ライフサイエンスコーパス: genetic model

1 Associations were analyzed under an additive genetic model.

2 this tradeoff using a stochastic population-genetic model.

3 genic contaminants of food, and an important genetic model.

4 ion procedure is employed to help choose the genetic model.

5 oms by logistic regression using an additive genetic model.

6 in a sample with 97% power for the additive genetic model.

7 y within COMT genotypes assuming an additive genetic model.

8 spite the shared underlying deletion in this genetic model.

9 e assembly for pea, Gregor Mendel's original genetic model.

10 atasets simulated under classical population genetic models.

11 complexity in channel types and scarcity of genetic models.

12 edical research as an activator of inducible genetic models.

13 gnificantly associated with GD in all of the genetic models.

14 the incidence of neural tube defects in some genetic models.

15 epithelial barrier has not been addressed in genetic models.

16 rphism and oral cancer susceptibility in all genetic models.

17 lack the flexibility of incorporating other genetic models.

18 enomic data under non-equilibrium population genetic models.

19 ith idiopathic-like scoliosis across diverse genetic models.

20 equire methods able to identify more complex genetic models.

21 e conidiation signaling was conserved in the genetic model A. nidulans and mediated by NapA, a homolo

22 n using logistic regression with an additive genetic model adjusting for age, gender, average intraoc

23 een the three tagSNPs and HCC risk under any genetic models after adjusting for potential confounders

24 linear regression analysis using an additive genetic model and associated ~35 million imputed variant

25 In this study, using a population genetic model and the chicken transcriptome, we assess w

26 ular plant Arabidopsis thaliana is a central genetic model and universal reference organism in plant

27 Here, using murine genetic models and cell ablation strategies, we have dem

28 ative contributions of STAT1 and STAT3 using genetic models and chromatin immunoprecipitation-sequenc

29 Review, we discuss recent insights into the genetic models and mechanisms that lead to sex differenc

30 al framework for the development of faithful genetic models and new therapeutic approaches.

31 ion of these fat cells and critically review genetic models and other experimental tools currently av

32 election (GWS) involves reliable statistical genetics models and methods.

33 novo mutation studies also inform population genetics models and shed light on the biology of DNA rep

34 interval [CI] = 1.02-1.42) under a dominant genetic model, and this risk was more evident in subgrou

35 were thought to be sufficient, live imaging, genetics, modeling, and simulations show that microtopog

36 pressure, and that explicitly (quantitative) genetic models are able to provide us with an understand

37 he development and application of population genetic models are described, which are intended to high

38 pancreas from both human patients and mouse genetic models, as well as chronic pancreatitis patient

39 selective pharmacological tool compounds and genetic models available to study these receptors, and p

40 eports on this topic are common for additive genetic models but not for additive-dominance models.

41 hus, even specific partial failures of mouse genetic modeling can be instructive to human tumor biolo

42 Reasoning that genetic models can provide an orthogonal and direct syst

43 lue of a new clinical-genomic model, Distant Genetic Model-Clinical Variable Model 6 (DGM-CM6), devel

44 Under recessive genetic model (controlling for age, sex and intracranial

45 If the genetic model, defined according to the mode of inherita

46 Here lipidomics and genetic models demonstrate a central role for procoagula

47 A genetic model depicting regulation of conidiation in A.

48 e that led to this proposal, and alternative genetic models do not support the G protein-biased MOPr

49 to the same genome (recipient or donor) and genetic model (dominant, recessive, or allelic) reported

50 In conditional genetic models, enforced expression of a LIN28-resistant

51 led with bioinformatics tools and population genetic models, facilitate quantification of microbiome

52 Furthermore, current quantitative genetic models fail to fully capture the heritable varia

53 nd amygdala of presymptomatic Tg2576 mice, a genetic model for Abeta accumulation.

