1 formulate and quantify general mechanisms of
genetic suppression.
2 at are involved in allosteric regulation and
genetic suppression.
3 Our systems also permitted
genetic suppression analysis and revealed that targets o
4 Thus our
genetic suppression analysis uncovers a previously unapp
5 eacetylase complex, show the same pattern of
genetic suppression,
and this suppression pattern differ
6 We have developed a new
genetic suppression assay to investigate the in vivo rol
7 Using a previously characterized branch site
genetic suppression assay, we generated second-site muta
8 dent splicing when coexpressed in an in vivo
genetic suppression assay.
9 Genetic suppression by mutations in MTH1 is likely to be
10 hese studies provide the first evidence that
genetic suppression can occur by providing critical biol
11 Genetic suppression data implicate the essential flankin
12 Analyses of over 10,000 putative
genetic suppression elements (GSEs) sequences revealed c
13 Using
genetic suppression experiments in human cells, we now d
14 wi/Snf is required for Mediator binding, and
genetic suppression experiments suggest that Swi/Snf and
15 ny mechanisms that explain the phenomenon of
genetic suppression have been described, but the wide va
16 cting results, whereas cellular models using
genetic suppression have precluded in vivo confirmation.
17 Surprisingly, little is known about
genetic suppression in archaea, and there has been no ch
18 This
genetic suppression is consistent with a role for APP in
19 The possible mechanism of the observed
genetic suppression is discussed.
20 ak direct physical interaction, although the
genetic suppression is not explained by simple changes i
21 recapitulated the phenotype observed by WRN
genetic suppression,
leading to DNA damage and inhibitio
22 This novel form of
genetic suppression may extend to other genes, pathways
23 The
genetic suppression observed when the FACT defect is com
24 Genetic suppression occurs when the phenotypic defects c
25 signalling by pharmacological inhibition or
genetic suppression of 'canonical' Notch/CSL/MAML1-depen
26 Genetic suppression of a DBF4 hypomorphic mutation by RP
27 This study highlights a striking example of
genetic suppression of a monogenic disease revealing a c
28 We have previously reported
genetic suppression of a strong hypomorphic allele, vibr
29 -overexpression of eIF1 or eIF5 reverses the
genetic suppression of an eIF4G HEAT domain Ts(-) mutati
30 These include
genetic suppression of an ionic current, embryonic as we
31 Genetic suppression of an N-terminal mutation in the Tyr
32 Strikingly, however,
genetic suppression of apoptosis in the Apaf1 mutant did
33 vation of mTOR with aa supplementation or by
genetic suppression of autophagic activation.
34 Genetic suppression of bilirubin synthesis by biliverdin
35 activated and released into the cytosol and
genetic suppression of caspase 4, cathepsin B, or apopto
36 Finally,
genetic suppression of dLipin rescues dTorsin-KO defects
37 This is in contrast with the
genetic suppression of EGFR* induction that led to signi
38 PP2 cause the same functional deficit as the
genetic suppression of enzyme expression.
39 Either
genetic suppression of EPAC1 or its pharmacologic inhibi
40 Genetic suppression of FoxO1 alters the intercellular co
41 in human neurons, chronic pharmacological or
genetic suppression of gamma-secretase increases synapse
42 rons, intrahippocampal infusion of oAbeta or
genetic suppression of GIRK channel activity in hippocam
43 Interestingly, chemical or
genetic suppression of glycolysis was sufficient to indu
44 al LTD and is attenuated by pharmacologic or
genetic suppression of GSK-3beta.
45 Furthermore, pharmacological or
genetic suppression of GSK3 promotes serine/one-carbon m
46 The combined
genetic suppression of hepcidin and IL-4/IL-13 in macrop
47 Genetic suppression of Hrd1 function in DCs protected mi
48 ssociated with EMT in LUAD patients and that
genetic suppression of ILK can limit EMT progression and
49 Pharmacological or
genetic suppression of innate immune signaling reduced v
50 Pharmacological or
genetic suppression of iNOS, or cardiomyocyte-restricted
51 ological pacemakers were recently created by
genetic suppression of inward rectifier potassium curren
52 d apoptosis were significantly suppressed by
genetic suppression of JNK activation.
53 armacologic inhibition (SP600125) as well as
genetic suppression of JNK activation.
54 Genetic suppression of KiSS1 in CDDP-sensitive cell line
55 atory T cells by pharmacological blockade or
genetic suppression of Kv1.3 might be beneficial for the
56 nd that compromise of this activity leads to
genetic suppression of mutants defective in actin filame
57 trategies including salicylate treatment and
genetic suppression of myeloid NF-kappaB signaling that
58 Genetic suppression of N-acetyl-l-aspartate (NAA) synthe
59 Genetic suppression of N-cadherin function interferes wi
60 Genetic suppression of NCX reduces both EADs and DADs.
61 In this model
genetic suppression of NRAS(V12) expression results in r
62 Further, pharmacologic or
genetic suppression of p38 MAPK activity, the latter ach
63 Genetic suppression of p53 reversed the PA1-1-driven mal
64 L-1R antagonist inhibition, pharmacologic or
genetic suppression of pro-IL-1beta processing to active
65 Genetic suppression of Pten or pharmacological treatment
66 ts, and mice with global or Sertoli-specific
genetic suppression of Rankl have increased male fertili
67 Genetic suppression of RAPTOR or RHEB ablated P-S6 and r
68 We further demonstrate that
genetic suppression of Src regulates the activity of the
69 Genetic suppression of STAG2 leads to a compensatory inc
70 Genetic suppression of Tam3 transposition, using the STA
71 Pharmacological or
genetic suppression of tau in the db/db diabetic mouse m
72 elatonin agonist, ramelteon, phenocopies the
genetic suppression of the Clock mutant phenotype observ
73 LPC-to-hepatocyte differentiation as well as
genetic suppression of the EGFR-ERK-SOX9 axis.
74 importance of condensin regulation by CDK7,
genetic suppression of the expression of SMC2, a core su
75 We hypothesized that
genetic suppression of the L-type calcium channel access
76 Removal of plk-3 results in quantitative
genetic suppression of the meiotic defects.
77 Genetic suppression of the metacaspase-autophagy pathway
78 on was further supported by the finding that
genetic suppression of the Toll/Dif and Imd/Relish infla
79 However, we observed that
genetic suppression of the transcription factor MYC alon
80 Genetic suppression of the type III blockade does not, h
81 Genetic suppression of these unc-86/VP16 phenotypes may
82 Pharmacological or
genetic suppression of UBA1 was sufficient to recapitula
83 Conversely,
genetic suppression of YAP1/WWTR1 (TAZ) enhanced G12Ci s
84 Genetic suppression or pharmacological inhibition of thi
85 Genetic suppression or pharmacological inhibition of thi
86 This
genetic suppression profile is similar to that of sec35-
87 This
genetic suppression provides compelling evidence that AP
88 Pharmacologic CLPP inhibition and
genetic suppression reduced organoid growth, cell viabil
89 Genetic suppression revealed that this synthetic lethali
90 iously identified substrate of Highwire, and
genetic suppression studies show that Wallenda/DLK is re
91 Genetic suppression studies using matrix metalloproteina
92 Genetic suppression tests showed that Bem4p and Bem1p re
93 This action, lifted upon NKA
genetic suppression,
tonically counteracts NKA's ATP-dri
94 To examine the basis of
genetic suppression,
we cloned, purified, and tested Fli
95 To explore the principles of
genetic suppression,
we examined both literature-curated
96 with the osmotic stabilizer sorbitol or via
genetic suppression with the kre5(W1166X) mutant.