ライフサイエンスコーパス: genetically modified

1 cal, organic, grass-fed, farmed/wild, or non-genetically modified.

2 tably, also unstimulated T cells were stably genetically modified.

3 - and interpatient heterogeneity, and can be genetically modified.

4 binant rotavirus (rSA11/NSP3-FL-UnaG) with a genetically modified 1.5-kb segment 7 dsRNA encoding ful

5 he presence of those dark states in both the genetically modified and the wild-type light harvesting

6 organism involved in such an event has been genetically modified and, if modified, to infer from its

7 HSCs) can be safely collected from the body, genetically modified, and re-infused into a patient with

8 has greatly improved the ability to generate genetically modified animal models of human diseases.

9 future uses of this knowledge for generating genetically modified animal models permissive for these

10 By using genetically modified animal models, pharmacologic inhibi

11 rs in situ in combination with sophisticated genetically modified animal models, together with bioche

12 tudies of presymptomatic, at-risk cases) and genetically modified animal models.

13 tools have revolutionized the generation of genetically modified animals including livestock.

14 y transferred to assess their persistence in genetically modified animals lacking distinct lung APC s

15 perimental results obtained in vitro or with genetically modified animals with human disease.

16 mice from different genetic backgrounds and genetically modified animals with in silico and in vitro

17 To generate genetically modified animals, CRISPR/Cas9-mediated genom

18 en interpreting results of experiments using genetically modified animals, since the genotypic compos

19 ased ST fiber proportion are demonstrated in genetically modified animals.

20 tial for exciting new cellular therapy using genetically modified anti-CD19 CAR T cells and discuss i

21 Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 a

22 Clinical responses to the genetically modified apples were compared to those seen

23 vel application by which immune cells can be genetically modified as potential therapeutics to treat

24 In the past, genetically modified ASFVs harboring deletions of virule

25 on ASFV virulence lead to the production of genetically modified attenuated viruses that induce prot

26 Therapy with genetically modified autologous T cells has shown great

27 We used both wild-type and genetically modified B. burgdorferi s. l. bacteria, reco

28 The use of live, genetically modified bacteria as delivery vehicles for b

29 ng note of caution on the employment of live genetically modified bacteria for the delivery of biolog

30 ng MDA-MB-468 or HT1080 xenografts and using genetically modified BALB/neuT mice, which spontaneously

31 ystems, murine tumor models in wild-type and genetically modified (beta2-AR-/-) mice, and adoptive tr

32 s of reduced Brd1 expression, we generated a genetically modified Brd1(+/-) mouse and subjected it to

33 Human HAP1 and A549 cells were genetically modified by clustered regularly interspaced

34 Zygotes at the 1-cell stage have been genetically modified by microinjecting the CRISPR/Cas9 c

35 MSCs are genetically modified by transfection with the mms6 gene

36 ated immune responses to PVM in a variety of genetically modified C57BL/6 mice.

37 These cells, if genetically modified, can be used as vehicles to deliver

38 avoidance of the undesired rendering of the genetically modified CD8 T cells susceptible to HIV infe

39 try, live-cell imaging, pulldown assays, and genetically-modified cell lines supported that roseltide

40 ified with ethyl esters preferentially label genetically modified cells that express a substrate-sele

41 bind to surface-expressed HaloTag enzyme on genetically modified cells.

42 ovel approach using a Cre-dependent virus in genetically modified ChAT::Cre rats, a species used for

43 ion, the demonstrated safety and activity of genetically modified chimeric antigen receptor (CAR) T c

44 Genetically modified conditional lethal strains have bee

45 vitro models allow the investigation of the genetically modified counter-regulator of motoneuron tox

46 Using DUSP4 transfection models and genetically modified CREM-deficient and CREMalpha-overex

47 s that may be important in future studies of genetically modified crickets for improved food producti

48 acterial source can be useful for developing genetically modified crops and can function similarly to

49 and examines the potential of microalgae and genetically modified crops as future sources of these im

50 Unlike genetically modified crops such as corn or soybean, sorg

51 ed the micropropagation of elite hybrids and genetically modified crops, but the mechanism responsibl

52 loss of milkweed resources for larvae due to genetically modified crops, pesticides, and fertilizers;

53 nt intensity, climate change, pesticides and genetically modified crops, pollinator management and pa

54 Genetically modified cultures have been grown for 1 year

55 ormal mice observing excessive scratching in genetically modified demonstrator mice.