54 mouse line (mice expressing Angpt2(443)), a genetic model for breast cancer and metastasis (MMTV-PyM

55 ge, sugar, and lignocellulosic biomass and a genetic model for C4 grasses due to its relatively small

56 etion syndrome, has attracted attention as a genetic model for common neuropsychiatric disorders beca

57 The fly's power as a genetic model for disease and neuroscience can be augmen

58 r support for investigations of 22q11DS as a genetic model for elucidating neurobiological mechanisms

59 Zea mays is an important genetic model for elucidating transcriptional networks.

60 Here we develop a population genetic model for estimating the number of sexual events

61 miR-431 transgenic mice are a unique genetic model for investigating the cellular features an

62 e procedure to handle the uncertainty of the genetic model for non-normal quantitative trait genetic

63 cidosis of dRTA patients, they provide a new genetic model for nonsyndromic deafness with enlarged ve

64 opment of the Drosophila larval wing disc, a genetic model for organogenesis.

65 The established genetic model for Primula heterostyly involves a diallel

66 light-induced photoreceptor injury and for a genetic model for RP.

67 ustralian Burmese cat provides a spontaneous genetic model for studying diabetes mellitus in humans.

68 r exploiting the powerful advantages of this genetic model for the dissection of the exercise-depende

69 melanogaster has been extensively used as a genetic model for the maintenance of nervous system's fu

70 The zebrafish is an elegant genetic model for the study of hematopoiesis due to its

71 We develop a spatially explicit population genetic model for these clines based on the known geneti

72 l provide opportunities to better understand genetic models for diseases and molecular mechanisms of

73 Using three genetic models for NSUN2 inactivation-knockout mice, pat

74 Genetic models for studying localized cell suicide that

75 mmarize recent studies that have established genetic models for the study of regulatory B cell functi

76 Here, we describe two genetic models generated to dissect the molecular functi

77 Through bivariate genetic modeling, genetic and environmental influences o

78 Under a variety of genetic models, gTDT showed increased power compared wit

79 ty of pharmacological tools as well as mouse genetic models has revealed several physiological action

80 Earlier studies that used a mouse genetic model have shown that a deletion of laminin alph

81 Recent studies of mouse genetic models have demonstrated that lysophosphatidylch

82 However, we also emphasize that primate genetic models have great potential to address many fund

83 lar disease (CVD) at baseline using additive genetic models (hazard ratio 1.17 [95% CI 1.01-1.36]; P

84 In genotoxic and genetic models, HCCs arose exclusively from hepatocytes

85 Spatial genetic modelling identified two waves of stepping-stone

86 We assumed an additive genetic model in an association analysis of imputed 2.5

87 o address this knowledge gap, we generated a genetic model in which a proteasome subunit, RPT3, which

88 We then applied quantitative genetic modeling in full-sisters and maternal half-siste

89 Such links have benefited from genetic modeling in the mouse, and in this review we hig

90 gard to fitness and that standard population genetic models in fact well predict observed levels of b

91 ptake of miRNAs in newborn mice, we employed genetic models in which newborn miR-375 and miR-200c/141

92 ith exceptional longevity, under a recessive genetic model, in 3 independent populations.

93 In females, the best genetic model included substantial effects of direct add

94 the hypothesis that a combined clinical and genetic model incorporating atrial fibrillation risk SNP

95 Consistent with data, population genetics models incorporating the trade-offs successfull

96 in preadipocytes in a mouse lineage-tracing genetic model increases adipogenesis, leading to obesity

97 Recent mouse genetic models indicate that chromosomal breakage is com

98 scent has been implemented in the population genetic model inference software Migrate Simulation stud

99 However, in practice, the genetic model is often unknown beforehand.

100 e, is known, the NPT derived under the given genetic model is optimal.

101 do not support the hypothesis that a simple genetic model is responsible for the majority of cases o

102 When the underlying genetic model is unknown, a robust test is preferred to

103 herapy offers potential treatment but use of genetic models is limited by their poor survival.

104 mputing the likelihood of complex population genetic models is often infeasible.

