ライフサイエンスコーパス: genetic variability

1 ctions in both the number of individuals and genetic variability.

2 s, differential pathological signatures, and genetic variability.

3 de immune detection and/or exhibit extensive genetic variability.

4 of genetic plasticity underlying transverse genetic variability.

5 of congenital infection, exhibits extensive genetic variability.

6 robustness in the face of environmental and genetic variability.

7 different growth conditions and/or inherent genetic variability.

8 s, and managed-breeding strategies to retain genetic variability.

9 ing breeding populations for repositories of genetic variability.

10 y by shared environmental factors and not by genetic variability.

11 This indicates a large degree of genetic variability.

12 f the viral genome and are a major source of genetic variability.

13 ble or change in time) and on the associated genetic variability.

14 contribution of different marked effects to genetic variability.

15 while the American C. dentata had the lowest genetic variability.

16 ross loci, may also lead to heterogeneity of genetic variability.

17 are often driven by mechanisms that promote genetic variability.

18 history that continue to influence levels of genetic variability.

19 ructure, extensive glycosylation, and marked genetic variability.

20 s6466849, rs10268496) that cover all TAS2R16 genetic variability.

21 ogy, vascular and metabolic risk factors and genetic variability.

22 sulate development against environmental and genetic variability.

23 Naturally occurring genetic variability across HIV-1 subtypes causes amino a

24 esponsible for heterogeneity of the level of genetic variability across loci.

25 Genetic variability across the three major histocompatib

26 Given the high genetic variability among and within E. coli pathotypes,

27 t differences in copy number are a source of genetic variability among D. v. virgifera.

28 To evaluate genetic variability among Entamoeba histolytica strains,

29 en deposition in the heart by exploiting the genetic variability among F2 progeny of 129P2 and FVBN/J

30 ism" to study complex disease phenotypes and genetic variability among individuals using patient-deri

31 diseases may be influenced by mitochondrial genetic variability among people living with human immun

32 (cytb), were analysed in silico to identify genetic variability among the four species and used, sub

33 l systems can serve as the interface between genetic variability and alterations in complex behaviora

34 stributions of offspring number on levels of genetic variability and among-population differentiation

35 ntifying its modulation by crop N status and genetic variability and analyzing its ecophysiological d

36 ection acting on linked sites, which reduces genetic variability and biases the frequency distributio

37 by examining the relationship between common genetic variability and brain endophenotype.

38 Our data highlight the genetic variability and capacity in causing outbreak by

39 atory syncytial virus-A (RSV A) genotype ON1 genetic variability and clinical severity in infants hos

40 The genetic variability and covalent modifications associate

41 We assessed the nature and pattern of genetic variability and differentiation in a panel of 10

42 the ISR was used to determine the worldwide genetic variability and distribution of P. gingivalis, a

43 rstanding of such fauna is limited and their genetic variability and evolutionary origins remain poor

44 A fine balance between genetic variability and genomic stability tunes plastici

45 The Italian and Iberian populations have low genetic variability and high linkage disequilibrium, but

46 Simplot was used to compare genetic variability and high-speed sequencing was used t

47 The strong associations between IL6R genetic variability and IL-6 concentrations deserve furt

48 Stable naive hPSCs with reduced genetic variability and improved functional pluripotency

49 sts that these differences can contribute to genetic variability and pathologic susceptibility.

50 deficiency virus type 1 (HIV-1), we analyzed genetic variability and PI resistance-associated substit

51 s with maladaptive gene flow or by enhancing genetic variability and reducing inbreeding depression,

52 wever, European populations showed a loss of genetic variability and significant genetic differentiat

53 As diverse agents of selection shape genetic variability and structure within species, we arg

54 We investigated the genetic variability and the effect of harvest year on th

55 constitutes a substantial fraction of total genetic variability and the importance of structural gen

56 d suggest a potential mechanism between MAPT genetic variability and the pathogenesis of neurodegener

57 ld will yield data that can account for both genetic variability and the role of critical development

58 arked effects within chromosomes, background genetic variability, and family heterogeneity.

59 Current genetic variability, and inferred past demographic chang

60 multistep nature of viral oncogenesis, host genetic variability, and the fact that viruses contribut

61 MAC strains show a wide genetic variability, and there is growing evidence sugge

62 oup of scientists expert in the field of HCV genetic variability, and those involved in development o

63 In species whose distribution and genetic variability are shaped by strong selection gradi

64 The pangenome concept describes genetic variability as the union of genes shared in a se

65 e the potential to show and emphasise common genetic variability associated with disease.

