ライフサイエンスコーパス: genetically

1 at were ascertained for FH clinically versus genetically.

2 Meristem arrest is also controlled genetically.

3 re exceptionally large sample sizes to study genetically.

4 mutating the eIF2alpha phosphorylation site, genetically(11) and pharmacologically inhibiting the ISR

5 Here, using a zebrafish model, we genetically ablate all embryonic tendon cells and find c

6 SS13 impacts tumor progression, TMPRSS13 was genetically ablated in the oncogene-induced transgenic M

7 of Muc5ac in pancreatic cancer pathology, we genetically ablated it in an autochthonous murine model

8 unction in DMD-affected skeletal muscles, we genetically ablated miR-133b in the mdx mouse model of D

9 We genetically ablated ten such lncRNAs, most of them trans

10 Galpha(q) is pharmacologically inhibited or genetically ablated, Gbetagamma can bind to PLCbeta but

11 many tumor types involves the interaction of genetically abnormal cancer cells with normal stromal ce

12 Because of the unique role of the mouse as a genetically accessible model system for mammalian brain

13 of liver regeneration, pharmacologically and genetically activated cell proliferation, and HCC.

14 Fast-growing, genetically amenable, and stress-tolerant cyanobacteria

15 As these viruses continue to diversify genetically and antigenically, it is critical to closely

16 mplicated in CHDs, Megf8 and Mgrn1, interact genetically and biochemically to regulate the strength o

17 d in vitro makes them easily accessible both genetically and for live assays such as fluorescence ima

18 Here, we report that PUT3 genetically and physically interacts with SOS1 and SOS2,

19 neuron function after injury and defines two genetically and temporally separable phases of dSarm sig

20 solates carrying erm(51) are closely related genetically and were likely selected by antimicrobial ex

21 .23 to 1.87) and 1.49 (95% CI: 1.07 to 2.08) genetically, and with corresponding hazard ratios of 1.0

22 elian inheritance of discrete traits and the genetically based correlation between relatives for quan

23 The hypothesis was tested that genetically based obesity measured by body mass index is

24 ed for the detection of infections that were genetically characterized by a panel of microsatellite l

25 This variant is genetically closest, with 98.73% homology, to the Ebola

26 Genetically, compared to Rickettsia_bellii_MEAM1 found e

27 It is a genetically complex and age-related disorder, with highe

28 ratoconus is a highly prevalent (1 in 2000), genetically complex and multifactorial, degenerative dis

29 ntiated pleomorphic sarcoma (UPS) are highly genetically complex soft tissue sarcomas.

30 ormed CNS through its role in the removal of genetically compromised cells.

31 ler DLPFC and insula GMV plausibly represent genetically conferred predispositional risk factors for,

32 um of the disease phenotype in our first 100 genetically confirmed carriers of biallelic repeat expan

33 ligible patients, 16 to 40 years of age with genetically confirmed FA and baseline modified Friedreic

34 and extension study in 8 adult patients with genetically confirmed WHIM syndrome.

35 pact likely loss-of-function variants in the genetically constrained gene with distinct phenotypes.

36 Even though plasticity in many traits is genetically controlled, whether and how plasticity's gen

37 values to these pairs: GWAS statistics from genetically correlated bipolar disorder, the effect size

38 tatistics of one disorder for the effects of genetically correlated traits to identify putative disor

39 PAU was genetically correlated with 138 phenotypes, including su

40 ependence (SNP-based heritability = 8.6%) is genetically correlated with 18 other smoking traits (r(g

41 Notably, neither resilience metric was genetically correlated with clinical Alzheimer's disease

42 Earlier male puberty timing is genetically correlated with several adverse health outco

43 Here, we block the molt by genetically dampening ecdysone production, creating an e

44 mbryogenesis(3,4) with mouse models that are genetically deficient for contactin-associated protein-l

45 Tumours in mice genetically deficient in low-molecular weight FGF2 (FGF2

46 in functionally distinct neuronal ensembles, genetically defined by the Fos- or Npas4-dependent trans

47 endent, allowing the circadian properties of genetically defined populations of cells to be studied i

48 Here, we evaluate the growth of genetically defined renal tumors and their association w

49 he efficacy in subgroups with clinically and genetically defined risk.