56 y increased reprogramming efficiencies using genetically modified donor cells, prospectively isolatin

57 Here, using genetically-modified DT40 B lymphocytes, along with vari

58 type females, whereas wild-type males prefer genetically modified females.

59 What consumers don't know about genetically modified food, and how that affects beliefs.

60 Genetically modified foods are a major concern around th

61 s widespread agreement among scientists that genetically modified foods are safe to consume(1,2) and

62 extremity of opposition to and concern about genetically modified foods increases, objective knowledg

63 cs decreases, but perceived understanding of genetically modified foods increases.

64 us polarization regarding nanotechnology and genetically modified foods.

65 or BP, and healthy subjects, as well as mice genetically modified for insulin signaling.

66 With a genetically modified form of the flavoenzyme TrmFO as a

67 oduce bioactive GAs in planta Furthermore, a genetically modified GA3ox5 variant in which these three

68 of photoswitch ligands and the complementary genetically modified GABA(A) receptor subunits.

69 oswitches (section 1) for photoactivation of genetically modified glutamate receptors (section 2).

70 benefits and costs on the production side of genetically modified (GM) and organic corn systems in Mi

71 ctants (PIPs) are biopesticides expressed in genetically modified (GM) crops and are typically macrom

72 lepias spp.) host plant, have been linked to genetically modified (GM) crops and associated herbicide

73 Because the number and diversity of genetically modified (GM) crops has significantly increa

74 With the large-scale release of genetically modified (GM) crops, there are ecological co

75 food supplements were found positive for the genetically modified (GM) elements P-35S and T-nos.

76 ation of Aquadvantage(R) GM salmon on future genetically modified (GM) fish to be commercialized.

77 With genetically modified (GM) food circulating on the market

78 In the debates surrounding biotechnology and genetically modified (GM) food, data from consumer polls

79 Despite heated debates over the safety of genetically modified (GM) food, GM crops have been expan

80 sure Standard requires a mandatory label for genetically modified (GM) food.

81 Genetically modified (GM) maize and their non-modified c

82 Glyphosate tolerant genetically modified (GM) maize NK603 was assessed as 's

83 the tissue microenvironment, via the use of genetically modified (GM) mice or agents such as antibod

84 d feed additives result from fermentation of genetically modified (GM) microorganisms.

85 drive the expression of phytotoxic BP100 in genetically modified (GM) rice.

86 th both type 1 and type 2 viruses, pigs were genetically modified (GM) to possess one of the followin

87 osum L. cv. Desiree) tubers, which have been genetically modified (GM) to reduce glycoalkaloid conten

88 was a key target for researchers engineering genetically modified (GM) tomatoes in the 1990s, but onl

89 of non-amplified genomic DNA extracted from genetically modified (GM)-Soy.

90 R, gene drives, RNAi, synthetic biology, and genetically modified [GM] insects and fish), provide a p

91 nvestigated the use of CHC to protect WT and genetically modified (GTKO.hCD46.hTBM) pig aortic endoth

92 ent donors and autologous transplantation of genetically modified hematopoietic stem cells, are curre

93 g existing conventional weed management with genetically modified, herbicide-tolerant (GMHT) crops, f

94 Genetically modified HIEs for innate immune genes are us

95 Genetically modified hiPSCs expressing CRBN E377V/V388I

96 Compared to methods that require genetically modified histones, our DNase-based approach

97 In mice, HO-1 overexpression by genetically modified HO-1 macrophage therapy was accompa

98 py, involving the transplantation of ex vivo genetically modified HSPCs are complex and not without r

