ライフサイエンスコーパス: genetically engineered

1 uantitative model of the aging landscape, we genetically engineered a long-lived equilibrium state ch

2 r phosmet detection in olive oil, based on a genetically-engineered acetylcholinesterase (AChE) immob

3 we generated an RPE-1 human cell line with a genetically engineered "analog-sensitive" PLK4(AS), whic

4 AM composition during gliomagenesis, we used genetically engineered and GL261-induced mouse models in

5 o create biosynthetic excitable tissues from genetically engineered and immortalized HEK293 cells wit

6 mes enabling cholesterol catabolism could be genetically engineered and introduced into human cells,

7 Employing inducible genetically engineered and orthotopic mouse models, we d

8 etection of response to temozolomide in both genetically engineered and patient-derived mutant IDH1 m

9 tified by HT-DBP induced tumor regression in genetically engineered and patient-derived xenograft (PD

10 ly attach disease-associated autoantigens to genetically engineered and to unmodified red blood cells

11 l-based assays, ex vivo palate cultures, and genetically engineered animal models have advanced our u

12 ilities and accelerated the pace of creating genetically engineered animal models.

13 ian Hydra vulgaris, using calcium imaging of genetically engineered animals to measure the activity o

14 uccess of immunotherapeutic approaches using genetically engineered antibodies and T cells modified w

15 and ('donor' neurons) bind to and activate a genetically-engineered artificial receptor on their syna

16 Here, we used cells from human tumors and a genetically engineered autochthonous mouse model of soft

17 elastomer hybrids that host various types of genetically engineered bacterial cells.

18 Here, as a proof of concept, genetically engineered BLNs, which display human epiderm

19 Genetically engineered Braf(V600E/WT) p53-null allograft

20 adly, we performed an organism-wide study in genetically engineered cancer models using mass cytometr

21 mechanistic studies applied to well-defined genetically engineered cell lines and tumors that initia

22 Here, it is reported that genetically engineered cell-membrane-coated magnetic nan

23 Research now supports this observation with genetically engineered cells and quantitative responses.

24 Using genetically engineered cells lacking all four TMTC genes

25 Notably, LmCen(-/-) is a genetically engineered centrin gene knock-out mutant str

26 lastin-like polypeptides (ELPs) constitute a genetically engineered class of 'protein polymers' deriv

27 en globally used in basic plant research and genetically engineered crops (1-4) .

28 Genetically engineered crops have been grown for more th

29 l changes; and (iii) onerous regulations for genetically engineered crops have only contributed to un

30 the studies involved in safety assessment of genetically engineered crops includes characterizing the

31 Ensuring equitable access to the benefits of genetically engineered crops requires affirmative polici

32 ss-resistance threaten the sustainability of genetically engineered crops that produce insecticidal t

33 Beyond reviewing scientific prospects for genetically engineered crops, we address the social inst

34 series of adoptive transfer experiments with genetically engineered donors and recipients demonstrate

35 rence in pHCA production yield between three genetically engineered E. coli strains was successfully

36 p-coumaric acid (pHCA) in the supernatant of genetically engineered Escherichia coli (E. coli) cultur

37 ELP-OPH was simply purified from genetically engineered Escherichia coli based on the uni

38 We hypothesized that microorganisms genetically engineered for low urease activity would ach

39 Serratia AS1 was genetically engineered for secretion of anti-Plasmodium

40 icroalgae oil from Phaeodactylum tricornutum genetically engineered for this purpose, as well as tall

41 To achieve this, we created the genetically-engineered [Fsp1-Flpo; (FSF)TGFbeta(CA)] mou

42 n synthetic biology, methods for stabilizing genetically engineered functions and confining recombina

43 Genetically engineered GCSF-R is similar to an antibody

44 modern farming, especially as it relates to genetically engineered (GE) crops.

45 d products for the presence of material from genetically engineered (GE) plants is typically done usi

46 Here, we examine the use of genetically engineered (GE) sterile female layer chicken

47 Tumors from genetically engineered glioblastoma mouse models initiat

48 eth cells (induced by maternal separation or genetically engineered) have intestinal expansion of E c

49 oietic stem cells and reconstitution of this genetically engineered hematopoietic system in mice.

