ライフサイエンスコーパス: genome-wide

1 umber of Wnt-responsive regulatory elements, genome-wide.

2 s very extensive transcriptional readthrough genome-wide.

3 tagmentation-based method for measuring the genome-wide activity of Cas9 in vitro.

4 Here, we aimed to uncover genome-wide alterations in uracil pattern upon drug trea

5 Genome-wide analyses also revealed that wild-type AID lo

6 Our genome-wide analyses identified one novel gene (NDUFB9)

7 Moreover, genome-wide analyses of accessible chromatin showed key

8 may be relevant for future population-scale genome-wide analyses of blueberry.

9 Whereas numerous structural and genome-wide analyses of roles for minimal G4s in transcr

10 The PRP was constructed from a genome-wide analysis of BBxgenotype interaction predicti

11 population than would be expected given the genome-wide ancestry frequencies.

12 First, we fine-mapped its GCN5 binding sites genome-wide and then used several global methodologies (

13 h that takes advantage of the newly emerged, genome-wide and tissue-specific expression quantitative

14 erative to augment quantity and diversity of genome-wide annotation data for the latest reference gen

15 Here we report a genome-wide annotation of transcriptional regulators in

16 Genome-wide annotations revealed 1,516 nucleotide-level

17 We describe a genome-wide approach to identify potential candidates fo

18 Genome-wide approaches including polygenic risk scores (

19 However, unbiased methods to profile GxE genome-wide are nascent and, as we show, cannot accommod

20 Here, we perform genome-wide assessment of chromatin accessibility of the

21 GRM3 (the gene coding for mGluR3) is also genome-wide associated with risk for schizophrenia.

22 g glycaemic traits and insulin resistance in genome wide association studies.

23 A genome wide association study demonstrated that both die

24 based on summary statistics from the largest genome-wide association analysis of MD (n = 135,458 case

25 A genome-wide association approach identifies the (P-fimbr

26 y cases and controls in the UK Biobank for a genome-wide association by proxy, which was meta-analyse

27 In the statistical analysis of genome-wide association data, it is challenging to preci

28 ere we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interva

29 es: randomly, evenly spaced, lowest p value (genome-wide association or epigenome-wide association st

30 me-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and transcriptomi

31 Genome-wide association studies (GWAS) are still the pri

32 Genome-wide association studies (GWAS) have discovered t

33 Previous genome-wide association studies (GWAS) have identified 1

34 Genome-wide association studies (GWAS) have identified 4

35 Genome-wide association studies (GWAS) have identified n

36 Genome-wide association studies (GWAS) have identified o

37 Genome-wide association studies (GWAS) have reported doz

38 e to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only

39 A meta-analysis of genome-wide association studies (GWAS) identified eight

40 ct of unmeasured geographical confounding on genome-wide association studies (GWAS) of complex human

41 We conducted genome-wide association studies (GWAS) of relative intak

42 Genome-wide association studies (GWAS) provide an unbias

43 nd a statistically significant enrichment of genome-wide association studies (GWAS) relevant genes in

44 m large populations have enabled informative genome-wide association studies (GWAS) that associate SN

45 s provide an exciting opportunity to perform genome-wide association studies (GWAS) to identify genet

46 Many recent investigations have leveraged genome-wide association studies (GWAS) to identify singl

47 riants and gastric cancer in six independent genome-wide association studies (GWAS) with a case-contr

48 rowing rapidly with the increasing number of genome-wide association studies (GWAS).

49 Breast cancer genome-wide association studies (GWASs) have identified

50 predictive polygenic risk scores (PRS) from genome-wide association studies (GWASs) including 55,105

51 biomedical computation, for instance in the genome-wide association studies (GWASs) that aim to dete

52 omplex diseases have been identified through genome-wide association studies (GWASs).

53 analyses of findings from a meta-analysis of genome-wide association studies (meta-GWASs) of the broa

54 Genome-wide association studies and analysis of strain-s

55 the size of reference population required in genome-wide association studies and genomic selection.

56 de available to approved MVP researchers for genome-wide association studies and other downstream ana

57 its T300A coding polymorphism identified by genome-wide association studies as linked with increased

58 susceptibility genes identified using public genome-wide association studies data were particularly e

59 Rationale: Genome-wide association studies have identified genetic

60 Genome-wide association studies have identified noncodin

61 While genome-wide association studies have identified suscepti

62 Genome-wide association studies have implicated thousand

63 Human genome-wide association studies have linked polymorphism

64 Genome-wide association studies have revolutionized our

65 In recent years, genome-wide association studies have shed light on the g

66 Genome-wide association studies have shown many variants

67 Genome-wide association studies have uncovered over a 10

68 Recent genome-wide association studies identified genetic varia

69 Data from genome-wide association studies in up to 215,551 partici

70 rk model for AF defined by effector genes in Genome-wide association studies loci.

