ライフサイエンスコーパス: genetic method

1 rong and advocated an alternative population genetic method.

2 GRIM-19, a novel growth suppressor, using a genetic method.

3 tates a re-evaluation of existing population genetic methods.

4 have been isolated by the application of two genetic methods.

5 gene of influenza virus A/WSN/33 by reverse genetic methods.

6 in motor neuron diversification using mouse genetic methods.

7 using biochemical, molecular biological, and genetic methods.

8 notypic and molecular chemical and molecular genetic methods.

9 iac p38 MAPK activity by pharmacological and genetic methods.

10 so far using predominantly immunological and genetic methods.

11 ombination has been obtained using indirect, genetic methods.

12 cortical interneurons using fate mapping and genetic methods.

13 was identified and mapped using quantitative genetic methods.

14 ifficult to study by existing biochemical or genetic methods.

15 vical lymph node, and spleen using molecular genetic methods.

16 with PCNA was established by biochemical and genetic methods.

17 re characterized by phenotypic and molecular genetic methods.

18 combination of biochemical, biophysical and genetic methods.

19 ill be increasingly accompanied by molecular genetic methods.

20 tiple molecular moieties through chemical or genetic methods.

21 ctivated NK cells or T cells by chemical and genetic methods.

22 , which can impede accurate diagnosis in all genetic methods.

23 mpirical studies using standard quantitative genetic methods.

24 is regularly reported and investigated using genetic methods.

25 of transcription factor function using slow genetic methods.

26 t Study at ages 21 and 26 using quantitative genetic methods.

27 ed neural fates in the brain without complex genetic methods.

28 from the retina in a sustained manner using genetic methods.

29 igh-resolution ocean modeling and population genetic methods.

30 m was investigated using cell biological and genetic methods.

31 ogens were largely hindered by an absence of genetic methods.

32 ors that can be targeted to cell types using genetic methods.

33 vivo was assessed using pharmacological and genetic methods.

34 ), promoter reporter analysis, and molecular genetic methods.

35 remain difficult to classify by traditional genetic methods.

36 e, or exceedingly difficult, using classical genetic methods.

37 idated as a drug target by both chemical and genetic methods.

38 kinase gene has been identified by a reverse genetics method.

39 stablished using phylogenetic and population genetics methods.

40 man and animal influenza vaccines by reverse genetics methods.

41 (MBP)-fused Nop58p by biophysical and yeast genetics methods.

42 1 (nad1) mutant was identified using reverse genetics methods.

43 Reactivating autophagy by pharmacological or genetic methods abolishes beige adipocyte maintenance in

44 ening approach involves a recently described genetic method allowing efficient production of mosaic f

45 The application of a second generation of genetics methods allows the dissection of moderate and m

46 ted whole genomes using classical population genetics methods alongside reference panels such as the

47 Using genetic methods also presents challenges due to the hybr

48 adult mice using an intersectional viral and genetic method and quantified the effects on synaptic in

49 Using molecular genetic methods and bioinformatics, we verify the intera

50 heir expression pattern, both by traditional genetic methods and by recent high-throughput expression

51 By analyzing viruses constructed by reverse-genetic methods and containing recombinant HAs, we estab

52 Using forward genetic methods and CRISPR/Cas9 gene editing, we identif

53 Using population genetic methods and epidemiological observations, we rep

54 J (V beta(c)) backcross mice using Mendelian genetic methods and immunized them with acetylcholine re

55 By genetic methods and mass spectrometry, we demonstrate th

56 Using genetic methods and mass spectrometry, we demonstrate th

57 have been identified by both biochemical and genetic methods and systematic attempts to understand th

58 population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology

59 Applying novel genetic methods and tools, we analyzed gene sets, tissue

60 ntified a mutation in nanos1 using a reverse genetics method and show that young female nanos mutants

61 Recent technological advances in reverse genetics methods and limitations of the conventional pro

62 One of the most versatile genetic methods applicable across species is CRISPR-Cas9

63 Although genetic methods are available to identify novel protein-

64 Behavioral-genetic methods are based on a solid foundation of theor

65 Existing population genetic methods are designed to model hundreds of random

66 However, these genetic methods are laborious, and limited for quantitat

67 e focus on the mouse, in which molecular and genetic methods are most advanced.

68 mpletion of the genome projects, alternative genetic methods are needed where large numbers of genes

69 Because genetic methods are not available for amphibian studies,

70 tudies using new cytological, molecular, and genetic methods are shedding some light on the processes

71 yperdiversity) mean that standard population genetics methods are not trustworthy.