50 LILRB1) transgenic mice, humanized mice, and genetically engineered HLA-G dimer, we demonstrated a no

51 stigated cellular and behavioral outcomes in genetically engineered human APOE targeted replacement (

52 Using genetically engineered human induced pluripotent stem ce

53 In this study, we used genetically engineered human induced pluripotent stem ce

54 nd their capacity to penetrate tumors(5), we genetically engineered human macrophages with CARs to di

55 omental adipocytes from Sparc knockout mice, genetically engineered human omental adipocytes in 3D co

56 e introduce a cancer modeling paradigm using genetically engineered human pluripotent stem cells (hiP

57 e at its low endogenous expression level, we genetically engineered human pluripotent stem cells (hPS

58 to individual homologous chromosomes using a genetically engineered hybrid mouse.

59 We generated genetically engineered inducible mice and showed that H3

60 protein genes of DENV-1, DENV-3, and DENV-4 genetically engineered into the attenuated TDV-2 genome

61 Here, we have used a genetically engineered knockin reporter mouse to map the

62 Methods: Genetically engineered KPC (KRas(LSL.G12D/+); p53(LSL.R1

63 Methods: Genetically engineered KPC mice (KRasLSL.G12D/+; p53LSL.

64 reatic cancer, next-generation sequencing of genetically engineered Kras-driven mouse pancreatic tumo

65 y on cellular transplantation into mice with genetically engineered liver injury, but these systems i

66 In genetically engineered lung and pancreatic cancer tumour

67 sensor system by utilizing self-assembly of genetically engineered M13 bacteriophage.

68 Students participating in the International Genetically Engineered Machine (iGEM) competition are on

69 Ps with brain-targeted exosomes derived from genetically engineered mammalian cells by using the mech

70 f the compounds and the minute quantities of genetically engineered material that may be available fo

71 However, genetically engineered MCH receptor-1 knockout (MCHR1-KO

72 ing antitumor immunity in B16 melanoma and a genetically engineered melanoma.

73 of the constituent Mn(2+) and Ca(2+) ions in genetically engineered membranes of the cyanobacterium S

74 plantation, atypical neurofibromas generated genetically engineered mice (GEM)-PNST similar to human

75 Genetically engineered mice (GEMs) have provided valuabl

76 Interfering in this process using genetically engineered mice affects hemostatic and throm

77 rs to metastasis and together with data from genetically engineered mice and experimental metastasis

78 xploit fluorescent reporters of cell type in genetically engineered mice and is compatible with fresh

79 hree-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograf

80 countered in children with NF1, we developed genetically engineered mice harboring two representative

81 Increasing or decreasing Cdk5 activity in genetically engineered mice has severe consequences on T

82 While genetically engineered mice have made an enormous contri

83 s into three groups: (i) inbred models, (ii) genetically engineered mice in which genes of interest a

84 Methods to create genetically engineered mice involve three major steps: h

85 Isolation of ECs from genetically engineered mice is important for downstream

86 Genetically engineered mice lacking PIKfyve in their mye

87 Using genetically engineered mice on different diets, we found

88 Recent studies with genetically engineered mice reported that during pulmona

89 ng human monoclonal antibodies by immunizing genetically engineered mice that have a full set of huma

90 Here, we used genetically engineered mice to investigate the effects o

91 ccination failed until recent experiments in genetically engineered mice were finally successful.

92 We have generated genetically engineered mice with inactivated Gas2.

93 PDAC) cells, patient-derived xenografts, and genetically engineered mice with Kras G12V and Cdkn2a-nu

94 ered in the therapeutic setting to Braf/Pten genetically engineered mice, Lm(at)-LLO causes a strong

95 By using genetically engineered mice, we found that IgE ablation

96 Studying genetically engineered mice, we found that the deletion

97 Genetically engineered mice, with human P2X7R, revealed

98 DAC tumors driven by Kras/Trp53 mutations in genetically engineered mice.

99 seen in spontaneous colon tumors arising in genetically engineered mice.

