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1 ferentiation potential and applicability for genetic screening.
2  immune response than pretreatment biopsy or genetic screening.
3 we can achieve high efficiency combinatorial genetic screening.
4 ese cells as a platform for loss-of-function genetic screening.
5 l in next generation chips for bioassays and genetic screening.
6 ambulatory ECG, an exercise stress test, and genetic screening.
7 new strategy for adult disease prevention by genetic screening.
8 utive ARVC families undergoing comprehensive genetic screening.
9 gene variants identified in long QT syndrome genetic screening.
10 virus (MCMV), as identified through unbiased genetic screening.
11 thod has clear advantages over in silico and genetic screening.
12 evelopment in zebrafish has been applied for genetic screening.
13  cells and show their application in forward genetic screening.
14 ibit widespread interactions in genome scale genetic screening.
15 ised an exon hierarchy analysis strategy for genetic screening.
16  for applications in medical diagnostics and genetic screening.
17 s, are needed to determine the usefulness of genetic screening.
18 linical features and provide a rationale for genetic screening.
19 rmination of the nonclinical implications of genetic screening.
20  particularly with the application of pooled genetic screening.
21 atosis that can be readily identified before genetic screening?
22 mportant implications for the development of genetic screening algorithms.
23 red in an age group frequently excluded from genetic screening algorithms.
24              Through targeted disruption and genetic screening, an increasing number of genes have be
25        Identification of the gene will allow genetic screening and a specific diagnosis for a disease
26  mutagenesis expands the toolbox for forward genetic screening and also provides direct evidence that
27                                    Continued genetic screening and analysis of Arabidopsis mutants ha
28 otype will help clinical diagnosis, targeted genetic screening and appropriate management.
29 nt of exon hierarchy analysis strategies for genetic screening and better understanding and recogniti
30                   The integration of forward genetic screening and biochemical profiling opens a path
31 n in food analysis, forensic investigations, genetic screening and biodiagnostics.
32 nt integration between the expected yield of genetic screening and cost may allow the formation of cr
33 ice increasingly relies on advanced imaging, genetic screening and devices.
34                                     Prenatal genetic screening and diagnostic testing can identify ma
35                                     Prenatal genetic screening and diagnostic tests are changing rapi
36               Here, through a combination of genetic screening and directed mutagenesis with the type
37                       In this study, we used genetic screening and downstream validation to identify
38 igh-risk populations that would benefit from genetic screening and enhanced surveillance.
39 sing both evolutionarily distant species for genetic screening and functional assessment to identify
40 s a common finding in aHUS patients and that genetic screening and functional tests of ADAMTS13 shoul
41 undant collection that is suitable for rapid genetic screening and gene discovery.
42                              High-throughput genetic screening and gene expression profiling of fcp1
43                    We use results of forward genetic screening and genetic analysis in our new model
44  the EpRE and interacts with the ER in yeast genetic screening and in vitro assays.
45  8 into 4-thiouridine has been identified by genetic screening and its role in 4-thiouridine generati
46   Through a combination of CRISPR-Cas9-based genetic screening and metabolomic analyses, we show that
47 ms (SNPs) has potential applications in both genetic screening and pharmacogenomics.
48 mutations, offering a promising approach for genetic screening and testing of LHON mutations.
49 f experimental approaches, including forward genetic screening and transcriptional profiling of suppo
50 rtant for applications in disease diagnosis, genetic screening, and drug discovery.
51 e natural history, the yield of familial and genetic screening, and the arrhythmogenic mechanisms in
52 i-lineage development, pan-tissue functional genetic screening, and tissue engineering.
53 o diagnose patients definitively, to perform genetic screening, and to delineate the clinical manifes
54 e sequencing, transposon mutagenesis forward genetic screening, and transcriptomics.
55 ellular antibody capture (IAC) is based on a genetic screening approach and is a facile methodology w
56    Here we report a novel, clinically guided genetic screening approach for the identification of onc
57 o gemcitabine, and a genome-wide CRISPR/Cas9 genetic screening approach identified only the pyrimidin
58                A simple, rapid, and flexible genetic screening approach identifies genes that drive r
59     In summary, our comprehensive functional genetic screening approach revealed modulation of resist
60 Here, we describe a pooled, loss-of-function genetic screening approach suitable for both positive an
61                                We employed a genetic screening approach to identify gain-of-function
62                 Here we use a pooled in vivo genetic screening approach using CRISPR-Cas9 genome edit
63                                   The guided genetic screening approach validated by this study offer
64                        We applied a scalable genetic screening approach, in vivo Perturb-Seq, to func
65                                      Using a genetic screening approach, we identify the ubiquitin-sp
66             Here, we present a network-based genetic screening approach: the transcriptional regulato
67 didate oncogenic drivers of HCC in a forward genetics screening approach.
