ライフサイエンスコーパス: genomic island

1 M-19226, carry a copy of trh within the T3SS genomic island.

2 sferred from other bacteria and represents a genomic island.

3 e clusters, seven phage regions and a mobile genomic island.

4 enes may also define a previously unreported genomic island.

5 long with bclA) may be part of an exosporium genomic island.

6 dvantage for strains that have acquired this genomic island.

7 ally at the recombination sites flanking the genomic island.

8 o modulating gene expression within the T3SS genomic island.

9 everal other E. coli strains, identifying 43 genomic islands.

10 nse systems and mobile genes and elements in genomic islands.

11 ransferred in trans, as are some mobilizable genomic islands.

12 in silico and experimental discovery of new genomic islands.

13 l family of T4SSs involved in propagation of genomic islands.

14 ied as a T4SS involved in the propagation of genomic islands.

15 located on presumptive horizontally acquired genomic islands.

16 16S ribosomal RNA sequences occurs mostly in genomic islands.

17 between habitats at relatively small linked genomic islands.

18 nreAXY genes, which often reside in putative genomic islands.

19 2SigFinder is more efficient in identifying genomic islands.

20 Its genome contains 6 prophages and 5 genomic islands.

21 for the capture and conjugative transfer of genomic islands.

22 spp. have relied on chromosomally integrated genomic islands.

23 ke domains, some of them encoded in putative genomic islands.

24 s adapted to the spread and rearrangement of genomic islands.

25 ial chromosomes accumulates in blocks termed genomic islands.

26 thways that also facilitate the formation of genomic islands.

27 ters are contained within self-transmissible genomic islands.

28 an integron structure, designated Salmonella genomic island 1 (SGI1), while we recently demonstrated

29 integrated prophage elements and Salmonella genomic island 1 encoding antibiotic resistance genes.

30 chromosome called PAGI-1 (for "P. aeruginosa genomic island 1").

31 sed on prophage-like elements and Salmonella genomic island 1, provide a simple method for identifyin

32 isolate from Australia was PCR positive for genomic island 11 or a putative transposase sequence, wh

33 4,[5],12:i:- strains carried the Salmonella genomic island-4 (SGI-4), which confers resistance to he

34 One 99-kb island, designated P. aeruginosa genomic island 5 (PAGI-5), was a hybrid of the known P.

35 ColM was detected within the exoU-containing genomic island A carried by certain pathogenic Pseudomon

36 ferent biosynthetic architectures, including genomic islands, a plasmid, and the use of spatially sep

37 traits are unique and distributed over five genomic islands, a prophage, and two plasmids.

38 55 and VN1291 genome possessed four kinds of genomic island: a cag pathogenicity island (cagPAI), two

39 pumilus maritimus SCM1' revealed a number of genomic islands absent in the Gulf of Maine population.

40 satory mutations in noncore genes located in genomic islands, although genetic reversions were also o

41 ribution of 81 genes belonging to 12 APEC O1 genomic islands among 828 human and avian ExPEC and comm

42 ter degree of similarity in gene content and genomic islands among strains within clades than between

43 s characteristics of a horizontally acquired genomic island and encodes homologues of type IV secreti

44 art and end of a region such as an operon or genomic island and expanded these ranges to add another

45 arative analysis revealed the presence of 18 genomic islands and 311 unique protein families involved

46 ns exhibited limited conservation of APEC O1 genomic islands and a distinct repertoire of virulence-a

47 a simple approach to identify phage-derived genomic islands and apply it to show that pathogens from

48 Acquired pathways are incorporated into genomic islands and are commonly exchanged within and be

49 nt, indicating a possible link between these genomic islands and c-di-AMP signalling.

50 account for the conjugative transfer of the genomic islands and may even encode autonomous replicati

51 cholerae infection but did contain putative genomic islands and other accessory virulence factors.

52 However, we observed subtle differences in genomic islands and prophages between the species.

53 In addition, we explore the diversity of genomic islands and their insertion sites among Gram-neg

54 DGR is found within a horizontally acquired genomic island, and it can theoretically generate 10(26)

55 he distribution of putative virulence genes, genomic islands, and insertion sequences across a collec

56 cleotide polymorphisms (SNPs), lacking three genomic islands, and probably having one or more tandem

57 Genomic islands are associated with microbial adaptation

58 Here, we discuss how a group of related genomic islands are evolutionarily ancient elements unre

59 hanisms that mediate the lateral transfer of genomic islands are for the most part unknown.

