ライフサイエンスコーパス: genetic susceptibility

1 ns may modify the risk of CVD, regardless of genetic susceptibility.

2 than in the half of the population with low genetic susceptibility.

3 diet intervention are different according to genetic susceptibility.

4 ther these associations might be modified by genetic susceptibility.

5 As), but little is known about the molecular genetic susceptibility.

6 er adherence to healthful-PDI, regardless of genetic susceptibility.

7 lieved to involve environmental exposure and genetic susceptibility.

8 alleles appear to be indicative of a common genetic susceptibility.

9 ts with the incidence of CVD considering the genetic susceptibility.

10 lt of higher viral loads, comorbidities, and genetic susceptibility.

11 on to advanced AMD, which may be modified by genetic susceptibility.

12 he human DQ8 gene, which confers moderate CD genetic susceptibility.

13 lieved to involve environmental exposure and genetic susceptibility.

14 individuals never develop HCC, suggesting a genetic susceptibility.

15 tions with other possible factors, including genetic susceptibility.

16 on the same importance as the tumor type and genetic susceptibility.

17 sure, genetic and epigenetic mechanisms, and genetic susceptibility.

18 rtant contributions of both radiotherapy and genetic susceptibility.

19 vergence varied depending upon the degree of genetic susceptibility.

20 port previous reports of a relationship with genetic susceptibility.

21 everal traits with significant sex biases in genetic susceptibilities.

22 tions are the same for people with different genetic susceptibilities.

23 loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes

24 nally concentrated on environmental stimuli, genetic susceptibilities, adaptive immune responses, and

25 priate experimental model which incorporates genetic susceptibility, aging and prolonged environmenta

26 ght to test whether HLA-C*06:02, the primary genetic susceptibility allele for psoriasis, predisposes

27 The aim of this study was to identify common genetic susceptibility alleles for gallbladder cancer.

28 These findings identified new genetic susceptibility alleles for lung cancer in never-

29 66Met mouse line to characterize how a known genetic susceptibility alters both baseline translationa

30 1 and REV1) suggests that exploration of how genetic susceptibility and environmental exposure may in

31 Genetic susceptibility and environmental factors (such a

32 that promote CHD, but the additive effect of genetic susceptibility and environmental factors is poor

33 1D) results from a complex interplay between genetic susceptibility and environmental factors that ha

34 ulated immune system, an altered microbiota, genetic susceptibility and environmental factors, but th

35 Genetic susceptibility and environmental influences are

36 concern that involves an interaction between genetic susceptibility and exposure to environmental cue

37 Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD.

38 Since an increased mortality reflects both genetic susceptibility and long-term impacts of parental

39 pisode of KA are due to differences in human genetic susceptibility and not to modifications of paras

40 dual variability in risk suggests a role for genetic susceptibility and provides an opportunity to id

41 study was to test the association between AF genetic susceptibility and recurrence after ablation usi

42 a link, as we currently understand, between genetic susceptibility and the environment in predisposi

43 The study of twins allows us to separate genetic susceptibility and the influence of environmenta

44 This study provides novel insight into the genetic susceptibility and therapeutic rationale of KBD.

45 ies might help to identify proxy measures of genetic susceptibility and thereby inform models of risk

46 orial and exogenous or endogenous exposures, genetic susceptibility, and chance have roles.

47 ccount for this variability include climate, genetic susceptibility, and environmental antigen exposu

48 ntioxidants might be modified by life stage, genetic susceptibility, and environmental sources of oxi

49 he interactions between enteric bacteria and genetic susceptibilities are major contributors of IBD e

50 for CAA, yet the mechanisms underlying this genetic susceptibility are unknown.

51 osure, and their potential interactions with genetic susceptibility, are largely unexplored.

52 explore the impact of aging and the role of genetic susceptibility as modifiers of risk in diseases

53 ry data suggest that novel factors including genetic susceptibility as well as social determinants of

54 lygenic risk scores (PRS), which capture the genetic susceptibility associated with a set of variants

55 est cell fate that exacerbate the widespread genetic susceptibility associated with RET.

