ライフサイエンスコーパス: genomics

1 ses with approaches in 'systems genetics and genomics'.

2 ing all lead to different policy options for genomics.

3 es and publicly available datasets in cancer genomics.

4 ovides an adequate basis for policymaking in genomics.

5 research and particularly the application of genomics.

6 ss screens are a key technique in functional genomics.

7 l data is central for conducting research on genomics.

8 pproaches that rely on molecular biology and genomics.

9 ization, reproductive biology, and polyploid genomics.

10 ross species is prevalent in the field of 3D genomics.

11 iar with, the concepts of DNA, genetics, and genomics.

12 pplication of NGS in the context of pathogen genomics.

13 racing, permitted by advances in single-cell genomics.

14 genomes is one of the ultimate challenges in genomics.

15 hers with little experience in computational genomics.

16 approaches in human genetics and functional genomics.

17 nologies have emerged as powerful players in genomics.

18 ratories is important for advancing clinical genomics.

19 the American College of Medical Genetics and Genomics.

20 in population, ecological, and conservation genomics.

21 mong variables such as those from functional genomics.

22 ontributions to the scientific literature in genomics.

23 we describe a workflow used for comparative genomics.

24 rtant implications in other domains, such as genomics.

25 ections for interpretable ML in genetics and genomics.

26 is limited, even with the promise of modern genomics.

27 ignment is central to many aspects of modern genomics.

28 e genetic variation resources for functional genomics.

29 n the reproductive tissue using evolutionary genomics.

30 ional effects of genetic mutations in cancer genomics.

31 n light of recent contributions from ancient genomics.

32 nd how it will remain useful in a new age of genomics.

33 providing comparable insights about disease genomics.

34 In cancer genomics, a key challenge is the fast generation of accu

35 the American College of Medical Genetics and Genomics (ACMG) and 5197 clinically relevant mendelian g

36 Population genomics analysis of T. sinense reveals its genetic dive

37 Moreover, comparative genomics analysis reveals that a greater number of activ

38 e world, lends itself ideally to single-cell genomics analysis.

39 Using large-scale comparative genomics and advanced orthology evaluation techniques, w

40 Large scientific projects in genomics and astronomy are influential not because they

41 o integrate the body of knowledge on Xenopus genomics and biology together with the visualization of

42 e that aims to bridge the gap between cancer genomics and classical immunology.

43 and integrated landscapes of Nannochloropsis genomics and epigenomics will promote and accelerate com

44 rces are of great importance for comparative genomics and evo-devo approaches.

45 t species, however, least is known about its genomics and evolution.

46 sis, immunology and vaccine development, and genomics and evolution.

47 Future comparative genomics and functional studies in closely related Rosac

48 scriptomes will facilitate future population genomics and gene-environment association studies on Dal

49 Here, we used a combination of comparative genomics and heterologous synthetic misexpression to iso

50 Genomics and imaging are undoubtedly similar in certain

51 The analogy between genomics and imaging has been an important touchstone in

52 Genomics and metabolomics associations identified 61 (5.

53 ations between multiple omics data including genomics and metabolomics data to identify biomarkers po

54 of Linnaeus lives on in the age of microbial genomics and metagenomics, we propose an automated appro

55 Ns to solve important problems in functional genomics and moleculargenetics.

56 d correct molecular derangements in disease, genomics and novel phenotypic assays are unevenly deploy

57 authors discuss anticipated contributions of genomics and other forms of large-scale data in public h

58 For each topic, we summarize current genomics and pharmacogenomics data resources such as pan

59 Comparative genomics and phylogenetic analyses within the Malassezia

60 proach is a tool for studying bee functional genomics and potentially for safeguarding bee health.

61 rage the growing number of large-scale human genomics and proteomics data to make in-silico target id

62 ng bacTRAP, with postmortem human functional genomics and quantitative genetics data.

63 ave described the interaction between tumour genomics and remodelling of the tumour microenvironment

64 ultistriata Here, we describe how functional genomics and reverse genetics have contributed to our un

65 munities, referred to initially as community genomics and subsequently as genome-resolved metagenomic

66 Using comparative genomics and surface plasmon resonance, we identified pa

67 Combining integrative genomics and systems biology approaches has revealed new

68 The goal of genomics and systems biology is to understand how comple

69 e NYU Abu Dhabi and NYU New York Centers for Genomics and Systems Biology.