105 his outcome has been proven for a variety of genetic models, it has not been proven in general for mu

106 Using a compelling array of genetic models, Kim et al. report in this issue of the J

107 minority and did not change post-stress in 2 genetic models lacking either Spi-C or VCAM-1 with impai

108 In particular, the use of non-additive genetic models may uncover new information about the gen

109 Using a sensitizing genetic model, Moon and colleagues provide compelling da

110 Together, this work provides a genetic model of a fracture nonunion and demonstrates th

111 Here we use a simple genetic model of Alexander disease, a progressive and se

112 igh Drinking in the Dark (HDID-1) mice are a genetic model of AUD risk that have been selectively bre

113 ts of interneuron transplantation in a mouse genetic model of autism.

114 s using transgenic (Tg)Notch3(R169C) mice, a genetic model of CADASIL, revealed functional defects in

115 romelalgia (IEM), a well characterized human genetic model of chronic pain, and studied a unique fami

116 lly restore SPINK1 function, present a novel genetic model of chronic pancreatitis.

117 63-Xbp1 double knockout mouse offers a novel genetic model of chronic tubulointerstitial kidney injur

118 Drosophila border cells represent a genetic model of collective migration within a cell-dens

119 The classical genetic model of colorectal cancer presents APC mutation

120 We have explored this in a genetic model of deficient SIRP-alpha signaling.

121 ered the muscle function of the mdx mouse, a genetic model of DMD.

122 Here, using a genetic model of DR, we show that the levels of polyunsa

123 ke social deficits in a well-validated mouse genetic model of Dravet syndrome (DS), a severe childhoo

124 Neoplastic transformation in a Drosophila genetic model of epidermal growth factor receptor (EGFR)

125 environment, supporting a multi-dimensional genetic model of ES.

126 n banding and angiotensin II infusion, and a genetic model of Etv1 cardiomyocyte-selective knockout (

127 e (Mn) export using flatiron (ffe/+) mice, a genetic model of Fpn deficiency.

128 etic mapping were used to analyze the murine genetic model of HIT.

129 ted sodium channels, is widely regarded as a genetic model of human pain.

130 s in the hypothalamus are increased in a rat genetic model of hypertension.

131 utionary model for aging with a quantitative genetic model of indirect genetic effects.

132 We pharmacologically activated SERCA2b in a genetic model of insulin resistance and type 2 diabetes

133 Here, we develop a population genetic model of malaria including these variations, and

134 ch responses and extend these results into a genetic model of MMP7 deficiency and gastric cancer.

135 squash (Cucurbita pepo) to test whether the genetic model of nectar secretion in Arabidopsis is supp

136 PI3Kgamma ablation in db/db diabetic mice, a genetic model of obesity-driven beta-cell failure and di

137 in ovarian cancer tissue, cell lines, and a genetic model of ovarian cancer stem cells.

138 ased FPN and increased TFR1 is observed in a genetic model of ovarian cancer tumor-initiating cells (

139 We used a genetic model of PAH, the Bmpr2 mutant mouse, to study t

140 MitoPark mice are a recently developed genetic model of PD that lacks the gene for mitochondria

141 The MitoPark mouse is a genetic model of PD that mimics many of the key characte

142 Previously, we have generated a genetic model of PKD using human pluripotent stem cells

143 als used in this study might represent a new genetic model of psychiatric diseases.

144 n alterations to cSCC development by using a genetic model of RDEB and organotypic skin cultures.

145 ere altered in the marrow and periphery in a genetic model of regulatory-associated protein of mTOR h

146 We developed an eco-genetic model of sea lamprey to examine factors affectin

147 Our analysis is based on a quantitative genetic model of sexual conflict, in which genes control

148 In a genetic model of spontaneous CKD, therapeutic delivery o

149 We studied a genetic model of spontaneous deep ICH using Col4a1(+/G49

150 cular phenotype akin to a channelopathy in a genetic model of SVD.