66 these analyses show that LV mass-associated genetic variability associates with diagnoses of cardiac

67 Here, we examine the levels of genetic variability at 13 (seven informative) loci in wi

68 ations (FST > 0.130) and discovered temporal genetic variability at a single site that was on par wit

69 , we examined the association between LP and genetic variability at candidate regulatory regions in 5

70 Notably, by Shannon entropy, higher genetic variability at HBsAg amino acid positions 130, 1

71 ucleotide polymorphisms and found widespread genetic variability at many of these loci.

72 Our findings point to genetic variability at the ADIPOR1 locus as a strong det

73 Genetic variability at the APOA1/C3/A4/A5 cluster has be

74 Additionally, we show that individual genetic variability at the Apobec1 locus results in diff

75 n polymorphisms comprehensively defining the genetic variability at the IL6 locus with diabetes risk.

76 Extensive population-level genetic variability at the Salmonella rfb locus, which e

77 of all these diseases are predisposed to by genetic variability at the same loci, strongly suggestin

78 We investigated whether genetic variability at this locus is a determinant of fr

79 In the pooled sample, genetic variability at this locus was associated with di

80 ction with other recent studies showing that genetic variability at this same locus are related to ch

81 The genetic variability between phenotypically distinct stra

82 Additional genetic variability between the seven B. subtilis 168 is

83 ive hybridization was employed to assess the genetic variability between two distinct clinical isolat

84 However, female choice can actually increase genetic variability by supporting a higher mutation rate

85 This study demonstrates that genetic variability can affect the outcome of cardiac su

86 Moreover, they show that intraspecific genetic variability can be as important as strong trophi

87 practice based on these recent discoveries, genetic variability clearly appears to affect pain perce

88 e Yellowstone grizzly bear has low levels of genetic variability compared with other Ursus arctos pop

89 The observed interactions between genetic variability, CVRFs, and MPV and its association

90 ence of a single genome does not reflect how genetic variability drives pathogenesis within a bacteri

91 rstly, it is responsible for the creation of genetic variability during meiosis by directing the form

92 kely to be responsible for the generation of genetic variability, even within inbred lines.

93 We sought to identify any common genetic variability exerting a large effect in risk for

94 We aimed to identify any common genetic variability exerting a moderate to large effect

95 Genotyping studies suggest that genetic variability exists among P. gingivalis strains;

96 Significant genetic variability exists in ppe37 genes across differe

97 valuable insights for measuring quantitative genetic variability for breeding and genetic studies in

98 According to the genetic variability for carotenoids and tocochromanols,

99 ried widely and the genotypes presented high genetic variability for carotenoids and tocochromanols.

100 lymorphisms to explore the full dimension of genetic variability for future cattle genomic research.

101 y a role in the expression of phenotypic and genetic variability for subsequent selection and evoluti

102 become ineffective owing to loss of additive genetic variability for the preferred traits.

103 likely than nonmutator phenotypes to acquire genetic variability from a more diverged set of donor ba

104 Extensive genetic variability, generally in gp120 and the gp41 ect

105 These data show that common genetic variability has a role in the disease.

106 Vascular endothelial growth factor (VEGF) genetic variability has been associated with altered ris

107 how genome structure and pathogen population genetic variability has been shaped by transposable elem

108 uman brain, because tools for assessing this genetic variability have not been available.

109 rames encode enzymes which may contribute to genetic variability, i.e., restriction-modification syst

110 dies have provided information on how common genetic variability impacts on the risk for the developm

111 understanding of the structure and extent of genetic variability in a breeding population of a crop i

112 f GRN is regulated by miRNAs and that common genetic variability in a miRNA binding-site can signific

113 strongest in Parkinson's disease (PD), where genetic variability in alpha-synuclein expression affect

114 s to hypothesize that it might contribute to genetic variability in ASFV.

115 Our data show that there is genetic variability in beta-carotene metabolism and may

116 In summary, the distribution of genetic variability in C. quercuum fusiforme is consiste

117 and that this relationship is underpinned by genetic variability in certain brain areas.