50 ible with sequential barcoding, and is fully genetically defined.

51 and other affective disorders; however, the genetically-defined neuronal subtypes and projections th

52 Recent studies have identified genetically-defined PVH subpopulations that control disc

53 However, many cells with genetically deleted cyclin Ds, which activate and confer

54 a CRISPR/Cas9-based engineering approach, we genetically deleted five large clusters of KRAB-ZFPs and

55 uthernmost population, on the other hand, is genetically depauperate and different from all other pop

56 suggest that pigmentation of this animal is genetically determined and dependent on a population of

57 Lipoprotein(a) levels are genetically determined and, when elevated, are a risk fa

58 We identify a genetically determined circuit-extending from the access

59 Small, genetically determined differences in transcription [exp

60 Second, we found that the virus in semen was genetically different in some participants compared to t

61 ces were detected between AV/RG and the most genetically different RE breed, using the novel QD measu

62 Either genetically directed deletion or acute optogenetic silen

63 lator of embryonic alveolar sac formation as genetically disrupting the Gorab gene in mice resulted i

64 on for host shifts being less likely between genetically distant species.

65 allelic frequencies grouping, an estimate of genetically distinct "clones" of cancer cells can be det

66 tion memory engram is formed and stored in a genetically distinct basolateral amygdala (BLA) neuronal

67 ce of a significant tropism for any of the 3 genetically distinct bat ACE2 proteins we examined indic

68 t is rarely infected with the agent of LB is genetically distinct from an abundant, expanding, and co

69 Seven genetically distinct LASV lineages have been identified.

70 infected young adult mice with either of two genetically distinct, persistent T. gondii strains (Prug

71 Observational studies indicate that the genetically divergent BCG strains have different effects

72 ern transcriptomic differences between these genetically divergent crosses.

73 f recombinant cells from a cross between two genetically divergent strains, we mapped 86 trans-acting

74 oria activity was followed by circulation of genetically diverse A(H1N1)pdm09 viruses, that were also

75 t both local and global CNSC populations are genetically diverse and that CNSC harbor carbapenemase-e

76 iably construct pangenomes from thousands of genetically diverse bacterial genomes that represent the

77 ions from the eastern Mediterranean are more genetically diverse compared with populations to the wes

78 Genetically diverse inbred strains are frequently used i

79 Blastocystis is a genetically diverse intestinal protist colonizing both h

80 genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cu

81 A sparse, stable, and genetically diverse population of ticks in the Southeast

82 variability in these Vpu functions among the genetically diverse viral subtypes that contribute to th

83 rsity through colony merging, resulting in a genetically diverse, yet cohesive, workforce.

84 randomization we analysed the association of genetically elevated levels of 36 blood cell traits (pla

85 pes identified 12 phenotypes associated with genetically elevated SHBG after Bonferroni correction fo

86 vances in the development and application of genetically encodable fluorescent and bioluminescent bio

87 hromophores with the inherent selectivity of genetically encodable systems, permitting imaging modali

88 TETs in mammalian cells by incorporation of genetically encoded 4,5-dimethoxy-2-nitrobenzyl-l-serine

89 We therefore engineered flies expressing a genetically encoded Ca(2+) indicator in the photorecepto

90 Using genetically encoded Ca(2+) sensors to directly examine C

91 ed large calcium currents, measured with the genetically encoded calcium indicator jRGECO1a.

92 Near-infrared (NIR) genetically encoded calcium ion (Ca2+) indicators (GECIs

93 We introduce rsCaMPARI, a genetically encoded calcium marker engineered from a rev

94 This work also presents a fully genetically encoded Cas12a system in an animal, laying o

95 vity further highlights the benefit of using genetically encoded catalysts to address chemoselectivit

96 GAVPO transactivator in combination with two genetically encoded cell-ablation technologies: the nitr

97 influenza virus hemagglutinins to engineer a genetically encoded cell-surface protein barcoding syste

98 Directed evolution of genetically encoded cytochrome P411 enzymes (P450s whose

99 Genetically encoded dopamine sensors based on green fluo

100 variety of editors have been created, but a genetically encoded editor that is both precise and effi

101 onitoring of NADH/NAD(+) in plants using the genetically encoded fluorescent biosensor Peredox-mCherr

102 inetics to GPCRs using a high quantum yield, genetically encoded fluorescent biosensor, and a data an

103 Genetically encoded fluorescent glutamate indicators (iG

104 tal ions, expanding the range of the current genetically encoded fluorescent protein-based sensors.

105 vances starting from identity marking with a genetically encoded fluorophore.

106 To address this, we used genetically encoded FRET biosensors of molecular tension

107 nt, with the amino acid selenocysteine being genetically encoded in 25 natural human proteins.

108 ily adapted to induce expression of numerous genetically encoded markers, antibiotic resistance genes

109 f monomeric NIR FPs, which are the brightest genetically encoded NIR probes.

110 pects for tailored design of highly evolved, genetically encoded organophosphorus scavengers and for

111 This highlights the potential for using genetically encoded periplasmic binding proteins such as

112 Here, we report the new version of genetically encoded photoactivatable (PA) Cre recombinas

113 nal chemical probe that can be targeted to a genetically encoded protein of interest (POI) through a

114 When expressed as genetically encoded reagents in cells, these monobodies

115 Here, we generated C-tag TNF as a genetically encoded reporter to study TNF shedding at th

116 Genetically encoded RNA devices have emerged for various

117 e photoregulation of gene expression using a genetically encoded RNA will likely facilitate high-reso

118 on the repeated initiation of a small set of genetically encoded rules.

119 iles of NT and NM release in the brain using genetically encoded sensors for in vivo studies.

120 e or morphogenetic control units that can be genetically encoded within desirable or designed protein

121 a soluble N'-terminal gammaC0C7 (endogenous [genetically encoded] N'-terminal domains C0 to C7 of car

122 e fluorescent probes combining advantages of genetically-encoded proteins such as green fluorescent p

123 Approaches to genetically engineer high HbF include de novo generation

124 tified by HT-DBP induced tumor regression in genetically engineered and patient-derived xenograft (PD

125 Here, it is reported that genetically engineered cell-membrane-coated magnetic nan

126 Using genetically engineered cells lacking all four TMTC genes

127 the studies involved in safety assessment of genetically engineered crops includes characterizing the

128 Genetically engineered GCSF-R is similar to an antibody

129 oietic stem cells and reconstitution of this genetically engineered hematopoietic system in mice.

130 stigated cellular and behavioral outcomes in genetically engineered human APOE targeted replacement (

131 In this study, we used genetically engineered human induced pluripotent stem ce

132 nd their capacity to penetrate tumors(5), we genetically engineered human macrophages with CARs to di

133 of the constituent Mn(2+) and Ca(2+) ions in genetically engineered membranes of the cyanobacterium S

134 plantation, atypical neurofibromas generated genetically engineered mice (GEM)-PNST similar to human

135 ng human monoclonal antibodies by immunizing genetically engineered mice that have a full set of huma

136 vivo, we have developed a method based on a genetically engineered mouse harboring a conditional Hal

137 Here, we present a new genetically engineered mouse model for non-AR-driven pro

138 In a genetically engineered mouse model of non-small cell lun

139 xperimental animals often hinders the use of genetically engineered mouse models (GEMM) in cancer res

140 Genetically engineered mouse models (GEMMs) of cancer ha

141 Redd1 deletion in genetically engineered mouse models (GEMMs) of KRAS-depe

142 iewed through the lens of fate mapping using genetically engineered mouse models and from the perspec

143 Ablation of Mir181ab1 in genetically engineered mouse models of Kras-driven lung

144 1 in normal tissue homeostasis, we generated genetically engineered mouse models where we can conditi

145 s of germline loss-of-function mutations and genetically engineered mouse models with inactivation of

146 In addition to patient samples and genetically engineered mouse models, we developed organo

147 in knockout, transgenic, and other types of genetically engineered mouse strains.