70 the American College of Medical Genetics and Genomics and the Association for Molecular Pathology cri

71 ed opportunities lie ahead for public health genomics and the realization of precision medicine, prov

72 integrated omics approach of patient-derived genomics and transcriptomics data suggested only minimal

73 he breast cancer data from TCGA, the largest genomics and transcriptomics database, support our findi

74 and tools for researchers doing comparative genomics and translational studies.

75 Complex Skin Diseases: Integrating Genetics, Genomics, and Disease Biology." The meeting emphasized t

76 nitor cells (HSPCs), single-cell proteomics, genomics, and functional assays.

77 aluable resource for the fields of virology, genomics, and human disease genetics.

78 n of cell-specific fate mapping, single-cell genomics, and human genetics adds novel insights into th

79 Advances in areas such as data analytics, genomics, and imaging have revealed individual patient c

80 burial sample using proteomics, in 91% using genomics, and in 51% using osteology.

81 has created inroads in pathology, radiology, genomics, and the analysis of electronic health record d

82 C-derived cells, conducted integrative human genomics, and used pharmacological studies targeting SMC

83 e, we developed a high-throughput functional genomics approach combining inducible CRISPR-interferenc

84 Our integrative genomics approach suggests that ERCC6 may be a previousl

85 ons, we used a hypothesis-driven integrative genomics approach to test the association of breast canc

86 tly prioritized with a convergent functional genomics approach using previous evidence in the field i

87 To address this, using a functional genomics approach, we have identified a small membrane-b

88 quantitative trait and a targeted genetical genomics approach, we have identified five separate cand

89 Using a functional genomics approach, we integrated transcriptomic data fro

90 ew describes how new CRISPR-based functional genomics approaches can uncover disease mechanisms and t

91 althy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a sing

92 In this Review, we discuss how genomics approaches have advanced our understanding of K

93 dentified centromere components(6)(,)(7) and genomics approaches to map and characterize the holocent

94 Genomics approaches, including de novo genome assemblies

95 ecent advances integrating metabolomics with genomics are discussed, yielding new insight into the me

96 c images and cellular-level information from genomics are needed.

97 Advances in genomics are opening new windows into the biology of sch

98 ice, small molecule inhibitors/agonists, and genomics assays.

99 the American College of Medical Genetics and Genomics/Association for Molecular Pathology and ClinGen

100 These results set the stage for genomics-based approaches in conservation strategies.

101 ation, and developing functional markers for genomics-based breeding in wheat.

102 Genomics-based neoantigen discovery can be enhanced by p

103 effective communication about genes, and as genomics becomes increasingly important in healthcare, t

104 -omics science, next-generation sequencing, genomics big data, and machine learning, could contribut

105 t al employs a full court press of genetics, genomics, biochemical, and advanced analytical technique

106 We also explore what comparative genomics, both structural and responsive, have added to

107 erged as an important technique in bacterial genomics, but cost and labor requirements limit large-sc

108 of diploid genomes, which will revolutionize genomics by revealing the full spectrum of human genetic

109 flow and documentation are demonstrated in a genomics case study available on Zenodo.

110 ) technology, largely represented by the 10x Genomics Chromium system, is able to measure the gene ex

111 n the first patient, sequenced using the 10X Genomics CNV solution with sequencing coverage ~0.03x, S

112 sequencing costs, is a pressing need of the genomics community.

113 with summary statistics from the Psychiatric Genomics Consortium (PGC) study of schizophrenia yielded

114 Chemical Probes' collated by the Structural Genomics Consortium (SGC) and identified the p300/CBP HA

115 er model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection.

116 ADHD meta-analytic data from the Psychiatric Genomics Consortium for discovery (N=19,210) and ADHD da

117 ta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of m

118 significant association from the Psychiatric Genomics Consortium genome-wide association study of sch

119 ) haplotypes in studies from the Psychiatric Genomics Consortium Major Depressive Disorder Working Gr

120 RICOPILI was created as the Psychiatric Genomics Consortium pipeline for GWAS and adopted by oth

121 e psychiatric disorders from the Psychiatric Genomics Consortium-schizophrenia (SCZ), bipolar disorde

122 the most recent results from the Psychiatric Genomics Consortium.

123 uld be handled in both clinical and research genomics contexts.