72 Current landscape genetics methods are often constrained by the subjectivi

73 Inhibition of JNK by chemical or genetic methods attenuated NaBT-induced PTEN expression.

74 By using the powerful genetic methods available for examining behavior in frui

75 Genetic methods available in mice are likely to be power

76 The genetic methods available in the fruit fly Drosophila an

77 hematopoiesis in zebrafish, discuss various genetic methods available in the zebrafish model for stu

78 Results suggest the potential for using genetic methods based on microsatellite loci data to com

79 of INs in L1, as well as the application of genetic methods based on the markers described here, wil

80 Genetics methods based on homologous recombination are u

81 d is distinguished from conventional forward genetic methods because it permits (1) unbiased declarat

82 substrates of kinases has proven elusive to genetic methods because of the tremendous redundancy and

83 in (FMG) into tumor cells, and incorporate a genetic method by which true hybrid formation can be una

84 We developed a reverse genetic method called ReporterSeq to comprehensively ide

85 We describe here a genetic method (called EGUF/hid) that uses both the GAL4

86 Here, using the cell-type selectivity of genetic methods, circuit mapping, and behavior assays, w

87 Using forward genetic methods combined with comparative genome hybridi

88 Today, modern molecular and genetic methods combined with sophisticated behavioral a

89 g secondary gene products, their labeling by genetic methods - comparable to GFP labeling of proteins

90 Molecular genetic methods confirmed the role of the Ivory Coast va

91 logenetic signal associated with traditional genetic methods could not resolve this uncertainty.

92 The availability of genetic methods, coupled with its physiological and meta

93 Unlike previous population genetic methods, DeepLOF utilizes a novel deep learning

94 Moreover, complementary genetic methods demonstrated the impact of Pten restorat

95 This means that many statistical genetic methods developed for searching for susceptibili

96 The new genetic methods developed in this work will promote expe

97 Classical genetic methods, driven by phenotype rather than hypothe

98 ria are considered non-amenable to classical genetic methods due to low cell densities, the inability

99 apply saturation mutagenesis and a chemical genetic method for allosterically modulating kinase glob

100 We report a new chemical genetic method for creating bivalent ligands of protein

101 d such high survival, we developed a forward-genetic method for efficient isolation of high-survival

102 al lesions in genomes (TILLING) is a reverse-genetic method for identifying point mutations in chemic

103 Here, we report a chemical genetic method for regulating the catalytic activity of

104 The AlstR/AL system is therefore a promising genetic method for selective and quickly reversible sile

105 ence of microbial opsin engineering, modular genetic methods for cell-type targeting and optical stra

106 ovides a synopsis of the currently available genetic methods for Chlamydia along with a comparison to

107 Structure methods are highly used population genetic methods for classifying individuals in a sample

108 It has been suggested that pharmacologic or genetic methods for enhancing glucokinase (GK) enzymatic

109 itic spines of hippocampal CA1 neurons using genetic methods for fluorescent labeling of dendritic sp

110 and Chinese rhesus macaques have encouraged genetic methods for identifying genetic differences betw

111 along with the development of new population genetic methods for identifying selection in sequence da

112 Genetic methods for neural circuit manipulation in mice

113 Genetic methods for neuronal silencing have great promis

114 In reviewing genetic methods for studying life history trade-offs, we

115 There is a critical need for genetic methods for the inducible expression of transgen

116 sruptive effect on widely applied population genetics methods for inferring recombination rates, for

117 tion strategy to previously reported reverse genetics methods for RV may enhance the efficiency of re

118 an partially substitute for powerful forward genetic methods (genome-independent) that have advanced

119 The application of genetic methods has begun to provide new insights into h

120 incapable of transmitting pathogens through genetic methods has long been a goal of vector geneticis

121 A new reverse genetics method has been developed to identify and isola

122 As a result, molecular genetic methods have become the gold standard for diagno

123 Over the past few decades, numerous genetic methods have been developed and applied to these

124 Yeast molecular genetic methods have been instrumental in the functional

125 Quantitative genetic methods have demonstrated adaptive variation in

126 Although biochemical and genetic methods have detected many activator-transcripti

127 ing formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS).

128 In this study, we apply population genetic methods in a novel manner to determine whether m

129 y analyses, biochemical studies, and in vivo genetic methods in Drosophila.

130 stimated ARGs in population- and statistical-genetic methods in general.