60 Genomic islands are hotspots for horizontal gene transfe

61 Genomic islands are mobile DNAs that are major agents of

62 Genomic islands are non-self-mobilizing integrative and

63 Genomic islands are responsible for unique aspects of ba

64 PCR-based analysis indicated that the large genomic islands are widely variable across a large colle

65 The identified genomic islands are within operons involved in type II s

66 hococcus genome, all located within the same genomic island as fciA and fciB These findings, along wi

67 phages, and were associated with 11 flexible genomic islands as well as virulence genes involved in a

68 le proteins appeared to correspond to silent genomic islands, as inferred through functional profilin

69 enome analysis was used to identify flexible genomic islands associated with in-hospital attributable

70 ed ExoU island A, revealed many plasmid- and genomic island-associated genes, most of which have been

71 Tn7-like transposons form genomic islands at a programmed insertion site in bacter

72 These elements form functionally diverse genomic islands at the specific site of Tn7 insertion ad

73 methods perform an overall test to identify genomic islands based on their local features.

74 the mechanism underlying mobilization of the genomic islands between strains are unexplained.

75 The proposed method was tested by genomic island boundary detection and identification of

76 However, genomic islands can also arise through evolutionary proc

77 While the recognition of genomic islands can be a powerful mechanism for identify

78 An approximately 50-kb genomic island carries genes encoding the T3SS structura

79 -encoding gene was interrogated and an 80-kb genomic island carrying exoU was identified.

80 Multiple genomic islands carrying mobile genetic elements; coding

81 Two open reading frames predicted from the genomic islands coded for enzymes belonging to the Nitro

82 These genomic islands comprise 672 kb of the 5,231-kb (12.8%)

83 A. baumannii resistance islands (AbaR)-type genomic islands conferring multidrug resistance.

84 in, and our findings challenge the view that genomic islands consist only of independently evolving m

85 sly published cohorts, we identify microbial genomic islands consistently associated with response to

86 A genomic island consisting of 14 open reading frames, orf

87 ed in identification of a conserved syntenic genomic island consisting of up to 33 core genes in 16 b

88 We find that two of the most pronounced genomic islands contain the ALX1 and HMGA2 loci, which a

89 supplementary tables and within ranges like genomic islands contain the majority of locus tags.

90 system were identified on a low-G+C-content genomic island containing 24 intact genes that appear to

91 , we describe the widespread occurrence of a genomic island containing nitrite and nitrate assimilati

92 these strains also possessed several unique genomic islands containing hypothetical genes with simil

93 phylococcal chromosome cassette mec (SCCmec) genomic island, containing the gene encoding resistance

94 at, in addition to encoding virulence genes, genomic islands contribute to the overall fitness of UPE

95 couples the actions of previously disparate genomic islands, defines VSP-1 as a pathogenicity island

96 a high genome conservation even within their genomic islands, despite their remote geographical local

97 cale and large-scale statistical testing for genomic island detection.

98 virulence factors, although phage-associated genomic islands dominated the accessory genomes of these

99 Additionally, five genomic islands, e.g. DNA fragments that facilitate hori

100 Here, we show that a widely distributed genomic island encoding tandem master regulators named F

101 The presence of genomic islands encoding multiple immunity proteins in s

102 nsferase ubiquitous among the diverse set of genomic islands encoding the serine-rich PsrP glycoprote

103 Genomic islands ETT2 and ETT2-AR are homologous to a T3S

104 Overall, the genomic islands examined provide targets for further dis

105 The clustered phage remnants formed genomic islands exhibiting distinct DNA physical signatu

106 This work presents the first example of genomic island formation by a DDE type transposon.

107 similar in gene content and organization to genomic islands found in group B streptococci (GBS), the

108 tion sequences were used as tags to identify genomic islands found in PSE9 but absent in PAO1.

109 ir O-antigen, capsulation phenotype, and the genomic islands found on their chromosomes.

