between genetic loci and increased susceptibility to autoimmune

42 We report 14 genetic loci and indicate several candidate genes that n

43 The method can be applied to all available genetic loci and is computationally fast.

44 ibrium (LD) measures the correlation between genetic loci and is highly informative for association m

45 and resolves their underlying combination of genetic loci and molecular mechanisms.

46 We sought to investigate commonalities in genetic loci and pathways between allergy and autoimmune

47 identify the relative importance of specific genetic loci and provide a direct avenue for combining h

48 NG Capture-C can be used to analyze many genetic loci and samples simultaneously.

49 e located in previously discovered IOP, VCDR genetic loci and showed strongest associations with IOP

50 We identify 23 novel genetic loci, and 9 loci with convincing evidence of gen

51 ire to Florida and used mtDNA, three nuclear genetic loci, and incorporated Bayesian analyses to reso

52 bilistic framework to infer repeat sizes for genetic loci, and we used this software to infer repeat

53 ipts are highly similar, indicating that the genetic loci are already poised to transcribe these nove

54 A large number of genetic loci are associated with adult body mass index.

55 Multiple genetic loci are associated with IBD, but altered functi

56 c health burden and it remains unknown which genetic loci are associated with kidney function in the

57 igate biosynthetic pathways of SRRPs as SRRP genetic loci are highly conserved.

58 biosynthetic pathways of SRRPs because SRRP genetic loci are highly conserved.

59 heritability, it is not clear which specific genetic loci are implicated in RAS.

60 and rs885479) and the extent to which other genetic loci are involved in red hair colour is less wel

61 association studies (GWAS) have identified 7 genetic loci as associated with PDB at the genome-wide l

62 plying the need for caution when considering genetic loci as therapeutic targets.

63 The existence of additional shared genetic loci, as well as potential shared pathobiologica

64 Sixty genetic loci associated with abdominal obesity, measured

65 Previous reports have implicated multiple genetic loci associated with AF, but the contributions o

66 Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one

67 We aimed to identify genetic loci associated with apoA-IV concentrations and

68 iation studies (GWAS) have revealed parasite genetic loci associated with artemisinin resistance.

69 ssociation studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), t

70 ciation Studies) have identified hundreds of genetic loci associated with atrial fibrillation (AF).

71 To investigate genetic loci associated with atrial fibrillation in the

72 ciation studies (GWASs) identified the first genetic loci associated with attention-deficit/hyperacti

73 andMe participants we increase the number of genetic loci associated with being a morning person from

74 genotype data, we have identified five novel genetic loci associated with BUA.

75 studies (GWASs) have identified thousands of genetic loci associated with cardiometabolic traits incl

76 ized European and Asian subjects to identify genetic loci associated with CCT.

77 variants enabled the identification of three genetic loci associated with CHIP status, including one

78 Novel candidate genetic loci associated with circulating FGF21 or FGF23

79 iation studies have previously identified 23 genetic loci associated with circulating fibrinogen conc

80 es by using FarmCPU R package to identify 17 genetic loci associated with cold tolerance.

81 ome-wide association studies have identified genetic loci associated with cutaneous squamous cell car

82 Genetic risk scores were conducted based on genetic loci associated with either H. pylori colonizati

83 e association study (GWAS) and identified 28 genetic loci associated with fibre quality in allotetrap

84 There is a limited understanding of how genetic loci associated with glycemic traits and type 2

85 studies (GWAS) have successfully identified genetic loci associated with glycemic traits.

86 This study aims to discover new genetic loci associated with heart rate from Exome Chip

87 ed multiple loci model (BLINK), revealed six genetic loci associated with HN and HT above the Bonferr

88 Reported genetic loci associated with IHPS explain only a minor p

89 Identifying genetic loci associated with increased risk of acute kid

90 ome-wide association studies have identified genetic loci associated with insulin resistance (IR) but

91 s: first, to facilitate the discovery of new genetic loci associated with intelligence; second, to ad

92 Multiple genetic loci associated with lipid levels have been iden

93 fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung

94 We identified 139 genetic loci associated with macular thickness at genome

95 e recent progress in the characterization of genetic loci associated with multiple sclerosis (MS) ris

96 We have identified 6 novel genetic loci associated with P-wave duration and 6 novel

97 Finally, we identified genetic loci associated with plasma APOL1 levels and tes

98 ociation studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk,

99 ies (GWAS) have identified approximately 100 genetic loci associated with prostate cancer risk.

