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1 ding-yeast pathway, we performed an unbiased genetic selection.
2 ne using ribosome binding site libraries and genetic selection.
3 f protein engineering that uses the power of genetic selection.
4 d biosensors and to engineer enzymes through genetic selection.
5 cts positive clones by positive and negative genetic selection.
6 ring infection were recently identified in a genetic selection.
7 00)-Arg(712) by using random mutagenesis and genetic selection.
8 X inactivation but the dominant mechanism is genetic selection.
9 ng a telomeric linear plasmid and a two-step genetic selection.
10 f Na+ tolerance to yeast, can be isolated by genetic selection.
11 herefore subjected to random mutagenesis and genetic selection.
12 ence-activated cell sorter (FACS) to perform genetic selection.
13 dered variants of dihydrofolate reductase by genetic selection.
14 ell-characterized evolutionary mechanism for genetic selection.
15 genes using unbiased genome-wide functional genetic selection.
16 lendar season and the desirable direction of genetic selection.
17 h affinity and specificity by direct in vivo genetic selection.
18 ents between 1N and 3N without involving any genetic selection.
19 ne approaches to search for evidence of such genetic selection.
20 ype levels by random mutagenesis of purF and genetic selection.
21 unction as logic gates were isolated by dual genetic selection.
22 ied site saturation strategy with functional genetic selection.
23 or by using RNAi in phenotype-based, forward genetic selections.
24 lly applicable to the analysis of a range of genetic selections.
25 ty of Red-mediated recombination in targeted genetic selections.
26 dified yeast two-hybrid system which enables genetic selection against a specific protein/protein int
27 erated the normally slow response to relaxed genetic selection against deafness that began in many We
28 is required to be paired, we observe strong genetic selection against viruses that contain a deletio
29 ge libraries, coupled with the benefits of a genetic selection, allowed us to identify rare, uniquely
31 ion strategies have traditionally focused on genetic selection and cost-effective ration formulation
32 rol initiation, respectively, we developed a genetic selection and identified seqA, datA, dnaN and hd
37 termination, were recovered in a powerful F1 genetic selection and used to investigate how sc was rec
40 individuals who are interested in population genetics, selection and evolution of polymorphic human g
41 ii) genes within de novo CNVs under negative genetic selection, and (iii) genes identified by clinica
42 uctase (VKORc1) as a reporter, we describe a genetic selection approach allowing the isolation of Esc
46 l aminoacyl-tRNA synthetase is generated and genetic selections are performed on the library in Sacch
47 Collectively, these results establish our genetic selection as a useful and potentially generaliza
48 unique opportunity to examine the impacts of genetic selection as humans adapted to multiple new envi
49 se explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS stud
51 clease (RNase A) and human angiogenin, and a genetic selection based on the intrinsic cytotoxicity of
54 fy rules linked to function, we leverage the genetic selection bias of condensate-promoting oncofusio
59 of a particular residue as revealed by this genetic selection correlated with its sequence conservat
65 breeding values was shown to have a greater genetic selection differential and reduced future diseas
70 ives of bacteriophage P22 that enable direct genetic selection for a specific RNA-protein interaction
71 unbalanced body conformation due to intense genetic selection for additional breast muscle (pectoral
76 further dissection of phosphate signaling by genetic selection for constitutive phosphate starvation
77 by profiling Drosophila strains subjected to genetic selection for differences in aggressiveness.
78 pproaches, including saturation mutagenesis, genetic selection for DNA-binding mutants, photo cross-l
79 e DNA binding by TBP in vivo, we performed a genetic selection for extragenic suppressors of a yeast
80 rofitability (p<0.01), but an improvement in genetic selection for fertility (p<0.01) and overall cow
82 Short Sleep lines of mice were developed by genetic selection for high or low alcohol sensitivity.
88 that are important for ligand specificity, a genetic selection for mutants of the inosine-guanosine-s
90 ptional regulation of PHO5, we carried out a genetic selection for mutants that express PHO5 constitu
91 ing domain barrier components, we designed a genetic selection for mutants with reduced negative supe
93 UR1 and BUR2 were previously identified by a genetic selection for mutations that increase transcript
94 w phosphatase, PTP3, have been isolated in a genetic selection for negative regulators of an osmotic
95 ) substitutions were previously isolated via genetic selection for photosynthetic ability at the 35 d
96 To this end, we applied a recently developed genetic selection for protein folding and solubility bas
101 lling the postharvest storage atmosphere and genetic selection for slow or late ripening varieties.
103 ifferential behavior provided the basis of a genetic selection for STE5 gain-of-function mutations.
106 in phospholipid biosynthesis, we performed a genetic selection for suppressors of the inositol auxotr
110 OL1 variants - which have undergone positive genetic selection for their ability to confer resistance
117 expression of a reporter gene are useful for genetic selections, high-throughput screening, and multi
118 ific disciplines of environmental design and genetic selection, however understanding the ecological
121 onucleotide formyltransferase (PurN) and, by genetic selection, identified PurN heterodimers capable
122 onal randomization of the loop, coupled with genetic selection in a glucokinase-deficient bacterium,
124 igand, suggesting that it is possible to use genetic selection in E. coli to discover synthetic ribos
125 m sequence mutagenesis coupled with positive genetic selection in E. coli yields large numbers of fun
130 random saturation mutagenesis coupled with a genetic selection in yeast to determine the relative imp
132 genes that play a role in this process using genetic selections in conventional cell culture systems.