110 ion of genes c3405 to c3410 from PAI-metV, a genomic island from Escherichia coli CFT073, results in

111 real biological data, 2SigFinder identified genomic islands from a single genome and reported robust

112 Here, we describe novel genomic islands from Photorhabdus that are involved in s

113 Genomic islands gained in the S flexneri 2a lineage over

114 acteria may accumulate blocks of DNA such as genomic islands (GEIs) that encode fitness or virulence

115 Clade I representative induced expression of genomic island genes in cultures and Southern California

116 is mutants having insertions in prophage and genomic island genes.

117 conditions, suggesting that within the T3SS genomic island, genes encoding proteins unrelated to the

118 s, Bacillunoic acids, which are encoded on a genomic island (GI).

119 PA80 also contains several genomic islands (GI's) encoding virulence and/or resista

120 Moreover, twelve genomic islands (GI) were identified in LAC-4 genome.

121 We identified a unique 46 KB genomic island (GI1) in all RT106 strains sequenced to d

122 Two additional genomic islands (GI2 and GI3) were also present in a sub

123 Virulence genes on mobile DNAs such as genomic islands (GIs) and plasmids promote bacterial pat

124 Genomic Islands (GIs) are clusters of genes that are mob

125 ose of this study was to examine the role of genomic islands (GIs) as sources of genomic diversity in

126 The acquisition of genomic islands (GIs) by horizontal gene transfer (HGT)

127 Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution

128 Among the prokaryotic genomic islands (GIs) involved in horizontal gene transf

129 Brucella genomic islands (GIs) share similarities in their genomi

130 We found that genomic islands (GIs) vary greatly among B. pseudomallei

131 bacterial genomes are relevant for detecting genomic islands (GIs), including pathogenicity islands (

132 d examined in vitro and in vivo stability of genomic islands (GIs), integrative conjugative elements

133 were commonly present in multidrug-resistant genomic islands (GIs), often located on plasmids or mobi

134 enes, which are known insertion hotspots for genomic islands (GIs).

135 hy part of the HGT process is facilitated by genomic islands (GIs).

136 prediction and interactive visualization of genomic islands (GIs, regions of probable horizontal ori

137 Seven previously unrecognized genomic islands (>30 kb) were delineated by CGH in addit

138 A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain

139 A gene cluster of the Haemophilus influenzae genomic island ICEHin1056 has been identified as a T4SS

140 iderable genomic diversity with >300 unique "genomic islands" identified, with the majority of these

141 city is supported by the identification of a genomic island in one of the sequenced CF isolates, enco

142 The metV genomic island in the chromosome of uropathogenic Escher

143 at the makCDBAE gene cluster is present as a genomic island in the vast majority of sequenced genomes

144 on pathogenic Neisseria species harboring a genomic island in their dif sites.

145 Genomic analysis identified eight genomic islands in chromosome 1 of V. anguillarum 775(pJ

146 oGI tool for reconstructing the histories of genomic islands in closely related bacteria.

147 genomics data indicate that these loci, and genomic islands in general, have exceptionally low recom

148 H-NST proteins are found in large genomic islands in pathogenic E. coli strains, which are

149 he discovery of novel anti-defense genes and genomic islands in phages, by providing a user-friendly

150 Genomic islands in this free-living photoautotroph share

151 These related genomic islands include the following well-characterized

152 sequences, 10 prophage-like regions, and 17 genomic islands, including the locus for enterocyte effa

153 tain a significant number of large and small genomic islands, including those carrying virulence dete

154 hat, in Enterobacteriaceae, the cluster is a genomic island integrated at the leuX locus, and the phy

155 Various genomic islands intersperse on the genome with transposo

156 This genomic island is absent from the close relative of N. m

157 ndicate that transfer initiation of the tfs4 genomic island is analogous to mechanisms underlying mob

158 tRNA genes appear to drive the remodeling of genomic islands-key reservoirs for flexible genes in bac

159 omes resistant to methicillin by acquiring a genomic island, known as staphylococcal chromosome casse

160 Many bacterial chromosomes contain genomic islands, large DNA segments that became incorpor

161 en compared with Pst DC3000, including large genomic islands likely to contribute to virulence and ho

162 arger data set consisting of maize assembled genomic islands (MAGIs) that had been aligned to ESTs.

163 e of an improved assembly of maize assembled genomic islands (MAGIs).