68                        We used two different genetic screening approaches to identify Saccharomyces c
69  of clinical phenotype in guiding individual genetic screening at this time.
70             We used a combination of forward genetic screening based on a Proline Dehydrogenase1 (PDH
71 sible for this progression, we carried out a genetic screening by an enhanced retroviral mutagen (ERM
72 to histopathologic examination and molecular genetic screening by clonotype primer-directed polymeras
73                                        Rapid genetic screening by restriction enzyme analysis of vira
74 e of interest is frequently achieved through genetic screening by RNA interference (RNAi) or knockout
75                   This approach can simplify genetic screening by targeting the gene for initial stud
76                                     Chemical genetic screening can be described as a discovery approa
77 in general and, in combination with chemical genetic screening, can be used to identify host cell fun
78   The detection of leukemia cells on newborn genetic screening cards ("Guthrie cards") of a small gro
79 t glucose has a role in fly biology and that genetic screenings carried out in flies may increase our
80       The findings demonstrate that unbiased genetic screenings combined with a clinically relevant m
81  single-cell trajectory analysis with pooled genetic screening could reveal the genetic architecture
82                         The use of molecular genetic screening currently has some legitimacy in certa
83 of the spectrum of disease and refinement of genetic screening, diagnostic tests, and surgical manage
84  have been identified in 71 plant species by genetic screening, direct cloning after isolation of sma
85  also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic
86                                              Genetic screening efforts with invertebrates have unrave
87 rebrospinal fluid, endocrine, metabolic, and genetic screening findings were normal or negative.
88                                              Genetic screening for a germline mutation at the RET gen
89 arcoded mutants unlocks the power of reverse genetic screening for a malaria parasite and will enable
90 e lhr1 mutant was isolated through a forward genetic screening for altered expression of the lucifera
91 breast cancer are often counseled to receive genetic screening for BRCA1 and BRCA2 mutations, the str
92 tors, are likely to alter fundamentally both genetic screening for celiac disease and its therapy.
93 6 at-risk subjects undergoing endoscopic and genetic screening for FAP.
94 s for Pro-16, Asp-18, and Asn-19 followed by genetic screening for functional proteins.
95 onent is missing, and (3) the need for rapid genetic screening for gene expression changes in living
96 ntal modifiers, and psychosocial outcomes of genetic screening for hemochromatosis.
97                          Research addressing genetic screening for hereditary hemochromatosis remains
98 te the benefit from, widespread or high-risk genetic screening for hereditary hemochromatosis.
99          Limitations: This review considered genetic screening for HFE-related hereditary hemochromat
100 se of hematopoietic stem cells to facilitate genetic screening for malaria host factors.
101                                              Genetic screening for molecules involved in Shiga toxin
102                                          Our genetic screening for mutations that resist CLE peptide
103  approaches have hindered systematic forward genetic screening for NMD factors in human cells.
104 Fireworks) that enables CRISPR-based forward genetic screening for NMD pathway defects in human cells
105 nvolving living cells facilitate large-scale genetic screening for novel biological activities.
106                           Patients underwent genetic screening for NPM1, FLT3-ITD, FLT3-D835, and CEB
107          This observation instigated further genetic screening for prostacyclin receptor variants on
108                                   Individual genetic screening for rare high-risk traits or for more
109 uction have already been defined, continuous genetic screening for regulators of innate immunity may
110  challenges faced by families as a result of genetic screening for SADS to enable equitable access to
111 ated gene disruption procedure and performed genetic screening for single P-element insertion mutatio
112     The assay allows simple, high throughput genetic screening for these common hematological disorde
113 is important for basic and medical research; genetic screening for those genes in Caenorhabditis eleg
114                                 Clinical and genetic screening for VHL in this family had a significa
115            The diffusion and availability of genetic screening gave a new relevance to the applicatio
116                                      Reverse genetic screening has been highly useful for determinati
117                                              Genetic screening has identified numerous variants of th
118                                              Genetic screening has reduced the incidence of untreatab
119 n the coding sequence or by splice variants, genetic screening has revealed a large number of missens
120                                 CRISPR-based genetic screening has revolutionized cancer drug target
121                                              Genetic screening has shed light on the molecular mechan
122 rs; however, routine guidelines for clinical genetic screening have been established only in the form
123  screening; 8,136 (4.508%) were positive for genetic screening (heterozygote, homozygote, or compound
124                                              Genetic screening identified an A896T substitution in a
125                        Subsequent functional genetic screening identified host factors that functiona
126                                              Genetic screening identified the gene sma0113 as needed
127                                      In vivo genetic screening identifies CCL2 as the top prometastat
128                                              Genetic screening identifies the atypical tetraspanin TM
129                                              Genetic screening identifies zebrafish mutants, such as
130               These findings may help direct genetic screening in a busy neurology outpatient setting
131 aChA), which is a novel platform for haploid genetic screening in animals to identify genes essential