137 that phenotypic adjustment and/or beneficial genetic selection is possible for some species, indicati
140 Since Top7 was created in the absence of genetic selection, it provides a rare opportunity to inv
144 rom the Finnish Twin Registry suggested that genetic selection may account for some of the physical-a
145 oped a rapid and broadly applicable in vitro genetic selection method based on T7 phage display.
151 bored in recipient pigs and that within-host genetic selection of IAV is more likely to occur in pigs
152 We have therefore developed a strategy for genetic selection of lineage-restricted precursors from
158 Mechanistically, this is not elicited via genetic selection of tumor subclones, but through an epi
159 on of LASV-LCMV domain-swapping experiments, genetic selection of viral variants, and site-directed m
161 on theory to assess the non-linear impact of genetic selection on field measures of epidemic risk and
163 based screen performed by imposing different genetic selections on thousands of yeast mutants in para
164 d hydrophobic core sequence, imposed without genetic selection or computer-based design, is sufficien
165 t the processes of zoonotic transmission and genetic selection or modification ensure that plasma-der
166 lting libraries are subjected to large-scale genetic selection or screening to identify those chimera
167 ctional trade-offs may limit the capacity of genetic selection or synthetic biology to simultaneously
169 r, suggest that they have been adapted under genetic selection pressure for optimal performance.
171 unction of the glycosome, we used a positive genetic selection procedure to isolate the first Leishma
172 We have previously employed an in vitro (genetic) selection procedure to select RNase P ribozyme
175 aturation mutagenesis technique and positive genetic selection provides a simple and efficient means
177 echanisms behind the rise of innovativeness (genetic selection, rational choice, and phenotypic plast
179 r these phenotypic trends are underpinned by genetic selection responses, and to evaluate the potenti
180 onucleotide-directed mutagenesis followed by genetic selection resulted in mutant GlnRS enzymes that
184 process called "pseudotaxis." Therefore, our genetic selection scheme generated suppressors of pseudo
187 and scoring for fitness in plants by in vivo genetic selection (SELEX) resulted in winning sequences
192 ec7p and its interacting proteins, we used a genetic selection strategy in which a human HepG2 cDNA l
196 This system can be used as an efficient genetic selection system to map protein-protein interact
197 ic LacI protein as an example, we describe a genetic selection system using a bidirectional reporter
198 so demonstrates that the P22 challenge phage genetic selection system, modified for use with a mammal
203 yeast two-hybrid system is the provision for genetic selection techniques that enable the identificat
205 is negative regulation, we developed a novel genetic selection that detects altered expression from t
210 hia coli that was previously identified by a genetic selection that rescued sensitivity to dithiothre
211 re and function in vivo, we have developed a genetic selection that ties the life of Escherichia coli
213 nd expression of these genes, we developed a genetic selection that uses transposon mutagenesis to id
215 terize the tagging process, we developed two genetic selections that link tmRNA activity to cell deat
217 nd culture procedure, which facilitates, via genetic selection, the differentiation of hES cells into
218 d infectivity was combined with quantitative genetics selection theory to assess the non-linear impac
221 To test this hypothesis, we have designed a genetic selection to detect a leading strand intermolecu
222 oorly in many cell types, can be modified by genetic selection to generate a nonpathogenic variant th
224 ted mutagenesis procedures were coupled with genetic selection to identify an "oxygen-insensitive" mu
225 his type of approach to form the basis for a genetic selection to identify proteins that exert an act
226 We used this observation as the basis for genetic selection to identify two alleles of umuD' and s
228 understand this patterning process, we used genetic selection to isolate mutants in the DIF-1 respon
229 nvolved in nuclear protein import, we used a genetic selection to isolate mutants that mislocalized a
230 dues at multiple positions and carried out a genetic selection to isolate variants that support life
231 RNA interference (RNAi) library in a forward genetic selection to study the mechanism of toxicity of
235 te these structures by using high-throughput genetic selections, unigenic evolution, and analyses of
241 albicans KEX2 homologue in Sap activation, a genetic selection was performed based on KEX2 function.
243 e domain of DnaC that interacts with DnaB, a genetic selection was used based on the lethal effect of
244 associated with active site substitutions, a genetic selection was used to find second site mutations
247 substitutions in the AUGC repeats, in vitro genetic selection was used to identify RNAs that bound c
249 d in transcription start site utilization, a genetic selection was used to isolate S. cerevisiae TFII
251 The combination of in vitro and in vivo genetic selections was crucial for obtaining RNA aptamer
256 tion of complexity, progressive and targeted genetic selections were employed to lessen and finally e
260 ecause domestication is a dynamic process of genetic selection, which may not be completely character
261 the ability to isolate intrabodies by direct genetic selection, which obviates the need for in vitro