56 hanisms, processes and diseases, and reveals genetic susceptibilities at a genomic scale.

57 arranted to better understand the underlying genetic susceptibility between PD and hormone-related ca

58 vation we examined for pleiotropy, or shared genetic susceptibility, between CRC and the 200 establis

59 ne diseases (AIDs) is not only attributed to genetic susceptibilities but also environmental factors,

60 tein levels were tested for association with genetic susceptibility by typing 112 single-nucleotide p

61 obes with hosts that contain a background of genetic susceptibility can play a role in autoimmune pat

62 is of depression in which chronic stress and genetic susceptibility cause changes in the strength of

63 of MR exists in the community, supporting a genetic susceptibility common to primary and nonprimary

64 e/chronic tics may have different underlying genetic susceptibility compared with OCD alone.

65 These results suggest that shared genetic susceptibility contributes modestly to MDD and A

66 As genetic susceptibility contributes to a large proportion

67 We hypothesized that genetic susceptibility contributes to risk of new-onset

68 stion that remains largely unanswered is how genetic susceptibility contributes to this process and,

69 hracyclines and cardiomyopathy suggests that genetic susceptibility could play a role.

70 rly life environmental factors with distinct genetic susceptibility elements at 5q22 (TSLP) and 2p23

71 ight result from a complex interplay between genetic susceptibility, environmental factors, and alter

72 The importance of genetic susceptibility, epigenetics, aging, and the mode

73 e major [C] allele of ABCB11 c.1331 T>C is a genetic susceptibility factor for HCV infection, but not

74 he apolipoprotein E (apoE) gene is the major genetic susceptibility factor for late-onset Alzheimer's

75 implicate this PARK2 germline mutation as a genetic susceptibility factor for lung cancer.

76 nucleotide polymorphism (SNP) in PROX1 is a genetic susceptibility factor for type 2 diabetes.

77 ting of 32 autoinflammatory genes to explore genetic susceptibility factor(s) to Schnitzler syndrome.

78 Most studies aiming to identify genetic susceptibility factors for LOAD have focused on

79 No confirmed genetic susceptibility factors have been identified usin

80 To identify additional genetic susceptibility factors of asthma in European Ame

81 ory lipid classes and subclasses, and common genetic susceptibility factors present in both disease l

82 n at average risk of breast cancer (no known genetic susceptibility, family history, previous breast

83 To further understand the genetic susceptibility for CLL and identify common loci

84 NGS panel in clinic and indicate a conserved genetic susceptibility for epilepsy between Chinese and

85 iated with reduced risk of GA and may modify genetic susceptibility for progression to GA.

86 Genetic susceptibility for schizophrenia had a much stro

87 n, and if glutamate can serve as a marker of genetic susceptibility for schizophrenia remains to be e

88 ibution of common polygenic variation to the genetic susceptibility for schizophrenia.

89 of cow's milk-based formula for infants with genetic susceptibility for type 1 diabetes reduced the c

90 ping GA independent of age, smoking, and AMD genetic susceptibility from the CFH or ARMS2 genes.

91 on, and both the psoriatic transcriptome and genetic susceptibility further implicate NF-kappaB in ps

92 these sarcoidosis phenotypes have different genetic susceptibility, genomic distributions, and cellu

93 cases of diabetes that occurred in the high genetic susceptibility group compared with the low genet

94 Risks were similar in the highest genetic susceptibility group for multiple islet autoanti

95 .8-fold divergent for children in the lowest genetic susceptibility group, decreasing incrementally i

96 c susceptibility group compared with the low genetic susceptibility group.

97 Genetic susceptibility has been implicated in congenital

98 , an agnostic, genome-wide search for shared genetic susceptibility has not been performed.

99 vironmental risk factors in conjunction with genetic susceptibility have been proposed with respect t

100 but the genes and pathways involved in this genetic susceptibility have remained elusive.