132                                              Genetic screening in both cases shows the heterozygous R
133                                      Through genetic screening in C. elegans, we uncover two metformi
134 ISPR-Cas12a-based approach for combinatorial genetic screening in cancer cells.
135                                        Thus, genetic screening in Drosophila can be successfully appl
136                                        Using genetic screening in Drosophila, we have identified Fasc
137 erence (RNAi) has become a powerful tool for genetic screening in Drosophila.
138  in the Dominican Republic, that could guide genetic screening in each location.
139                         We used the power of genetic screening in human cells and found that RVFV uti
140 oxicity mechanism, made possible by unbiased genetic screening in human cells, suggests that the sele
141 el autophagy factors and pathways by forward genetic screening in mammalian cells.
142 interference (RNAi) for its potential use in genetic screening in mice.
143 emonstrate the feasibility of using RNAi for genetic screening in mice.
144    Our experience with the HNP suggests that genetic screening in patients could identify at-risk car
145 ted in databases, and one (A243G) found in a genetic screening in patients with diabetes.
146                      In vitro mutational and genetic screening in Salmonella enterica serovar Typhimu
147 ene-level investigation of these mechanisms, genetic screening in the axolotl requires an extensive c
148                                              Genetic screening in the budding yeast Saccharomyces cer
149                       Concurrent hearing and genetic screening in the whole newborn population in Bei
150 is enterprise has been joined by large-scale genetic screening in the zebrafish, where a number of in
151 ecently described a yeast assay suitable for genetic screening in which simple religation nonhomologo
152 e address this need by using high-throughput genetic screening in yeast to select variants of the iro
153                              We used forward genetic screening in zebrafish to test the hypothesis th
154 f haploid cell lines has facilitated forward genetic screenings in mammalian cells.
155                  Transposon-mediated forward genetics screening in mice has emerged as a powerful too
156                 Unbiased in vivo genome-wide genetic screening is a powerful approach to elucidate ne
157 entiviral short hairpin RNA (shRNA)-mediated genetic screening is a powerful tool for identifying los
158                                      Haploid genetic screening is a powerful tool to reveal factors i
159                                              Genetic screening is becoming possible on an unprecedent
160                        It is unknown whether genetic screening is indicated in the general population
161                                              Genetic screening is not necessary to diagnose or initia
162             While locomotor-based behavioral genetic screening is successful in identifying genes in
163                                              Genetic screening is the most powerful method through wh
164                                      Routine genetic screening is unlikely until management is improv
165 , for example, by using computer testing and genetic screening, is an area of ongoing research.
166 pel-Lindau (VHL) disease in whom clinical or genetic screening led to the detection of surgically res
167           Here, we circumvent aforementioned genetic screening limitations and present methods for a
168                                 Preoperative genetic screening may guide intraoperative management to
169 with a high prevalence of BRCA1/2 mutations, genetic screening may significantly increase average sur
170                Here, we use a combination of genetic screening, MD simulations, and biochemical and m
171 e have developed a novel retrovirus-mediated genetic screening method in cultured cells.
172 ighlights the utility of our straightforward genetic screening method in identifying new drug combina
173          To achieve this goal, we used a new genetic screening method using enhanced retroviral mutag
174                            Here we present a genetic screening method using photo-highlighting for ca
175         To overcome this limitation, a novel genetic screening method was devised to convert type IIS
176                                    We used a genetic screening methodology, a human cell line bearing
177 decades to achieve with conventional forward genetic screening methods and mammalian cell cultures.
178 f gene expression can complement traditional genetic screening methods for the identification of gene
179                           Using differential genetic screening methods, we show that defective KSHV i
180 a parasites is hampered by a lack of reverse genetic screening methods.
181 ble for traits difficult to analyze by other genetic screening methods.
