ライフサイエンスコーパス: geranyl

1 abeled with 3-azido-2-methyl-5-methoxy-[3H]6-geranyl-1,4-benzoquinone ([3H]azido-Q) followed by SDS-p

2 inity label 3-[3H]azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone (azido-Q), a substrate analogue

3 h the trisubstituted alkene end-group of the geranyl 1Z-CH(3) to give 2Z-CH(3), (ii) acid-catalyzed k

4 xplain why plasticity induced by the odorant geranyl acetate (which is attractive) shows no CP althou

5 lanone-B, as well as to the general odorants geranyl acetate and hexanol.

6 overed three CYPs selectively upregulated by geranyl acetate using transcriptional profiling.

7 Geraniol, geranial, and geranyl acetate were the most abundant compounds.

8 s from surfaces (stearic acid) and from air (geranyl acetate) than groomed antennae.

9 ly-reported aroma active rice volatiles were geranyl acetate, beta-damascone, beta-damascenone, and a

10 cene, (E)-2-hexenal tended to decrease while geranyl acetate, citronellal, neral tended to increase u

11 ation of the appropriate anilines with 8-oxo-geranyl acetate, followed by ester hydrolysis, chlorinat

12 For the cyclization of geranyl acetate, it was found that the cleavage of the l

13 Linalool, Geranyl acetate, Limonene, Camphor, Geraniol, and other

14 tion of Azocompost alone increased levels of geranyl acetate.

15 synthetic intermediate readily prepared from geranyl acetate.

16 h the geranyl-diphosphate pathway (neryl and geranyl acetates) and some terpenoids were found in the

17 included 6-methyl 5-hepten-2-one (6-MHO) and geranyl acetone (GA) with average yields of 0.22 and 0.1

18 ir high OAVs, cis-linalool oxide (furanoid), geranyl acetone, and cinnamyl acetate were identified as

19 -jasmone, 2-acetylpyrrole, farnesyl acetone, geranyl acetone, cadinol, cubenol and dihydroactinidioli

20 Wild type Nm23-H1 had higher geranyl and farnesyl pyrophosphate kinase activities tha

21 The phosphorylation of geranyl and farnesyl pyrophosphates by Nm23 proteins pro

22 report that Nm23 proteins can phosphorylate geranyl and farnesyl pyrophosphates to give triphosphate

23 at VvGT7 may contribute to the production of geranyl and neryl glucoside during grape ripening.

24 benzyl-beta-D-glucopyranoside, prunasin and geranyl-beta-D-glucopyranoside (GGP), respectively.

25 placement by the less hydrophobic isoprenoid geranyl causes severely delayed oocyte activation.

26 d stereoselectively in just three steps from geranyl chloride or neryl chloride, providing a short an

27 ferences in the structures of functionalized geranyl chlorides can significantly impact their abiliti

28 Geranyl-CoA carboxylase (GCC) is essential for the growt

29 ne in MCC, which blocks access by the larger geranyl-CoA substrate.

30 that CoQ analogs with long decyl (CoQ(D)) or geranyl (CoQ(2)) tails partition into detergent micelles

31 We synthesized a geranyl dimer that binds to the central pocket with micr

32 ated as a possible C-methyltransferase, with geranyl diphosphate (1) and S-adenosylmethionine gave th

33 e the corresponding chlorinated analogues of geranyl diphosphate (3-ClGPP) and farnesyl diphosphate (

34 antly to beta-cubebene, while Mg17 converted geranyl diphosphate (C(5)) to alpha-terpineol.

35 in plants typically proceeds through either geranyl diphosphate (C10) or trans-farnesyl diphosphate

36 noid coupling reactions to give a mixture of geranyl diphosphate (chain elongation), chrysanthemyl di

37 phosphate synthase 1 (PcIDS1) yields 96% C10-geranyl diphosphate (GDP) and only 4% C15-farnesyl dipho

38 nd dimethylallyl diphosphate (DMAPP) to form geranyl diphosphate (GPP) and between IPP and GPP to giv

39 es, which are derived from linear precursors geranyl diphosphate (GPP) and lavandulyl diphosphate (LP

40 hosphate (BPP), which is itself derived from geranyl diphosphate (GPP) by the enzyme ( +)-bornyl diph

41 The TPS, termed LlTPS, converted geranyl diphosphate (GPP) into a mixture of monoterpenes

42 S1 catalyzing the irreversible conversion of geranyl diphosphate (GPP) to geraniol.

43 ed with dimethylallyl diphosphate (DMAPP) or geranyl diphosphate (GPP) to give the corresponding chlo