100 rimary sarcomas efficiently in wild type and genetically engineered mice.

101 d-test" cycle paradigm, massive libraries of genetically engineered microbes can be constructed and t

102 value-added chemicals.Screening libraries of genetically engineered microbes for secreted products is

103 Using genetically engineered mimics of polyubiquitylated PCNA,

104 ologous differentiation, yielding a faithful genetically engineered model of this cancer type.

105 red to CCR, ICR decreased tumor incidence in genetically engineered models (RR = 0.57; 95% CI: 0.37,

106 Deletion of Mycl in two genetically engineered models of SCLC resulted in strong

107 GF-1 and leptin and increases adiponectin in genetically engineered models.

108 ed both in A549 lung cancer cells as well as genetically engineered mouse adenocarcinoma tissues.

109 By using a genetically engineered mouse expressing a G protein-bias

110 vivo, we have developed a method based on a genetically engineered mouse harboring a conditional Hal

111 tumor growth properties, we first created a genetically engineered mouse line lacking functional Muc

112 verexpression of Muc5ac was also observed in genetically engineered mouse lung adenocarcinoma tissues

113 re, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages

114 y collects fluorescently labeled CTCs from a genetically engineered mouse model (GEMM) for several ho

115 We generated a PIK3CA genetically engineered mouse model (PIK3CA-GEMM) in whic

116 ine resistance by utilizing tissues from the genetically engineered mouse model and human pancreatic

117 Integrating a genetically engineered mouse model and human prostate ca

118 the early lesion of pancreatic cancer, in a genetically engineered mouse model and in human patient

119 in treating GATA4-deficient lung cancers in genetically engineered mouse model as well as patient-de

120 The Th-MYCN genetically engineered mouse model develops rapidly prog

121 Here, we present a new genetically engineered mouse model for non-AR-driven pro

122 sk neuroblastoma, we generated a MYCN-driven genetically engineered mouse model in which the tamoxife

123 Using a genetically engineered mouse model incapable of undergoi

124 In a genetically engineered mouse model of cancer, GUS inhibi

125 Here we report the development of a genetically engineered mouse model of gastric adenocarci

126 ls from primary tumors and metastases from a genetically engineered mouse model of human small cell l

127 s and in an autochthonous, highly aggressive genetically engineered mouse model of LUAD, driven by ac

128 programmed cell death-1 (PD-1) blockade in a genetically engineered mouse model of melanoma driven by

129 TTM also provided a survival advantage in a genetically engineered mouse model of melanoma, and when

130 cal memory and controlled tumour growth in a genetically engineered mouse model of melanoma.

131 umor burdens in syngeneic tumor models and a genetically engineered mouse model of melanoma; to our k

132 In a genetically engineered mouse model of mutant Kras with c

133 gression and chemoresistance, we developed a genetically engineered mouse model of MYCN-overexpressin

134 In a genetically engineered mouse model of non-small cell lun

135 We analyzed plasma samples from a genetically engineered mouse model of pancreatic cancer

136 dy, we used a tumor cell line derived from a genetically engineered mouse model of PDA to investigate

137 In an autochthonous genetically engineered mouse model of PDA, halofuginone

138 Sensory denervation of a genetically engineered mouse model of PDAC led to loss o

139 preclinical mouse model represents the first genetically engineered mouse model of poorly differentia

140 Herein, we describe a genetically engineered mouse model of PSCC, by co-deleti

141 a conditional knockout of Coronin 1C with a genetically engineered mouse model of PTEN/BRAF-driven m

142 Using RapidCaP, a genetically engineered mouse model of Pten/Trp53 mutant

143 OR as a putative tumor suppressor, we used a genetically engineered mouse model to delete exons 9/10

144 Using a genetically engineered mouse model to generate a rich me

145 To visualize TRPV1-lineage axons, a genetically engineered mouse model was used in which a f

146 In this study, we established a new genetically engineered mouse model with Bccip deficiency

147 wed for the sensitive detection of DIPG in a genetically engineered mouse model, and probe uptake cor

148 an medulloblastoma compared to a MYCN-driven genetically engineered mouse model.