164 as chromosomal loci and mediate plasmid and genomic island maintenance through post-segregational ki

165 Genomic islands may contain functional variants involved

166 These 'mobilizable genomic islands' (MGIs) require many ICE-encoded factors

167 in multiple strains of the same species, and genomic islands missing in a given species are often res

168 Three genomic island mutants (Delta PAI-aspV, Delta PAI-metV,

169 se accessory genes were often organized into genomic islands (n = 387) with base composition biases,

170 staphylococcal cassette chromosome (SCC) and genomic island nuSaalpha.

171 The genomic islands nuSaalpha and nuSabeta are found in almo

172 arding the diversification and spread of the genomic island nuSabeta, highlighting the central role o

173 Here, we demonstrated that the genomic island, nuSabeta, encoding an array of virulence

174 , has been linked to the presence of a small genomic island occurring in two configurations (CA4-A an

175 cal and phylogenetic associations of the pks genomic island of extraintestinal pathogenic Escherichia

176 Recently, we identified a genomic island of Proteus mirabilis, a common agent of c

177 e syringomycin (syr) and syringopeptin (syp) genomic island of Pseudomonas syringae pv. syringae.

178 in an O55:H7-like progenitor, with 27 of 33 genomic islands of >5 kb and specific for O157:H7 (O isl

179 encoding diDNases are found predominantly in genomic islands of Actinomycetes and Clostridia, which,

180 Here, the genomic islands of APEC O1 were compared to those of oth

181 es revealed neither evidence for substantial genomic islands of divergence around genes involved in H

182 tion and (2) that even extreme prominence of genomic islands of divergence can be an unreliable indic

183 ocated within one of two exceptionally large genomic islands of divergence separating the Anopheles g

184 ent of local adaptation and the evolution of genomic islands of divergence.

185 ptation sometimes cluster together, forming "genomic islands of divergence." Divergence hitchhiking t

186 Interestingly, similar numbers of genomic islands of elevated dXY are observed in sympatri

187 Genomic islands of interest were investigated experiment

188 and the presence of three laterally acquired genomic islands of likely ecophysiological value.

189 On the contrary, genomic islands of S. gordonii strains contain additiona

190 Such genomic islands of speciation have been described in per

191 ainder of the genome, resulting in isolated "genomic islands of speciation." We conducted an experime

192 studies of emerging species have identified genomic "islands" of elevated differentiation against a

193 46 fish, we identified 98 clearly demarcated genomic "islands" of high differentiation and demonstrat

194 of chromosomal DNA from cyptic oriTs within genomic islands or elsewhere on the chromosome could be

195 and boundary detection and identification of genomic islands or functional features of real biologica

196 ta on each genome such as predicted operons, genomic islands or transcriptomic data, when available.

197 ed to date originated from temperate phages, genomic islands, or prophages (4-8) , and shared propert

198 he presence of certain horizontally acquired genomic islands, or the expression of other virulence tr

199 ILE(FH5)) and the NR-II virulence region of genomic island PAGI-5 (ILE(FH4)).

200 Acquisition of genomic islands plays a central part in bacterial evolut

201 aseolicola where isolates that have lost the genomic island PPHGI-1 carrying the effector gene avrPph

202 Several genes within O-islands (genomic islands present in EHEC but absent from E. coli

203 s located on mobile genetic elements such as genomic islands, prophages, pathogenicity islands, and t

204 Thus, genomic islands provide abundant material for the experi

205 coli (UPEC) strain CFT073 contains 13 large genomic islands ranging in size from 32 kb to 123 kb.

206 We identified 22 E. coli RS218-derived genomic islands (RDIs), using a comparative genome analy

207 tion results in homogenization of the entire genomic island region (~1.5% of the genome) between spec

208 A subset of genomic island regions, including these loci, appears to

209 Analysis of these genomic islands revealed an integrase-associated island

210 to a previously described in vivo-expressed genomic island (Rv0960-Rv1001).