131 Results from studies using molecular and genetic methods in humans and rodents suggest that brain

132 These studies illustrate the utility of genetic methods in M. maripaludis and show the enhanced

133 We have used genetic methods in Methanococcus maripaludis to study ni

134 Using genetic methods in mice, we found that several days befo

135 In contrast, powerful genetic methods in the fruit fly Drosophila allow effici

136 dvances that have been made, using primarily genetic methods, in identifying molecules responsible fo

137 ently, the combination of flow cytometry and genetic methods, in which modifications of the replicati

138 Applications of this genetic method include phenotypic analysis of existing m

139 These mutants were mapped using classical genetic methods, including backcrosses to demonstrate re

140 ts to engineer the cloned genome by standard genetic methods involving the URA3/5-fluoroorotic acid (

141 and suggest that using multiple independent genetic methods is essential when probing the functions

142 This novel in vivo reverse genetics method is a potentially suitable delivery platf

143 or genes in solid tumors by classical cancer genetics methods is difficult and slow.

144 rmined apolipoprotein(a) isoform size with a genetic method (kringle IV type 2 [KIV2] repeats in the

145 The goal of this work was to develop a genetic method of determining the serotype of Bcc isolat

146 Thus, our genetic method of screening for pol beta mutator mutants

147 There are four standard genetic methods of covalently tagging a protein with a f

148 Genetic methods of manipulating or eradicating disease v

149 Existing genetic methods of neuronal targeting do not routinely a

150 e responsible for these disorders, a forward genetics method of gene discovery was used to identify a

151 ainfluenza virus type 2 (hPIV2) by a reverse genetics method of recombinant virus production.

152 Behavioural genetic methods offer a largely untapped means to invest

153 Most existing imaging genetics methods only analyze the baseline neuroimaging

154 ever, the direct application of quantitative genetic methods, originally developed in animal breeding

155 ken as hypotheses to be tested by additional genetic methods, particularly in species for which detai

156 the two proteins by biochemical and reverse genetics methods paves the way for rational drug design

157 wide association studies and other discovery genetics methods provide a means to identify previously

158 Genetic methods provided lines lacking ISA1 or ISA2.

159 printed by a combination of well-established genetic methods (pulsed-field gel electrophoresis [PFGE]

160 cording phenotype, which begins with forward-genetic methods represented by random physical and chemi

161 The cloning of E(var)3-9 by classical genetic methods revealed that it encodes a protein with

162 to manipulate the HAC vector by recombinant genetic methods should allow us to further define the el

163 are experimentally validated by physical and genetic methods, showing that cells exploit a mechanism

164 lating CYP3A4 expression, and used molecular genetics methods (siRNA/shRNA gene knockdown and CRISPR-

165 Here, we optimize a reverse genetics method specifically for the rescue of sylvatic

166 rresponding recombination rate by population genetic methods tends to be inflated.

167 To evaluate this assumption, we developed a genetic method that can inducibly deplete targeted prote

168 Effective genetic methods that allow systematic study of anti-apop

169 analyzed using recently developed population genetic methods that have enabled the estimation of tran

170 These MR and aQTL analyses represent systems genetic methods that may be broadly applied to supplemen

171 segregant analysis and association analysis, genetic methods that require no prior knowledge of seque

172 that result can be detected using population genetic methods that test for signatures of balancing se

173 Here we demonstrate with genetic methods that the Drosophila peripheral nerve is

174 In contrast to traditional population genetics methods that usually make the unrealistic assum

175 By using genetic methods, the effects of bile and bile acids were

176 werful new microchemical tools and molecular-genetic methods, three new classes of proteins have been

177 We report the use of a genetic method to block synaptic activity acutely in the

178 We describe a yeast genetic method to detect and analyze RNA-protein interac

179 lustrates the ability of our novel landscape genetic method to detect the impacts of relatively recen

180 We have developed a genetic method to determine the active orientation of di

181 We have developed a simple genetic method to differentiate between genuine morphant

182 A yeast-based genetic method to discover novel nuclear receptor intera

183 nisms of polymerase fidelity, we developed a genetic method to identify mammalian pol beta mutator mu

184 I used a genetic method to investigate the location and function

185 We developed a genetic method to isolate other mutant DnaAs that circum

186 Here, we used an intersectional genetic method to label and manipulate neurons in the mi

187 We used a genetic method to label pre and postsynaptic sites in gr

188 Deploying a genetic method to place robust expression of GOF BK chan

189 We used a genetic method to progressively eliminate the vast major

190 Here we apply a chemical genetic method to rapidly and selectively inactivate a m

191 The yeast two-hybrid system is a powerful genetic method to screen cDNA libraries to identify prot

192 Here we use a genetic method to selectively inhibit neurotransmission

193 A powerful genetic method to study protein-protein interaction is t

194 Here we have used genetic methods to address these issues.

195 To this end, we are pursuing genetic methods to alter the cell recognition domain of

196 the malignant cell populations and molecular genetic methods to assay for somatic loss of the normal

197 We applied quantitative genetic methods to assess the heritability of RA and to

198 a coli genetic system that permits bacterial genetic methods to be applied to the study of essentiall

199 Here, we use both physical and genetic methods to characterize the trapped DNA.

200 In this study we use genetic methods to compare dispersal patterns in a Briti

201 scribed infecting A. virginalis, and we used genetic methods to confirm the identity of the virus.