149 creatic neuroendocrine tumors (PanNETs) in a genetically engineered mouse model.

150 tumor growth in a spontaneous breast cancer genetically engineered mouse model.

151 studies were identified, including 11 using genetically engineered mouse models (908 animals with 38

152 Genetically engineered mouse models (GEMM) have been cru

153 Preclinical studies using genetically engineered mouse models (GEMM) have the pote

154 xperimental animals often hinders the use of genetically engineered mouse models (GEMM) in cancer res

155 Although genetically engineered mouse models (GEMMs) are commonly

156 Genetically engineered mouse models (GEMMs) of cancer ha

157 Genetically engineered mouse models (GEMMs) of Kras muta

158 Redd1 deletion in genetically engineered mouse models (GEMMs) of KRAS-depe

159 can be achieved using organoids derived from genetically engineered mouse models (GEMMs), wild-type o

160 s and a better signal to background ratio in genetically engineered mouse models (GEMMs).

161 a series of ex vivo and in vivo studies with genetically engineered mouse models and diabetic human m

162 iewed through the lens of fate mapping using genetically engineered mouse models and from the perspec

163 Herein, we leverage genetically engineered mouse models and human biospecime

164 n KRAS mutant tumors has been established in genetically engineered mouse models and human tumor cell

165 re dependent NRG1 signaling in vivo, in both genetically engineered mouse models and human xenograft

166 In both genetically engineered mouse models and murine xenograft

167 Here, by using genetically engineered mouse models and organoids, we as

168 By developing genetically engineered mouse models and primary pancreat

169 that ICR exerts greater anticancer effect in genetically engineered mouse models but weaker cancer pr

170 Conventional genetically engineered mouse models enable the study of

171 Here, using a panel of 16 distinct genetically engineered mouse models for breast cancer, w

172 They describe novel genetically engineered mouse models harboring cancer-ass

173 Genetically engineered mouse models have demonstrated th

174 Genetically engineered mouse models have identified mech

175 Genetically engineered mouse models have revolutionized

176 Here, we use Rad51ap1-knockout mice in genetically engineered mouse models of breast cancer to

177 We used genetically engineered mouse models of glioma and quanti

178 Genetically engineered mouse models of HGSC recapitulati

179 clinically relevant autochthonous tumours in genetically engineered mouse models of intestinal cancer

180 Ablation of Mir181ab1 in genetically engineered mouse models of Kras-driven lung

181 Here, we show in genetically engineered mouse models of locally induced e

182 In genetically engineered mouse models of lung and pancreat

183 In genetically engineered mouse models of lung cancer, expr

184 respectively, was evaluated in implanted and genetically engineered mouse models of lymphoma and in a

185 Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited t

186 y significantly inhibited tumor formation in genetically engineered mouse models of pancreatic cancer

187 In genetically engineered mouse models of PDA, Rgs16::GFP i

188 prostate cancer-associated SPOP mutations in genetically engineered mouse models of SPOP-mutant prost

189 Loss of EphA2 function in both human and genetically engineered mouse models of TNBC reduced tumo

190 Impairing Gata6 in genetically engineered mouse models reduces the prolifer

191 Genetically engineered mouse models reveal that ERG over

192 Genetically engineered mouse models that employ site-spe

193 the clinical features of NF1 and the use of genetically engineered mouse models to define the molecu

194 Here, we review the application of genetically engineered mouse models to radiosensitize tu

195 que opportunity to create a versatile set of genetically engineered mouse models useful for COVID-19

196 1 in normal tissue homeostasis, we generated genetically engineered mouse models where we can conditi

197 s of germline loss-of-function mutations and genetically engineered mouse models with inactivation of

198 ible lentiviral systems, tumor initiation in genetically engineered mouse models, and gene-targeting

199 nt-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be conver

200 In xenograft and genetically engineered mouse models, the WDR4/PML axis e

201 In addition to patient samples and genetically engineered mouse models, we developed organo

202 Among candidate transporters investigated in genetically engineered mouse models, we provide evidence

203 Here, using genetically engineered mouse models, we provide preclini

204 Kras driven pancreatic carcinogenesis using genetically engineered mouse models.

205 against skin carcinogenesis was examined in genetically engineered mouse models.