99 Gene therapy with genetically modified human CD34(+) hematopoietic stem an

100 Using genetically modified human cells that are deficient in D

101 l cell cultures, including the production of genetically modified human neural progenitor cells (hNPC

102 y based on epitope mapping data to develop a genetically modified hypoallergenic variant showing prot

103 Adoptive transfer of genetically modified immune cells holds great promise fo

104 BR/08 was the most pathogenic in genetically modified immunocompromised mice [BALB scid a

105 Several chemically or genetically modified insulins have been developed that t

106 by performing experimental infections in two genetically modified invertebrate models (Drosophila mel

107 c maturation of iPS-HPCs, and indicates that genetically modified iPS-HSCs will be of value for resea

108 We used genetically modified isolates and recombinant P. falcipa

109 Quo (2) by measuring the calcium response in genetically modified Jurkat T-cells under varying ligand

110 Previously, we have shown that genetically modified Leishmania donovani parasites, here

111 tronic spectroscopy with the availability of genetically modified light harvesting complexes, to reve

112 aturally occurring, cell culture-adapted, or genetically modified live attenuated ASFV.

113 erimental vaccines have been developed using genetically modified live attenuated ASFVs where viral g

114 are currently undergoing testing, including genetically modified live-attenuated parasite vaccines.

115 ntibiotic resistance-conferring plasmids and genetically modified lytic phages.

116 Second, a genetically modified MA104 cell line was used in which s

117 d to be the optimal administration route for genetically modified macrophages, which accomplished tar

118 ese changes result in a mating preference of genetically modified males for wild-type females, wherea

119 al, high-frequency region of the cochleae of genetically modified mice (including models of human her

120 Mechanistic studies were carried out using genetically modified mice and depletion of lymphocyte su

121 Using genetically modified mice and inhibitor treatments, we f

122 Interestingly, both genetically modified mice gained significantly less body

123 Sharp tuning in genetically modified mice has been attributed to decreas

124 Genetically modified mice have advanced our understandin

125 Genetically modified mice have been used extensively to

126 Recent experiments in genetically modified mice have demonstrated that mutatio

127 nd-healing assay was performed in 3 types of genetically modified mice having various Nur77 activitie

128 Here we describe compound genetically modified mice in which expression of the end

129 we used both pharmacological inhibitors and genetically modified mice models to investigate the iden

130 The study of renal miRNAs, using genetically modified mice or by perturbing endogenous mi

131 escent imaging of kidney sections from these genetically modified mice revealed that RhoA and AQP2 ac

132 vations, altogether with those obtained from genetically modified mice targeting individual CRMPs and

133 f CD103(+) DCs in cGN using several lines of genetically modified mice that allowed us to reduce the

134 In this work, we used genetically modified mice to allow conditional expressio

135 We also used genetically modified mice to define the roles of Chi3l1

136 In this study, we use genetically modified mice to investigate the role of Gal

137 In this study, we used genetically modified mice to study the light responses a

138 Implications for studies involving genetically modified mice treated with topical agents an

139 Studies with genetically modified mice were performed.

140 ugs acting on the endocannabinoid system and genetically modified mice were used.

141 In this study, we used genetically modified mice with a mutation (KR389-390AA)

142 We then show that genetically modified mice with CARMA3-deficient AECs hav

143 as 40% suppressed ventricular arrhythmias in genetically modified mice with catecholaminergic polymor

144 tes in regulating intact FGF23 production in genetically modified mice without and with adenine-induc

145 By analyzing cell lines, genetically modified mice, and HCC tissues, we found tha

146 Our findings in cells, genetically modified mice, and human vascular specimens

147 bal and regional ischemia/reperfusion (I/R), genetically modified mice, and primary cell culture, to