124 ent American College of Medical Genetics and Genomics criteria with incorporation of signal-to-noise

125 potential applications for plant functional genomics, crop improvement and crop protection, but the

126 Finally, by integrating genomics data and pathway analysis, we find that the dif

127 Genomics data due to its sparse, high-dimensional and no

128 cogenomics data resources such as pan-cancer genomics data for cancer cell lines (CCLs) and tumors, a

129 cancer whole genome sequences and functional genomics data from the Encyclopedia of DNA Elements (ENC

130 fforts to increase the reusability of public genomics data has been to focus on the inclusion of qual

131 -to-use computational system for analysis of genomics data sets, designed to accelerate biomedical di

132 age, projectR, to perform TL for analyses of genomics data via TL of clustering, correlation and fact

133 ion in the portal is quantified by combining genomics data with rich proteomic annotations.

134 Integrating high-throughput functional genomics data with this information can help identifying

135 erformed a meta-analysis of pooled published genomics data, andwe present a comprehensive literature

136 e increasing amount and complexity of bovine genomics data, BGD continues to advance its practices in

137 application to connect life scientists with genomics data.

138 both mechanisms has been confirmed in cancer genomics data.

139 to store, update, explore, and analyze phage genomics data.

140 Using a radio-genomics dataset, Statistical RMS was significantly asso

141 With an ever-expanding genomics dataset, there are many opportunities for gener

142 DrEdGE increases the utility of large genomics datasets by removing technical obstacles to ind

143 As the number of genomics datasets grows rapidly, sample mislabeling has

144 Access to large-scale genomics datasets has increased the utility of hypothesi

145 cs with large-scale collection of functional genomics datasets spanning enhancer activity, transcript

146 Functional genomics describes a field of biology that uses a range

147 In this new era in cancer genomics, discoveries from studies conducted on an inter

148 ncorporate outside resources from the larger genomics ecosystem, and demonstrate how the tools can be

149 ver the past decade, large-scale integrative genomics efforts have enhanced our understanding of this

150 Genomics efforts have found relationships among rhythmic

151 selection on drought stress, and can inform genomics-enabled breeding for climate-resilient cereals.

152 he most commonly used scRNA-seq protocol-10x Genomics enables us to improve the study resolution of A

153 normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphopro

154 In the genomics era, the availability of large biomedical datas

155 With the advent of the Genomics Era, there is an unprecedented opportunity to a

156 Functional genomics experiments generate genomewide signal profiles

157 Bioinformatic analysis and functional genomics experiments suggested a correlation of the most

158 aise the current knowledge of blood pressure genomics, explore the causal pathways for hypertension i

159 We highlight how genomics extends beyond consensus-level sequencing of th

160 th practices, and an increasing relevance of genomics for everyday life.

161 nd emerging frontiers of cancer genetics and genomics from the perspective of global cancer preventio

162 In genomics, generating a high-quality genome assembly/anno

163 We used genomics, genetic, biochemical, and microscopic approach

164 not just microbiological - but encompassing genomics, genetics, oceanography, ecological, earth obse

165 re common in many scientific domains such as genomics, geology and economics.

166 to American College of Medical Genetics and Genomics guidelines.

167 ent American College of Medical Genetics and Genomics guidelines.

168 Here, we describe how genomics has been historically used to investigate Ebola

169 Single-cell genomics has enabled inferences on the physiology, virul

170 and continuing after its completion in 2003, genomics has progressively come to have a central and ca

171 Genomics has the potential to dramatically improve our a

172 Single-cell genomics has transformed our ability to examine cell fat

173 armaceutical companies has decreased even as genomics has uncovered the large number of biosynthetic

174 struction of chromosomes, known as synthetic genomics, has emerged as a novel approach to genetic man

175 Recent advances in genomics have dramatically advanced our understanding of

176 Although advances in cancer genomics have dramatically enhanced our understanding of

177 Advances in genomics have expedited the improvement of several agric

178 advances in chemical biology and functional genomics have facilitated exploration of targeting epige

179 Advances in genomics have led to an appreciation that introgression

180 in high-throughput sequencing and regulatory genomics have led to the identification of regulatory el

181 Recent advancements in genomics have made it easier than ever to investigate th

182 ion efforts are supported by the comparative genomics here, although several changes are proposed, in

183 cific Biosciences and NGS barcoding from 10x Genomics hold the potential for far more comprehensive v

184 Combined with single-cell genomics, humanized mice can facilitate functional preci

185 Comparative genomics identified differential distribution of the gen

186 Large-scale single-cell genomics, imaging technologies, and the Human Cell Atlas

187 tudy demonstrates the utility of single-cell genomics in discovering disease-associated cytologic sig

188 Our data highlight the power of single-cell genomics in dissecting, in its many forms, intra-tumoral

189 be a significant breakthrough in associative genomics in the big data era.