151 Fruit flies are a far cry from the quaint genetic model of the past, but rather, continue to evolv

152 Drosophila antennal lobe of both sexes as a genetic model of this question.

153 id-onset progressive cerebellar atrophy, but genetic modeling of SCA13 by expressing this pathogenic

154 during other conditions, similar to multiple genetic models of 5-HT system dysfunction in mice.

155 aluable pharmacological probes to complement genetic models of ABHD12-regulated (lyso)-PS/PI metaboli

156 tation into immunodeficient mice to generate genetic models of clonal hematopoiesis and neoplasia.

157 litis and adenomatous polyps in chemical and genetic models of colon carcinogenesis.

158 promises antitumor immunity in syngeneic and genetic models of colorectal cancer (CRC), which can be

159 ein hyperacetylation, previously observed in genetic models of defective mitochondrial function, also

160 breeding load in small populations, assuming genetic models of deleterious mutations which account fo

161 ted, and reversed established nephropathy in genetic models of diabetes.

162 use of statistics to analyse genetic data to genetic models of evolutionary processes.

163 Moreover, genetic models of G protein-biased opioid receptors and

164 l neurons in ex vivo brain slices from mouse genetic models of HD were studied using electrophysiolog

165 levels are not always detected across these genetic models of human dystonia, the D2R-mediated parad

166 s tremendous public health concern, very few genetic models of IDA are available to study its progres

167 We show how to embed quantitative genetic models of inheritance of labile traits into age-

168 Instead, we rely on well-established genetic models of linkage disequilibrium.

169 Using genetic models of mast cell deficiency, we demonstrate t

170 Here, we discuss genetic models of mouse DC development and function that

171 not been proven in general for multiallelic genetic models of mutation, migration, and recombination

172 address this knowledge gap, we infected two genetic models of Nod1 deficiency with the H. pylori cag

173 itness advantage for E. coli in chemical and genetic models of non-infectious colitis.

174 posed animals to cyst development, either in genetic models of polycystin-1/2 reduction or in respons

175 in adult offspring, which is consistent with genetic models of reduced IgCAM expression, to suggest c

176 Our methodology combines quantitative genetic models of social interactions with stochastic pr

177 velopmental Cell, Yin et al. (2018) describe genetic models of Sonic Hedgehog (SHH) subgroup of medul

178 he expected genomic footprints of population genetic models of sweepstakes reproduction are very diff

179 cy on rodent neurons using pharmacologic and genetic models of the disease.

180 ignatures that challenge standard population genetic models of these processes.

181 Genetic models of this disorder have been created by sel

182 genetic variation, using a simple population genetics model of mutational effects on fitness componen

183 + IA or proven/probable IA using a different genetic model or time to IA (3 months vs 2 years) compar

184 Activating or suppressing Hh signaling, with genetic models or pharmacological agents used in cancer

185 of asexual nematodes closely related to the genetic model organism Caenorhabditis elegans.

186 ts of variation in walking kinematics in the genetic model organism Drosophila.

187 nsory feedback shapes active locomotion in a genetic model organism exhibiting simple locomotion-the

188 rosophila melanogaster is a unique, powerful genetic model organism for studying a broad range of bio

189 The availability of a genetic model organism with which to study key molecular

190 Here we utilize a tractable genetic model organism, Caenorhabditis elegans, to study

191 More complex mammalian brains and genetic model organisms including zebrafish have been st

192 ished in the early 1900s as one of the first genetic model organisms owing to its short generation ti

193 Several quantitative genetics models predict that species escaping extinction

194 Multivariate genetic modeling revealed that global FA contributed ind

195 Quantitative genetic models revealed significant additive genetic var

196 Quantitative genetic models revealed stronger genetic correlation of

197 Univariate quantitative genetic models revealed that all phenotypes (schizophren

198 erformed under the assumption of an additive genetic model, revealed several imputed SNPs (eg, rs1152

199 terization of a LMBR1/LIMR-type protein in a genetic model reveals an important role in modulating BM

200 Under the quantitative genetic model, sampling from the high extreme of the dis

201 Using a genetic model, sequence variant data can be generated ei

202 Population genetic models show that senescence for these maternal e

203 redundancy in quantitative versus population genetic models, show how this contributes to signatures

204 A mathematical population-genetics model showed how tolerance boosts the chances f

205 e investigations in cereal crops and related genetic model species such as Brachypodium distachyon.