148 SG-DUC1 and mSG-PAC1 cells were derived from genetically modified mice, homozygous for floxed alleles

149 In Kras(G12D)/Pdx1-Cre/Tp53/Rosa(YFP) genetically modified mice, oral administration of SLC-01

150 n proteomic screen of endothelial cells from genetically modified mice, R-Ras, known to promote vesse

151 Using genetically modified mice, we addressed the contribution

152 Using platelets from humans and genetically modified mice, we demonstrate that binding o

153 During our examination of genetically modified mice, we discovered a series of pro

154 Using genetically modified mice, we found that imiquimod-induc

155 Using genetically modified mice, we have shown that renal phos

156 Using genetically modified mice, we show a dynamic role of RGS

157 Using a combination of genetically modified mice, we show that the coordinated

158 Using genetically modified mice, we systematically examined th

159 r phenotype of liver damage than those using genetically modified mice, with the exception of the chr

160 es to inflammatory sites was investigated in genetically modified mice.

161 ospholamban and the ryanodine receptor using genetically modified mice.

162 Wild type and genetically modified mice.

163 the in vivo function of patient-derived and genetically modified microglia.

164 e a promising alternative to monocultures of genetically modified microorganisms for complex biotrans

165 an impressive array of applications based on genetically modified microorganisms.

166 CTCs) in two mouse models of mammary cancer: genetically modified MMTV-PyMT mice and orthotopically g

167 We incorporate information provided by genetically modified models, as well as pre-clinical and

168 Genetically modified mosquitoes are being tested, but th

169 We observed that genetically modified mosquitoes with increased immune ac

170 ancer cell lines (D54 and D54-EGFRvIII), and genetically modified mouse astrocytes (wild type, p53-/-

171 The ability to differentiate genetically modified mouse embryonic stem (ES) cells int

172 In this study, we used a genetically modified mouse line carrying the fat-1 gene

173 we review how recent advances obtained using genetically modified mouse lines bring new insights into

174 Here, we generated genetically modified mouse lines to better characterize

175 the generation and analysis of a variety of genetically modified mouse lines.

176 overy following a burn injury, we utilized a genetically modified mouse model (Pax7(CreER) -DTA) that

177 Here, we used a genetically modified mouse model and human patient data

178 nisms of severe PAH and identified the first genetically modified mouse model with obliterative vascu

179 lectrophysiological recordings together with genetically modified mouse models and human genetics hav

180 We found that 58% of articles involving genetically modified mouse models did not completely add

181 The proliferation of genetically modified mouse models has exposed phenotypic

182 Here we use several genetically modified mouse models to demonstrate that ex

183 was tested in mechanistic studies using two genetically modified mouse models with either constantly

184 en-induced arthritis by using PGRN and IL-10 genetically modified mouse models.

185 number of animals used in the production of genetically modified mouse models.

186 ecome a standard tool for the development of genetically modified mouse models.

187 Although thousands of genetically modified mouse strains have been cryopreserv

188 We developed a collection of genetically modified mouse strains recapitulating human

189 techniques, cell biology, and reagents from genetically modified murine models to test their hypothe

190 In addition, genetically modified mutant activated PC, with a high af

191 hydrodynamic effects of mastigonemes using a genetically modified mutant lacking the fibrous structur

192 unogenic after a single, human-range dose in genetically modified MV-susceptible mice.

193 By generating genetically modified newborn mice that specifically lack

194 ngs provide the first demonstration that the genetically modified non-human primate can be used for t

195 proposed method, we show detection of WT and genetically modified nonhalotolerant cells (Salmonella t

196 Genetically modified nonhuman primates (NHP) are useful

197 Mice (genetically modified or bone marrow-derived mast cell-re

198 viability and a normal karyotype, and can be genetically modified or differentiated into multiple cel

199 Mostly used genetically modified or tumor-prone models are less reli

200 real sample environment of extracted DNA of Genetically Modified Organism products.