100 Our results highlight multiple novel genetic loci associated with PWD, and underscore the sha

101 ciation studies (GWASs) have identified many genetic loci associated with raised serum urate concentr

102 ropean participants and identified 336 novel genetic loci associated with refractive error.

103 tion studies (GWAS) have identified over 100 genetic loci associated with rheumatoid arthritis (RA),

104 The goals of this study were to identify genetic loci associated with serum magnesium in an Afric

105 nalysis of strain-specific variants revealed genetic loci associated with several goldfish phenotypes

106 ce, suggesting there are common and distinct genetic loci associated with these diseases, providing n

107 We identified 10 genetic loci associated with total 25(OH)D, 7 loci assoc

108 Here, we test these predictions using the genetic loci associated with total expression variation

109 The detection of genetic loci associated with variation in stem quality t

110 suggested that the interactions between two genetic loci at ADRB2 and PTGER4 is important in determi

111 ation studies (GWAS) have implicated several genetic loci at the genome-wide level of statistical sig

112 ionship by reviewing the evidence for shared genetic loci between T2D and CHD; by examining the forma

113 ts from the availability of large numbers of genetic loci by detecting clusters of loci that are asso

114 This included 11 newly associated genetic loci (C1orf198, PLEK, OSMR-AS1, NUGGC/SCARA5, GR

115 Diversity at pathogen genetic loci can be driven by host adaptive immune selec

116 ysis framework in which hundred thousands of genetic loci can be tested simultaneously for associatio

117 ew studies now show that changes in the same genetic loci can drive the evolution of the same trait i

118 peans, and the issue of to what extent these genetic loci can predict blood lipid levels increases ov

119 plasmid, and the use of spatially separated genetic loci, can lead to molecules with virtually ident

120 Our findings suggest that some of the genetic loci conferring AMD susceptibility in East Asian

121 However, identifying genetic loci conferring longevity and low morbidity in s

122 non-additive interactions between different genetic loci-constrains evolutionary pathways, blocking

123 a complete understanding of how these known genetic loci contribute to an increased disease risk in

124 chiatric disorders are "polygenic"-that many genetic loci contribute to risk.

125 ation among laboratory mice, to identify the genetic loci controlling rotarod performance and its rel

126 nd contribute to heritability beyond that of genetic loci currently known to affect CAD risk.

127 ls of G9a-dependent H3K9me2 at ILC3-specific genetic loci, demonstrating that G9a-mediated repression

128 d robust identification of approximately 100 genetic loci determining plasma lipid parameters.

129 documented that selection affected multiple genetic loci distributed across the genome, particularly

130 s retroviruses comprise millions of discrete genetic loci distributed within the genomes of extant ve

131 that several previously known WBC-associated genetic loci (e.g. the African Duffy antigen receptor fo

132 de association study (GWAS) identifying >100 genetic loci, encompassing a total of 341 protein-coding

133 tions with phylogenetic analyses to identify genetic loci (epitopes) under strong immune selection.

134 ed GWAS to obtain 297 SNP associations at 11 genetic loci, explaining up to 36% of the variation of 1

135 ber of genetic loci for many species or many genetic loci for a few species.

136 We identified genetic loci for active tameness through selective breed

137 We have identified REs at multiple genetic loci for AF and found that loss of an RE at the

138 ur results nearly double the number of known genetic loci for atrial fibrillation, provide insights i

139 de association studies for identifying novel genetic loci for blood pressure, lipids, hypertension, e

140 h healthy controls and suggest several novel genetic loci for CHD.

141 enhance statistical power to identify novel genetic loci for depression.