206 ) that is flexible to encompass a variety of genetic models such as additive, dominant and compound h

207 Other genetic models such as recessive, dominant, or overdomin

208 A four-locus population genetic model suggests that such an effect can pertain i

209 Population genetic modeling suggests that at least some of these in

210 analysis using hypothesis-driven population genetic models suggests the colonization of the Atlantic

211 gether, the results from our study in murine genetic models support the notion that infection may rep

212 maging at the cellular level in roots of the genetic model system Arabidopsis (Arabidopsis thaliana).

213 ing GPCR-mediated behaviors, we utilized the genetic model system Caenorhabditis elegans Our studies

214 t of Fanconi Anemia (FA) signaling, a unique genetic model system for studying human aging or cancer,

215 Here, we exploit a genetic model system to establish a mechanistic link bet

216 network collapse, validating Drosophila as a genetic model system to investigate keratin dynamics.

217 ng so, FA provides researchers with a unique genetic model system to study cancer etiology.

218 r bedding plant that has a long history as a genetic model system.

219 hototaxis using Drosophila melanogaster as a genetic model system.

220 butterflies and unlock their potential as a genetic model system.

221 Using static and inducible genetic model systems and chromatin studies, we develope

222 Work on genetic model systems such as Drosophila and mouse has s

223 s been the limited availability of effective genetic model systems that could be used to identify the

224 t, and emphasizes the power of using defined genetic model systems.

225 Fbxw7 in endometrial cancer through defined genetic model systems.

226 However, current genetic models targeting cilia completely ablate the com

227 We developed a murine genetic model that allows for inducible and reversible V

228 Furthermore, a polygenic genetic model that explains adaptation to contrasting be

229 eases and developmental defects that require genetic models that can exploit these genome editing tec

230 and population genetics can be reconciled by genetic models that include the complexities of social s

231 cological ERK/MAPK inhibitors and the use of genetic models that only partially reduce total ERK/MAPK

232 Using a dominant genetic model, the 4q25 SNP, rs2200733, predicted a 1.4-

233 Recent progress in rapid combinatorial genetic modelling, the development of a genetically immu

234 Combining two tractable genetic models, the bacterium E. coli and the nematode C

235 Combining two tractable genetic models, the bacterium E. coli and the nematode C

236 A "two-hit" genetic model therefore underlies a key phenotypic trans

237 Using the unbiased Smpd3(-/-) genetic model, this study shows that the perturbed Golgi

238 ls and present Dictyostelium as a convenient genetic model to characterize these pathways.

239 Even though addition of this limited genetic model to COMPASS did not improve prediction of p

240 Here, we present a genetic model to differentiate the roles of these two fu

241 are specifically impaired, and utilized this genetic model to directly test the role of glutamatergic

242 r the FAAH 385A allele may therefore offer a genetic model to evaluate the impact of elevations in AE

243 Here we apply a simple orthogonal genetic model to evaluate the roles of genetic (additive

244 and that flatiron mice provide an excellent genetic model to explore the role of this exporter in Mn

245 ila is and will continue to be a fundamental genetic model to identify new disease-causing variants,

246 UK Biobank participants and use a multitrait genetic model to identify risk loci for glaucoma.

247 after laser injury: i) by using an inducible genetic model to inhibit specifically proliferating PDGF

248 obacter litoralis DSM 8509, as a comparative genetic model to investigate GSR.