148 Genetically engineered Nf1(flox/flox);PostnCre(+) mice,

149 Here, we use genetically engineered orthotopic mouse models of breast

150 o aid the attribution of outbreaks caused by genetically engineered pathogens, and thus protect again

151 This study showcases the only genetically engineered system capable of serving the dua

152 pigs with all PERVs inactivated can also be genetically engineered to eliminate three xenoantigens a

153 Here, megakaryocyte progenitor cells are genetically engineered to overexpress PD-L1 to produce i

154 t resistance threatens the benefits of crops genetically engineered to produce insecticidal proteins

155 In a genetically-engineered mouse model of lung adenocarcinom

156 A non-functional and non-genetically evolving viral reservoir along with an HIV-1

157 These contradictory findings prompted us to genetically explore the role of eIF2alpha phosphorylatio

158 These assays utilize GPCRs genetically fused to an N-terminal HiBiT peptide (1.3 kD

159 ciferase-based signal amplifiers (rILSAs) by genetically fusing luciferase (Nluc) with antimouse IgG1

160 en the epigenetic chromatin cycle falters, a genetically hardwired mechanism offers robustness to a d

161 ); 2) a uniform dose-response profile across genetically heterogeneous cancer cell lines relative to

162 Dilated cardiomyopathy (DCM) is a genetically heterogeneous cardiac disease characterized

163 AML is a genetically heterogeneous disease and understanding how

164 e-Tooth neuropathy (CMT2) are clinically and genetically heterogeneous diseases characterized primari

165 Inherited PPGL is a highly genetically heterogeneous disorder but the most frequent

166 Primary ciliary dyskinesia (PCD) is a genetically heterogeneous syndrome that results from def

167 al muscle and bone, tendon is a surprisingly genetically heterogeneous tissue.

168 Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology

169 Pancreatic ductal adenocarcinoma (PDAC) is a genetically heterogeneous, biologically aggressive malig

170 Our results suggest that refractive error is genetically heterogeneous, driven by genes that particip

171 Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease g

172 igate the most severe manifestations of this genetically heterogenous disease.

173 a-CEHC glucuronide); MR analysis showed that genetically high levels of these metabolites were associ

174 Schizophrenia is genetically highly heterogeneous, involving severe ultra

175 Islets of Langerhans were isolated from genetically identical 10-week-old female New Zealand Obe

176 ocellular HbF expression pattern, even among genetically identical cells, remains unknown.

177 e and direction of change can differ between genetically identical female and male Daphnia magna, whi

178 different average lifespans between the two genetically identical genders.

179 ated that transfer of these microbiomes into genetically identical hosts was sufficient to modulate E

180 f TEs exhibit variable methylation levels in genetically identical individuals, and this is associate

181 may operate in parallel with subcircuits of genetically identical neurons that serve specialized and

182 ssion can generate phenotypic diversity in a genetically identical population of cells, but it is unc

183 T (T(EM)) cells contained HIV-1 DNA that was genetically identical to viral sequences derived from pr

184 is dependent upon all individual mice being genetically identical, which in turn is dependent on the

185 that participate in double fertilization are genetically identical.

186 D is alpha-synuclein (alphaS), which is both genetically implicated and accumulates in Lewy bodies ri

187 is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerativ

188 The 'genetically improved farmed tilapia' (GIFT) stock, found

189 and their roles in synaptic transmission, we genetically inactivated mTORC1 or mTORC2 in cultured mou

190 Genetically increased body mass index was causally assoc

191 th was restored in ore1-2 knockout plants by genetically inducing cell elimination in cells overlying

192 ow failure, these data provide evidence that genetically influenced common variation in telomere leng

193 ir promotion by some as a potential tool for genetically informed policy.

194 atification of high-risk individuals and for genetically-informed prioritization of drug targets for

195 on, 2% of proviruses that persist on ART are genetically intact by sequence analysis.

196 We showed that rare, genetically intact proviruses could be detected in child

197 t attenuates Hedgehog signaling strength and genetically interact to regulate digit number, body patt

198 n interactions of a poorly characterized and genetically intractable organism such as Ot.

199 loped a multicolor reporter allele system to genetically label and trace polyploid cells in situ.

200 Genetically labeled mice established that L1 neurons are

201 sive motor symptoms and premature death, but genetically lacks corticospinal neurons and other subcer

202 acture produce more exotic patterns that are genetically linked to the formative stress field.