44 MoeN5 catalyzes the reaction of geranyl diphosphate (GPP) with the cis-farnesyl group in

45 is hypothesized to originate from 10-carbon geranyl diphosphate (GPP), 15-carbon farnesyl diphosphat

46 te (IPP), dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), farnesyl diphosphate (FPP), a

47 ere the C(10) product of the first addition, geranyl diphosphate (GPP), is the substrate for the seco

48 wers include three monoterpenes derived from geranyl diphosphate (GPP), myrcene, (E)-beta-ocimene and

49 (Humulus lupulus L.) trichomes, derives from geranyl diphosphate (GPP), the common precursor of monot

50 Geranyl diphosphate (GPP), the precursor of many monoter

51 Geranyl diphosphate (GPP), the precursor of most monoter

52 modifies an acyclic isoprenoid diphosphate, geranyl diphosphate (GPP), to yield a noncanonical acycl

53 solic NUDX1 hydrolase which dephosphorylates geranyl diphosphate (GPP).

54 imethylallyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP).

55 th dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to give (E,E)-FPP (C15).

56 ted L. x intermedia CINS (LiCINS), converted geranyl diphosphate (the linear monoterpene precursor) p

57 tene->xanthoxin->ABA)2(terpense->diterpense->geranyl diphosphate ->C20 ->GA).

58 engineer their isoprene donor specificities (geranyl diphosphate [GPP] versus dimethylallyl diphospha

59 nzyme activity level (7-fold), and in planta geranyl diphosphate and geranylgeranyl diphosphate level

60 e overexpressed a bifunctional spruce IDS, a geranyl diphosphate and geranylgeranyl diphosphate synth

61 values of 21 and 51 microM were obtained for geranyl diphosphate and Mn2+, respectively.

62 Incubation of geranyl diphosphate and S-adenosylmethionine with a mixt

63 zyme was functionally expressed and produced geranyl diphosphate as its major product.

64 functional hybrid heterodimer that generated geranyl diphosphate as product in each case.

65 to all known monoterpene cyclases, which use geranyl diphosphate as substrate and invoke a cationic i

66 on in Escherichia coli and enzyme assay with geranyl diphosphate as substrate, subsequent analysis of

67 icate that, contrary to the textbook view of geranyl diphosphate as the "universal" substrate of mono

68 he monoterpene bornyl diphosphate (BPP) from geranyl diphosphate by BPP synthase using state of the a

69 Geranyl diphosphate C-methyltransferase (GPPMT) from Str

70 lly synthesized as stable analogs of omega,E-geranyl diphosphate in which the labile diphosphate moie

71 enchol synthase, plant cyclases that convert geranyl diphosphate into products with closely related b

72 The data from both organisms suggest that geranyl diphosphate is the allylic substrate for two dis

73 Geranyl diphosphate is the precursor of monoterpenes, a

74 , except for a relatively low K(m) value for geranyl diphosphate of 0.2 microm.

75 dition of isopentenyl diphosphate to omega,E-geranyl diphosphate or omega,Z-neryl diphosphate yieldin

76 FDS-1 prefers geranyl diphosphate over dimethylallyl diphosphate as an

77 t cells overexpressing Rv1086 incubated with geranyl diphosphate showed a 5-fold increase of [(14)C]i

78 Geranyl diphosphate synthase (GPPS) catalyzes the conden

79 myrcene, in transgenic tobacco by elevating geranyl diphosphate synthase (GPS) activity.

80 erized Lavandula x intermedia cDNAs encoding geranyl diphosphate synthase (LiGPPS), geranylgeranyl di

81 phate synthase (SlDXS), Arabidopsis thaliana geranyl diphosphate synthase 1 (AtGPS) and Mentha x pipe

82 The relative levels of geranyl diphosphate synthase and farnesyl diphosphate sy

83 the hybrid possesses characteristics of both geranyl diphosphate synthase and geranylgeranyl diphosph

84 Geranyl diphosphate synthase belongs to a subgroup of pr

85 synthases; yet it is absolutely required for geranyl diphosphate synthase catalysis.

86 diphosphate synthase, which are homodimers, geranyl diphosphate synthase from Mentha is a heterotetr

87 phosphate pathway were overexpressed, and a geranyl diphosphate synthase from the plant Abies grandi

88 nd recombinant enzymes, thus confirming that geranyl diphosphate synthase is a heterodimer.

89 Immunogold labeling of geranyl diphosphate synthase occurred within secretory c

90 ate synthase 1 (AtGPS) and Mentha x piperita geranyl diphosphate synthase small subunit (MpGPS.SSU) o

91 These results indicate that the geranyl diphosphate synthase small subunit is capable of

92 expression in Escherichia coli of the Mentha geranyl diphosphate synthase small subunit with the phyl

93 l subunits of peppermint (Mentha x piperita) geranyl diphosphate synthase, spearmint (Mentha spicata)

94 Geranyl diphosphate synthase, which catalyzes the conden

95 sion of the two together produced functional geranyl diphosphate synthase.

96 proceed via an RR-dependent isomerization of geranyl diphosphate to 3S-linalyl diphosphate, as shown

97 terpene cyclase limonene synthase transforms geranyl diphosphate to a monocyclic olefin and constitut

98 ersion of the ubiquitous terpenoid precursor geranyl diphosphate to the iridoid loganic acid.

99 te; however, one truncated protein converted geranyl diphosphate to the monoterpene limonene.

100 en proposed to proceed by the cyclization of geranyl diphosphate to y-terpinene, followed by a series

101 r isopentenyl diphosphate, 38 micrometer for geranyl diphosphate, and 16 micrometer for neryl diphosp

102 mation of the prenyl diphosphate precursors, geranyl diphosphate, farnesyl diphosphate, and geranylge

103 se in that it adds only one isoprene unit to geranyl diphosphate, generating the 15-carbon product (E

104 , myrcene and (E)-beta-ocimene, derived from geranyl diphosphate, in addition to a major phenylpropan

105 catalyzed the formation of 18O-geraniol from geranyl diphosphate, indicating that the reaction mechan

106 the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-A; resolution in

107 s the addition of isopentenyl diphosphate to geranyl diphosphate, neryl diphosphate, omega,E,E-farnes

108 terminal domain catalyzes the cyclization of geranyl diphosphate, orienting and stabilizing multiple

109 l diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene bi

110 ncapable of converting the natural substrate geranyl diphosphate, via the enzymatically formed tertia

111 ase (GES) activity, generating geraniol from geranyl diphosphate, was shown to be localized exclusive

112 additional product, the regular monoterpene geranyl diphosphate, when incubated with isopentenyl dip

113 e formation of 10 volatile monoterpenes from geranyl diphosphate, with 1,8-cineole predominating.

114 rm yeast peroxisomes into microfactories for geranyl diphosphate-derived compounds, focusing on monot

115 for activity and produces only geraniol from geranyl diphosphate.

116 e, Rv1086, adds one isoprene unit to omega,E-geranyl diphosphate.

117 , respectively, as their major products from geranyl diphosphate.

118 carboxamide intermediate 2 at carbon 6 with geranyl diphosphate.

119 e (C(50)) from isopentenyl diphosphate and E-geranyl diphosphate.

120 hosphate and isopentenyl diphosphate to form geranyl diphosphate.

121 ation of both geraniol and (R)-linalool from geranyl diphosphate.

122 r content of some compounds related with the geranyl-diphosphate pathway (neryl and geranyl acetates)

123 for rat farnesyl diphosphate (FPP) synthase (geranyl-diphosphate:isopentenyl-diphosphate geranyltrans

124 Regiospecifically labeled geranyl diphosphates ((2E,6E)-[1,1,8,8,8-(2)H(5)]- and (

125 ophylls-e, including a previously unreported geranyl ester of 4-i-butyl bacteriochlorophyll-e.

126 ctivity in Escherichia coli by using labeled geranyl, farnesyl, and geranylgeranyl diphosphates as su

127 the diphosphate derivatives of isopentenyl, geranyl, farnesyl, geranylgeranyl, and presqualene.

128 c mevalonate (MVA) pathway by a bifunctional geranyl/farnesyl diphosphate synthase, RcG/FPPS1, produc

129 ynthase CotB2, commencing with the substrate geranyl geranyl diphosphate and terminating with the car

130 yl geranyl transferase I, and the effects of geranyl geranyl transferase I inhibitors on cell cycle,

131 s by the closely related prenyl transferase, geranyl geranyl transferase I, and the effects of gerany

132 pt analysis suggested that the heterodimeric geranyl(geranyl)diphosphate synthase [G(G)PPS] is involv

133 Furthermore, our data suggest that double geranyl-geranyl groups are required for Rab proteins to

134 t is completely different from the G protein-geranyl-geranyl interaction face of the Ig-like domain o

135 ects the time-course of translocation of the geranyl-geranyl lipid tail of Cdc42 from the outer leafl

136 yme A) and farnesyl-pyrophosphate but not by geranyl-geranylpyrophosphate or cholesterol.