101 inucleotide repeat disorders and any further genetic susceptibilities in individual disorders, geneti

102 The results support genetic susceptibility in the familial recurrence of ASD

103 otype of type 1 diabetes resulting from high genetic susceptibility in the first six decades of life.

104 tial progress has been made in understanding genetic susceptibility in the past 5 years on the basis

105 cts are most pronounced in individuals whose genetic susceptibility increases responsiveness to catec

106 focused on the hypothesis that an underlying genetic susceptibility interacts with folate-sensitive m

107 In subjects with moderate genetic susceptibility, intestinal microbiota changes ma

108 (IBD) involves interactions between the host genetic susceptibility, intestinal microflora and mucosa

109 Genetic susceptibility is likely involved in nasopharyng

110 EoE genetic susceptibility is mediated by EoE-specific and g

111 reported in GAD, however direct evidence for genetic susceptibility is missing.

112 e-responsive CD4(+) T cells in the lung, and genetic susceptibility is primarily linked to HLA-DPB1 a

113 f age-related macular degeneration (AMD) and genetic susceptibility is unknown.

114 High risk for disease, in those with genetic susceptibility, is predicted by the presence of

115 ction, for which the goal is to discover new genetic susceptibility loci by leveraging G-E interactio

116 s of Paneth cells associated with particular genetic susceptibility loci can be used to define specif

117 Advances have been made in identifying genetic susceptibility loci for autoimmune diseases, but

118 To search for additional genetic susceptibility loci for breast cancer, here we p

119 rols of East Asian women to search for novel genetic susceptibility loci for breast cancer.

120 We discuss genetic susceptibility loci for CD and how these affect

121 Genetic susceptibility loci for Crohn's disease (CD) are

122 To identify genetic susceptibility loci for DLBCL, we conducted a me

123 rdiotoxicity, leading to the hypothesis that genetic susceptibility loci for hypertension may serve a

124 To identify genetic susceptibility loci for MacTel, we performed a g

125 study substantially increases the number of genetic susceptibility loci for NSCLP and provides impor

126 Known genetic susceptibility loci for type 2 diabetes (T2D) ex

127 While numerous genetic susceptibility loci have been identified for cli

128 nflammatory skin disorder for which multiple genetic susceptibility loci have been identified, but fe

129 influencing dyslipidemia and currently; 157 genetic susceptibility loci have been reported to be ass

130 imated heritability for PsA, the majority of genetic susceptibility loci identified to date are share

131 Here we map common genetic susceptibility loci in European ancestry women f

132 CRC by incorporating information from common genetic susceptibility loci.

133 adenocarcinoma may be attributable to shared genetic susceptibility loci.

134 cestry information has been used to identify genetic susceptibility loci.

135 FTO is the strongest known genetic susceptibility locus for obesity.

136 We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 w

137 Some DTC tests for genetic susceptibilities look for only a few known mutat

138 In sum, developing a genetic susceptibility map and keeping it updated are ef

139 ues by developing a nicotine dependence (ND) genetic susceptibility map based on the results obtained

140 on of environmental risk factor exposure and genetic susceptibility may contribute to the etiology of

141 ught to be mediated by the interplay between genetic susceptibility, microbial dysbiosis, and environ

142 ked to early life stress, and epigenetic and genetic susceptibility might explain some aspects of ado

143 y of environmental influences and individual genetic susceptibility modulates disease presentation an

144 Therefore, we examined the shared genetic susceptibility modulating schizophrenia and brai

145 ariants at the PARK2 locus contribute to the genetic susceptibility of ADHD.

146 ny studies have attempted to investigate the genetic susceptibility of Attention-Deficit/Hyperactivit

147 h autoimmunity and have implications for the genetic susceptibility of autoimmune disease.

148 Our analysis supports a broader role for genetic susceptibility of both sporadic and familial cas

149 Unraveling the genetic susceptibility of complex diseases such as chron

150 imental transmission model for assessing the genetic susceptibility of goats to scrapie.