118 ng, the molecular mechanism(s) through which genetic variability in Chrna7 may contribute to alpha7 n

119 eristics of the virus, including the extreme genetic variability in circulating viral isolates worldw

120 We propose a model where ASE requires genetic variability in cis, a difference in the sequence

121 herapy and suggest that detailed analysis of genetic variability in clinical trial cohorts can lead t

122 Thus, genetic variability in CTGF expression directly modulate

123 on wound biology has shown the importance of genetic variability in determining the initial inflammat

124 Genetic variability in DNM3 modifies age of onset for LR

125 rait loci (QTLs) were detected that underlay genetic variability in En Interestingly, four of them co

126 can be used as surrogate markers and whether genetic variability in germline ERBB2 (formerly HER2 or

127 trend, as well as the likely high degree of genetic variability in heat tolerance, suggests that mor

128 Despite this, there has been little work on genetic variability in human gene expression and almost

129 Recent claims that patterns of genetic variability in human mitochondria show evidence

130 Patterns of genetic variability in human populations are profoundly

131 background of myelination, the clinical and genetic variability in hypomyelinating leukodystrophies,

132 Here we investigated genetic variability in induced responses to stemborer eg

133 strate specific and differential patterns of genetic variability in inhibition of sucrose intake by d

134 To characterize ethnicity-dependent genetic variability in JPH2 and to identify homozygous J

135 ) are believed to contribute strongly to the genetic variability in living beings, in particular thei

136 Recently, the genetic variability in lysosomal storage disorders has b

137 ence studies generally confirm the extensive genetic variability in modern maize is consistent with a

138 been an abundance of publications describing genetic variability in molecules relevant to transplant

139 he concomitant use of other drugs and common genetic variability in monoamine regulation present addi

140 e gene content, functional significance, and genetic variability in natural microbial communities.

141 polysaccharides) of triticale as well as the genetic variability in nutritional composition have been

142 These data indicate the importance of genetic variability in opioid modulation of sucrose inta

143 orphisms (tSNPs) accounting for > 92% of the genetic variability in PLA2G2A were identified and disti

144 ain the incidence of secondary infection and genetic variability in populations containing or lacking

145 natural selection has resulted in high CD36 genetic variability in populations of African descent.

146 relatively unbiased picture of the extent of genetic variability in protein sequences within populati

147 nts, platelet dysfunction can be a result of genetic variability in proteins that mediate inside-out

148 The molecular mechanisms that mediate genetic variability in response to alcohol are unclear.

149 Although recombination is a major source of genetic variability in retroviruses, no recombinant stra

150 been underway to control this parasite, but genetic variability in S. japonicum populations could re

151 uman EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain inj

152 for previously reported associations between genetic variability in serotonin transporter function an

153 Escherichia coli pathotypes reveal extensive genetic variability in the argW-dsdCXA island.

154 Genetic variability in the behavioral responses of exper

155 Together, these data indicate that genetic variability in the CRP gene is associated with s

156 s novel insight into the association between genetic variability in the leptin gene and anemia in HIV

157 suggested that in many neurological diseases genetic variability in the loci predisposing subjects to

158 c sequencing to evaluate the contribution of genetic variability in the pathogenesis of amyotrophic l

159 o warfarin was more strongly associated with genetic variability in the pharmacologic target of warfa

160 We investigated whether genetic variability in the PPARA gene, coding for the ph

161 c improvement depends on the availability of genetic variability in the primary gene pool.

162 The observed significant genetic variability in the response of wheat to heat str

163 Here, we examined patterns of genetic variability in the trans-continentally distribut

164 survival probability of individuals and the genetic variability in their germ cells.

165 While the limited genetic variability in these animals prevents us from ma

166 Here, we show that genetic variability in these regions can be explained by

167 Investigation of the effects of genetic variability in this gene on brain function could

168 injury (AKI), the influence of mitochondrial genetic variability in this process remains unclear.

169 s studies have targeted the contributions of genetic variability in this system to human brain activi

170 However, the contributions of genetic variability in this system to individuals' cogni

171 pulsed characters and the expected level of genetic variability in those control variables.

172 hese studies emphasize the potential role of genetic variability in transplantation, and provide the

173 exome, and Sanger sequencing to analyze the genetic variability in TREM2 in a series of 1092 patient

174 at genome size is negatively correlated with genetic variability, independent of phylogeny, body size

175 Genetic variability influences susceptibility to the pot

176 tions have been made that would suggest that genetic variability influencing allograft survival reach

177 controlled breeding practices has segregated genetic variability into distinct dog breeds that posses

178 Genetic variability is a hallmark of RNA virus populatio

179 This genetic variability is affected by the adaptive immune r

180 used to detect biological pathways in which genetic variability is associated to variation in gene e

181 nding-oligomerization domain function due to genetic variability is associated with an increased susc

182 Therefore, knowledge of its DNA genome and genetic variability is central to preventing and treatin

183 a strongly discontinuous model for how human genetic variability is distributed and shows how individ

184 eletions (<1Kb), a significant proportion of genetic variability is due to copy number variation (CNV

185 Although genetic variability is known to greatly impact on the hu

186 bjected to regulation by naturally occurring genetic variability is of relevance for the understandin

187 accelerate bacterial adaptation when desired genetic variability is present within DNA fragments of u

188 or chaperone function in the context of high genetic variability is proposed.