137 ce with Rac3 activity, for example, by using geranyl-geranyltransferase inhibitors, may provide a pos

138 Gewurztraminer glycosides, geranyl glucoside and guaiacyl glucoside were investigat

139 concentration, Gewurztraminer glycosides and geranyl glucoside gave significant fruity flavour, altho

140 eal juices and wines have been enriched with geranyl glucoside, typical of white varieties, and guaia

141 sed aromatic core with an attached 10-carbon geranyl group derived from isoprenoid (terpene) metaboli

142 es to explore the structural features of the geranyl group in the context of A-form RNA and its effec

143 In vivo, Orf2 attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-deriv

144 and precisely aligns the double bond of the geranyl group with respect to the FAD cofactor, thus pro

145 oselective intramolecular transfer of prenyl/geranyl groups from isoprene donors to an electron-rich

146 (S)-Dimethylallyl (DMASPP), (S)-geranyl (GSPP), (S)-farnesyl (FSPP), and (S)-geranylgera

147 onger (C20) isoprenols as well as N-acetyl-S-geranyl-L-cysteine (C10) did not inhibit the response to

148 itor of methylation, but not AGC (N-acetyl-S-geranyl-L-cysteine), an inactive analog of AFC.

149 tion, acting at least partly via blockade of geranyl lipid production downstream of HMG-CoA reductase

150 The method was extended with geranyl migration in eight-step total syntheses of heric

151 cal, signal peptide-dependent pathway, but a geranyl-modified attractant would require an alternative

152 voiding late-stage installation of prenyl or geranyl moieties as in previous approaches.

153 s the sole enzyme required for cyclizing the geranyl moiety.

154 synthesized terpenyl-ss-D-glycopyranosides (geranyl, neryl, citronellyl, myrtenyl) were subjected to

155 n the reaction mixtures of L-tryptophan with geranyl or farnesyl diphosphate.

156 contain 5-carbon (dimethylallyl), 10-carbon (geranyl) or 15-carbon (farnesyl) isoprenoid chains posse

157 hains or metabolites via the condensation of geranyl- or isopentenyl-diphosphate moieties by geranylt

158 chain was synthesized through coupling with geranyl phenyl sulfide and Bouveault-Blanc reduction.

159 butyl phosphate, 3-buten-1-yl phosphate, and geranyl phosphate, were evaluated as alternative substra

160 lthough the catalytic efficiency was low for geranyl phosphate.

161 c analyses show that pyrophosphates 1a-e and geranyl pyrophosphate (GPP) transfer with a lower effici

162 mevalonate pathway to provide a high flux of geranyl pyrophosphate and introduced a heterologous, mul

163 s reveal that inhibition is competitive with geranyl pyrophosphate and is of a slow, tight binding ch

164 ic steps beyond the yeast native metabolites geranyl pyrophosphate and tryptophan to catharanthine an

165 These agents bind to the dimethylallyl/geranyl pyrophosphate ligand pocket and induce a conform

166 hapalindoles from cis-indole isonitrile and geranyl pyrophosphate through a presumed biosynthetic Co

167 ting for the route from phosphomevalonate to geranyl pyrophosphate, are missing, as are the enzymes f

168 he tested metabolites, including mevalonate, geranyl pyrophosphate, farnesyl pyrophosphate, and ubiqu

169 E2 formed the linear monterpene myrcene from geranyl pyrophosphate, whereas hop SESQUITERPENE SYNTHAS

170 osphate with dimethylallyl pyrophosphate and geranyl pyrophosphate.

171 osphate with dimethylallyl pyrophosphate and geranyl pyrophosphate.

172 ternary complex of bacitracin A, zinc, and a geranyl-pyrophosphate ligand at a resolution of 1.1 A.

173 n complex with GPP or the substrate analogue geranyl S-thiolodiphosphate (GSPP) along with S-adenosyl

174 termined in complex with substrate analogues geranyl-S-thiolodiphosphate and 2-fluorogeranyl diphosph

175 In one, the geranyl side chain binds to either S1 or S2 and the adam

176 Crystal structures reveal the geranyl side chain of amorfrutin B as the cause of its p

177 activity in vitro established that VrtC is a geranyl transferase that catalyzes a regiospecific Fried