206 ategies against metastatic melanoma, using a genetically engineered mouse rather than xenograft model

207 yroid gland epithelial cells and a series of genetically engineered mouse strains as model systems to

208 in knockout, transgenic, and other types of genetically engineered mouse strains.

209 e these processes and suppress metastasis in genetically engineered mouse transplantation models of D

210 In a genetically-engineered mouse model of lung adenocarcinom

211 Using genetically engineered murine liver models, we show that

212 MYCN-targeted small-molecule inhibitors in a genetically engineered murine model of MYCN-driven neuro

213 s response to vascular-targeted therapy in a genetically engineered murine model of neuroblastoma.

214 ired metastatic locations) isolated from two genetically engineered murine models of OS.

215 n contributes to tumorigenesis, we establish genetically engineered murine models with Arid1a and/or

216 ferentiation into macrophages in vitro Using genetically engineered murine pre-B cells that secrete d

217 resses tumour growth and extends survival of genetically-engineered murine models of PDA.

218 including patient-derived xenograft and the genetically engineered mutant KRAS-driven lung cancer mo

219 Genetically engineered Nf1(flox/flox);PostnCre (+) mice,

220 Genetically engineered Nf1(flox/flox);PostnCre(+) mice,

221 in gene editing have enabled the creation of genetically engineered non-human-primate models, which m

222 Here we use genetically engineered, non-transformed primary murine c

223 variety of conditions to test the ability of genetically engineered nonarrhythmogenic stabilizer cell

224 in-resistant Staphylococcus aureus (MRSA) is genetically engineered on to the surface of cell membran

225 metastatic angiosarcoma independent of other genetically engineered oncogenes or tumor suppressor los

226 These data suggest that a combination of a genetically engineered oncolytic reovirus and topoisomer

227 sive overview of preclinical models covering genetically engineered organisms, models of transplantat

228 Here, we use genetically engineered orthotopic mouse models of breast

229 of this study was to evaluate the impact of genetically engineered OX3097D-Bol olive fly on three no

230 measuring the electrogenicity of hundreds of genetically engineered P. aeruginosa mutants is needed.

231 o aid the attribution of outbreaks caused by genetically engineered pathogens, and thus protect again

232 Using CRISPR/Cas9 genome editing to generate genetically engineered PfCRT variants in the parasite, w

233 roach to generate anephrogenic foetuses in a genetically engineered pig model.

234 al groups have reported extended survival of genetically engineered pig organs in nonhuman primates,

235 is problem could be resolved if kidneys from genetically engineered pigs offered an alternative with

236 Overall, genetically engineered plant defenses can benefit plant

237 The first genetically engineered plants were grown commercially in

238 Developing genetically engineered probiotics holds great promise as

239 iological adhesives are presented, including genetically engineered protein-based adhesives and biomi

240 their structural and functional properties, genetically engineered protein-based hydrogels have emer

241 cademia as well as industry routinely create genetically engineered proteins as a part of their resea

242 The development of genetically engineered proteins that can control cell ex

243 To accomplish this, genetically engineered proteins were previously required

244 With a genetically engineered pulse of GATA-binding protein 6 (

245 are tethered covalently and specifically to genetically engineered receptors.

246 s, fluctuations are typically assessed using genetically engineered reporter cell lines that produce

247 Here, we established a genetically engineered SCCB model and a cohort of patien

248 port of a recombinant rotavirus containing a genetically engineered segment 7 dsRNA.IMPORTANCE Previo

249 ated from their mothers as newborns and mice genetically engineered (Sox9(flox/flox)-vil-cre on C57BL

250 Here, we genetically engineered strains of Cryptosporidium to mak

251 We used genetically engineered strains of mouse norovirus (MNV)

252 ere incubated with RBC isolated from various genetically engineered swine or from humans.