189 breeds F(is) was consistently low suggesting genetic variability is sufficiently available for breede

190 lity and disease, and have shown that common genetic variability is unlikely to explain the entire ge

191 ene copy number variation, a major source of genetic variability, is important for several genes that

192 iduals extinguish conditioned fears, such as genetic variability, learning capacity and conditions un

193 is issue of Neuron, Cruchaga et al. identify genetic variability linked to altered levels of tau prot

194 Host genetic variability may contribute to susceptibility of

195 is reasonable to expect that a wide range of genetic variability may exist given all of the different

196 activity based on drug-drug interactions or genetic variability may therefore influence glibenclamid

197 olerance to various stresses and loss of the genetic variability needed to correct that.

198 E on the offspring appear to be moderated by genetic variability, neurobehavioral disinhibition, and

199 t a single site that was on par with spatial genetic variability observed over distances of 15,000 km

200 ery little is known about the occurrence and genetic variability of (pro)phages within the Bifidobact

201 ty of a phiKMVvirus to dramatically increase genetic variability of a co-infecting phage), highlighti

202 ative effects on the sexual reproduction and genetic variability of Agave plants increasing their vul

203 ed by functional studies and analysis of the genetic variability of AGER in patients with CF.

204 specific drugs a nd vaccines is the study of genetic variability of allpublicly available HCV sequenc

205 Almost all theories for the genetic variability of characters assume measurements on

206 e phenotypic and mutational spectrum and the genetic variability of DNAJC3, we analyzed 8,603 exomes,

207 s, understanding the mechanisms by which the genetic variability of EPO affects the mortality of T2D

208 We further estimated the genetic variability of gut microbes, with Bacteroides sp

209 mers or probe mismatches related to the high genetic variability of HDV and, possibly, to the complex

210 tudy this question making use of the natural genetic variability of human populations, which allows u

211 The host genetic variability of immune response to HIV and immune

212 viruses was used to assess the impact of the genetic variability of influenza A(H3N2) viruses on infl

213 butes in phenotypically relevant ways to the genetic variability of many organisms.

214 ructures of recently evolved halophytes, the genetic variability of model plants, and endemic halophy

215 s result is mirrored by field surveys of the genetic variability of natural strains of yeast.

216 d for the first time the fine-scale temporal genetic variability of new settlers and their origins in

217 The genetic variability of nine genes in 12 isolates and str

218 Assessing the genetic variability of plant performance under heat and

219 Genetic variability of Plasmodium falciparum underlies i

220 We assessed the impact of the whole common genetic variability of PROX1 (80 SNPs) on type 2 diabete

221 rapies and vaccines that may bypass the wide genetic variability of RNA viruses.

222 Here, we characterized the genetic variability of RSV during 5 seasons, and evaluat

223 eport, for the first time, we associated the genetic variability of SCN4A with the development of ess

224 Overall, our data reveal that the genetic variability of Seg-10/NS3 differentially modulat

225 The genetic variability of SIVsm strains among PCs may influ

226 tions and leaves a distinct signature in the genetic variability of species.

227 r account for only a small proportion of the genetic variability of tested diseases.

228 The genetic variability of the ADIPOQ gene and circulating a

229 Here we show that genetic variability of the gene encoding PKCalpha (PRKCA

230 nderstanding of the population structure and genetic variability of the genus Mycobacterium, we condu

231 Because of the genetic variability of the HIV-1 envelope glycoproteins

232 Genetic variability of the host may have large impact on

233 erogeneous disease such as HCM with the vast genetic variability of the human genome, and high freque

234 llow the scientific community to explore the genetic variability of the immunoglobulin (Ig) and T cel

235 For example, genetic variability of the mu-opioid receptor (MOR)-enco

236 Genetic variability of the PFam54 gene array suggests th

237 tion of the disease may be influenced by the genetic variability of the plcD region.