201 ld-type ACT1 promoter.Genetic isolation of a genetically modified organism represents a useful strate

202 We illustrate our method on genetically modified organism, inhibition, dynamic range

203 Cultivation of genetically modified organisms (GMOs) and their use in f

204 The CRMs available in the field of genetically modified organisms (GMOs) are characterized

205 Methods to detect the presence of genetically modified organisms (GMOs) are evolving const

206 The steady increase in commercialization of genetically modified organisms (GMOs) demands low-cost,

207 The increased use of genetically modified organisms (GMOs) is accompanied by

208 containment systems are needed to neutralize genetically modified organisms (GMOs) that pose ecologic

209 EU regulations on the mandatory labeling of genetically modified organisms (GMOs) with a minimum con

210 ed by NBTs do not fall under the umbrella of genetically modified organisms (GMOs), their commerciali

211 ulation in supporting consumer acceptance of genetically modified organisms (GMOs).

212 des a robust strategy for the containment of genetically modified organisms and the development of sa

213 successfully exploited for biocontainment of genetically modified organisms by phosphite-dependent gr

214 Discrimination of genetically modified organisms is increasingly demanded

215 Genetically Modified Organisms, have been entered our fo

216 osafety Research (ISBR) focused on so-called genetically modified organisms.

217 r, and prevention of environmental escape by genetically modified organisms.

218 have low allergenicity and do not come from genetically modified organisms.

219 SPR/Cas9 systems) into embryos, for creating genetically modified organisms.

220 The use of genetically modified P. falciparum revealed that PfEMP1

221 Genetically modified PAEC significantly prolonged clotti

222 potential interventions, and propagation of genetically modified parasites.

223 Propitious concepts such as genetically modified phages, antibacterial oligonucleoti

224 s beyond 90 days was recently reported using genetically modified pigs and a clinically applicable dr

225 Genetically modified pigs missing specific organs are ke

226 m aureum, pothos ivy, and that the resulting genetically modified plant has sufficient detoxifying ac

227 overview of the biosafety and regulation of genetically modified plants and details different regula

228 the risk and safety assessment of RNAi-based genetically modified plants is also elucidated.

229 environmental risk and safety assessment of genetically modified plants is explained, and aspects of

230 In some cases, this might require the use of genetically modified plants when R genes cannot be intro

231 suggesting that pre-transplant perfusion of genetically modified porcine organs with CHC may benefit

232 Genetically modified primary human airway cultures estab

233 These findings were made in genetically modified primary human T cells and have a cl

234 and is often addressed by the development of genetically modified produce or chemical additives and i

235 rget retrograde infection of pseudotyped and genetically modified rabies virus evidence was found for

236 Thus, the novel genetically modified rats and data sets obtained in this

237 Here we used genetically modified rats and mice of both sexes to show

238 n rats with wild-type or mutated Add3 and in genetically modified rats with overexpression or knockou

239 f antioxidants between the wild-type and the genetically modified raw tomatoes were confirmed, but an

240 We have developed a genetically modified recombinant NDV (rNDV) that has muc

241 ding ASFV virulence led to the production of genetically modified recombinant viruses that, while att

242 A genetically modified, recombinant form of Newcastle dise

243 Studies in genetically modified rodent models suggest that activati

244 ating histological changes and physiology in genetically modified rodents.

245 His-tagged hGH variants in the cytoplasm of genetically modified Rosetta-gami B DE3 Escherichia coli

246 o digestion model, showed an increase in the genetically modified samples.

