ライフサイエンスコーパス: genetics

1 ontexts (e.g., cancer, mouse genetics, yeast genetics).

2 neering, synthetic biology, microbiology and genetics.

3 e use of immunostaining, methylation, and/or genetics.

4 anisms of CAR T-cell cytotoxicity and cancer genetics.

5 ts remains a major challenge in evolutionary genetics.

6 ty and the historical aspect of conservation genetics.

7 wed by analysis of their roles using reverse genetics.

8 s predictive models that leverage microbiome genetics.

9 lds of virology, genomics, and human disease genetics.

10 nique attributes for live imaging and facile genetics.

11 the extracted microbial metabolite and human genetics.

12 ily by the environment when compared to host genetics.

13 anel, for a variety of indications, by Ambry Genetics.

14 e DNA markers are essential for breeding and genetics.

15 machine learning with theoretical population genetics.

16 and how they are changing the field of mouse genetics.

17 dings of particular relevance to psychiatric genetics.

18 s limiting wider applications of conditional genetics.

19 ngs, ERG phenotype, and microscopy/molecular genetics.

20 onal analysis of genetic variants in reverse genetics.

21 es and traits is a grand challenge in modern genetics.

22 , published in The American Journal of Human Genetics.

23 nal adaptation in early pregnancy than fetal genetics.

24 er further distinguished in genetics and non-genetics.

25 tion they can convey in the context of human genetics.

26 ation and multiscale approaches in landscape genetics.

27 l for answering many questions in population genetics.

28 OCD for the best model, and direct additive genetics accounted for 35% (95% credible interval: 32.3%

29 ate mapping, single-cell genomics, and human genetics adds novel insights into the complexity of SMC

30 This study demonstrates that host genetics affects rumen bacterial community composition.

31 Brain imaging genetics aims to reveal genetic effects on brain phenoty

32 reased clinical experience in cardiomyopathy genetics, an improved understanding of the disease proce

33 Reverse genetics analyses showed that the ability to induce a ro

34 To address this, we perform a systems genetics analysis of the gut transcriptomes from 38 DGRP

35 A combination of reverse genetics and assays with Ifnar (-/-) mouse models reveal

36 ative structural biology combined with yeast genetics and biochemistry to highlight the specific func

37 Here, by combining mouse genetics and biochemistry with clinical tissue analysis,

38 re involve tailoring of therapy based on the genetics and biology of each tumour and the clinical cha

39 We used a combination of quantitative genetics and biophysics to rule out broad classes of mod

40 asses diverse areas of biology, ranging from genetics and biophysics to signal transduction and physi

41 is a need for scientific information on the genetics and breeding of A. digitata, including cytogene

42 view summarizes the current knowledge of the genetics and candidate modifier genes in PXE, a multifac

43 Here, we use human and mouse genetics and cell biological and biochemical approaches

44 h utilizing different genomes, understanding genetics and characterizing germplasm with efficient man

45 Cell biological analyses, genetics and chemical interference demonstrate that one

46 ovarian cancer xenografts (PDX), similar in genetics and chemotherapy responsiveness to human tumors

47 By integrating gene expression profiling, genetics and comprehensive phenotyping, we found that, p

48 Here, we use genetics and cryo-electron microscopy (cryo-EM) to study

49 s based on a combination of compelling human genetics and emerging preclinical data.

50 e pathogenesis, and the relationship between genetics and environment in the context of host defense.

51 To investigate how host genetics and environment influenced the oral microbial c

52 ropean cohorts (Epidemiological Study on the Genetics and Environment on Asthma and the European Comm

53 gnised but less explored is the interplay of genetics and environment within the broader blood lipido

54 tifactorial, with disease risk determined by genetics and environmental factors.

55 ted cardiotoxicity and highlight how patient genetics and epigenetics can facilitate researchers and

56 g the HA protein of H5N1 HPAIV using reverse genetics and evaluated the induction of neutralizing ant

57 the past 5 years have clarified the anatomy, genetics and function of the immune system within the ce

58 We combined yeast genetics and Gag mutational analysis with Gag-ESCRT bind

59 anscriptome provides essential reference for genetics and gene expression studies in rat disease and

60 ndings have important implications for human genetics and genome evolution.

61 dly applicable reference cohort for clinical genetics and genomic association studies, and for unders

62 according to the American College of Medical Genetics and Genomics and the Association for Molecular

63 based on current American College of Medical Genetics and Genomics criteria with incorporation of sig

64 ant history and emerging frontiers of cancer genetics and genomics from the perspective of global can

65 ied according to American College of Medical Genetics and Genomics guidelines.