238 Levels and genetic variability of the PON1 position 192 isoforms (G

239 Our study revealed high genetic variability of the S. epidermidis genome, new ma

240 this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for on

241 (RSV) within communities may result from the genetic variability of the virus and associated evolutio

242 atients who survived EVD, in some cases, the genetic variability of the virus resulted in deleterious

243 cine will need to overcome the extraordinary genetic variability of the virus, where most variation o

244 accomplishing these goals is the tremendous genetic variability of the virus, with some genes differ

245 The genetic variability of these isolates within phylogeneti

246 ium; however, the prevalence, expression and genetic variability of this protein in native marine mic

247 A multilocus genetic score reflecting genetic variability of this signature is associated with

248 on mutations within rdxA, possibly revealing genetic variability of this trait in C. jejuni due to sp

249 nown regarding the generation and effects of genetic variability of virus replication in the natural

250 used on epidemiological investigation of the genetic variability of well-documented strains of Y. pes

251 associated with GRN haploinsufficiency, and genetic variability on the wild-type GRN allele might ha

252 we seek new insight into mechanisms driving genetic variability on this island, using a Critically E

253 om neurodegeneration possibly as result from genetic variability, or to variable degree from brain le

254 ease, while others do not; and what roles do genetic variabilities play in the individual immune resp

255 her evidence of the important role that host genetic variability plays in the determination of diseas

256 Genetic variability, population structure and gene flow

257 To better understand the genetic variability present among pediatric strains and

258 The remarkable genetic variability present within the species is reflec

259 Single-clone algal cultures (lacking genetic variability) produced short cycle periods and ty

260 In worldwide populations, SNCA genetic variability remains the most reproducible risk f

261 Further disease-related common genetic variability remains to be identified and the wor

262 targets contribute significantly to the non-genetic variability seen within and across individuals,

263 rvival of Egfrtm1Mag homozygous embryos, the genetic variability segregating within the outbred popul

264 Our findings establish that genetic variability, smoking, and COPD all influence CST

265 Genetic variability substantially influences muscle mass

266 The low genetic variability suggests that evolutionary pressure

267 which species are able to retain more useful genetic variability than they 'should', for example by e

268 roviding parasite populations with extensive genetic variability that accelerates selection of drug r

269 d may serve as a mechanism for meningococcal genetic variability that avoids the fitness costs encoun

270 is circuitry may arise, in part, from common genetic variability that contributes to risk for MDD.

271 ed to use a genome-wide approach to identify genetic variability that directly affects LRRK2 Gly2019S

272 Recent work has emphasised the marked genetic variability that exists in the Fc receptor locus

273 valuable in providing new insights into the genetic variability that is present in a particular spec

274 Potential sources of genetic variability that may contribute to the disorder'

275 is driven by the advantages conferred by the genetic variability that results from transposition, in

276 nted by other researchers to identify common genetic variability that results in minor and moderate r

277 characterized by significant phenotypic and genetic variability the genetic matrix has a strong infl

278 sis; the classical vs balance hypothesis for genetic variability; the neutral theory of molecular evo

279 oncentrate on maintaining this high level of genetic variability through both in and ex-situ conserva

280 ility of Illumina data and uses inter-sample genetic variability to assign reads to isolates, which o

281 t transformation, but limitations imposed by genetic variability, tumor heterogeneity, availability o

282 Knowledge of genetic variability underlying drug resistance and other

283 selection, which is predicted to reduce the genetic variability underlying such traits.

284 High genetic variability was found for En under both scenario

285 The role of genetic variability was tested by comparing triploids ge

286 0 sequences from various BTV strains display genetic variability, we assessed the impact of different

287 Despite genetic variability, we found no difference in the sever

288 ertheless, comparably high levels of neutral genetic variability were retained as these declines are

289 SNPs genotypes, explaining >92% of the locus genetic variability, were determined in 519 patients wit

290 he weight given to within- and between-breed genetic variability, were used in order to estimate the

291 xpansive growth to water deficit has a large genetic variability, which is higher than that of photos

292 inese chestnut C. mollissima had the highest genetic variability, while the American C. dentata had t

293 into the mechanistic and network effects of genetic variability, with improved statistical power to

294 opulations in T-705-treated mice had greater genetic variability, with more frequent transversion eve

295 y is reflected in substantial ecological and genetic variability within and among Trichinella taxa, a

296 mapping within the linkage region suggested genetic variability within DNM3 as an age-of-onset modif

297 The selected plants were cloned to reduce genetic variability within each genotype.

298 he factors limiting photosynthesis and their genetic variability within extant germplasm must be unde

299 d comparative genomics provides a measure of genetic variability within natural populations and ident

300 TFV is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence