ライフサイエンスコーパス: genetically altered

1 recombinant human Orc2 subunit that had been genetically altered.

2 lies in which insulin signaling activity was genetically altered.

3 ated when the M cell oscillator is absent or genetically altered.

4 ific TRPV1 phosphorylation event in vivo, we genetically altered a major PKC phosphorylation site, mo

5 ectin on adipose tissue in mouse models with genetically altered adiponectin levels.

6 Using combinations of genetically altered and immunodepleted mice, we found ev

7 ES cell lines that can be expanded in vitro, genetically altered, and differentiated into cell types

8 lines, in which MSR gene expression has been genetically altered, and observed a positive correlation

9 By using a variety of different genetically altered animal models and biophysical experi

10 cid transporters, and emerging evidence from genetically altered animal models for some of these prot

11 ere are endless possibilities for generating genetically altered animal models with which to gain ins

12 easingly powerful flow cytometry analysis of genetically altered animals (knockouts and transgenics)

13 aptive immune systems, are being explored in genetically altered animals and in exposure models of th

14 ulting from altered gene expression (e.g. in genetically altered animals or in human genetic disorder

15 ion mechanisms offers the opportunity to use genetically altered animals to specifically target these

16 In the modern era, the incorporation of genetically altered animals, pharmacologic manipulation,

17 longitudinal studies in animals and to study genetically altered animals.

18 Further, our results reveal that genetically altered arborization or ablation of the PVD

19 riments in which CSQN expression levels were genetically altered as well as to reproduce nanoscopic m

20 air pathways for PARP-DNA complexes using 30 genetically altered avian DT40 cell lines with preestabl

21 d, perhaps, endogenous antigens generated by genetically altered bone marrow cells.

22 LK) is a receptor tyrosine kinase that, when genetically altered by mutation, amplification, chromoso

23 tain cellular behaviors that mirror those of genetically altered cell lines.

24 Genetically altered cell sizes had little effect on tiss

25 s, differentiating cell culture systems, and genetically altered cells and animals.

26 Single cell measurements of the genetically altered cells are shown to be consistent wit

27 Genetically altered cells in the superficial portions of

28 When these genetically altered cells were placed within the in vivo

29 evolution in creating synthetic libraries of genetically altered cells with relative ease.

30 ay influence diseases that derive from a few genetically altered cells, such as cancer.

31 onsidered epigenetic processes that act upon genetically altered cells.

32 for 12 months after the implantation of the genetically altered cells.

33 fe mechanisms to terminate therapy or remove genetically altered cells.

34 requires an efficient mechanism to eliminate genetically altered cells.

35 osis (ALS), may derive from a small focus of genetically altered cells.

36 have bearing upon Na(+) channel function in genetically altered channels and under pathophysiologic

37 opportunity to examine the ultrastructure of genetically altered cisternal synapses.

38 n defective enamel, and the diverse group of genetically altered conditions is collectively known as

39 Our data indicate that genetically altered core pathways and regulatory process

40 We find that mice bearing genetically altered cytoplasmic region of ephrinB2 have

41 Surprisingly, aged mice but not mice with genetically altered DC function had greater production o

42 d starvation at 30 degrees C in strains with genetically altered DnaK content.

43 ction of dopamine in feeding and locomotion, genetically altered, dopamine-deficient mice were treate

44 anism of survivin gene regulation that, when genetically altered during the process of tumorigenesis,

45 ated cell populations derived from normal or genetically altered embryonic stem cells in vitro.

46 Polymerase activity of the genetically altered enzyme on primed M13 DNA is only 12%

47 erties and heat inactivation profiles of the genetically altered enzyme over-produced at 30 degrees C

48 To examine the role of this region, a genetically altered enzyme that lacked residues 144-157

49 We generated or obtained flies with genetically altered expression of each of three Drosophi

50 and proximity ligation assays in cells with genetically altered expression of the studied molecules.

51 Implantation of genetically altered fibroblasts that produce factor VIII

52 ytes, embryonic stem cells, tetratoma cells, genetically altered fibroblasts, smooth muscle cells, an

53 The genetically altered gene 4 proteins were examined for th

54 B virus (HBV) positive, seeking to identify genetically altered genes and pathways implicated in HBV

55 presented in these sets, the majority of the genetically altered genes have so far unknown roles in b

56 leotide to DNA polymerase, we have used four genetically altered gp4 to demonstrate that both the RNA

57 However, a recently developed mouse model of genetically altered hearing (Tectb(-/-)) shows decreased

58 atitis model, particularly those requiring a genetically altered host or specific immunologic reagent

59 aluation of immune responses associated with genetically altered HSCs, including primary immunodefici

60 ally (and hence microscopically) similar but genetically altered human colon cancer cell lines, HT29

61 methods to generate and propagate normal and genetically altered human hematopoietic cells are increa

62 te human melanocytic neoplasia and show that genetically altered human tissue facilitates functional

63 sess tactile and thermal hypersensitivity in genetically altered (i.e., TLR4 knockout and point-mutan

64 By contrast, bioluminescence imaging of genetically altered immortalized esophageal cells reveal

65 r cell surface expression in response to the genetically altered immune environment to evade host rec

66 betes, the underlying metabolic effects of a genetically altered immune system are poorly understood.

67 naling pathways and processes that were each genetically altered in 67 to 100% of the tumors.

68 otein in the development of cancer, as it is genetically altered in a large number of sporadic human

69 , including IKZF1, TCF3, EBF1, and PAX5, are genetically altered in a large portion of the human B-li

70 ity that has not previously been found to be genetically altered in any human cancer.

71 To determine whether PIK3CA is genetically altered in brain tumors, we performed a larg

72 , nine do not contain genes previously shown genetically altered in cancer, whereas the remaining 13

73 TGF-beta receptors and Smads have been found genetically altered in certain human cancers, no mutatio

74 delta anion was genetically altered in cultured dorsal root ganglion neu

75 The PI3K pathway is genetically altered in excess of 70% of breast cancers,

76 Using T cell-specific murine lines genetically altered in expression of p38alpha, and mice

77 Although IRF4 is not genetically altered in most myelomas, they are nonethele

78 en reported of both PKMTs and PRMTs that are genetically altered in specific human cancers, and in se

79 ines of the wild tobacco Nicotiana attenuata genetically altered in specific well-characterized defen

80 , we have analyzed tumor development in mice genetically altered in the genes for fibronectin or alph

81 Mice genetically altered in the IGF-II system were combined i

82 dopsis mutants (tt4, tt5, and fah1) that are genetically altered in their composition of phenolic com

83 is unknown whether these or other genes are genetically altered in these tumors.

84 majority of these genes were not known to be genetically altered in tumors and are predicted to affec

85 frequency, many of which are not known to be genetically altered in tumors.

86 ements XP-E extracts in vitro, but it is not genetically altered in XP-E patients.

87 ften aberrantly activated, particularly when genetically altered, in human cancers.

88 pendent upon reciprocal interactions between genetically altered "initiated" cells and the dynamic mi

89 By using genetically altered ion channels as reporters, we were a

90 inase activation states, suggesting that non-genetically altered kinases can be essential "nodes" for

91 explanation for the phenotypes of cells with genetically altered levels of the two dehydratases.

92 melanogaster females that had been mated to genetically altered males that lack sperm and/or Acps.

93 and inflammatory cells in wild-type (WT) and genetically altered mice (ST3Gal-III heterozygotes, Fuc-

94 wever, more recent work-including studies on genetically altered mice and data from microarray analys

95 Using genetically altered mice and E2F4 mutant proteins we dem

96 plied to targeting strategies for generating genetically altered mice and gene therapy.

97 u ligand-binding assays with the analysis of genetically altered mice and in vitro models to demonstr

98 Further studies in genetically altered mice and other models will improve u

99 Both the genetically altered mice and the rats treated with TLR4

100 ion in the microcirculation of wild-type and genetically altered mice by real-time in vivo microscopy

101 Genetically altered mice deficient in ER-phagy demonstra

102 In the current studies we used genetically altered mice deficient in MPO to investigate

103 Recent work using genetically altered mice demonstrates that T cell matura

104 Additional experiments using genetically altered mice either deficient in perforin or

105 The growing availability of genetically altered mice has focused attention on the ne

106 Analysis of genetically altered mice has revealed that mutations in

107 The use of genetically altered mice has revolutionised biomedical r

108 Rodent models and genetically altered mice have recently become available

109 Inhibitors and genetically altered mice identify a critical role for es

110 This study used genetically altered mice in an established model of card

111 Using genetically altered mice in which expression of the tumo

112 for induction of focal cerebral ischemia in genetically altered mice include occurrence of subarachn

113 Genetically altered mice including both transgenic and k

114 Genetically altered mice lacking all lymphoid cells due

115 toreceptors in a more direct manner, we used genetically altered mice lacking functional M2 and/or M4

116 Genetically altered mice lacking HMGN1 and HMGN2 protein

117 By using genetically altered mice lacking specific vesicle-associ

118 Genetically altered mice lacking ZP3 (Zp3(tm/tm)) do not

119 The availability of genetically altered mice may provide a valuable tool for

120 In addition, loss of SNAP-23 using genetically altered mice or shRNA targeted to SNAP-23 le

121 and splenic macrophage (splnMphi) from these genetically altered mice overproduce inflammatory cytoki

122 cells identified in mutant, toxin-exposed or genetically altered mice post-meiosis, reflect abnormal

123 ort to this model, recent in vivo studies of genetically altered mice question whether ZP3 and/or Gal

124 Subsequent studies in genetically altered mice revealed that NK-cell interfero

125 Application of this model to other genetically altered mice should prove useful for studyin

126 Testing this hypothesis in genetically altered mice showed that the corresponding a

127 Our novel findings in genetically altered mice suggest that activation of the

128 Study of thymocytes from the genetically altered mice suggests that the cause of the

129 ne beta-hydroxylase knockout mice (Dbh(-/-), genetically altered mice that are completely devoid of e

130 ) and CD8(+) T cell-depleting strategies and genetically altered mice that did not express MHC class

131 Liver regeneration studies with genetically altered mice that either prematurely express

132 llagen in the skin, tongue, and esophagus of genetically altered mice that express type VII collagen

133 blood pressure, we engineered a new line of genetically altered mice that lack endothelial angiotens

134 ubtype(s) involved in this activity, we used genetically altered mice that lacked functional M1-M5 mA

135 Here, we review in vivo studies in genetically altered mice that support the notion that mo

136 Cerebral blood flow responses in these genetically altered mice to changes in PO2 demonstrate t

137 We used protein engineering of mouse APC and genetically altered mice to clarify mechanisms for the e

138 Using genetically altered mice to enhance or disrupt extracell

139 We have used genetically altered mice to generate compound functional

140 used a glutamate analog injection model and genetically altered mice to investigate the relationship

141 A utilization observed during heart failure, genetically altered mice were subjected to pressure over

142 These genetically altered mice were used to determine which of

143 B-AR, or alpha2C-AR agonists or antagonists, genetically altered mice were used to identify the molec

144 Genetically altered mice with a selective deletion of th

145 By combining the analysis of genetically altered mice with in vitro models, we demons

146 By combining analysis of genetically altered mice with in vitro models, we show h

147 Genetically altered mice with reductions in the NR1 subu

148 xpressed in cultured epithelial cell models, genetically altered mice, and human mutants.

149 ll, these models, which can be translated to genetically altered mice, are amenable to study with sta

150 Patients, and genetically altered mice, are unable to produce choleste

151 eart we generated gain- and loss-of-function genetically altered mice, as well as knock-in mice with

152 Tissue samples from wild type mice, genetically altered mice, Long Evans rats, and cultured

153 her by a Cdk5-specific inhibitor or by using genetically altered mice, results in increased dopamine-

154 the background strain used to generate most genetically altered mice, the C57BL/6 mouse, is vulnerab

155 aring to study this epileptogenic process in genetically altered mice, we determined whether the back

156 Using genetically altered mice, we identified two innate immun

157 aging to compare area maps in wild type with genetically altered mice.

158 standard for comparison with the retinas of genetically altered mice.

159 rpreting findings derived from studies using genetically altered mice.

160 startle paradigm for assessing cognition in genetically altered mice.

161 udied Eimeria infections of a broad range of genetically altered mice.

162 ic receptor kinase betaARK1) in two types of genetically altered mice.

163 ocorticoids, as demonstrated by infection of genetically altered mice.

164 thymic epithelial cells (TECs) in normal and genetically altered mice.

165 e used two previously characterized lines of genetically altered mice: estrogen receptor-alpha (ER al

166 mined that the same phenomenon occurs in non-genetically altered mice: LSO neurons were 5-HT-immunore

167 nexins was explored using several strains of genetically altered mice: mice with an inactivated Cx32

168 L. pneumophila detection and clearance using genetically altered mouse hosts in which the macrophages

169 Using genetically altered mouse lines with varying degrees of

170 Here, by using the genetically altered mouse melanocytes expressing an endo

171 Genetically altered mouse models constitute unique syste

172 Studies in genetically altered mouse models have shown that dysregu

173 sary to preserve cardiac function, we used 2 genetically altered mouse models that have an attenuated

174 This review focuses on the three genetically altered mouse models that have been the most

175 Using genetically altered mouse models we show that the migrat

176 In this study, we took advantage of 2 genetically altered mouse models with overexpression or

177 s has greatly facilitated the development of genetically altered mouse models.

178 ect pathways in achieving tolerance, we used genetically altered mouse strains in two ways: 1) MHC cl

179 To address these issues, we have employed genetically altered mouse strains that either express th

180 ified by reduced B-cell viability in several genetically altered mouse strains.

181 MLIs in the formation of fear memory using a genetically-altered mouse line (PC-Deltagamma2) in which

182 in which disease phenotypes are assessed in genetically altered murine models of disease.

183 Furthermore, using wild-type and genetically altered murine models of heart failure induc

184 models of autoimmune encephalomyelitis with genetically altered myelination.

185 ded in the identification of a population of genetically altered, neoplastic cells in these tumors.

186 We genetically altered neuronal activity in each neuronal s

187 on the methods and potential applications of genetically altered nonhuman primates in biomedical rese

188 EGFR is the most common genetically altered oncogene in glioblastoma (GBM), but

189 In tumor cells, genetically altered or abnormally expressed proteins pro

190 PP2A has been shown to be genetically altered or functionally inactivated in many

191 dopsins were expressed in cells expressing a genetically altered PERK protein, Fv2E-PERK.

192 The carrier protein is planned to be genetically altered pertussis toxoid.

193 AI) algorithms, which precisely identify the genetically altered phenotype.

194 tment on the retinal structures of mice with genetically altered photoreception.

195 attachment to these cell types, a library of genetically altered pneumococci with defects in exported

196 nuclear magnetic resonance (NMR) analysis of genetically altered polysaccharides.

197 that foci of apocrine metaplasia can share a genetically altered precursor cell with an associated ca

198 e we present a method to selectively isolate genetically altered primary cell cultures based on the p

199 ion spectroscopy and biochemical analysis of genetically altered primases.

200 Prominent examples include genetically altered receptor tyrosine kinases and dysreg

201 Further characterization of this genetically altered region revealed that it represents a

202 Oncolytic viruses are genetically altered replication-competent viruses that i

203 istration of anti-SCF antibodies or by using genetically altered, SCF-deficient mice, inhibits hepato

204 combined immunodeficient (SCID) mice and in genetically altered SCID mice expressing human PDGFRalph

205 ss, establishing direct associations between genetically altered splicing and complex traits has rema

206 The genetically altered strain was found to produce ErA, how

207 relevance of each receptor subtype, we used genetically altered strains of "knock-out" mice lacking

208 With myriad genetically altered strains on the C57BL/6 background an

209 LTBMC with genetically altered stromal cells offers an in vitro mod

210 Monitoring genetically altered T cells is an important component of

211 free antigen, local delivery of cytokines by genetically altered T cells, and interference with the f

212 h states have been previously observed for a genetically altered T7 and they are observed here for wi

213 he exchange can be monitored by the use of a genetically altered T7 DNA polymerase (gp5-Y526F) in whi

214 A genetically altered T7 DNA polymerase, T7 polDelta401-40

215 This genetically altered threshold for activation of MRL T ce

216 mpliant titins in a novel mouse model with a genetically altered titin splicing factor; integrative a

217 These studies utilized a yeast strain genetically altered to bypass a deletion of the normally

218 In these studies, we used mice genetically altered to contain no circulating antibody,

219 e, we examined repair in vivo in human cells genetically altered to disrupt or regulate the function

220 osinophilia, IgE production, and AHR in mice genetically altered to express either p31 Ii or p41 Ii i

221 Falpha-knockout (TNFalpha-KO) mice that were genetically altered to express elevated levels of tmTNFa

222 LZ1EBV, a recombinant EBV genetically altered to express LZ1, a derivative of LMP1

223 hain of Fc receptors (FcgammaR(-/-)) or mice genetically altered to lack circulating Ab (J(H)D) with

224 CdtB toxicity is not circumvented in yeast genetically altered to lack DNA damage checkpoint contro

225 he use of HPA-9b-specific MKs that have been genetically altered to lack nearby terminal sialic acid

226 The cells genetically altered to overexpress calpastatin display d

227 Additionally, animals genetically altered to overexpress MnSOD showed a signif

228 visiae has large number of genes that can be genetically altered to produce a multiple or pleiotropic

229 s in bone marrow, we assessed mice that were genetically altered to produce osteoblast-specific, acti

230 plantation of myelin-forming cells from pigs genetically altered to reduce the hyperacute response in

231 fic inhibitors and was not detected in cells genetically altered to remove TACE activity.

232 gene drive methods, in which mosquitoes are genetically altered to spread drive alleles throughout w

233 transplantation requires the engraftment of genetically altered totipotent hematopoietic stem cells

234 e by expanding its spectrum of action toward genetically altered tumor cells incapable of apoptosis.

235 Selective targeting of these genetically altered tyrosine kinases has resulted in sig

236 e of direct mutation and discuss whether non-genetically altered tyrosine kinases or their associated

237 A genetically altered vaccinia virus that is unable to rep

238 In parallel experiments, genetically altered VEGF164-deficient (VEGF120/188) mice

239 Recombinant wild-type Hsp27 and a genetically altered version of Hsp27 that is perpetually

240 In the present study we utilized a genetically altered version of M33 (termed R131A) in com

241 ene did not impair the replication of such a genetically altered virus in cultured cells.

242 It is hoped that these genetically altered viruses, in which the hemagglutinin

243 One strategy employs vectors--typically genetically altered viruses--for the delivery of exogeno

244 ific metabolic regulatory pathways have been genetically altered within the heart.