247 Here, we show that the genetically modified soybean oil Plenish, which came on

248 By using genetically modified stem cells and specific inhibitors,

249 We previously reported that a genetically modified strain of Mycobacterium smegmatis c

250 dy the biology of the RPE from wild-type and genetically modified strains of mice between the ages of

251 s that can preferentially target GSCs; thus, genetically modified strains that further optimize safet

252 Genetically modified T cells expressing chimeric antigen

253 Genetically modified T cells expressing chimeric antigen

254 Genetically modified T cells expressing engager molecule

255 Adoptive cell therapy with genetically modified T cells has generated exciting outc

256 Adoptive T cell therapy (ACT) with genetically modified T cells has shown impressive result

257 Purpose Adoptive transfer of genetically modified T cells is being explored as a trea

258 Recently, the success of genetically modified T cells that express chimeric antig

259 vely transferred back to the individual, the genetically modified T cells will hopefully provide dura

260 himeric antigen receptor T cells (CAR-T) are genetically modified T cells with a chimeric antigen rec

261 optive T-cell therapy and the development of genetically modified T cells, most notably CAR T-cell th

262 in 2,200- to 2,500-fold ex vivo expansion of genetically modified T cells, with 84% CAR expression, a

263 In the present study, we genetically modified the IRF5 and IRF4 signaling to expl

264 We genetically modified the Plasmodium falciparum K13 locus

265 Genetically modified TMV VLPs express both surface attac

266 vestigated the competitiveness of mosquitoes genetically modified to alter expression of their own an

267 Adoptive transfer of T cells genetically modified to express a cancer-specific T-cell

268 adoptive transfer of T cells that have been genetically modified to express a CD19-specific chimeric

269 Autologous T cells that have been genetically modified to express a chimeric antigen recep

270 Purpose T cells genetically modified to express chimeric antigen recepto

271 Adoptive transfer of T cells genetically modified to express chimeric antigen recepto

272 Autologous stem cells that have been genetically modified to express dystrophin are a possibl

273 virus, Epstein-Barr virus, or adenovirus and genetically modified to express HER2-CARs with a CD28.ze

274 RS-CoV-2 infects mice only if they have been genetically modified to express human ACE2.

275 (1)H-MRS of two cell lines genetically modified to express IDHmut showed that XL765

276 ultiple myeloma (MM) with autologous T cells genetically modified to express kappa.CAR (kappa.CARTs).

277 by a transgenic Plasmodium knowlesi parasite genetically modified to express PvDBP and to prevent ret

278 n between platelets and CTCs, platelets were genetically modified to express surface-bound tumor necr

279 cherichia coli BL21 (E coli BL21) strain was genetically modified to express the Morganella morganii

280 a1 is a novel target in testis that could be genetically modified to improve the bioavailability of F

281 paBbeta/NF-kappaB signaling, as well as mice genetically modified to overexpress IkappaBbeta, we show

282 Bt cotton was genetically modified to produce insecticidal proteins ta

283 hines in a virulent Shigella flexneri strain genetically modified to produce minicells capable of int

284 us indicating that a single regulator can be genetically modified to promote growth rate and reproduc

285 Adoptive immunotherapy with T cells genetically modified to recognize tumors is a promising

286 Genetically modified, transgenic hyperfibrinogenic (HFg)

287 Using genetically modified (TT305/6VA and T305D) mice, we iden

288 ects induced in both naturally occurring and genetically modified tumor-infiltrating lymphocytes (TIL

289 be engineered to enter B-cell follicles, we genetically modified unselected CD8 T cells to express C

290 T cells were genetically modified using DNA plasmids from the SB plat

291 ted a human application of T cells that were genetically modified using the Sleeping Beauty (SB) tran

292 Importantly, animals infected with this genetically modified virus were protected from developin

293 Using this genetically modified virus, we were able to vaccinate sw

294 Genetically modified viruses allow for cell-type-specifi

295 ic vaccinees could result in introduction of genetically modified viruses into sustainable tick-verte

296 sults highlight the significant potential of genetically modified VLPs as selective nanostructured pr

297 travenous infusion of autologous CD34+ cells genetically modified with a lentiviral vector encoding f

298 hich uses visible light to control the cells genetically modified with light-gated ion channels, is a

299 sm for studying development and disease, and genetically modified zebrafish provide an essential tool

300 r couple virus discovery with immunology, we genetically modified zebrafish to visually report on vir