203 esults demonstrate that delta(13) C(leaf) is genetically linked to WUE(plant) , likely to be through

204 identify ATP13A3, which has been previously genetically linked with pulmonary arterial hypertension,

205 viduals with atrial fibrillation, those with genetically lower levels of factor XI are at reduced ris

206 y have implications for EE-exposure risk for genetically lupus-prone individuals.

207 cribe how to use this method to label and/or genetically manipulate cells in the neonatal rat and mou

208 Using genetically manipulated human and mouse cells, and ex vi

209 These findings provide evidence for genetically mediated dysregulation of early neuronal con

210 igated an OR(His) variant of Arabidopsis OR, genetically mimicking the melon OR(His) allele, and foun

211 benefits and costs on the production side of genetically modified (GM) and organic corn systems in Mi

212 organism involved in such an event has been genetically modified and, if modified, to infer from its

213 ovel approach using a Cre-dependent virus in genetically modified ChAT::Cre rats, a species used for

214 Genetically modified conditional lethal strains have bee

215 s that may be important in future studies of genetically modified crickets for improved food producti

216 by performing experimental infections in two genetically modified invertebrate models (Drosophila mel

217 In this study, we used genetically modified mice with a mutation (KR389-390AA)

218 CTCs) in two mouse models of mammary cancer: genetically modified MMTV-PyMT mice and orthotopically g

219 ecome a standard tool for the development of genetically modified mouse models.

220 hydrodynamic effects of mastigonemes using a genetically modified mutant lacking the fibrous structur

221 viability and a normal karyotype, and can be genetically modified or differentiated into multiple cel

222 ulation in supporting consumer acceptance of genetically modified organisms (GMOs).

223 s beyond 90 days was recently reported using genetically modified pigs and a clinically applicable dr

224 n rats with wild-type or mutated Add3 and in genetically modified rats with overexpression or knockou

225 We have developed a genetically modified recombinant NDV (rNDV) that has muc

226 Studies in genetically modified rodent models suggest that activati

227 His-tagged hGH variants in the cytoplasm of genetically modified Rosetta-gami B DE3 Escherichia coli

228 RS-CoV-2 infects mice only if they have been genetically modified to express human ACE2.

229 r couple virus discovery with immunology, we genetically modified zebrafish to visually report on vir

230 we investigated PGC development in rats, by genetically modifying Prdm14, a unique marker and an ess

231 nsgene to avoid the host immune response (by genetically modifying these components), as well as opti

232 ged male and female APP/PS1 transgenic mice, genetically null for the beta2 nAChR subunit gene, showe

233 is a putative transcriptional repressor and genetically opposes the function of its relatives DORNRO

234 Genetically or pharmacologically inhibiting expression o

235 Inhibition of autophagy, either genetically or pharmacologically with chloroquine, syner

236 Inhibition of PKA activity genetically, or pharmacologically by activation of the P

237 The gCM shell genetically overexpressing SIRPalpha variants with remar

238 evolved populations of Escherichia coli with genetically perturbed TMs for 1,000 generations.

239 tatistically significant association between genetically predicted alcohol consumption and overall ca

240 Genetically predicted alcohol consumption was consistent

241 There was no evidence of associations of genetically predicted alcohol consumption with heart fai

242 t associations of biochemically measured and genetically predicted differences in blood 25(OH)D with

243 herapeutic targets because they did not have genetically predicted effects on any of the other phenot

244 We found no association of genetically predicted PCOS with risk of diabetes, CHD, o

245 -0.89; p = 0.0012); and per unit increase in genetically-predicted log-transformed CRP was 1.18 (95%

246 -1.27; p = 2 x 10(-5)); per unit increase in genetically-predicted log-transformed IL-6 was 0.74 (95%

247 epression per standard deviation increase in genetically-predicted triglycerides was 1.18 (95% CI 1.0

248 The greater increase in BMI in genetically predisposed individuals over time was appare

249 s-reactive IgG4 antibodies may lead to FS in genetically predisposed individuals.