66 ted into current American College of Medical Genetics and Genomics guidelines.

67 r-omics analyses with approaches in 'systems genetics and genomics'.

68 Through the integration of experimental genetics and genomics, our study provides useful resourc

69 delines from the American College of Medical Genetics and Genomics, pathogenic/likely pathogenic vari

70 While both the American College of Medical Genetics and Genomics/Association for Molecular Patholog

71 To elucidate the roles of genetics and geography in LTL variability across humans,

72 parasite developmental stages using reverse genetics and holds great potential to identify novel dru

73 e specific expertise beyond basic Drosophila genetics and husbandry, and confocal microscopy.

74 Using genetics and mathematical modeling, we develop an altern

75 s highlight gaps in our current knowledge of genetics and molecular mechanisms of complex phenotypes

76 is a heterogeneous disease characterised by genetics and morphology.

77 biochemical framework for interpreting plant genetics and mutant phenotypes.

78 tudy of lateral motor biases, its underlying genetics and neurodevelopment.

79 rs, with the latter further distinguished in genetics and non-genetics.

80 vances in this field regarding the molecular genetics and pathogenic mechanisms of CDAs, through an a

81 mating evolutionary parameters in population genetics and phylogenetics.

82 The complex underlying genetics and poor mechanistic understanding has caused a

83 n of REA data collection and use in clinical genetics and precision health research.

84 Advances in genetics and proteomics approaches have fostered signifi

85 However, genetics and SES are correlated, and no prior study has

86 Fields as diverse as human genetics and sociology are increasingly using polygenic

87 We develop new methods based on population genetics and variance components models to build between

88 understanding the relationships between host genetics and viral infections, the contributions of resp

89 diseases have unique clinical presentations, genetics, and available therapies.

90 This study combines in silico, molecular genetics, and biochemical analyses to characterize both

91 Advances in molecular biology, optics, genetics, and bioinformatics have opened the door to map

92 to comprehensively incorporate neuroimaging, genetics, and environmental factors to investigate the n

93 of, nor familiar with, the concepts of DNA, genetics, and genomics.

94 g in many aspects, including cell-of-origin, genetics, and pathology.

95 a combined strategy of functional screening, genetics, and proteomics we discovered a strain of Staph

96 quences, we perform phylogenetic, population genetics, and structural bioinformatics analyses.

97 8; 95% CI, 1.03, 2.73, P = .03), interest in genetics (aOR, 2.89; 95% CI, 1.95, 4.29, P = .001), and

98 tophthora infestans, we initiated a chemical genetics approach by screening for a stage-specific inhi

99 Taking a classical genetics approach coupled with genome-wide analysis, we

100 In this study, we used a systems genetics approach to identify and evaluate regulators of

101 onic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo.

102 Here, we used a landscape genetics approach to investigate population relatedness

103 and efficiency in the execution of a systems genetics approach to study P. falciparum biology.

104 Here, we used a landscape genetics approach to test whether isolation by distance,

105 We took a reverse genetics approach, using CRISPR/Cas9 to generate mutatio

106 Using a reverse-genetics approach, we show that genes controlling pectin

107 Here we review mouse cellular systems genetics approaches for characterizing the influence of

108 y, we developed, for the first time, reverse genetics approaches for the generation of recombinant TC

109 se cell populations enables in vitro systems genetics approaches for uncovering the basic properties

110 ons by biochemical, biophysical, and reverse genetics approaches provide a better understanding of th

111 These reverse genetics approaches represent an excellent tool to inves

112 me of the recent progress made using systems genetics approaches to uncover novel mechanisms and mole

113 ating recombinant TCRV (rTCRV) using reverse genetics approaches, which paves the way to study the bi

114 neurocognition using animal models and human genetics approaches.

115 To realize the promise of CRISPR-Cas9-based genetics, approaches are needed to quantify a specific,

116 riorities for future studies of early growth genetics are aggregation of large samples of diverse anc

117 We survey how the recent developments in genetics are beginning to provide social scientists with

118 Advances in human genetics are shedding light on the genetic architecture

119 variation in the population is controlled by genetics as shown by the single-gene mutations that conf

120 ces have recently opened the door to forward genetics as well as extremely efficient and precise geno

121 encing analysis at the Department of Medical Genetics at La Timone Hospital (Marseille, France).

122 Mendelian genetics attributes loss-of-function mutations in key mi

123 Reverse genetics based on a tandem minus-strand complementary DN

124 These findings, obtained through genetics-based approaches, complement and extend previou

125 Since the utility of classical molecular genetics beyond model species is limited, the vast speci

126 Answering genetics' big data questions often needs an interdiscipl

127 We utilized molecular genetics, biochemistry, and cryo-electron microscopy (cr

128 -A CRISPR system of Listeria seeligeri Using genetics, biochemistry, and structural biology, we found

129 ow is therefore fundamental to areas such as genetics, bioengineering, and food safety.

130 have important implications for how reverse genetics can be scaled in culturable Plasmodium species.

131 ngs demonstrate that pre-existing hereditary genetics can impact progression and survival outcomes of

132 & Myocarditis, Cardiomyopathies/Congenital & Genetics, Cardio-Oncology, Coronary Disease & Interventi

133 ble to biologists to study the developmental genetics, cell biology and morphogenesis that underlie t

134 entation together with important advances in genetics, cell biology and spectroscopy.

135 These findings suggest that genetics, cell of origin, and tumor cell plasticity dete

136 visual neuroscience, consciousness science, genetics, chronobiology, and biological and clinical psy

137 Here, we integrate quantitative genetics, coevolutionary theory and network science to e

138 Using the UK Biobank population imaging-genetics cohort (n = ~40,000, aged 40-69 years when recr

139 s to be an invaluable resource for the maize genetics community and has yielded insights into the gen

140 que psoriasis have been in its pathogenesis, genetics, comorbidities, and biologic treatments.

141 t and took part in the Consortium on Lithium Genetics (ConLi(+)Gen) study.

142 cs from the International Multiple Sclerosis Genetics Consortium (IMSGC) meta-analysis, including 14,

143 ing summary-level data from the Global Lipid Genetics Consortium (n = 188,577) and UK Biobank Cardiov

144 trated using summary data from Global Lipids Genetics Consortium GWAS across multiple lipid traits.

145 ion using summary data from the Early Growth Genetics Consortium GWAS of birthweight and a large biob

146 Ten centers from the AF Genetics Consortium identified patients who had undergon

147 the genes and SNPs reported in Global Lipids Genetics Consortium were identified using additional fun

148 amatically advanced our understanding of how genetics contributes to host resistance or susceptibilit

149 for free, public distribution via the Maize Genetics Cooperation Stock Center.

150 Keeping quantitative genetics current requires keeping old concepts that rema

151 Here, using imaging-genetics data from a discovery sample of 27,034 individu

152 New imaging technologies, biomarkers and genetics data will probably necessitate ongoing revision

153 ance on rodents for understanding pancreatic genetics, development and islet function could limit pro

154 The goals of quantitative genetics differ according to its field of application.

155 8) and will have broad utility in population genetics, disease-association studies, and diagnostic sc

156 ibution supports a relationship between host genetics, dose of the at-risk GH, age at treatment onset

157 ed for CMBCD, focusing on 3 primary drivers (genetics, environment, and behavior) and 2 metabolic dri

158 They describe how genetics, epigenetics, and the 3D genome architecture ar

159 Complex interaction between genetics, epigenetics, environment, and nutrition affect

160 emerged as a powerful tool in complex trait genetics, existing methods for fitting variance componen

161 binding site in the viral genome by reverse genetics failed to allow recovery of viable virus, and t

162 n lower proliferation, consistent with human genetics findings.

163 biota, host transcriptomics, epigenomics and genetics from matched inflamed and non-inflamed colonic

164 epresent a crucial step toward translational genetics, from highlighting the impact of mutations on p

165 om Lemke et al employs a full court press of genetics, genomics, biochemical, and advanced analytical

166 Autism genetics has progressed in parallel with technology, fro

167 pproach, though underutilized in psychiatric genetics, has several useful features for the field.

168 Developments in imaging, therapy and genetics have all contributed to changing the concept of

169 Recent advances in psychiatric genetics have been made possible through large-scale col

170 oth chronic cardiometabolic risk factors and genetics have been shown to contribute to the developmen

171 describe how functional genomics and reverse genetics have contributed to our understanding of this i

172 how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which th

173 Reverse genetics have facilitated genome-scale knockout screens

174 Mouse genetics have increased our understanding of how barrels

175 Advancements in molecular genetics have revealed that hybridization may be common

176 The role of human genetics in determining clinical response to the virus r

177 To increase the use of genetics in heart failure clinics, increased availabilit

178 Systems genetics in laboratory mice (Mus musculus) enables data-

179 Both reverse and forward genetics in mice are currently gaining momentum through

180 highlights the need for greater study of HCM genetics in non-White populations.

181 r current understanding of the role of mtDNA genetics in relation to human cancers.

182 virus, suggesting a potential role for host genetics in the moderation of HIV-1 acquisition.

183 novel insights regarding the contribution of genetics, in combination with known treatment-related ri

184 the cornerstones of mathematical population genetics, in further discussions of evolutionary genomic

185 development, cardiomyocyte function, and CHD genetics-in discrete subpopulations of cardiomyocytes.

186 dies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immun

187 econd, I describe new methods in statistical genetics, including genome-wide association studies and

188 ss-phenotype association analysis of imaging genetics indicates a potential link between FAM222A and

189 Understanding how genetics influence mammographic features is important be

190 Systems genetics is an emerging field that aims to understand th

191 Social science genetics is concerned with understanding whether, how an

192 A major question in human genetics is how sequence variants of broadly expressed g

193 llors and other providers with experience in genetics is necessary.

194 ant breeding, the main focus of quantitative genetics is on identifying candidates with the best geno

195 enetic cause, and the field of heart failure genetics is progressing rapidly.

196 A deep understanding of its genetics is therefore required for both biomedical and e

197 A primary goal of human genetics is to identify DNA sequence variants that influ

198 whole-genome sequencing for studies of human genetics is to interrogate all forms of variation, inclu

199 A key challenge in human genetics is to understand the geographic distribution of

200 One of the major questions in human genetics is what percentage of individuals in the genera

201 becomes to define whether using emerging new genetics knowledge can improve care for patients both be

202 Using a validated genetics-led target prioritization algorithm (Pi) of gen

203 Data on genetics, lifestyle, and diet were harmonized.

204 as this enhance the resolution of molecular genetics, make genome editing easier, and may be useful

205 were thought to be sufficient, live imaging, genetics, modeling, and simulations show that microtopog

206 cancer have transformed our ability to link genetics, molecular mechanisms and phenotypes.

207 were investigated using approaches including genetics, molecular/cell biology, pathogenicity and tran

208 ncestry) from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed a Multi-Trai

209 on of the molecular evolution and population genetics of AMP genes reveals more evidence for adaptive

210 fers a self-consistent framework to link the genetics of an organism to the reproducible architecture

211 patterns in neural networks for studying the genetics of AUD.

212 d understanding of the molecular biology and genetics of bladder cancer has evolved the way localized

213 s elegans is a useful model for studying the genetics of both behaviors.

214 insights and recent knowledge gained in the genetics of CHC biosynthesis, which is just beginning to

215 nderstanding the evolution, development, and genetics of chiral variation in snails, and place it in

216 consumption only partially overlaps with the genetics of clinically defined AUD.

217 coveries with important implications for the genetics of complex human diseases.

218 obin A(1c) reduction to sulfonylureas in the Genetics of Diabetes Audit and Research in Tayside Scotl

219 study evaluating genotyped patients from the Genetics of Diabetes Audit and Research Tayside Scotland

220 e association studies have shed light on the genetics of early growth and its links with later-life h

221 Our study elucidates the genetics of gene expression in neonatal immune cells, an

222 s could be related to sex differences in the genetics of gene expression regulation.

223 sociation studies, and for understanding the genetics of healthy ageing.

224 We characterized the genetics of hearing loss throughout the Palestinian popu

225 The genetics of human longevity has long been studied, and i

226 iseases, as well as other emerging topics in genetics of longevity, such as micro-ribonucleic acid (m

227 re, we synthesize major advances made in the genetics of monarch migration, which includes the discov

228 Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide asso

229 Research into the molecular genetics of osteoarthritis (OA) has been substantially b

230 ncestry and we know relatively little of the genetics of Parkinson's disease in other populations.

231 The genetics of phenotypic responses to changing environment

232 To better understand the genetics of schizophrenia, we studied the illness in the

233 n a variety of related topics, including the genetics of speciation, estimation of selection coeffici

234 In the Study to Understand the Genetics of the Acute Response to Metformin and Glipizid

235 However, the genetics of their biosynthesis is not fully understood,

236 The genetics of these pattern elements has been of great int

237 or accurate interpretations of the ancestral genetics of this population.

238 ailed insight into the molecular biology and genetics of this unique group of land plants.

239 Our finding provides new insight into the genetics of WBLM and enhance our understanding of sarcop

240 es, little is known about the impact of host genetics on salivary metabolites.

241 Utilizing genetics, optogenetics, and calcium imaging, we identify

242 o other viruses for which convenient reverse genetics or lentiviral surface display systems are avail

243 emphasize how a holistic approach involving genetics, physiology, and cellular and developmental bio

244 vity, such as micro-ribonucleic acid (miRNA) genetics, polygenic risk scores, environmental pollutant

245 r collecting and using such data in clinical genetics practice.

246 Surveying clinical genetics professionals and researchers (n = 448), we fou

247 The platform combines Ares Genetics' proprietary database ARESdb with state-of-the-

248 Forward genetics provides an excellent tool to find, in an unbia

249 d Scopus were searched for terms relating to genetics, psychiatric disorders and machine learning, in

250 study, we combined in vitro assays, reverse genetics, quantitative N-terminomics, transcriptomics, a

251 ms of action, and the interactions with host genetics remain obscure.

252 lar diseases, such as heart failure, systems genetics represents a powerful strategy to obtain mechan

253 Computational genetics researchers currently re-implement simulation m

254 s off-shore cays, and applied the population genetics results for assignment of Management Unit (MU)

255 ding genes, therefore, requires crossing the genetics results with functional data.

256 Here, a chemical genetics screen of kinase inhibitors revealed phosphoino

257 OR, 2.89; 95% CI, 1.95, 4.29, P = .001), and genetics self-efficacy (aOR, 2.38; 95% CI, 1.54, 3.67, P

258 We validate key predictions with mouse genetics, showing the importance of endoderm-derived sig

259 ransformation, we review the fundamentals of genetics, signalling and pathogenesis underlying oncopro

260 First, I revisit the first law of behavioral genetics stating that everything is heritable, and I des

261 These human genetics studies and recent in utero animal modeling wor

262 is has attracted increasing attention in the genetics studies of human diseases.

263 rovides an important resource for functional genetics studies of maize.

264 rker in genetic association and evolutionary genetics studies.

265 a powerful tool for both forward and reverse genetics studies.

266 ys) are fundamental resources for functional genetics studies.

267 ent center, genotyping array, and population genetics substructure.

268 We utilized a reverse genetics system to generate a GFP reporter virus to expl

269 Using the reverse genetics system, we show that it is possible to modify o

270 ered facilitated cascade testing whereby the genetics team identified and contacted ARRs by telephone

271 records and national registries to germline genetics, the time-to-event data analysis has attracted

272 production is strongly associated with host genetics, this study for the first time shows the distin

273 hat the heterogeneity is related to distinct genetics. This review summarizes a recently compiled ana

274 important for the progress of human disease genetics; this requires finding strategies to detect fun

275 ses from the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta Analysis) consortium.

276 Here, we combine metabolomics and genetics to characterize the cells' response to acute gl

277 Here we employed reverse genetics to investigate the role of Arabidopsis cellulos

278 We therefore used intersectional genetics to manipulate the cell-autonomous TTFLs of VPAC

279 Here we have use genetics to separate HIV-1 nuclear import cofactor depen

280 To circumvent the limitations in using genetics to understand virulence lipids, we developed a

281 MPRAs are powerful molecular genetics tools that can be used to screen thousands of u

282 Gaining a comprehensive understanding of the genetics underlying cancer development and progression i

283 ouse resources to elucidate the role of host genetics, underlying molecular mechanisms governing SARS

284 orest models integrated gut microbiome, host genetics, urine metabolome, measures of physiology and a

285 antitative proteomics, lipidomics, and mouse genetics, we characterize epidermal barrier maintenance

286 Using mouse genetics, we found that the balance between T-box transc

287 Using reverse genetics, we generated a rotavirus with a phosphomimetic

288 By combining time-lapse imaging with genetics, we here identify the lysosomal Ca2+ channel Tr

289 advances in connectome mapping and neuronal genetics, we lack theoretical and computational tools to

290 Coupling transcriptomics with genetics, we show that emerging hair progenitors produce

291 man erythropoiesis in vitro Using Drosophila genetics, we show that PSEDN members function with GATA

292 Age, menopausal status, prior UTI, and host genetics were top factors defining the urobiome with inc

293 Here, fluorescence microscopy and genetics were used to confirm the central role of GLR3.3

294 as of cardiac magnetic resonance imaging and genetics, which are able to provide useful rick predicti

295 Here we combined biochemistry and genetics with correlative light and electron microscopy

296 By combining quantitative genetics with genome editing, we show how multiple SVs t

297 characterizations, combining intersectional genetics with multiple transcriptomic modalities to achi

298 Here, we integrated NDD genetics with single-cell RNA sequencing data to assess

299 dividuals were undiagnosed despite extensive genetics workups.

300 ous biological contexts (e.g., cancer, mouse genetics, yeast genetics).