151 on studies (GWAS) have been conducted on the genetic susceptibility of hepatitis B virus (HBV)-relate

152 mplex gene-environment interactions in which genetic susceptibility of HLA type 2 antigen presentatio

153 odulated transcriptional regulation, and the genetic susceptibility of PD.

154 failure of memory T cell responses; and (v) genetic susceptibility of the host.

155 le knowledge about underlying mechanisms and genetic susceptibility of the various adverse effects.

156 er variation in Fcgr3 partially explains the genetic susceptibility of the Wistar-Kyoto (WKY) rat to

157 H pathogenesis and indicate that part of the genetic susceptibility overlaps with that for other immu

158 This relation could be modified by genetic susceptibility, particularly related to the C3 g

159 nic risk scores (PRS) provide a personalized genetic susceptibility profile that may be leveraged for

160 ity of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL).

161 R3 and HLA-DR2, is one of the most important genetic susceptibility regions for systemic lupus erythe

162 r disease (CVD) across people with different genetic susceptibility remains uncertain.

163 -average risk due to their family history or genetic susceptibility.See related commentary by Niehoff

164 To identify genetic variants contributing to genetic susceptibility shared across interview-generated

165 of autoimmunity and type 1 diabetes in lower genetic susceptibility strata.

166 ve pulmonary disease are never-smokers, most genetic susceptibility studies have not focused on this

167 sease phenotypes that require both aging and genetic susceptibility, such as pronounced dendrite dege

168 between cumulative environmental factors and genetic susceptibility, such that no one factor dictates

169 ing from the dysfunctional interplay between genetic susceptibility, the immune system, and commensal

170 diotoxicity and perhaps by identification of genetic susceptibilities to cardiovascular diseases; opt

171 lassify people according to their underlying genetic susceptibility to a disease is increasing with n

172 To identify human genetic susceptibility to A(H7N9) infection, we performe

173 ay account for a significant fraction of the genetic susceptibility to AD and FTD.

174 Our findings indicate shared genetic susceptibility to AD and small vessel stroke and

175 Studies examining surrogate markers of genetic susceptibility to AF, such as family history and

176 mon variants explains a larger proportion of genetic susceptibility to AF.

177 e cell cycle as central mechanisms governing genetic susceptibility to ALL.

178 ity variants, but is associated with reduced genetic susceptibility to Alzheimer and coronary artery

179 in understanding the molecular basis for the genetic susceptibility to atherosclerosis.

180 sociated interventions in a mouse model with genetic susceptibility to autoimmune disease.

181 HLA alleles, which play a major role in the genetic susceptibility to autoimmune diseases, or C4 hap

182 he genetic and biological basis of inherited genetic susceptibility to BCP-ALL and the influence of c

183 Genetic susceptibility to beryllium-induced disease is s

184 These results provide further insight into genetic susceptibility to breast cancer and will improve

185 Epidemiologic data on genetic susceptibility to cardiovascular effects of arse

186 Understanding of the host genetic susceptibility to carriage of, and infections, d

187 he genetic and biological basis of inherited genetic susceptibility to CLL.

188 Genetic susceptibility to colorectal cancer is caused by

189 using biology to inform analyses to identify genetic susceptibility to complex diseases.

190 end, we investigated the association of the genetic susceptibility to complex traits with human life

191 n vitamin D receptor (VDR) polymorphisms and genetic susceptibility to components of the metabolic sy

192 SES groups to reduce the expression of their genetic susceptibility to coronary artery disease.

193 indication that MCC might confer alterative genetic susceptibility to CRC in individuals with schizo

194 Genetic susceptibility to CRC in the general population

195 sight into the biological basis of inherited genetic susceptibility to CRC, and identify risk factors

196 he genetic and biological basis of inherited genetic susceptibility to CRC.

197 he genetic and biological basis of inherited genetic susceptibility to CRC.

198 Study of the genetic susceptibility to CRS might be a valuable strate

199 Most genetic susceptibility to cutaneous melanoma remains to

200 morbidity and we therefore hypothesized that genetic susceptibility to CVID may overlap with autoimmu

201 d the importance of pancreatic beta-cells in genetic susceptibility to diabetes.

