ライフサイエンスコーパス: geranylgeranyltransferase

1 Combining a farnesyltransferase and geranylgeranyltransferase 1 inhibitor, namely, L-778123,

2 yltransferases, farnesyltransferase (FT) and geranylgeranyltransferase-1 (GGT), in the pathogenesis o

3 The complete loss of Rab geranylgeranyltransferase activity appears to be lethal

4 Loss of protein geranylgeranyltransferase activity results in colonies o

5 (D44N) that, when geranylgeranylated by Rab:geranylgeranyltransferase (GGTase II) in cell-free syste

6 nase (MAPK), and preserves the processing of geranylgeranyltransferase (GGTase) I and GGTase II prote

7 (VSMCs), insulin stimulated the activity of geranylgeranyltransferase (GGTase) I and increased the a

8 hibitors for farnesyltransferase (FTase) and geranylgeranyltransferase (GGTase) I as well as combinat

9 on and activation of farnesyltransferase and geranylgeranyltransferase (GGTase) II.

10 Furthermore, like the type I protein geranylgeranyltransferase (GGTase-I), FTase can also ger

11 Inhibition of geranylgeranyltransferase has no effect on levels of JNK

12 This study provides evidence that geranylgeranyltransferase I (GGT) is an important signal

13 Geranylgeranyltransferase I (GGTase I) catalyzes the tra

14 Treatment of H-Ras transgenic mice with the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-21

15 f oncogenic K-Ras4B is more sensitive to the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-28

16 in action on farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) using Chinese ham

17 erase (FTase), while modification by protein geranylgeranyltransferase I (GGTase I) was not detected.

18 ing with CIIL, a motif that is recognized by geranylgeranyltransferase I (GGTase I).

19 FTase and the closely related family member geranylgeranyltransferase I (GGTase I).

20 Protein geranylgeranyltransferase I (GGTase-I) and Rab geranylge

21 tein farnesyltransferase (FTase) and protein geranylgeranyltransferase I (GGTase-I), enzymes involved

22 nt and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI), GGTI-2418, and its m

23 omoted the phosphorylation and activation of geranylgeranyltransferase I (GGTI-I), increased the amou

24 Both can be prenylated by either protein geranylgeranyltransferase I (PGGT-I) or protein farnesyl

25 tif permits this protein to be prenylated by geranylgeranyltransferase I but not II both in cell-free

26 Inhibition of geranylgeranyltransferase I by GGTi-298, but not farnesy

27 Geranylgeranyltransferase I controls the function of a v

28 he activity of FTase, but not of the related geranylgeranyltransferase I enzyme, in peripheral blood

29 ) that occurs due to modification of RhoB by geranylgeranyltransferase I in drug-treated cells.

30 e have now examined the effect of insulin on geranylgeranyltransferase I in MCF-7 breast cancer cells

31 ransformed NIH3T3 cells both FTI-276 and the geranylgeranyltransferase I inhibitor GGTI-297 are requi

32 We have recently reported that the geranylgeranyltransferase I inhibitor GGTI-298 arrests h

33 The geranylgeranyltransferase I inhibitor GGTI-298 has recen

34 ibitor of prenyltransferases, but not by the geranylgeranyltransferase I inhibitor, GGTI-298, or the

35 ly, we have designed farnesyltransferase and geranylgeranyltransferase I inhibitors (FTI-277 and GGTI

36 Geranylgeranyltransferase I inhibitors (GGTIs) are prese

37 Geranylgeranyltransferase I inhibitors (GGTIs) represent

38 ts farnesyltransferase inhibitors (FTIs) and geranylgeranyltransferase I inhibitors (GGTIs) upregulat

39 t known whether both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for

40 nt with tipifarnib suppressed FTase (but not geranylgeranyltransferase I) in bone marrow and peripher

41 re highly selective for FTase over GGTase I (geranylgeranyltransferase I).

42 Geranylgeranyltransferase-I (GGT-I) is a heterodimeric e

43 tein farnesyltransferase (FTase) and protein geranylgeranyltransferase-I (GGTase-I) catalyze the pren

44 Protein geranylgeranyltransferase-I (GGTase-I) catalyzes the tra

45 we demonstrate that in human tumor cells the geranylgeranyltransferase-I (GGTase-I) inhibitor GGTI-29

46 is post-translationally modified by protein geranylgeranyltransferase-I (GGTase-I).

47 d) over the related prenyltransferase enzyme geranylgeranyltransferase-I (GGTase-I).

48 d expression of the Rho-A prenylation enzyme geranylgeranyltransferase-I (GGTase-I).

49 selective farnesyltransferase (FTI-277) and geranylgeranyltransferase-I (GGTI-298) inhibitors.

50 Protein geranylgeranyltransferase-I (PGGT-I) and protein farnesy

51 mily of peptidomimetic inhibitors of protein geranylgeranyltransferase-I (PGGTase-I) are reported.