142 We identified genetic loci for gene expression variations through expr

143 Previous studies have identified two genetic loci for macronutrient intake, but incomplete co

144 gbird and the ability to obtain thousands of genetic loci for many individuals permit the investigati

145 ts has been analyzed using a small number of genetic loci for many species or many genetic loci for a

146 association studies have identified several genetic loci for PR interval, but it remains to be deter

147 scale analyses have begun to identify robust genetic loci for schizophrenia, providing an opportunity

148 phism (SNP) genotyping array to identify the genetic loci for SET and SDW through a genome-wide assoc

149 on patterns of repetitive, as well as single genetic loci from pure cell-free DNA from peripheral blo

150 systems genetics framework to integrate risk genetic loci from the largest body mass index (BMI) geno

151 Over 100 genetic loci harbor schizophrenia-associated variants, y

152 Many detected genetic loci harbor variants that associate with multipl

153 Genetic loci harboring four genes originally discovered

154 hese concepts to study the activities of all genetic loci has completely upended how today's cancer b

155 Fourteen genetic loci have been associated with atrial fibrillati

156 To date, over 20 genetic loci have been convincingly associated with COPD

157 ed for, and to date only a limited number of genetic loci have been definitively implicated.

158 However, very few genetic loci have been identified, and the underlying me

159 esium levels are highly heritable, and a few genetic loci have been reported involving regulation of

160 Although a small number of genetic loci have been reported to be associated with va

161 Only a few genetic loci have been reported to interact with ELTS ex

162 Over 100 associated genetic loci have been robustly associated with schizoph

163 Whereas hundreds of genetic loci have been shown to be involved in the regul

164 A growing number of genetic loci have been shown to influence individual pre

165 Genetic loci have not yet been identified by genome-wide

166 Fourteen genetic loci have previously been associated with smokin

167 It has been estimated that >1,000 genetic loci have yet to be identified for breast cancer

168 Two genetic loci, HDAC9 and RAP1GAP, were associated with ab

169 and shoot growth characteristics revealed 10 genetic loci highly associated with the responsiveness o

170 Genetic loci identified by conditional false discovery r

171 enic risk score for schizophrenia across 108 genetic loci identified by the Psychiatric Genomics Cons

172 TTK and other genetic loci identified in our study may contribute to t

173 The additional genetic loci identified in this large meta-analysis of c

174 tly unknown despite the increasing number of genetic loci identified that increase disease risk.

175 ggregate effect on blood pressure of all the genetic loci identified to date is small.

176 Despite thousands of genetic loci identified to date, a large proportion of g

177 low-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two

178 Ten genetic loci in 7 genes [complement factor H (CFH), age-

179 Our study implicates 3 new genetic loci in CAVS pathogenesis, which constitute nove

180 Novel genetic loci in CHD cases were significantly enriched fo

181 Two novel genetic loci in FOLH1 and VNN1 are reported in associati

182 pecific ESCC microRNA family arises from two genetic loci in mammals: miR-290/miR-371 and miR-302.

183 nomic approaches have implicated hundreds of genetic loci in neurodevelopmental disorders and neurode

184 We identified 12 genetic loci in total for TMR(ex) and TMR(rec), of which

185 Yeast (SATAY) allows one-step mapping of all genetic loci in which transposons can insert without dis

186 ome wide association studies have identified genetic loci including SLC44A2 which may regulate thromb

187 We identified six genetic loci, including five novel loci, significantly a

188 death in PD is largely unknown, but several genetic loci, including leucine-rich repeat kinase 2 (LR

189 viduals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, po

190 al variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D

191 Hundreds of genetic loci increasing risk for neuropsychiatric disord

192 In complex genetic loci, individual enhancers interact most often w

193 Known genetic loci influencing blood cell production account f

194 Using LTA analysis, we identified genetic loci influencing BP.

195 Recent studies have identified many genetic loci influencing circulating lipid levels and st

196 GWASs for discovery and characterization of genetic loci influencing hematologic traits.

197 We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) thr

198 Our aim was to identify genetic loci influencing the recovery process using accu

199 ity traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.