253 To address this possibility, we introduced a genetically engineered switch receptor construct, compri

254 This study showcases the only genetically engineered system capable of serving the dua

255 Genetically engineered T cells are powerful new medicine

256 Treatment consisted of autologous genetically engineered T cells expressing a T-cell recep

257 Adoptive transfer of genetically engineered T cells expressing antigen-specif

258 Adoptive immunotherapy with genetically engineered T cells has the potential to trea

259 Genetically engineered T cells have shown promising acti

260 imeric antigen receptor) T cells (CARTs) are genetically engineered T cells that express CARs, with i

261 Genetically engineered T-cell therapy is an emerging tre

262 iet (HFD) induced diabetic mouse model and a genetically engineered T2DM rat model.

263 ility of tocochromanols in tomato fruits and genetically engineered their biosynthetic pathway.

264 n is magnetogenetics, where ion channels are genetically engineered to be closely coupled to the iron

265 e describe a novel model of SFTS in hamsters genetically engineered to be deficient in a protein that

266 ging of MDA-MB-231 human breast cancer cells genetically engineered to brightly express membrane-targ

267 In the future, the pigs will also be genetically engineered to control the adaptive immune re

268 On the other hand, platelets have been genetically engineered to correct inherited bleeding dis

269 Yeast cell lines were genetically engineered to display Hepatitis C virus (HCV

270 The phage is genetically engineered to display many copies of an iden

271 pigs with all PERVs inactivated can also be genetically engineered to eliminate three xenoantigens a

272 successful application on Arabidopsis lines, genetically engineered to enhance thiamine content.

273 lycogen synthase-3beta inhibitor TWS119, and genetically engineered to express a CD19-specific chimer

274 ucted a clinical trial of allogeneic T cells genetically engineered to express a chimeric antigen rec

275 nistering autologous CD4(+) T cells that are genetically engineered to express an MHC class II-restri

276 T cells genetically engineered to express CARs can specifically

277 T cells genetically engineered to express chimeric antigen recep

278 (CMV) vaccine (V160) derived from AD169 and genetically engineered to express CMV pentameric complex

279 Adipose-derived stem cells (ASCs) were genetically engineered to express recombinant secretory

280 Analyses of mice genetically engineered to harbour these human TPM1 and V

281 Mice were genetically engineered to inactivate BRG1 specifically i

282 Bacteria can be genetically engineered to kill specific pathogens or inh

283 Mice genetically engineered to lack Ccr2 and wild-type mice w

284 infusion of bone marrow-derived macrophages genetically engineered to overexpress murine MCAD marked

285 Here, megakaryocyte progenitor cells are genetically engineered to overexpress PD-L1 to produce i

286 he following: Live bacterial sensor strains, genetically engineered to produce a dose-dependent amoun

287 t resistance threatens the benefits of crops genetically engineered to produce insecticidal proteins

288 thalamic stem/progenitor cells that had been genetically engineered to survive in the ageing-related

289 They can be genetically engineered to target nanoparticles, cells, t

290 wn commercially in 1996, and the most common genetically engineered traits are herbicide and insect r

291 targets for genetic containment of exotic or genetically engineered trees.

292 We further demonstrate that our genetically engineered tumor model is a representative t

293 To bridge ACT with a pathogen, we genetically engineered tumor-specific CD8 T cells in vit

294 of ORAI1 at the leading edge was studied in genetically engineered U2OS cells lacking ORAI1 expressi

295 Here we used genetically engineered ubiquitin (Ub) proteins in order

296 n which endogenous MerTK was replaced with a genetically engineered variant that is cleavage-resistan

297 ll lines, along with primary infection using genetically engineered viral particles coupled with rece

298 We find that iNSCs genetically engineered with optical reporters and tumour

299 ensor relies on immobilized HEK293 spheroids genetically engineered with powerful red- and green-emit

300 mpacts presynaptic release by establishing a genetically engineered zebrafish line in which we can fr