190 Considering the importance of genomics in the development of any crop, this analysis u

191 genome editing has revolutionized functional genomics in vertebrates.

192 We also review recent advances in genomics including its evolving role in prognosis, in el

193 As part of the advances in genomics, increasingly accurate deep sequencing and nove

194 uated the PRSs in two biobanks: the Michigan Genomics Initiative (MGI), a longitudinal biorepository

195 across species(7,8), in stark contrast with genomics initiatives(9).

196 will lead to more widespread integration of genomics into almost all areas of biomedical research, t

197 reas of biomedical research, the adoption of genomics into mainstream medical and public-health pract

198 Genomics is a sequence-based informatics science and a t

199 Single-cell genomics is essential to chart tumor ecosystems.

200 r knowledge of enset diversity, genetics and genomics is required to support breeding programs and co

201 A core task of genomics is to identify the boundaries of protein coding

202 We present Knowledge Engine for Genomics (KnowEnG), a free-to-use computational system f

203 As microbial genomics makes increasingly important contributions to c

204 nted on the burden of disease, epidemiology, genomics, management, and control strategies for invasiv

205 OmicsDI integrates proteomics, genomics, metabolomics, models and transcriptomics datas

206 The improvements in genomics methods coupled with readily accessible high-th

207 arthropod evolution, and animal evolutionary genomics more widely.

208 LIA-accredited Electronic Medical Record and Genomics Network sequencing centers and the six CLIA-acc

209 e, we used an integrative approach including genomics, network reconstruction, and mutational analysi

210 In 2013, the International Genomics of Alzheimer's Project (IGAP) did a meta-analys

211 GSMR applied to the International Genomics of Alzheimer's Project dataset revealed a signi

212 ent outcomes: 1) AD diagnosis (International Genomics of Alzheimer's Project), 2) maternal family his

213 zing drug pharmacogenomics profiles from the Genomics of Drug Sensitivity in Cancer database, we show

214 tics, in further discussions of evolutionary genomics of highly fecund populations.

215 sent to the African Centre of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's Uni

216 The genomics of primary prostate cancer differ from those of

217 of this study is to better characterize the genomics of Spitz neoplasms and assess whether the integ

218 n of whether this expanding knowledge of the genomics of T2D provides insight into the etiologic rela

219 Comparative genomics of Vellore isolates was performed to infer tran

220 cronutrient contents, recent developments in genomics offer an opportunity to accelerate marker disco

221 Population genomics offers innovative approaches to test hypotheses

222 hes are available to estimate sex-osteology, genomics, or proteomics, but little is known about the r

223 the integration of experimental genetics and genomics, our study provides useful resources and gene m

224 , we provide a brief history of single-virus genomics, outline how this emergent method has facilitat

225 wo breast cancer patients using Illumina/10x Genomics, Pacific Biosciences (PacBio), and Oxford Nanop

226 the American College of Medical Genetics and Genomics, pathogenic/likely pathogenic variants in 23 kn

227 Here, using an evolutionary genomics pipeline to compare 208 complete genomes, we an

228 uates them as a relatively simple functional genomics platform for identification of mutations associ

229 ovide an overview of contemporary functional genomics platforms, highlighting areas of distinction an

230 Single-cell RNA sequencing (10x Genomics, Pleasanton, Calif) was utilized to compare the

231 n the complexity and diversity of the cancer genomics profiles, it is challenging to identify distinc

232 applied to large-scale bacterial comparative genomics projects but the reconstruction of plasmids fro

233 trate PCS inference through neuroscience and genomics projects of our own and others.

234 Big data era in genomics promises a breakthrough in medicine, but sharin

235 ces to the most relevant resources providing genomics, proteomics, and cancer-related information.

236 Integrating RNA-seq, comparative genomics, proteomics, and machine learning to study the

237 We integrate the genomics, proteomics, and phosphoproteomics of 480 clini

238 erging, being identified when "omics" tools (genomics, proteomics, and transcriptomics) are applied t

239 assembled from repositories in the fields of genomics, proteomics, genetic variants, pathways, chemic

240 nitization procedure allowing raw functional genomics reads to be shared while minimizing privacy lea

241 Assays in mitochondrial genomics rely on accurate read mapping and variant calli

242 Targeted functional genomics represents a powerful approach for studying gen

243 A major goal of comparative genomics research is modeling changes in DNA sequences b

244 Although pathway databases are critical in genomics research, the fast progress of biomedical scien

245 used as a monocot model system in functional genomics research.