182 A (allene oxide synthase, AOS) using reverse genetics screening methods.
183  the planarian flatworm as a simple chemical-genetic screening model for nervous system regeneration
184                                              Genetic screening of 133 unaffected Hungarian Vizslas re
185                                              Genetic screening of 171 patients with frontotemporal lo
186                                      Forward-genetic screening of 3237 R(1) lines resulted in identif
187                                     Finally, genetic screening of 44 patients revealed >/=2 ABCA4 mut
188                                              Genetic screening of a further 367 isolated dystonia sub
189                            We recommend that genetic screening of aHUS includes analysis of CFH and C
190                                              Genetic screening of an E. coli genomic library was perf
191                             In this study, a genetic screening of an E. coli genomic library was perf
192 lies of CCHS probands with PHOX2B mutations, genetic screening of appropriate family members is indic
193 zygous for the C282Y mutation ascertained by genetic screening of blood donors; and patients presenti
194 w findings are informative and encourage the genetic screening of cancer patients in order to identif
195 efore, serve as a useful diagnostic tool for genetic screening of certain syndromic ciliary diseases.
196                        Recently, genome-wide genetic screening of common DNA sequence variants has pr
197 ese results support the use of comprehensive genetic screening of desmosomal genes for arrhythmic ris
198                                      Through genetic screening of dilated cardiomyopathy patients, we
199  germ cell manipulation, artificial gametes, genetic screening of embryos and gene editing of embryos
200                                     Chemical genetic screening of endothelial tube formation provides
201 ions and FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat exp
202                                      Routine genetic screening of HCM patients for specific mutations
203            An alternative to population-wide genetic screening of healthy individuals would exploit t
204 ethodology provides an accurate approach for genetic screening of imprinting related disorders in new
205                        By a loss-of-function genetic screening of individual IFN-stimulated genes (IS
206                       Concurrent hearing and genetic screening of newborns is expected to play import
207  frequency impact variant categorization for genetic screening of nonsyndromic hearing loss (NSHL) an
208                                    Following genetic screening of Parkinson's disease patients and he
209                                              Genetic screening of patients diagnosed with macular dys
210                               Interestingly, genetic screening of patients with dilated cardiomyopath
211  2012, the authors have included FLNC in the genetic screening of patients with inherited cardiomyopa
212             To maximize clinical benefits of genetic screening of patients with nephrotic syndrome (N
213  through characterization of mutant mice and genetic screening of patients.
214 aintenance in plants, we performed a forward genetic screening of PIN2:PIN1-HA;pin2 Arabidopsis (Arab
215                      In treatment decisions, genetic screening of related donors for hematopoietic st
216                                   Predictive genetic screening of relatives of patients with hypertro
217 known MeCP2 isoform has implications for the genetic screening of Rett syndrome patients and for stud
218                                   Therefore, genetic screening of SCN9A, SCN10A and SCN11A should be
219                                              Genetic screening of symptomatic patients or asymptomati
220 ses a MELAS-like phenotype, and suggests the genetic screening of the MRM2 gene in patients with a m.
221                                     Based on genetic screening of this model, we identified three RNA
222                      Our model suggests that genetic screening of this population could prolong avera
223 a long-term monitoring program, we performed genetic screening of thousands of non-invasive samples c
224                                      Further genetic screening of unrelated PCD subjects identified a
225                Altogether, this and previous genetic screening of yeast led to the identification of
226 plexed CRISPR/Cas9 can be used for recessive genetic screening or high-throughput cancer gene validat
227                  Here, we describe a forward genetic screening paradigm exploiting CRISPR-mediated ge
228                                       In our genetic screening, Pink1 and Park genes were identified
229                          We discuss how each genetic screening platform can provide unique insight in
230 pan assays limit their usefulness as a broad genetic screening platform for research on aging.
231                            A high-throughput genetic screening platform in a single-celled photosynth
232             For these reasons, comprehensive genetic screening platforms have been developed with the
233 gm with significant potential for developing genetic screening platforms in mammalian cells.
234            The mutants were isolated using a genetic screening procedure which eliminates mutations t
235        The pedigree is the first step in the genetic screening process and can guide the clinician in
236  who were consecutively identified through a genetic screening program as carriers of a RET mutation
237                                              Genetic screening programs in unselected individuals wit
238                  Our work shows that forward genetic screening provides a powerful route to identify
239  preclinical tool for drug testing and large genetic screening relevant to the study of executive dys
240                Our re-analysis of a previous genetic screening result in Caenorhabditis elegans shows
241 l ordering and correct interpretation of the genetic screening results.