250 ither through receptor-specific drug intake, genetically predisposed irregular 5-HT receptor density,

251 prevalence of obesity was steeper among the genetically predisposed.

252 onses that reflect both adaptive learned and genetically programmed innate defense systems.

253 of tissue-resident macrophages, resulting in genetically programmed susceptibility to bacterial infec

254 y proxied inhibition of NPC1L1 and PCSK9 and genetically proxied circulating LDL cholesterol levels.

255 In BRCA1/2 mutation carriers, genetically proxied HMG-CoA reductase inhibition was ass

256 Primary exposure was genetically proxied inhibition of HMG-CoA reductase and

257 Genetically proxied inhibition of HMG-CoA reductase was

258 G-CoA reductase and secondary exposures were genetically proxied inhibition of NPC1L1 and PCSK9 and g

259 Among carriers of large CHIP clones, genetically reduced IL-6 signaling abrogated this risk.

260 Conversely, genetically reducing phosphorylation of eukaryotic initi

261 Here, we show that genetically reducing the protein tau prevents behavioral

262 xpression and assess its ability to identify genetically regulated expression solely from RNA-sequenc

263 ntified significant associations between the genetically regulated gene expression (GReX) of ZC3H12B

264 ith pancreas cancer with at least 2 affected genetically related relatives.

265 eby leading to interacting individuals being genetically related.

266 When NFIB and NFIX are genetically removed, the stemness epigenetic landscape i

267 omb Repressive Complex 2 (PRC2) silencing is genetically required by FCA to repress FLC Overall, our

268 w evidence that different "Canaanite" groups genetically resemble each other more than other populati

269 ity and that the truncation of Ma1 to ma1 is genetically responsible for low fruit acidity in apple.

270 Genetically restoring Gli3 repressor rescues the decreas

271 ns with non-canonical amino acids (NCAAs) by genetically restricting the expression of the mutant tRN

272 Persisters are a sub-population of genetically sensitive bacteria that survive antibiotic t

273 Because BRCA1 activities can be genetically separated, compound heterozygosity for funct

274 Genetically silencing Purkinje cell neurotransmission bl

275 We describe two genetically similar V(H)6-1 bnAb clonotypes from the sam

276 rome coronavirus 2 (SARS-CoV-2-Nluc) that is genetically stable and replicates similarly to the wild-

277 Healthy, genetically susceptible adults were inoculated with NV L

278 ds from nymphs, males and females feeding on genetically susceptible and resistant bovine hosts and t

279 Autoimmunity usually appears in genetically susceptible children with the development of

280 dly associated with exacerbation of EAE in a genetically susceptible host, which was functionally con

281 microbial, and immune-mediated factors in a genetically susceptible host.

282 g on eating behavior change, particularly in genetically susceptible individuals.

283 mune-mediated reaction to ingested gluten in genetically susceptible persons.

284 Using cell-specific and genetically targeted approaches we have confirmed an ind

285 analyses confirmed that rationally designed, genetically targeted assembly of functional polymers not

286 apply to other recombinase systems and other genetically targeted organisms.

287 ent means for monitoring calcium dynamics in genetically targeted populations of neurons rely on deli

288 e genetic testing resulted in utilization of genetically targeted primary disease prevention at short

289 The first wave of genetically targeted therapies for cancer focused on dru

290 We show genetically that the antibacterial activities of the com

291 l, we altered the structure of osteoblast HS genetically to make it incapable of binding to OPG.

292 This work makes Spizellomyces a genetically tractable model for comparative cell biology

293 the development of similar systems in other genetically tractable organisms for multiplexed conditio

294 t several decades as investigators turned to genetically tractable systems.

295 s a critical advancement toward making squid genetically tractable.

296 rogrammability of the LC gels is achieved by genetically tuning the charge density of protein backbon

297 olfactory neuroepithelium (CNON cells) as a genetically unaltered cellular model to elucidate the ne

298 utility and potential of exome sequencing in genetically unique populations, such as the SWAI populat

299 n protein (PrP) expression in the brain is a genetically validated therapeutic hypothesis in prion di

300 macologically with MEK1/2 inhibitor U0126 or genetically with bone marrow-derived macrophages or DCs