202 This is one of the first studies to assess genetic susceptibility to dioxins.

203 phisms of the classical HLA genes as driving genetic susceptibility to disease, our study additionall

204 To further elucidate genetic susceptibility to DLBCL, we sought to validate t

205 ve transfer experiments, we demonstrate that genetic susceptibility to EAE lies within the innate imm

206 ence of an additional region of interest for genetic susceptibility to endometrial cancer.

207 ese results may advance our understanding of genetic susceptibility to EOC.

208 nomic analyses improved our understanding of genetic susceptibility to epithelial ovarian cancer (EOC

209 in the UK Biobank cohort who were tested for genetic susceptibility to esophageal adenocarcinoma (a p

210 lation of ERK2 signaling might contribute to genetic susceptibility to FASD.

211 These data substantiate that genetic susceptibility to GBM and non-GBM tumors are hig

212 uggesting a broader role for this network in genetic susceptibility to HGSOC.

213 ism were related to reduced manifestation of genetic susceptibility to high WHR (p = 0.007; p = 0.003

214 Our data reveal important differences in genetic susceptibility to HSCT-associated TMA based on r

215 esting impaired HNF4A binding could underlie genetic susceptibility to IBD.

216 gle-nucleotide polymorphisms associated with genetic susceptibility to in-hospital acute kidney injur

217 In addition, genetic susceptibility to increased heart rate is associ

218 Systematic identification of genetic susceptibility to infection is being undertaken

219 ggesting that factors--such as divergence in genetic susceptibility to infection--may influence infec

220 s are also highly relevant for understanding genetic susceptibility to influenza virus infections in

221 Furthermore, genetic susceptibility to later menopause is associated

222 ociation studies have been used to study the genetic susceptibility to leprosy,while whole exome sequ

223 We demonstrate that genetic susceptibility to LOY is associated with non-hae

224 dings provide further evidence for inherited genetic susceptibility to lung cancer and its biological

225 n 1000 candidate-gene association studies on genetic susceptibility to lung cancer have been publishe

226 Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal ba

227 g in pathogenesis and overcoming MIF-related genetic susceptibility to many rheumatic diseases.

228 Furthermore, our results suggest that the genetic susceptibility to MDD differs between adult- and

229 er cases and 5,110 cancer-free controls) and genetic susceptibility to mLOY.

230 istent with MGUS being a marker of inherited genetic susceptibility to MM.

231 ar and cellular mechanisms underlying common genetic susceptibility to MVP and implicate established

232 lobally the biological mechanisms underlying genetic susceptibility to MVP to better characterize its

233 data suggest that the ADM gene modulates the genetic susceptibility to nephropathy progression.

234 erall, these analyses offer an evaluation of genetic susceptibility to NFT, a common end point for mu

235 6 C/T nonsynonymous (p.Glu167Lys) variant in genetic susceptibility to nonalcoholic fatty liver disea

236 Our analyses indicate that host genetic susceptibility to norovirus and rotavirus infect

237 s of NSCL/P advance our understanding of the genetic susceptibility to NSCL/P.

238 are no published studies investigating host genetic susceptibility to NTS in African populations.

239 a relatively lower risk for manifestation of genetic susceptibility to obesity (p < 0.001); the moder

240 Genetic susceptibility to obesity can be partly mediated

241 Common genetic susceptibility to obesity has been shown to modi

242 However, the mechanisms through which genetic susceptibility to obesity operates are not well

243 estraint, and weakest in the highest tertile.Genetic susceptibility to obesity was partially mediated

244 many studies have focused on identifying the genetic susceptibility to obesity, we performed a GWAS o

245 control over eating appear to attenuate the genetic susceptibility to obesity.

246 ical activity, moderate the manifestation of genetic susceptibility to obesity.

247 e whether eating behaviors mediate or modify genetic susceptibility to obesity.Genetic risk scores fo

248 s suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat

249 Mechanisms of genetic susceptibility to ozone-induced lung inflammatio

250 We sought to investigate genetic susceptibility to PA.

251 t a genetic basis, little is known about the genetic susceptibility to PAD, especially in non-Europea

252 family history meets criteria for FPC and/or genetic susceptibility to pancreatic cancer.