242 domonas reinhardtii, previously recovered by genetic screening, results from a leucine 290 to phenyla
243 lowed by quantitative proteomic analysis and genetic screening revealed multiple regulators of N-medi
244                                          Our genetic screening revealed varying mutation frequencies
245                                Surprisingly, genetic screening reveals that yeast FTase can modify se
246                                 This forward genetic screening scheme is useful and applicable to any
247                     Systematic, wide-ranging genetic screening should be offered in pES; the genetic
248                                    Extensive genetic screening should become a standard procedure to
249 er strategy has come to be known as "cascade genetic screening." Since the carrier risk of close rela
250 esults demonstrate the power of our chemical-genetic screening strategies for pinpointing the physiol
251                 In this study, we describe a genetic screening strategy and demonstrate its use in sc
252    We developed a versatile, high-throughput genetic screening strategy by coupling gene mutagenesis
253                               We developed a genetic screening strategy called insertional mutagenesi
254 tional mutagenesis and depletion (iMAD) is a genetic screening strategy for dissecting complex intera
255 hat CRISPR can be used as a powerful reverse genetic screening strategy in vivo in a vertebrate syste
256   Based on yeast growth rescue, we present a genetic screening strategy that identified RACK1 as an E
257                           Here we describe a genetic screening strategy to isolate fertilization muta
258    Broad application of this highly parallel genetic screening strategy will not only facilitate the
259  development of study models or as a tool in genetic screening studies, including those aiming to dis
260  should be adopted in future mechanistic and genetic screening studies.
261                                   The recent genetic screening study in Caenorhabditis elegans has li
262                                              Genetic screening study of the MTATP6 gene in 64 pedigre
263                                              Genetic screening, such as that used most frequently for
264                                      Forward genetic screening suggests that multiple receptors are i
265 ion of T cell targets, we developed a hybrid genetic screening system where the Sleeping Beauty (SB)
266                                Using a yeast genetic screening system, we identify Lhx3 point mutants
267 g engineered transposons is a potent forward genetic screening technique used to identify cancer gene
268                        In addition, use of a genetic screening test raises concerns regarding possibl
269 search and clinical laboratories as low cost genetic screening tests.
270 here is a need for practical, cost-efficient genetic screening tests.
271              Here, we report the design of a genetic screening that uncovered Dma1 as another E3 liga
272           Here, we performed high-throughput genetic screenings that provide a novel global map of th
273 nd mice are suitable for pharmacological and genetic screening to detect effects on expression of LDL
274         Our studies demonstrate the power of genetic screening to discover cancer drivers that are di
275 substitutions at this position were found in genetic screening to exhibit a dominant lethal phenotype
276 s in this group highlights the importance of genetic screening to identify abnormalities that may be
277 he new conserved CA proteins will facilitate genetic screening to identify patients with a form of pr
278          Here, we have used forward chemical genetics screening to identify DFPM-insensitive loci by
279 ages of FO-SPR as a high resolution and fast genetic screening tool that can compete with the current
280            As CRISPR-Cas is a relatively new genetic screening tool, it is important to assess its fu
281 o observed that although not detected in our genetic screening, two cold shock-inducible proteins, na
282                                              Genetic screening used a combination of single-gene test
283                                    Following genetic screening using a shade-responsive luciferase re
284 hat improves the efficiency of combinatorial genetic screening using an effective strategy for clonin
285                                Combinatorial genetic screening using CRISPR-Cas9 is a useful approach
286                                              Genetic screening using flagellin mutants of L. pneumoph
287  complementary approach, we discuss parallel genetic screening using next-generation sequencing follo
288                                              Genetic screening using random transposon insertions has
289 seful for high-throughput pharmacological or genetic screening using rodent models.
290 creening using enhancer trapping and forward genetic screening using transposon insertional mutagenes
291                                 The yield of genetic screening was low (14%), despite familial diseas
292                           Through a chemical genetic screening, we have identified a small molecule,
293 , from a cell-based high-throughput chemical genetic screening, we identified a small molecule SC79 t
294  By coupling in vivo ribosome profiling with genetic screening, we provide direct evidence that oncog
295                               Using chemical genetic screening, we tested a library of known phosphat
296 ulators and their cellular targets, chemical genetic screenings were performed with triazine-based co
297 , autoantibody panel, infectious etiologies, genetic screening, whole exome sequencing, and the phage
298 allel pooled genome-wide CRISPR-Cas9 forward genetic screening with a highly quantitative and sensiti
299 esults also pave the way for high-throughput genetic screening with CRISPR/Cas.
300 ions constrain sensitivity and throughput of genetic screening with single-cell transcriptomics reado

 
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