71 results from an independent meta-analysis of genome-wide association studies of ADHD diagnosis and sy

72 Recent genome-wide association studies of age-at-onset in Hunti

73 e Mendelian randomization were obtained from genome-wide association studies of circulating sphingoli

74 Genome-wide association studies of neurological diseases

75 GKQ locus is the 3rd strongest risk locus in genome-wide association studies of Parkinson disease (PD

76 A polygenic risk score (PRS) derived from genome-wide association studies of posttraumatic stress

77 nderlying molecular mechanisms, we performed genome-wide association studies of the urinary concentra

78 k variants for brain disorders identified by genome-wide association studies reside in the noncoding

79 ned how expanding electrocardiographic trait genome-wide association studies to include ancestrally d

80 variable-adjusted, trait-specific univariate genome-wide association studies using 1000-G imputed sin

81 Rationale: GWAS (Genome-Wide Association Studies) have identified hundred

82 s that can be used to interpret results from genome-wide association studies, and we discuss current

83 and evaluated heritability enrichment in 64 genome-wide association studies, emphasizing schizophren

84 Genome-wide association studies, followed by exome-wide

85 he biological and clinical interpretation of genome-wide association studies, with some therapies dev

86 enes associated with type 2 diabetes risk in genome-wide association studies.

87 forming meta-analyses with 2 independent EoE genome-wide association studies.

88 located within a PD risk locus identified by genome-wide association studies.

89 thods focus on individual common variants in genome-wide association studies.

90 ability models using summary statistics from genome-wide association studies.

91 formatics pipeline characterizing non-coding genome-wide association study (GWAS) association finding

92 g 17 mouse organs with body mass index (BMI) genome-wide association study (GWAS) data from >457,000

93 Here we report a large genome-wide association study (GWAS) for longitudinal sm

94 ents causing this deficiency, we performed a genome-wide association study (GWAS) for root Na(+) /K(+

95 Our genome-wide association study (GWAS) identified one nove

96 conferring mutations in genomic data include genome-wide association study (GWAS) methodologies, test

97 A recent genome-wide association study (GWAS) of 59 cerebrospinal

98 A Genome-Wide Association Study (GWAS) of DT696 derivative

99 We performed a large, genome-wide association study (GWAS) of two previously v

100 A genome-wide association study (GWAS) revealed variants i

101 duals, we detect ASAS events associated with genome-wide association study (GWAS) signals of complex

102 We carried out a genome-wide association study (GWAS) using a panel of 51

103 In stage one of this two stage genome-wide association study (GWAS), we included indivi

104 A recent metabolite genome-wide association study (mGWAS) investigated the r

105 We performed a genome-wide association study and analysed the most rece

106 (ASD) often pose a challenge for traditional genome-wide association study approaches in defining a c

107 A metabolite-based genome-wide association study combined with genetic mapp

108 zation of a uniquely extensive collection of genome-wide association study data, while ensuring safe

109 Here, we report a multi-trait genome-wide association study for male puberty timing wi

110 set with genotype data from the largest PTSD genome-wide association study identified the interneuron

111 We performed a genome-wide association study in Arabidopsis (Arabidopsi

112 We conducted a genome-wide association study of Lifetime Anxiety Disord

113 We did a genome-wide association study of NKTCL in multiple popul

114 on summary statistics from a European-based genome-wide association study perform poorly in Mexican

115 Here we integrate genome-wide association study results with single-cell t

116 In addition, we used a genome-wide association study to identify loci that are

117 and TG with weights from a UK Biobank-based genome-wide association study with ~324K samples.

118 ciation study approaches to evaluate whether genome-wide association study-defined genomic risk for a

119 linically important disease entity through a genome-wide association study.

120 ntigen (HLA) alleles were analyzed through a genome-wide association study.

121 Weights were based on an international genome-wide association study.

122 ic valve area measurements were submitted to genome-wide association testing, followed by polygenic r

123 the importance of following up findings from genome-wide association through replication studies, pre

124 ave used quantitative trait loci mapping and genome-wide association to identify genetic loci to impr

125 Here, we used genome-wide association to identify loss-of-function (LO

126 sticity in these traits was investigated via genome-wide association, which also enabled the identifi

127 nformation capture (4C) analysis to identify genome-wide associations between EBV episomes and host c

128 eport heritability, genetic correlations and genome-wide associations of these cortical measures acro

129 While findings were less robust, genome-wide associations were also observed with rs15117

130 like Zld, influences chromatin accessibility genome-wide at cellularization, suggesting both are pion

131 ures of resected DSBs in mouse spermatocytes genome-wide at nucleotide resolution.