249 We present a versatile genetic model to investigate the complex relationship be

250 elopment, and this mutant represents a novel genetic model to investigate the mechanisms of vascular

251 Our approach uses a population genetic model to relate effective migration rates to exp

252 peline that uses Caenorhabditis elegans as a genetic model to screen for phenotype-changing missense

253 combined population genetic and quantitative genetic model to show how this conflict becomes resolved

254 anogaster egg-laying site selection offers a genetic model to study a simple form of value-based deci

255 We develop an individual-based, eco-genetic model to study how mating systems and fitness tr

256 hus, Nedd4-2 heterozygous mice provide a new genetic model to study inflammatory pain.

257 enorhabdus nematophila, and is emerging as a genetic model to study symbiosis and pathogenesis.

258 myoblast fusion has been used as a powerful genetic model to unravel mechanisms underlying cell-cell

259 We also applied quantitative genetic modeling to estimate the contribution of genetic

260 suggesting potential for developing clinical-genetic models to identify patients with PD at increased

261 Here, we combine Xenopus and mouse genetic models to identify that the transcription factor

262 has made possible the generation of targeted genetic models to interrogate uniplex function in vivo.

263 associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and co

264 We generated new mouse genetic models to selective ablate one of POMC-neuron en

265 Here we used two genetic models to show that continuous transforming grow

266 Here we utilize multiple mouse genetic models to uncover a role for PI3KC2alpha in regu

267 We also use a simple population-genetics model to demonstrate that when both male aggres

268 a haplotype method based on the quantitative genetics model towards the utilization of functional and

269 morphocline for domesticated rice, propose a genetic model underlying complex panicle traits, and dem

270 Similarly, a genetic model using Myd88/Trif-deficient mice, which lac

271 cribe two errors made in defining population genetic models using the msprime coalescent simulator th

272 By constructing genetic models via frequentist and Bayesian association

273 A full genetic model was applied to association mapping for ana

274 anoids propagated from primary tumors in the genetic model was further developed.

275 Quantitative genetic modeling was used to decompose the cross-disorde

276 Multivariate quantitative genetic modeling was used to estimate common genetic inf

277 Using mouse genetic models we show major differences in Jag and Dll

278 Using a double mutant genetic model, we confirm that DBC1 suppresses B cell ac

279 By using C. elegans as a genetic model, we could visualize mitochondrial morpholo

280 Using a mouse genetic model, we demonstrated that altered ensembles ar

281 Importantly, using a second genetic model, we were able to attribute all altered beh

282 Using murine genetic models, we demonstrated that GP96 is required fo

283 Specifically, using murine genetic models, we determined that SEC63 deficiency sele

284 ecific loss-of-function and gain-of-function genetic models, we determined that this in vivo toxin se

285 sed on evidence gained from studies on mouse genetic models, we have identified tyrosine phosphorylat

286 In additive genetic models, we identified nonsignificant association

287 oaches along with loss- and gain-of-function genetic models, we identified OCT4-dependent mechanisms

288 lung adenocarcinoma mouse models, including genetic models, we show that autochthonous tumors that l

289 Using in vivo genetic models, we show that HIFalpha in oligodendroglia

290 Using several genetic models, we show that macrophage FLT1 signaling i

291 Using this and other genetic models, we showed that Treg cells shaped the tra

292 Clinical and clinical/genetic models were developed to predict 5-year freedom

293 T in humans is directly mirrored in a murine genetic model, where inbred mouse strains are differenti

294 We propose a novel temporal imaging genetic model which performs the multi-task sparse canon

295 shment of exercise protocols for short-lived genetic models will be critical for deciphering fundamen

296 d overall survival (OS) using a log-additive genetic model with adjustment for age, sex, and age-adju

297 using logistic regression under an additive genetic model with adjustment for age, sex, body mass in

298 n MuSCs by combining in vivo mouse molecular genetic models with ex vivo studies.

299 Here, we used zebrafish genetic models with low activity of Mitfa (MITF-low) and

300 nt (interaction parameter = 1.54, p = 0.001) genetic models without any heterogeneity (I(2) = 0.0%);