202 Here, we use standard association genetic methods to correlate 3563 single nucleotide poly

203 lution) done in concert with biochemical and genetic methods to define the sorting platform interacto

204 arkable progress has been made in developing genetic methods to detect small molecules in vivo, many

205 he local response to cell death by using two genetic methods to elevate cell death rates.

206 Use of genetic methods to estimate effective population size (N

207 Use of single-sample genetic methods to estimate effective population size ha

208 between these hypotheses, we used population genetic methods to estimate larval dispersal among five

209 Here, we use molecular and genetic methods to examine the functional activity of th

210 Here, we use genetic methods to explore the relationship between C. e

211 ent indicators of neural activity, viral and genetic methods to express these indicators, chronic ani

212 Here, we have utilized biochemical and yeast genetic methods to further characterize Dhr1.

213 stepwise greenCUT&RUN transcend traditional genetic methods to globally map signaling hubs and trans

214 sms, limiting the effectiveness of classical genetic methods to identify miRNA functions.

215 and as such it has not been possible to use genetic methods to introduce oncogenic alterations into

216 tick cells in vitro when it is coupled with genetic methods to isolate and complement B. burgdorferi

217 We developed and applied quantitative genetic methods to long-term datasets from 19 wild bird

218 mily 2 PspA (from strain TIGR4) by molecular genetic methods to make an isogenic pair of strains expr

219 Researchers have used chemical synthesis and genetic methods to make these proteins and more: protein

220 ere, we use a combination of biochemical and genetic methods to map the p7 interaction site to within

221 grated proteomic, tissue transcriptomic, and genetic methods to prioritize targets causal in human he

222 We used molecular genetic methods to re-evaluate subspecies partitions and

223 Here, we used genetic methods to remove AChRs selectively from muscle.

224 ing techniques are combined with traditional genetic methods to scrutinize and compare dynamic proces

225 dify a naturally occurring circuit, by using genetic methods to select functional circuits and evolve

226 al (fast scan cyclic voltammetry), and viral/genetic methods to selectively delete Th in fibers inner

227 We used chemical genetic methods to show that drug-mediated transactivati

228 wever, there are no simple and generalizable genetic methods to study neuronal or glial cell morpholo

229 In the present study, we have used genetic methods to study the role of membrane or soluble

230 n rodents that take advantage of optical and genetic methods to test these classic ideas by recording

231 of virus allows the application of DNA-based genetic methods to the study of PaV structure and assemb

232 d, precluding the application of traditional genetic methods to these organisms and their interaction

233 We used this reverse genetics method to generate a panel of viruses with chim

234 loop 1 insertion mutant, and we used reverse-genetics methods to confirm the identities of suppressor

235 e have been major developments of population genetics methods to estimate both rates of recombination

236 d phenotypes and enable molecular population genetics methods to finely resolve uncharacterized funct

237 nthetic origins, and the microbiological and genetic methods used for their discovery.

238 A genetic method was developed to detect such structures i

239 he activity of mPFC neurons using a chemical-genetic method was sufficient to convert the resilient b

240 The application of population genetic methods was demonstrated on a particularly abund

241 Using various biochemical and genetic methods we further demonstrate that Bicoid molec

242 Using a bump-and-hole-based chemical-genetic method, we have rapidly and selectively manipula

243 Here, by using both biochemical and genetic methods, we demonstrate the existence of EndA-me

244 As a complementary approach to these classic genetic methods, we describe a plasmid-based library met

245 a combination of biochemical, molecular, and genetic methods, we have found that the phylogenetically

246 Using both biochemical and genetic methods, we have isolated a novel subunit of the

247 uorescent indicators with cell-type specific genetic methods, we here develop Rhodamine-based Voltage

248 Using an array of biochemical and molecular genetic methods, we mapped the interaction interface bet

249 Using multiple genetic methods, we show that ATPase phospholipid transp

250 Using genetic methods, we show that lon-1 lies downstream of t

251 Using genetic methods, we show that ryr-1 is the previously id

252 included in the present study, and advanced genetic methods were applied to investigate the repeat c

253 Secular changes in genetic methods were observed, with genome sequencing ap

254 Pharmacological, molecular, and genetic methods were used to further understand the role

255 Pharmacological and genetic methods were used to inhibit the function of cor

256 Genetic methods were used to trap pilus subunits during

257 ificity can be achieved using intersectional genetic methods which restrict reporter expression to ce

258 armyworm strain identification in Africa by genetic methods, with the possibility discussed that the