246 e annotation, and students to participate in genomics research.

247 With an explosion in genomics resources and a rapidly expanding toolbox over

248 obial genomes while human and model organism genomics resources include Ensembl, Ensembl genomes and

249 izing feature selection methods and multiple genomics resources including 1000 Genomes Project and Hu

250 e enset genome to develop molecular markers, genomics resources, and characterize enset landraces whi

251 Human genomics revealed enrichment of genome-wide association

252 Comparative genomics reveals an unexpected diversity in the molecula

253 tutions performing NGS sequencing for cancer genomics should incorporate the step of merging MNV as a

254 -based analyses for mycobacterial functional genomics, simultaneously establishing the utility of thi

255 a 3-dimensional "risk space." Although NAFLD genomics sometimes appears to be "lost in translation,"

256 eVAR Index enables practitioners who are not genomics specialists to assess the likely reactivity of

257 nes from the MIxS standards developed by the Genomics Standard Consortium (GSC) and adopted by the th

258 er treatment in clinical studies, functional genomics studies and computational studies and discuss t

259 The advances of large-scale genomics studies have enabled compilation of cell type-s

260 Cancer genomics studies have identified thousands of putative c

261 any crops has been achieved, crop functional genomics studies have stepped into the big-data and high

262 study paving the way for further single cell genomics studies in Leishmania.

263 le preparation and genotyping, most genebank genomics studies in self-pollinating species are conduct

264 Such image-driven functional genomics studies may be expected to appear at an acceler

265 B. distachyon, which will aid in functional genomics studies of other C3 grasses.

266 nificant technical challenge for most cancer genomics studies performed at less than 100x mean resolu

267 ped to variants and genes through functional genomics studies that combine annotation of variants, ge

268 necks hindering crop breeding and functional genomics studies.

269 ed, in part, because of a lack of functional genomics studies.

270 imulation plays a central role in population genomics studies.

271 pulation-imaging datasets: UK Biobank, Brain Genomics Superstruct Project, and Enhancing NeuroImaging

272 directly on epigenomic data on a variety of genomics tasks.

273 Similar genomics techniques can also be applied to the character

274 Recent advances in image-based 3D genomics techniques have enabled direct tracing of chrom

275 se large isolate collections and comparative genomics techniques, linked to phenotype studies, to und

276 Transformative single-cell genomics technologies and spatial multiplex in situ meth

277 ing so, we lay the foundation for population genomics, theoretical, and experimental approaches to un

278 As we enter an exciting new stage in maize genomics, this retrospective will summarize the design a

279 important goal for many fields spanning from genomics to antisense therapy and diagnostics.

280 We used large-scale comparative genomics to assess the genetic diversity, phylogeography

281 ine-scale geographic sampling and population genomics to determine patterns of gene flow across two h

282 We combined functional genomics to identify a missing pathway enzyme, protein e

283 rly understood.Objectives: To use functional genomics to identify cellular mechanisms associated with

284 s the most compelling recent applications of genomics to investigate the mechanisms underpinning bee

285 Despite the wide use of genomics to investigate the molecular basis of rare cong

286 s issue of Blood, Yang and colleagues use 3D genomics to make an important contribution to the list o

287 hlight the contributions of ancient pathogen genomics to multidisciplinary endeavors and describe som

288 ntal in applications ranging from functional genomics to precision medicine and is a conjectured sour

289 Here, we applied comparative genomics to study 90 antimicrobial resistant (AMR) S. en

290 thus genome expands the power of comparative genomics to understand traits of importance to Andropogo

291 iology and treatment efficacy by integrating genomics, transcriptomics and protein profiling includin

292 erstanding the complex relationships between genomics, transcriptomics, and proteomics requires the d

293 ces in various omics technologies, including genomics, transcriptomics, epigenomics, proteomics and m

294 Combining genomics, transcriptomics, metabolomics, and biochemistr

295 High-throughput technologies for genomics, transcriptomics, proteomics, and metabolomics,

296 Using comparative genomics, we found a robust association between the DUF3

297 Among those tools is single-virus genomics, which yields sequenced reference genomes from

298 e impact of integrating microbial population genomics with host metadata and demonstrate how host env

299 insight into the landscape of breast cancer genomics with the genomic characterization of tumors off

300 search priorities and opportunities in human genomics, with an emphasis on health applications.