200 ssic method allowing researchers to identify genetic loci involved in viral replication and pathogene

201 udies (GWASs) have identified a multitude of genetic loci involved with traits and diseases.

202 We also identified several novel genetic loci involving or regulating hematopoietic trans

203 nt association with pigmented spots at three genetic loci: IRF4 (rs12203592, P=1.8 x 10(-27)), MC1R (

204 We identified 2 genetic loci (kininogen 1 and kallikrein B) influencing

205 entified 451 causal variants, which underlie genetic loci known to affect gene expression.

206 he temporal context of selection on specific genetic loci known to differentiate modern domestic chic

207 Observed associations were not modified by genetic loci known to influence fasting glucose or insul

208 We identified ten genetic loci known to influence proximal DNA methylation

209 abolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence m

210 urrent study are to examine whether genes in genetic loci linked to fat distribution can be linked to

211 main objective of this study was to identify genetic loci linked to risk of contracting a bloodstream

212 nome-wide significant linkage, revealing new genetic loci linked to specific immune traits.

213 Significant associations were found in nine genetic loci (MCL1-ENSA, GCKR, AGR3-AHR, ADH1B, ALDH1B1,

214 Recent studies have detected genetic loci modifying the age at onset of motor symptom

215 Among the 3 genetic loci most strongly associated with AF, the chrom

216 0 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, i

217 ells in a nonrandom fashion, with particular genetic loci occupying distinct spatial regions.

218 Through a genome-wide screen for the genetic loci of M. tuberculosis that inhibit MHC class I

219 We identify 27 genetic loci, of which 22 have not previously been repor

220 A total of 67 genetic loci, of which 65 loci have been reported in pre

221 No robustly associated genetic loci or variants for childhood intelligence have

222 aspect (sex, genomic background, individual genetic loci), or by a DNA-inferred aspect (BMI, age).

223 our in the UK Biobank identify 145, 36 and 4 genetic loci (P < 1x10(-8)), respectively.

224 ormation on ohnolog status to identify novel genetic loci predisposing to CHD.

225 Identifying the genetic loci regulating differences in the pattern of ph

226 Few genetic loci regulating FVII activity and/or levels have

227 The meta-analysis identified 13 novel genetic loci regulating FVIII and VWF plasma levels, 10

228 Our objective for this study was to identify genetic loci regulating SU in a multigenerational family

229 er, these findings not only expand the known genetic loci required for ESX-1 secretion in M. marinum

230 richment analysis showed that the associated genetic loci resided within binding motifs for adipogeni

231 ciparum played a key role in determining the genetic loci responsible for drug resistance, virulence,

232 th limited taxon sampling and a small set of genetic loci, resulting in weakly supported (and sometim

233 a mapping approach that is able to identify genetic loci segregating within the lines, we identified

234 Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Fi

235 The genetic loci showed associations with putative signaling

236 n large populations have identified multiple genetic loci, specific genes, and specific variants incr

237 We identified 39 genetic loci specifically associated in cis with activat

238 I, NADH2, 16S rRNA and 12S rRNA- and nuclear genetic loci such as 5.8S rRNA, Internal Transcribed Spa

239 ssociation study permitted identification of genetic loci that affect most of the target flavor chemi

240 identified and functionally verified several genetic loci that affect the expression of cytolytic tox

241 tives yields important fitness benefits, but genetic loci that allow recognition of unfamiliar kin ha

242 Our findings reveal two genetic loci that are associated with acute kidney injur

243 ave identified 52 independent variants at 34 genetic loci that are associated with age-related macula

244 wide association studies have revealed novel genetic loci that are associated with coronary heart dis

245 y novel disease associations and to fine-map genetic loci that are associated with prostate and other

246 We distil genetic loci that are broadly relevant for many cognitiv

247 ts a systematic approach to broadly identify genetic loci that can be used to improve membrane protei

248 ase of unprecedented progress in identifying genetic loci that cause variation in traits ranging from

249 al corneal thickness have identified several genetic loci that contribute to a cumulative risk for ke

250 pression Quantitative Trait Loci (eQTL), the genetic loci that contribute to heritable variation in g

251 eQTLs are genetic loci that correlate with RNA transcript levels.