211 tics in staphylococci, mecA, is carried on a genomic island, SCCmec (for staphylococcal cassette chro

212 These diverse genomic islands shared a common evolutionary origin, ins

213 tains all 11 ARGs within an ~25 Kbp chimeric genomic island showing strong patterns of recombination

214 ene transfer within the symbiotic plasmid or genomic island shown here suggests that such diterpenoid

215 A genomic island similar to an island originally identifie

216 The absence of strain- and group-specific genomic islands, some of which appear to be prophages an

217 cA, is carried on a large (20 kb to > 60 kb) genomic island, staphylococcal cassette chromosome mec (

218 ne repertoire including the acquisition of a genomic island strongly enriched in glycosyltransferase

219 Notably, the expression of several genomic islands, such as GTF-B/C, TnSmu, CRISPR1-Cas and

220 Genomic islands, such as pathogenicity islands, contribu

221 Notably, the expression of genes in several genomic islands, such as TnSmu1 and TnSmu2, was differen

222 on junctions after targeting all of the four genomic islands, suggesting a common mechanism of deleti

223 The host-specific requirements of these genomic islands support a model in which the acquisition

224 et al. describe a new type of transmissible genomic island that can be mobilized by co-resident inte

225 ated from human were found to be missing the genomic island that carries genes encoding cytolethal di

226 xin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pat

227 Aeromonas caviae Sch3N possesses a small genomic island that is involved in both flagellin glycos

228 lar architecture consisting of several large genomic islands that are dispensable for growth in bacte

229 In each pair, we identify genomic islands that are, on average, elevated in both r

230 l cassette chromosome) mec cassettes, mobile genomic islands that confer methicillin resistance.

231 icity islands (PAIs) are a specific group of genomic islands that contribute to genomic variability a

232 Several genes or genomic islands that have not been reported previously (

233 d the taxonomic and evolutionary patterns of genomic islands that modify DNA with 7-deazapurines.

234 We analyzed repeat sequences to identify genomic islands that, together with other approaches, su

235 Here we identify a genomic island (the prp gene cluster) in N. meningitidis

236 s to the corresponding PAO1 tRNA(Lys)-linked genomic island, the pathogenicity islands of strain PA14

237 binations of infrequently transferred stable genomic islands: those moving primarily through transfor

238 of novel genetic material, such as the exoU genomic island, through horizontal gene transfer may enh

239 between these populations and found two such genomic "islands." Through growth-rate assays, we found

240 s a large gene cluster, which is a part of a genomic island, TnSmu2.

241 (ORFs) within the approximately 49.7-kb T3SS genomic island to identify potential effector proteins.

242 Comparison of the sequenced ExoU-encoding genomic islands to the corresponding PAO1 tRNA(Lys)-link

243 The two genomic islands together contain genes homologous to a t

244 -dependent receptors, and is part of a 24 kb genomic island unique to the A. macleodii 'surface clade

245 an-genome analysis revealed 983 genes in 323 genomic islands unique to K. aerogenes isolates, includi

246 The examination of genomic islands unique to our strain revealed the presen

247 Content of the genomic islands varies, with one containing a prophage a

248 Both genomes carry S. aureus genomic islands vSAa, vSAB, and vSAy.

249 The genomic islands VSP-1 and VSP-2 distinguish El Tor from

250 lution of a novel exchangeable meningococcal genomic island was defined for the important human patho

251 In this study, the 132-kb syr-syp genomic island was found to be organized into five polyc

252 A genomic island was identified in the Haemophilus influen

253 Targeting lacZ within the largest 102-kbp genomic island was lethal to wild-type cells and resulte

254 Two genomic islands were co-present within 41 (21%) genomes

255 Eleven of these genomic islands were individually deleted from the genom

256 of the locus of enterocyte effacement (LEE) genomic island, which encodes a type III secretion syste

257 The pks genomic island, which is harbored by extraintestinal pat

258 y the kib gene cluster located within a rare genomic island, which was recently acquired by horizonta

259 buted throughout the chromosome except in 14 genomic islands, which generally had lower GC content th

260 bute biological function to several putative genomic islands, which may then be further characterized

261 d gene clusters are concentrated in specific genomic islands, which represent hot spots for BGC acqui

262 Significant synteny is seen in the entire genomic island with genomic regions from Salmonella ente

263 port of a diverse family of related syntenic genomic islands with a deep evolutionary origin, and our

264 pathway that recruits axis proteins to broad genomic islands with high gene density.

265 y are distinguished by the presence of three genomic islands with putative roles in metabolism and ce

266 iquitous mobile genetic elements present as "genomic islands" within bacterial chromosomes.

267 ted MGEs, in silico prediction revealed four genomic islands without essential genes in lengths from