253 HLA locus and imply that the immune-related genetic susceptibility to PD is likely to be more widesp

254 a major step towards the elucidation of the genetic susceptibility to PD.

255 To characterize genetic susceptibility to PM-associated QT prolongation

256 lial dysfunction and remodeling, or enhanced genetic susceptibility to pulmonary vascular disease thr

257 he genetic and biological basis of inherited genetic susceptibility to RCC.

258 lts are the first reported evidence of human genetic susceptibility to S. aureus infection.

259 to design an ex vivo platform that recreates genetic susceptibility to T-cell-mediated damage.

260 inal organoid-based platform that re-creates genetic susceptibility to T-cell-mediated tissue injury

261 Genetic susceptibility to T1D causes alterations in the

262 TCR sequences are important determinants of genetic susceptibility to T1D.

263 Loss of GM-CSF signalling or genetic susceptibility to TB (C3HeB/FeJ mice) result in

264 18 loci, together accounting for >15% of the genetic susceptibility to testicular germ cell tumour (T

265 ur study provides important insights linking genetic susceptibility to the underlying mechanism of RG

266 se data provide substantial new evidence for genetic susceptibility to this B cell malignancy and poi

267 These data provide further evidence for genetic susceptibility to this B-cell hematological mali

268 ne genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely

269 tion studies have found >60 loci that confer genetic susceptibility to type 1 diabetes (T1D).

270 It is not known how frequently genetic susceptibility to type 1 diabetes leads to a dia

271 INTERPRETATION: Genetic susceptibility to type 1 diabetes results in non

272 were in the half of the population with high genetic susceptibility to type 1 diabetes than in the ha

273 the half of the population with high or low genetic susceptibility to type 1 diabetes.

274 Genetic susceptibility to type 2 diabetes is primarily d

275 lanoma (UM) has been strongly suggested, the genetic susceptibility to UM is currently vastly unexplo

276 ing candidate genes and WMH to elucidate the genetic susceptibility to WMH and tested associated vari

277 Genetic susceptibility to young-onset type 1 diabetes is

278 ed weight gain, particularly in those with a genetic susceptibility toward overweight.

279 major histocompatibility complex-associated genetic susceptibility translates into autoimmune diseas

280 In univariate analysis, higher AF genetic susceptibility trended towards a higher risk of

281 ximum likelihood analysis to explore whether genetic susceptibility underlies the association between

282 cardiomyocytes (CMs), and to explore whether genetic susceptibility underlies the pathophysiology of

283 ically ill ICU patients, suggesting there is genetic susceptibility underlying this common clinical c

284 h the measure could be a potential marker of genetic susceptibility, useful in early detection and st

285 to establish the molecular identity of such genetic susceptibility variants by genome-wide associati

286 to the likely functional targets of germline genetic susceptibility variants for ovarian cancer.

287 diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success

288 that body fatness accentuates the effects of genetic susceptibility variants in hypertriglyceridemia,

289 We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis

290 Higher AF genetic susceptibility was associated with younger age a

291 AF genetic susceptibility was measured using a previously d

292 This genetic susceptibility was recently linked to polymorphi

293 onment, and growing interests in the role of genetic susceptibility, we assessed the relative contrib

294 ith improved understanding of the underlying genetic susceptibility, we can identify targets to halt

295 Patients with higher AF genetic susceptibility were younger (P<0.001) and had fe

296 disease that results from the interaction of genetic susceptibility with aging and environmental fact

297 at ADHD frequently co-occurs with and shares genetic susceptibility with autism spectrum disorder (AS

298 should integrate underlying risk related to genetic susceptibility with cell-type specific epigeneti

299 The interaction of genetic susceptibility with lifestyle factors may play a

300 n of adherence to the Mediterranean diet and genetic susceptibility with progression to advanced AMD.