52 geranylgeranylation by the specific protein geranylgeranyltransferase-I inhibitor, GGTI-298, blocked

53 ween protein farnesyltransferase and protein geranylgeranyltransferase-I. plp mutants also have alter

54 ned the effect of insulin on the activity of geranylgeranyltransferase II (GGTase II) in 3T3-L1 fibro

55 ch delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face

56 All nascent Rab proteins are prenylated by geranylgeranyltransferase II, which recognizes the Rab s

57 e enzymes and in mutant mice hypomorphic for geranylgeranyltransferase II.

58 The geranylgeranyltransferase inhibitor GGTI-298, but not th

59 Lovastatin and a geranylgeranyltransferase inhibitor reduce the TGFbeta1-

60 Herein, we demonstrate that geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an

61 We studied the mechanisms by which geranylgeranyltransferase-mediated prenylation controls

62 induced by inhibitors of HMG-CoA reductase, geranylgeranyltransferase, or RhoA kinase was blocked by

63 The protein geranylgeranyltransferase Pggt1b is up-regulated in sing

64 n farnesyltransferase (PFTase) and a protein geranylgeranyltransferase (PGGTase-I) alkylate cysteines

65 uble-geranylgeranylated by heterodimeric Rab geranylgeranyltransferases (Rab-GGTs).

66 Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-alpha-like subunit th

67 ranylgeranyltransferase I (GGTase-I) and Rab geranylgeranyltransferase (RabGGTase) catalyze these mod

68 ab GTPases regulating vesicle traffic by Rab geranylgeranyltransferase (RabGGTase) requires a complex

69 In summary, Tempura functions as a new geranylgeranyltransferase that regulates the subcellular

70 witched to that of a closely related enzyme, geranylgeranyltransferase type I (GGTase I) by a single

71 tein farnesyltransferase (FTase) and protein geranylgeranyltransferase type I (GGTase I) catalyze the

72 tein farnesyltransferase (FTase) and protein geranylgeranyltransferase type I (GGTase I) catalyze the

73 Protein geranylgeranyltransferase type I (GGTase I) catalyzes th

74 Geranylgeranyltransferase type I (GGTase-I) inhibitors (

75 n) by protein farnesyltransferase (FTase) or geranylgeranyltransferase type I (GGTase-I) is essential

76 The activity of protein geranylgeranyltransferase type I (GGTase-I) is widely be

77 Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which norma

78 odify CAAX proteins: farnesyltransferase and geranylgeranyltransferase type I (GGTase-I).

79 tein farnesyltransferase (FTase) and protein geranylgeranyltransferase type I (GGTase-I).

80 odified by a closely related enzyme known as geranylgeranyltransferase type I (GGTase-I).

81 otein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I (GGTase-I).

82 oward FTase over the related enzyme, protein geranylgeranyltransferase type I (GGTase-I).

83 e, which encodes the beta-subunit of protein geranylgeranyltransferase type I (PGGT I).

84 Protein geranylgeranyltransferase type I (PGGTase-I) catalyzes t

85 However, protein geranylgeranyltransferase type I activity is required fo

86 sis, protein farnesyltransferase and protein geranylgeranyltransferase type I are not required for vi

87 Protein farnesyltransferase and protein geranylgeranyltransferase type I catalyze the transfer o

88 ablishment and the undifferentiated state of geranylgeranyltransferase type I mutant plants.

89 otein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I or II (GGTase-I and GGT

90 binding of the peptide substrate for protein geranylgeranyltransferase type I was very weak.

91 mice with T-cell-specific disruption of the geranylgeranyltransferase type I, beta subunit gene (Pgg

92 A closely related enzyme, protein geranylgeranyltransferase type I, carries out a similar

93 ha subunit shared by farnesyltransferase and geranylgeranyltransferase type I.

94 tein farnesyltransferase (FTase) and protein geranylgeranyltransferase type I.

95 ranslational modification of Rab proteins by geranylgeranyltransferase type II requires that they fir

96 tein farnesyltransferase (FTase) and protein geranylgeranyltransferase type II, which require both Zn

97 otein farnesyltransferase (FTase) or protein geranylgeranyltransferase type-I (GGTase-I) for proper f

98 Protein geranylgeranyltransferase type-I (GGTase-I), one of two

99 tein farnesyltransferase (FTase) and protein geranylgeranyltransferase type-I (GGTase-I).

100 Protein geranylgeranyltransferase type-I (PGGTase-I) catalyzes a

101 Yeast protein geranylgeranyltransferase type-II (PGGTase-II) catalyzes

102 ups to Rab proteins by the homologous enzyme geranylgeranyltransferase type-II.

103 ltransferase (FNTA), which is also shared by geranylgeranyltransferase, was isolated as a specific cy

104 Host farnesyltransferase and class I geranylgeranyltransferase were both involved in the lipi

105 Photoaffinity labeling of human protein geranylgeranyltransferase with (32)P-labeled forms of th