132 his issue, even in single-cell Hi-C data, is genome-wide averaging (piling-up) of peaks, or other fea

133 lated to the redundant associations observed genome-wide between gene expression spatial patterns and

134 We determined genome-wide binding of FXR isoforms in mouse liver organ

135 ChIP-seq in multiple mouse species to create genome-wide binding profiles and associate them with TAD

136 Resistance altered the ER genome wide-binding pattern, leading to decreased expres

137 Genome-wide bioinformatic analysis of promoters from R.

138 is currently available that has investigated genome-wide changes in gene expression during the normal

139 Thus, ANP32E dramatically influences genome-wide chromatin accessibility through subtle refin

140 Genome-wide chromatin interaction mapping, using Hi-C, r

141 Using genome-wide clustered regularly interspaced short palind

142 Genome-wide CNV breakpoint association showed not only s

143 minant IGH and MYD88(L265P) mutation and the genome-wide copy number aberration (CNA) profiles of ind

144 Genome-wide copy number profiling revealed a high degree

145 We conducted an in vivo genome-wide CRISPR activation screen in CTCs from breast

146 ulate cellular ATP-the ATPome-we conducted a genome-wide CRISPR interference/activation screen integr

147 mation and tumorigenesis, here we employed a genome-wide CRISPR knockout screening approach to system

148 l genomic strategy, DEADPOOL, we performed a genome-wide CRISPR screen and identified IPO11 as a requ

149 Here, we perform a genome-wide CRISPR screen using an endogenous cholestero

150 cytotoxic T lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically

151 Genome-wide CRISPR screens enable systematic interrogati

152 scalable cancer-spheroid model and performed genome-wide CRISPR screens in 2D monolayers and 3D lung-

153 Here we performed genome-wide CRISPR screens in Vero-E6 cells with SARS-Co

154 The genome-wide cross-trait analysis features in several ana

155 hitherto there is no comprehensive survey of genome-wide CTCF binding patterns across different human

156 e included from two national registries with genome-wide data and two local cohorts, and further inco

157 the history of these movements, we generated genome-wide data for 11 ancient individuals from the isl

158 phenotypes and externalizing behaviours with genome-wide data for EDU/SES.

159 Taken together, our genome-wide data help to resolve multiple contentious se

160 We assembled genome-wide data on 89 individuals dating from ~9,000-50

161 sequencing, a comprehensive study surveying genome-wide disease-associated genes in adults with deep

162 Genome-wide DNA bisulfite sequencing revealed that the T

163 Genome-wide DNA methylation and gene expression are comm

164 We tested for RDCs by our genome-wide DSB identification approach that captures DS

165 the proliferation of paralogous genes during genome-wide duplication events(4).

166 H2 leads to a near-complete loss of H4K20me3 genome wide, dysregulated gene expression and delayed ES

167 ion for high-throughput analysis of nuclease genome-wide effects by sequencing' (CHANGE-seq), a scala

168 some inhibitor MG132, and we further explore genome-wide effects of proteasome inhibition on the chro

169 is the most important approach for profiling genome-wide epigenetic changes such as histone modificat

170 ive genomic approaches to generate the first genome-wide estimates of genetic diversity within dwarf

171 ing 30 distinct shared genomic segments with genome-wide evidence (p = 2.02E-07-1.30E-18) of segregat

172 We collected genome-wide exon data for 110 (~80%) species in the grou

173 ave addressed these questions in a series of genome-wide experiments coupled to a novel bioinformatic

174 re, we use chromatin immunoprecipitation and genome-wide expression analyses to study a possible role

175 Notably, genome-wide expression analysis uncovered a melanocytic

176 lead to a proportional change in the rate of genome-wide expression and plant growth.

177 st with previous findings, demonstrated that genome-wide expression in our new murine model more clos

178 We determined genome-wide expression patterns over an annual dormancy

179 , but only modest (1.4-7.8%) perturbation in genome-wide expression was observed.

180 Here, we describe a genome-wide forward screen that shows that glucosylceram

181 of immune cells and inhibitory checkpoints, genome-wide frequencies of copy number alterations, muta

182 Cellular integrity, migration, and genome-wide gene expression changes were examined in 16H

183 that exposure to POPs differentially alters genome-wide gene transcription in the adipose tissue fro

184 Here, we integrate estimates of genome-wide genetic variation with demographic and niche

185 minimized sonication step, to produce robust genome-wide H3K27ac maps from clinical samples.