252 In addition, we also identified genetic loci that could represent undescribed anti-adhes

253 Genetic loci that ensure productivity in challenging env

254 We identified 12 new genetic loci that exceeded genome-wide significance, imp

255 m three independent LGG datasets to identify genetic loci that govern tumor aggressiveness and poor s

256 We identified 4 novel genetic loci that implicate inflammatory and glial proli

257 We identify 12 new genetic loci that implicate known components of the circ

258 introduce a powerful method for identifying genetic loci that influence protein expression in the ye

259 Supergenes are clusters of linked genetic loci that jointly affect the expression of compl

260 ome-wide association studies have identified genetic loci that jointly make a considerable contributi

261 n unbiased linkage analysis to determine the genetic loci that may limit the size of the NK cell comp

262 genes encoding these enzymes are located in genetic loci that orchestrate the depolymerization of ye

263 al, genetic and structural dissection of the genetic loci that orchestrates glycosaminoglycan metabol

264 wide association studies identified over 100 genetic loci that significantly associate with schizophr

265 We consider the number of genetic loci that underlie ASDs and the relative contrib

266 We identified three genetic loci that were associated with neck or shoulder

267 This study aims to identify new CAD genetic loci through a large-scale linkage analysis of 2

268 hole body lean body mass and find five novel genetic loci to be significantly associated.

269 ciation studies have linked approximately 60 genetic loci to coronary risk.

270 mor DNA sequencing at 42 clinically relevant genetic loci to detect mutations, translocations, and co

271 ping and genome-wide association to identify genetic loci to improve micronutrient contents, recent d

272 in 2018 alone, taking the total number of BP genetic loci to over 1000.

273 e linked common variants at approximately 35 genetic loci to stroke risk.

274 study identified 74 independently associated genetic loci, to our knowledge previously unreported (P

275 that can effectively generate indels in four genetic loci (two active and two inactive) and demonstra

276 sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimat

277 Genetic loci undergo both stochastic motion around their

278 tion studies (GWAS) have identified numerous genetic loci underlying human diseases, but a fundamenta

279 grade inflammation and identified many novel genetic loci underlying inflammation that may serve as t

280 rs covarying with latitude interact with the genetic loci underlying plant resistance to control rust

281 ome-wide association mapping to identify the genetic loci underlying the diversity of leaf senescence

282 evidence of disease association at five new genetic loci upon meta-analysis of all patient collectio

283 uced changes in RSA were associated with 100 genetic loci using genome-wide association studies.

284 The median coverage across all genetic loci was 20x and sequence accuracy was >=99.8% c

285 The genetic loci were amalgamated into a weighted genetic ri

286 The top genetic loci were explained between 1.7% (Ang-2) and 11.

287 Four of the identified genetic loci were significantly associated with gene exp

288 Type 2 diabetes-associated genetic loci were significantly associated with higher r

289 Identifying genetic loci where DNA methylation is associated with ch

290 esults from genetic trade-offs at individual genetic loci, where adaptation to one set of environment

291 Insights into genetic loci which are under selection and their functio

292 276 population) and 21 (Kali Aus population) genetic loci, which were contributed by both the traditi

293 the diploid F. cylindrus genome consists of genetic loci with alleles that are highly divergent (15.

294 dy size and that anthropometric traits share genetic loci with developmental and psychiatric disorder

295 Further, TWAS identified 5 additional genetic loci with imputed gene expression levels differi

296 h widespread changes in DNA methylation (187 genetic loci with P < 1 x 10(-7), range P = 9.2 x 10(-8)

297 It is also primarily caused by genetic loci with parent-of-origin effects, suggesting a

298 aits with finite, detectable associations of genetic loci with phenotypic variation in addition to hi

299 and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.

300 hat our approach works particularly well for genetic loci with very small minor allele frequencies.