186 imbalance in CpG methylation between alleles genome-wide have been described but their algorithmic ti

187 multiple gene regulatory processes including genome-wide histone modification, transcriptional regula

188 Our results suggest a general strategy for genome-wide identification and characterization of silen

189 In this study, we performed a genome-wide identification and expression analysis of ge

190 In this study, we report the genome-wide impacts of introgressed chromosomes derived

191 corporates H2A.V (the fly ortholog of H2A.Z) genome-wide in an ATP-dependent manner, like the yeast S

192 map A(syn)-T Hoogsteen and unpaired adenines genome-wide in vivo.

193 cluster the genetic risk profiles for 3,025 genome-wide independent loci across 19,155 disease class

194 egulation has not been examined at a plastid genome-wide level and for many genes, it is unknown whet

195 defining host-bacterial interactions at the genome-wide level, including screens that harness CRISPR

196 We quantified genome-wide levels of DNA methylation in peripheral bloo

197 ntify a specific, molecular phenotype across genome-wide libraries of genetic perturbations.

198 o identify these components, we screened the genome-wide library of viable yeast deletion mutants for

199 uired to stabilize heterochromatin silencing genome-wide, likely by preventing replicative stress.

200 Furthermore, genome-wide loss of DNA methylation caused a loss of O-G

201 Using genome-wide loss-of-function and gain-of-function geneti

202 We characterized the occurrence of bursts of genome-wide loss-of-heterozygosity (LOH) in Saccharomyce

203 etic diversity analysis revealed significant genome-wide losses of variation among the three stages a

204 ease progression in a cell-type-specific and genome-wide manner.

205 arching for statistically enriched dots on a genome-wide map.

206 Genome-wide mapping of epidermal 5-hmC in murine psorias

207 two pathogenic Cryptococcus yeast species by genome-wide mapping of translation and of mRNA 5' and 3'

208 Here, we integrate genome-wide measures of mRNA expression, miRNA expressio

209 ifferentiation, and support a model in which genome-wide methylation changes are transduced to differ

210 ecules that could have a role in the altered genome-wide methylation profile: the long noncoding RNA

211 In the discovery phase, we performed genome-wide miRNA expression profiling of 124 fresh, pai

212 ution of cytosine methylation, thus enabling genome-wide monitoring of methylation maintenance.

213 r than recently published approaches, making genome-wide multilocus analysis of longitudinal traits p

214 Here, using CRISPR Cas9 genome-wide mutagenesis to screen for genetic determinan

215 Here, through a genome-wide mutant screen of human antigen-presenting ce

216 Genome-wide nasal epithelial DNAm and gene expression we

217 Genome-wide occupancy data show that BRD4 enriches at ma

218 Genome-wide occupancy maps of transcriptional regulators

219 We developed a method called GOTI (genome-wide off-target analysis by two-cell embryo injec

220 mes of EHA105 and K599 were resequenced, and genome-wide off-target analysis was applied to investiga

221 However, CBEs such as BE3 can cause genome-wide off-target changes via sgRNA-independent DNA

222 Comparing matched genome-wide off-target, chromatin modification and acces

223 This screen utilized the most extensive genome-wide ORF collection to date, covering 90% of huma

224 Genome-wide pathway analysis showed total of 16 enriched

225 ng set of powerful tools with which to study genome-wide patterns of gene expression.

226 xpression compendia to reconstruct TRNs in a genome-wide perspective.

227 A body mass index (BMI) genome-wide polygenic score (BMIGPS) was generated by su

228 Genome-wide profiling during reprogramming reveals CoRES

229 This enables routine genome-wide profiling of chromatin proteins and modifica

230 Our analyses provide the first genome-wide profiling of DNA hydroxymethylation of the f

231 Using genome-wide profiling of the H3K27ac histone modificatio

232 A genome-wide PRS for CAD comprising 6 579 025 genetic var

233 Genome-wide PRS showed evidence of association with unca

234 Genome-wide PRSs were more strongly associated with CHD

235 nvestigated associations of "restricted" and genome-wide PRSs with CHD in three major racial and ethn

236 interrogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into it

237 ailability of large biomedical datasets with genome-wide readouts has the potential to transform targ

238 lations largely manifested as differences in genome-wide recombination rate rather than remodeling of

239 tunes transcription factor availability via genome-wide redistribution and couples BRAF to tumorigen

240 le germline of mice, we demonstrate that the genome-wide reorganization of super-enhancers (SEs) driv

241 boratory to determine the repair pattern and genome-wide repair map of Mycobacterium smegmatis We fin

242 ion assay and the excision repair sequencing genome-wide repair mapping method developed in our labor

243 Here, we characterize a genome-wide RNA decay pathway that reduces the half-live

244 ff-target effects in KID-KCs, as detected by genome-wide RNA sequencing.

245 e generated during development, we performed genome-wide RNA tomography sequencing on zebrafish, chic

246 ential resistance mechanisms, we performed a genome-wide RNAi screen in BRCA2-deficient mouse embryon

247 However, the genome-wide role of CSB/Rad26 in TC-NER, particularly in

248 ntifying genotype-phenotype association on a genome-wide scale over macroevolutionary time is feasibl

249 to elucidate the distribution of damage on a genome-wide scale.

250 spliced and intron-retained transcripts on a genome-wide scale.

251 ble tools to study DSB repair at a local and genome-wide scale.

252 Previous genome-wide scans found many non-coding variants under s

253 quitin-conjugating enzyme E2 variant 1) in a genome-wide screen designed to identify novel effectors

254 A genome-wide screen in a Caenorhabditis elegans model of

255 A previous genome-wide screen revealed that depletion of 14 RNA spl

256 In this study, a genome-wide screen was performed to identify genes that,

257 Using a genome-wide screen, we identify centriole distal appenda

258 Here, using genome-wide screening, we find that SAT1 selectively con

259 hold promise for functional gene studies and genome-wide screens in human pluripotent stem cells (hPS

260 ein by genotyping assays and high-throughput genome-wide sequencing of DNA translocations, this is ac

261 om different patients with VRL had no common genome-wide signatures.

262 associated with the reproductive subtype at genome-wide significance (PRDM2/KAZN, P = 2.2 x 10-10; I

263 hich 21 (including 5 novel CpG sites) passed genome-wide significance after meta-analysis.

264 rs1055153) located in the gene WWTR1 reached genome-wide significance in association with mental comp

265 Seventy-three loci reached genome-wide significance in the meta-analysis, including

266 identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 x 10(-8)).

267 ci, TMEM40 and BAG3, associated with EF at a genome-wide significance level.

268 ms (SNPs) associated with GDF-15 levels with genome-wide significance were related to VTE.

269 nd three loci for mitochondrial abundance at genome-wide significance.

270 agnosis as well as aggressiveness; 183 reach genome-wide significance.

271 We identify one genome-wide significant association (rs146350366, minor

272 ur European ancestry meta-analysis and three genome-wide significant associations for multiple consec

273 ructed weighted polygenic scores using known genome-wide significant associations for T2D, fasting gl

274 The authors identified novel genome-wide significant associations near genes involved

275 tablished in twin studies, identification of genome-wide significant loci has been difficult.

276 Our GWAS results identified one genome-wide significant locus associated with each of th

277 Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) a

278 ssociation studies have identified 44 common genome-wide significant risk loci for late-onset Alzheim

279 usually strong shared ancestry and detect 12 genome-wide significant signals.

280 and GWAX, based on the number of independent genome-wide-significant loci across all diseases (for ex

281 Here a genome-wide small interfering RNA screen and reporter as

282 Here, we evaluate genome-wide SNP annotations from two previous deep learn

283 using a set of five putative MDD biomarkers, genome-wide SNP data, and 27 clinical, demographic and l

284 Through a genome-wide SNP genotyping of 736 C. arabica accessions,

285 ubgenera (Amygdalus, Prunus and Cerasus) for genome-wide SNP identification and to assess genetic div

286 We identify a total of 868,476 genome-wide SNPs, of which 194,709 are unique across 18

287 Genome-wide spatial transcriptomics analysis provides an

288 eview, I summarize the conclusions of recent genome-wide studies of selection, highlight some importa

289 s using genetic instruments from a different genome-wide study and sensitivity analysis to address po

290 The present study delivers a comprehensive genome-wide study of CNVs affecting barley gene content

291 of heritability within 2,868 annotations of genome-wide transcription factor occupancy, and identifi

292 d animals and compare them in the context of genome-wide transcriptional landscapes.

293 o explore how DAP associations contribute to genome-wide transcriptional regulation.

294 In genome-wide transcriptional studies, we found that ZIKV

295 Genome-wide transcriptome analysis determined by RNA-seq

296 Here, we present the first much-needed genome-wide transcriptome study that provides unique ins

297 Genome-wide transcriptomic analyses have revealed abunda

298 98 to 34.92%, depending on the model) of the genome-wide variation in population-level genetic variat

299 To characterize RNA-capsid binding sites genome-wide within mature RNA virus particles, we have d

300 use passage of Pol II through +1 nucleosomes genome-wide would obligate H2A.Z turnover, we propose th